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[ CAS No. 863971-56-6 ] {[proInfo.proName]}

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Chemical Structure| 863971-56-6
Chemical Structure| 863971-56-6
Structure of 863971-56-6 * Storage: {[proInfo.prStorage]}
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Product Details of [ 863971-56-6 ]

CAS No. :863971-56-6 MDL No. :
Formula : C68H103N11O16 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 1330.61 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 863971-56-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 863971-56-6 ]

[ 863971-56-6 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1269997-07-0 ]
  • [ 863971-56-6 ]
  • [ 1608127-16-7 ]
YieldReaction ConditionsOperation in experiment
33% With triethylamine In N,N-dimethyl-formamide 9.7 Example 9-7. Synthesis of DIBAC-vc-PABA-MMAF 41 (Schematically depicted in Scheme 11) DIBAC-amine 29, commercially available from ClickChemistryTools (430 mg, 1.50 mmol) was dissolved in DCM (15 mL) and treated with glutaric acid anhydride (213 mg, 1.87 mmol) and Et3N (647 μ., 4.67 mmol)_at rt. The reaction was stirred for 2h, followed by the addition of DSC (478 mg, 1.87 mmol). After another 2 h of stirring at rt, DCM (30 mL) was added and the reaction was washed with H20 (3 x 20 mL). The organic phase was dried over Na2S04and the solvent removed under reduced pressure. Flash chromatography (0: 100-2:98 EtOAc:MeOH) afforded the DIBAC-OSu ester (368 mg, 0.75 mmol, 48%).Next, to a solution of the DIBAC-OSu ester (1 mg, 0.003 mmol) in DMF (0.2 mL) was added vc-PABA-MMAF (2 mg, 0.002 mmol) and triethylamine (1 μ, 0.007 mmol). The solution was stirred overnight followed by concentration. Purification with HPLC (reversed phase, MeCN:H20 + 0.1% TFA) gave 41 (0.9 mg, 0.0006 mmol, 33%). LCMS analysis gave one peak with mass 1510.40 (expected for C8iHn3Ni20i6 = 1510.83).
  • 2
  • [ 863971-56-6 ]
  • [ 68528-80-3 ]
  • C70H107N11O18 [ No CAS ]
YieldReaction ConditionsOperation in experiment
29% With pyridine; at 20℃; for 3h; All Val-Cit-PAB-MMAF prepared from 67 mg of Fmoc-Val-Cit-PAB-MMAF, was suspended in pyridine (2 mL),and added to a solution of <strong>[68528-80-3]disuccinimidyl suberate</strong> (74 mg, 0.2 mmol, 4 eq.), in pyridine (1 mL). Reaction mixture wasstirred at room temperature. After 3 hrs ether (20 mL) was added. Precipitate was collected, washed with additionalamount of ether. Reddish solid was suspended in 30% MeOH/CH2Cl2, filtered trough a pad of silica gel with 30%MeOH/CH2Cl2 as an eluent. Compound 17 was obtained as white solid, 20 mg (29% yield). ES-MS m/z 1388.5 [M-H]-
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