869335-69-3|4-Chloro-3-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridine| Ambeed

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Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate;tris-(dibenzylideneacetone)dipalladium(0); In tert-butyl alcohol;	Example 58A 3-Fluoro-N-(2-fluoro-4-nitrophenyl)-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine-4-amine A solution of 20 mg (0.06 mmol) of 4-chloro-3-fluoro-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine, 11.5 mg (0.074 mmol) of <strong>[369-35-7]2-fluoro-4-nitroaniline</strong>, 5.6 mg (0.006 mmol) of tris(dibenzylideneacetone)dipalladium, 5.8 mg (0.012 mmol) of dicyclohexyl(2',4',6'-triisopropyl-biphenyl-2-yl)phosphine and 12.7 mg (0.09 mmol) of potassium carbonate in 1.00 ml of degassed tert-butanol is stirred in a sealed pressure vessel at 100 C. for 3 h. After cooling to RT, the reaction mixture is filtered through kieselguhr, the kieselguhr is washed with ethyl acetate and the solvent is removed from the filtrate. The residue is purified by preparative HPLC. Yield: 21.5 mg (67% of theory) LC-MS (Method 1): Rt=2.56 min. MS (ESI pos.): m/z=445 (M+H)+.

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Prevention
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Response
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P378
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Storage
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P401
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Disposal
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Ghs Hazard Statements

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
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H226	Flammable liquid and vapour
H227	Combustible liquid
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H230	May react explosively even in the absence of air
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H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
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H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
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Health hazards
Code	Phrase
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H302	Harmful if swallowed
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H310	Fatal in contact with skin
H311	Toxic in contact with skin
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H316	Causes mild skin irritation
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H318	Causes serious eye damage
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H320	Causes eye irritation
H330	Fatal if inhaled
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H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

CAS No. :	869335-69-3	MDL No. :
Formula :	C₁₄H₁₀ClFN₂O₂S	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	324.76	Pubchem ID :	-
Synonyms :

Signal Word:		Class:
Precautionary Statements:		UN#:
Hazard Statements:		Packing Group:

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[ 869335-69-3 ] Synthesis Path-Downstream 1~2

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