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CAS No. : | 773873-72-6 | MDL No. : | MFCD06200977 |
Formula : | C8H5F3O2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | NBBPHMUHCCIOJQ-UHFFFAOYSA-N |
M.W : | 190.12 | Pubchem ID : | 2783211 |
Synonyms : |
|
Num. heavy atoms : | 13 |
Num. arom. heavy atoms : | 6 |
Fraction Csp3 : | 0.12 |
Num. rotatable bonds : | 2 |
Num. H-bond acceptors : | 5.0 |
Num. H-bond donors : | 0.0 |
Molar Refractivity : | 37.6 |
TPSA : | 26.3 Ų |
GI absorption : | High |
BBB permeant : | Yes |
P-gp substrate : | No |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -5.98 cm/s |
Log Po/w (iLOGP) : | 2.06 |
Log Po/w (XLOGP3) : | 2.08 |
Log Po/w (WLOGP) : | 3.15 |
Log Po/w (MLOGP) : | 3.21 |
Log Po/w (SILICOS-IT) : | 2.98 |
Consensus Log Po/w : | 2.7 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 1.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -2.54 |
Solubility : | 0.55 mg/ml ; 0.00289 mol/l |
Class : | Soluble |
Log S (Ali) : | -2.26 |
Solubility : | 1.04 mg/ml ; 0.00547 mol/l |
Class : | Soluble |
Log S (SILICOS-IT) : | -3.31 |
Solubility : | 0.0923 mg/ml ; 0.000485 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 1.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 1.54 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
712 mg | at 60℃; for 5 h; Cooling with ice | Methanol (20 mL)Was added thionyl chloride (0.61 mL)And the mixture was stirred for 5 minutes under ice cooling.3,4,5-trifluorobenzoic acid (1.00 g) was added under ice-cooling,After raising the temperature to 60 ° C., the mixture was stirred for 5 hours.After cooling to room temperature, it was concentrated under reduced pressure.The residue was purified by silica gel column chromatography (ethyl acetate / hexane) to give the title compound (712 mg) as a colorless oil. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium carbonate; In dimethyl sulfoxide; at 110℃; for 1h; | (1) A mixture of 150 mg of tert-butyl [(1R)-1-(1-naphthyl)ethyl][(4-phenylpiperidin-3-yl)methyl]carbamate, 96.2 mg of <strong>[773873-72-6]methyl 3,4,5-trifluorobenzoate</strong>, 93.3 mg of potassium carbonate, and 1.0 mL of DMSO was stirred at 110C for 1 hour. After cooling to room temperature, to the reaction mixture was added water, followed by extraction with ethyl acetate. The organic layer was washed with water and saturated brine in this order, and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (hexane-ethyl acetate) to obtain 127 mg of methyl 4-[3-({(tert-butoxycarbonyl)[(1R)-1-(1-naphthyl)ethyl]amino}methyl)-4-phenylpiperidin-1-yl]-3,5-difluorobenzoate as a colorless foamy substance. ESI+: 615 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium carbonate; In tetrahydrofuran; dimethyl sulfoxide; at 20 - 100℃; | (1) To a mixture of 116 mg of <strong>[773873-72-6]methyl 3,4,5-trifluorobenzoate</strong>, 113 mg of potassium carbonate, and 2.0 mL of DMSO was added 181 mg of a solution of tert-butyl [(1R)-1-(1-naphthyl)ethyl][(3-phenylpiperidin-4-yl)methyl]carbamate in 3.0 mL of THF at room temperature. It was stirred at 100C overnight, and then cooled. To the reaction mixture was added water, followed by extraction with ethyl acetate, and the organic layer was then washed with water and saturated brine in this order, and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure to obtain 248 mg of methyl 4-[4-({(tert-butoxycarbonyl)[(1R)-1-(1-naphthyl)ethyl]amino}methyl)-3-phenylpiperidin-1-yl]-3,5-difluorobenzoate as a crude product. FAB+: 615 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium carbonate; In tetrahydrofuran; dimethyl sulfoxide; at 100℃; | (1) A mixture of 191 mg of tert-butyl [4-(2-fluorophenyl)piperidin-3-yl]methyl}[(1R)-1-(1-naphthyl)ethyl]carbamate, 118 mg of <strong>[773873-72-6]methyl 3,4,5-trifluorobenzoate</strong>, 114 mg of potassium carbonate, and 2.0 mL of THF - 2.0 mL of DMSO was stirred at 100C overnight. After cooling, to the reaction mixture was added water, followed by extraction with ethyl acetate, and then drying over anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (hexane-ethyl acetate) to obtain 147 mg of methyl 4-[(3R,4S)-3-({(tert-butoxycarbonyl)[(1R)-1-(1-naphthyl)ethyl]amino}methyl)-4-(2-fluorophenyl)piperidin-1--yl] -3,5-difluorobenzoate as a colorless amorphous substance. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
3% | With methanol; sodium;Reflux; | General procedure: To 10 mL of absolute methanol was added 10 mmol of sodium and then 4-methylpiperazin-1-yl biguanidine x 2HCl (5 mmol) [19] and the appropriate carboxylic acid ester (5 mmol). The reaction mixture was refluxed for 15-30 h and 10 mL of water was added and stirred in the room temperature for 0.5 h. The precipitate was separated and crystallized from methanol. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
General procedure: 3-(2,6-Dichlorophenoxy)-1H-indazole (75.0 mg; 0.27 mmol; 1.00 eq.) and tetrahydrofuran (3.00 mL) were stirred at room temperature in a round bottom flask under nitrogen atmosphere. Sodium hydride 60% in mineral oil (21.5 mg; 0.54 mmol; 2.00 eq.) was added portion wise. After 15 minutes, methyl-6-chloro-nicotinic acid (92.2 mg; 0.54 mmol; 2.00 eq.) was added and the reaction mixture was stirred at 80 C for 16 hours. The reaction mixture was cooled and diluted with ethyl acetate (50 mL). The organic layer was washed with a saturated solution of NH4Cl (20 mL) and brine (20 mL). The organic layer was dried over MgSO4, filtered and concentrated. The residue, methanol (5.00 mL) were stirred in a round bottom flask. A 10 M solution of sodium hydroxyde (1.00 mL; 10.0 mmol; 37.2 eq.) was added and the reaction mixture was stirred at 50 C for 16 hours. The reaction mixture was cooled and diluted with ethyl acetate (20 mL) and water (10 mL). The pH of the aqueous layer was adjusted to 1 using a 3 M solution of hydrochloric acid. The aqueous layer was extracted with ethyl acetate (50 mL). The organic layers were dried over MgSO4, filtered and concentrated. The residue was purified using preparative LCMS.6-(3-(2,6-Dichlorophenoxy)-1H-indazol-1-yl)nicotinic acid was isolated as a beige solid (41.0 mg; 36.6%).1 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
712 mg | With thionyl chloride; at 60℃; for 5h;Cooling with ice; | Methanol (20 mL)Was added thionyl chloride (0.61 mL)And the mixture was stirred for 5 minutes under ice cooling.3,4,5-trifluorobenzoic acid (1.00 g) was added under ice-cooling,After raising the temperature to 60 C., the mixture was stirred for 5 hours.After cooling to room temperature, it was concentrated under reduced pressure.The residue was purified by silica gel column chromatography (ethyl acetate / hexane) to give the title compound (712 mg) as a colorless oil. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
301 mg | With caesium carbonate; In N,N-dimethyl-formamide; at 130℃; for 1h;Microwave irradiation; | The compound (330 mg) obtained in Example 74a,Indole (244 mg), cesium carbonate (848 mg),N, N-Dimethylformamide (5 mL)Was stirred at 130 C. under microwave irradiation for 1 hour.After cooling to room temperature, 1 N hydrochloric acid was added. After extraction with ethyl acetate, the organic layer was dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure.The residue was purified by silica gel column chromatography (ethyl acetate / hexane) to give the title compound (301 mg) as a white solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
149 mg | With potassium carbonate; In N,N-dimethyl-formamide; at 40℃;Inert atmosphere; | 4-Methyl-5-(pyridin-2-yl)-4H-1 ,2,4-triazole-3-thiol (157 mg, 1 eq), methyl 3,4,5- trifluorobenzoate (156 mg, eq) and potassium carbonate (261 mg, 2.3 eq) were suspended in 2 ml of DMF under an argon atmosphere. The resulting mixture was warmed to 40C and stirred overnight. The reaction mixture was diluted with 10 ml of ethyl acetate and 10 ml of water. The phases were separated and the aqueous layer was re-extracted with additional ethyl acetate (3x). The organic phases were combined and washed with brine (2x), dried over sodium sulphate, filtered and concentrated. The crude reaction was purified by flash chromatography (Grace Reveleris X2, hexane: ethyl acetate). 149 mg of clean product was obtained (Dudutiene et al., Bioorg. Med. Chem. (2013), 21(7), 2093-2106; International Patent Application WO03/062225). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Bu tert-Butyl malonate (1 1 .4g, 52.73 mmol, 2 equiv) was added dropwise to a suspension of NaH (1 .5 equiv) in 70 mL of anhydrous DMF. After 5 min of stirring at rt, methyl 3,4,5- trifluorobenzoate (5g, 26.3 mmol, 1 equiv) was added. The reaction mixture was stirred for 3h at rt (formation of a white precipitate was observed), diluted with water and extracted with EtOAc. After concentration, the residue was purified by column chromatography. 1 1 .0gof inseparable mixture of the product and tert-Butyl malonate in 1 :3 ratio (by NMR) was obtained. This mixture was used in the next step without further purification. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
tert-Butyl cyanoacetate (1 1 .4g, 52.73 mmol, 2 equiv) was added dropwise to a suspension of NaH (1.5 equiv) in 70 mL of anhydrous DMF. After 5 min of stirring at rt, <strong>[773873-72-6]methyl 3,4,5-trifluorobenzoate</strong> (5g, 26.3 mmol, 1 equiv) was added. The reaction mixture was stirred for 3h at rt, diluted with water and extracted with EtOAc. After concentration the residue was purified by column chromatography, then diluted in 20 mL of anhydrous DCE and treated with TFA (8.6 mL, 10 equiv) under reflux o/n. The solvent was evaporated, the residue was dissolved in DCM, washed with NaHC03 saturated solution, dried over Na2S04 and concentrated. The crude product was purified by column chromatography. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
59.79% | With potassium carbonate; In N,N-dimethyl-formamide; at 120℃; for 12h; | Methyl 3,4,5-trifluorobenzoate (500 mg, 2.63 mmol),Displaced three times with 4-bromophenol (500 mg, 2.89 mmol), potassium carbonate (1 g, 7.25 mmol) in DMF (5 mL).The reaction solution was heated to 120 C for 12 h. Cool to room temperature,It was then diluted with tert-butyl methyl ether (20 mL) and water (20 mL). Static layering,The organic phase was concentrated under reduced pressure to give the title compound as white solid.(650mg, 59.79%) |
59.79% | With potassium carbonate; In N,N-dimethyl-formamide; at 120℃; for 12h;Inert atmosphere; | [00207]. A mixture of <strong>[773873-72-6]methyl 3,4,5-trifluorobenzoate</strong> (500 mg, 2.63 mmol), 4-bromophenol (500 mg, 2.89 mmol), potassium carbonate(1 g, 7.25 mmol) and DMF (5 mL) was degassed with nitrogen 3 times and stirred at 120 C for 12 hours. The mixture was cooled to rt and diluted with tert-butyl methyl ether (20 mL) and water (20 mL). The reaction mixture was stood and layered, the organic layer was concentrated in vacuo to get the title compound as a white solid (650 mg, 59.79%). ?H N1VIR (400 1VIH4 DM50-c/6) 7.87- 7.80 (m, 2H), 7.60 - 7.53 (m, 2H), 7.08 - 7.00 (m, 2H?), 3.90 (s, 3H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
3.55 g | With potassium carbonate In dimethyl sulfoxide at 20℃; for 48h; | 7 Preparation of methyl 3 ,5 -difluoro-4- [3- [3 -[ [(methoxycarbonyl)amino]methyl] --4-methyl - phenyi] - 1 /7-pyrazoi · 1 -yijbenzoate (Compound 70) To a mixture of methyl iV-[[2-methyl-5-(l/f-pyrazol-3-yl)phenyl]methyl]carbamate (2.58 g, 10.5 mmol) (see PCT Patent Publication WO 2008124092 for a method of preparation) and methyl 3,4,5-trifluorobenzoate (2.41 g, 12.6 mmol) in dimethyl sulfoxide (10 mJL) was added potassium carbonate (4.35 g, 31.5 mmol). The reaction mixture was stirred at room temperature for 48 h and diluted with ethyl acetate. The resulting mixture was washed with saturated aqueous ammonium chloride solutioin (4x), dried over magnesium sulfate, filtered and concentrated under reduced pressure. The resulting material was purified by column chromatography (eluting with a gradient of 10 to 50% ethyl acetate in hexanes) to provide the title compound, a compound of the present invention, as a light pink solid (3.55 g) H NMR (CDC13): d 7.76 (d, 2H), 7.74 (m, 2H), 7.68 (d, 1H), 7.24 (d, 1H), 6.80 (d, 1H), 4.87 (hr s, 1H), 4.42 (d, 2H), 3.97 (s, 3H), 3.70 (s, 3H), 2.37 (s, 3H). |
3.55 g | With potassium carbonate In dimethyl sulfoxide at 20℃; for 48h; | 7 Preparation of methyl 3,5-difluoro-4-[3-[3-[[(methoxycarbonyl)amino]methyl]-4-methyl- phenyl]- 17/-pyrazol- l-yl]benzoate (Compound 70) To a mixture of methyl /V-[[2-methyl-5-(l//-pyrazol-3-yl)phenyl]methyl]carbamate (2.58 g, 10.5 mmol) (see PCT Patent Publication WO 2008124092 for a method of preparation) and methyl 3,4,5-trifluorobenzoate (2.41 g, 12.6 mmol) in dimethyl sulfoxide (10 mL) was added potassium carbonate (4.35 g, 31.5 mmol). The reaction mixture was stirred at room temperature for 48 h and diluted with ethyl acetate. The resulting mixture was washed with saturated aqueous ammonium chloride solution (4x), dried over magnesium sulfate, filtered and concentrated under reduced pressure. The resulting material was purified by column chromatography (eluting with a gradient of 10 to 50% ethyl acetate in hexanes) to provide the title compound, a compound of the present invention, as a light pink solid (3.55 g). H NMR (CDCI3): δ 7.76 (d, 2H), 7.74 (m, 2H), 7.68 (d, 1H), 7.24 (d, 1H), 6.80 (d, 1H), 4.87 (br s, 1H), 4.42 (d, 2H), 3.97 (s, 3H), 3.70 (s, 3H), 2.37 (s, 3H). |
3.55 g | With potassium carbonate In dimethyl sulfoxide at 20℃; for 48h; | 7 Preparation of methyl 3,5-difluoro-4-[3-[3-[[(methoxycarbonyl)amino]methyl]-4-methyl- phenyl]- 17/-pyrazol- l-yl]benzoate (Compound 70) To a mixture of methyl /V-[[2-methyl-5-(l//-pyrazol-3-yl)phenyl]methyl]carbamate (2.58 g, 10.5 mmol) (see PCT Patent Publication WO 2008124092 for a method of preparation) and methyl 3,4,5-trifluorobenzoate (2.41 g, 12.6 mmol) in dimethyl sulfoxide (10 mL) was added potassium carbonate (4.35 g, 31.5 mmol). The reaction mixture was stirred at room temperature for 48 h and diluted with ethyl acetate. The resulting mixture was washed with saturated aqueous ammonium chloride solution (4x), dried over magnesium sulfate, filtered and concentrated under reduced pressure. The resulting material was purified by column chromatography (eluting with a gradient of 10 to 50% ethyl acetate in hexanes) to provide the title compound, a compound of the present invention, as a light pink solid (3.55 g). H NMR (CDCI3): δ 7.76 (d, 2H), 7.74 (m, 2H), 7.68 (d, 1H), 7.24 (d, 1H), 6.80 (d, 1H), 4.87 (br s, 1H), 4.42 (d, 2H), 3.97 (s, 3H), 3.70 (s, 3H), 2.37 (s, 3H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: potassium carbonate / dimethyl sulfoxide / 48 h / 20 °C 2: sodium tetrahydroborate; methanol / 20 °C 3: Dess-Martin periodane / tetrahydrofuran / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: potassium carbonate / dimethyl sulfoxide / 48 h / 20 °C 2: sodium tetrahydroborate; methanol / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1: potassium carbonate / dimethyl sulfoxide / 48 h / 20 °C 2: sodium tetrahydroborate; methanol / 20 °C 3: Dess-Martin periodane / tetrahydrofuran / 20 °C 4: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 0 - 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
56.2% | With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 130℃; for 12h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 12 h / 130 °C 2: lithium hydroxide monohydrate / ethanol / 12 h / 90 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 12 h / 130 °C 2: lithium hydroxide monohydrate / ethanol / 12 h / 90 °C 3: N-ethyl-N,N-diisopropylamine; O-(7-azabenzotriazol-1-yl)-n,n,n',n'-tetramethyluronium hexafluoro-phosphate / N,N-dimethyl-formamide / 12 h / 0 - 25 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 12 h / 130 °C 2: lithium hydroxide monohydrate / ethanol / 12 h / 90 °C 3: N-ethyl-N,N-diisopropylamine; O-(7-azabenzotriazol-1-yl)-n,n,n',n'-tetramethyluronium hexafluoro-phosphate / N,N-dimethyl-formamide / 12 h / 0 - 25 °C 4: trichlorophosphate / toluene / 1 h / 140 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 5 steps 1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 12 h / 130 °C 2: lithium hydroxide monohydrate / ethanol / 12 h / 90 °C 3: N-ethyl-N,N-diisopropylamine; O-(7-azabenzotriazol-1-yl)-n,n,n',n'-tetramethyluronium hexafluoro-phosphate / N,N-dimethyl-formamide / 12 h / 0 - 25 °C 4: trichlorophosphate / toluene / 1 h / 140 °C 5: sodium tetrahydridoborate; methanol / 0.5 h / 25 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 6 steps 1.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 12 h / 130 °C 2.1: lithium hydroxide monohydrate / ethanol / 12 h / 90 °C 3.1: N-ethyl-N,N-diisopropylamine; O-(7-azabenzotriazol-1-yl)-n,n,n',n'-tetramethyluronium hexafluoro-phosphate / N,N-dimethyl-formamide / 12 h / 0 - 25 °C 4.1: trichlorophosphate / toluene / 1 h / 140 °C 5.1: sodium tetrahydridoborate; methanol / 0.5 h / 25 °C 6.1: 2-chloro-1-methyl-pyridinium iodide / dichloromethane / 0.5 h / 25 °C 6.2: 1 h / 0 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 7 steps 1.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 12 h / 130 °C 2.1: lithium hydroxide monohydrate / ethanol / 12 h / 90 °C 3.1: N-ethyl-N,N-diisopropylamine; O-(7-azabenzotriazol-1-yl)-n,n,n',n'-tetramethyluronium hexafluoro-phosphate / N,N-dimethyl-formamide / 12 h / 0 - 25 °C 4.1: trichlorophosphate / toluene / 1 h / 140 °C 5.1: sodium tetrahydridoborate; methanol / 0.5 h / 25 °C 6.1: 2-chloro-1-methyl-pyridinium iodide / dichloromethane / 0.5 h / 25 °C 6.2: 1 h / 0 °C 7.1: N,N,N-tributylbutan-1-aminium fluoride / tetrahydrofuran / 0.5 h / -78 °C |
Tags: 773873-72-6 synthesis path| 773873-72-6 SDS| 773873-72-6 COA| 773873-72-6 purity| 773873-72-6 application| 773873-72-6 NMR| 773873-72-6 COA| 773873-72-6 structure
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P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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