[ CAS No. 75460-28-5 ] {[proInfo.proName]}

Name: 75460-28-5|18-Bromo-2,3,5,6,8,9,11,12,14,15-decahydrobenzo[b][1,4,7,10,13,16]hexaoxacyclooctadecine|98%
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SKU: A208286
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Quality Control of [ 75460-28-5 ]

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Product Details of [ 75460-28-5 ]

CAS No. :	75460-28-5	MDL No. :	MFCD00143200
Formula :	C₁₆H₂₃BrO₆	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	XHHZIFBFFGIFNI-UHFFFAOYSA-N
M.W :	391.00	Pubchem ID :	2734267
Synonyms :

Safety of [ 75460-28-5 ]

Signal Word:	Warning	Class:
Precautionary Statements:	P261-P305+P351+P338	UN#:
Hazard Statements:	H302-H315-H319-H335	Packing Group:
GHS Pictogram:

Application In Synthesis of [ 75460-28-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 75460-28-5 ]

[ 75460-28-5 ] Synthesis Path-Downstream 1~24

1
[ 14098-24-9 ]
[ 75460-28-5 ]

Reference： [1]Chemistry Letters,1986,p. 1467 - 1470
[2]Journal of Organometallic Chemistry,1988,vol. 346,p. 267 - 276

2
[ 75460-28-5 ]
[ 1079-66-9 ]
[ 107163-52-0 ]

Yield	Reaction Conditions	Operation in experiment
76%	With n-butyllithium In tetrahydrofuran 1.) -90- -95 deg C; 2.) from -90 deg C to RT, 4 h;
66%	With n-butyllithium; ammonium chloride; triethylamine In tetrahydrofuran at -90 - 20℃; for 4h;

Reference： [1]Okano, Tamon; Iwahara, Masahiro; Suzuki, Takayoshi; Konishi, Hisatoshi; Kiji, Jitsuo [Chemistry Letters, 1986, p. 1467 - 1470]
[2]Okano, Tamon; Iwahara, Masahiro; Konishi, Hisatoshi; Kiji, Jitsuo [Journal of Organometallic Chemistry, 1988, vol. 346, p. 267 - 276]

3
[ 75460-28-5 ]
[ 60835-74-7 ]
[ 14098-24-9 ]

Reference： [1]Russian Chemical Bulletin,1995,vol. 44,p. 116 - 123
Izvestiya Akademi Nauk, Seriya Khimicheskaya,1995,p. 121 - 128

4
[ 75460-28-5 ]
[ 68-12-2 ]
[ 60835-74-7 ]
[ 14098-24-9 ]

Reference： [1]Russian Chemical Bulletin,1995,vol. 44,p. 116 - 123
Izvestiya Akademi Nauk, Seriya Khimicheskaya,1995,p. 121 - 128

5
[ 75460-28-5 ]
[ 81833-15-0 ]
[ 306773-14-8 ]

Yield	Reaction Conditions	Operation in experiment
71%	With piperidine; copper(l) iodide; triphenylphosphine at 80℃; for 2h;

Reference： [1]Xia, Wen-Sheng; Schmehl, Russell H.; Li, Chao-Jun [Tetrahedron, 2000, vol. 56, # 36, p. 7045 - 7049]

6
[ 89343-06-6 ]
[ 75460-28-5 ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
83%	With copper(l) iodide; triethylamine at 80℃;
	With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 80℃;	5 The acetylene-containing crown ether represented by the chemical formula 15 was synthesized as follow.[0118] First, tri(isopropyl )silylacetylene was reacted with commercially available 4’-brombenzo-18-crown 6-ether inthe presence of PdCl2(PPh3)2, copper iodide, and triethylamine at a reaction temperature of 80°C. Next, tetra butylammonium fluoride was reacted to the reactant for desilylation and the synthesis was thereby feasible.[0119] The crown ether containing intramolecularly triazapentalenes represented by the chemical formula 16 was

Reference： [1]Pan, Yongchun; Lu, Meng; Peng, Zhonghua; Melinger, Joseph S [Organic and biomolecular chemistry, 2003, vol. 1, # 24, p. 4465 - 4470]
[2]Current Patent Assignee: HOKKAIDO UNIVERSITY - EP2684881, 2014, A1 Location in patent: Paragraph 0117; 0018

7
[ 98437-23-1 ]
[ 75460-28-5 ]
[ 854520-15-3 ]

Yield	Reaction Conditions	Operation in experiment
73%	With sodium carbonate In tetrahydrofuran; toluene at 80℃;

Reference： [1]Kotha, Sambasivarao; Kashinath, Dhurke [Synthesis, 2005, # 6, p. 971 - 976]

8
[ 5720-05-8 ]
[ 75460-28-5 ]
[ 854520-09-5 ]

Yield	Reaction Conditions	Operation in experiment
76%	With sodium carbonate In tetrahydrofuran; toluene at 80℃;

Reference： [1]Kotha, Sambasivarao; Kashinath, Dhurke [Synthesis, 2005, # 6, p. 971 - 976]

9
[ 5720-07-0 ]
[ 75460-28-5 ]
[ 854520-10-8 ]

Yield	Reaction Conditions	Operation in experiment
76%	With sodium carbonate In tetrahydrofuran; toluene at 80℃;

Reference： [1]Kotha, Sambasivarao; Kashinath, Dhurke [Synthesis, 2005, # 6, p. 971 - 976]

10
[ 5122-94-1 ]
[ 75460-28-5 ]
[ 854520-14-2 ]

Yield	Reaction Conditions	Operation in experiment
65%	With sodium carbonate In tetrahydrofuran; toluene at 80℃;

Reference： [1]Kotha, Sambasivarao; Kashinath, Dhurke [Synthesis, 2005, # 6, p. 971 - 976]

11
[ 87199-17-5 ]
[ 75460-28-5 ]
[ 854520-11-9 ]

Yield	Reaction Conditions	Operation in experiment
77%	With sodium carbonate In tetrahydrofuran; toluene at 80℃;
91 %	With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate In 1,2-dimethoxyethane; water at 80℃; Inert atmosphere;	3.2. Synthesis of Formyl Crown Ethers 1c-e by Suzuki Coupling General procedure: General method for Suzuki coupling: In a round bottom flask under nitrogen atmosphere,40-bromobenzo-18-crown-6 ether (150 mg, 0.38 mmol) was dissolved in a mixtureof 1,2-dimethoxyethane (6 mL) and deionized water (2 mL) at room temperature andboronic acid (0.46 mmol), tetrakis(triphenylphosphine)palladium(0) (27 mg, 0.023 mmol),and potassium carbonate (315 mg, 2.28 mmol) were added. The mixture was heated at80 C for about 24 h until the disappearance of the halide (checked by TLC). After coolingto room temperature, the mixture was transferred to an extraction funnel and saturatedNaCl solution (10 mL) was added, followed by extraction with ethyl acetate (3 15 mL).The organic extracts were combined and washed with water (20 mL) and 10% aqueousNaOH (20 mL). The organic extract was dried over anhydrous magnesium sulfate, filtered,and evaporated to dryness. The crude extract was purified by column chromatographyon silica gel using dichloromethane and mixtures of increasing polarity with methanol(up to DCM/MeOH, 9:1) as the eluent. The fractions containing the pure compound werecombined and evaporated to dryness. 3.2.1. Phenylbenzocrown 1cStarting from 4-formylphenylboronic acid (69 mg, 0.46 mmol), phenylbenzocrown1c was obtained as a light brown oil (143 mg, 91%). 1H NMR (400 MHz, CDCl3): 3.63-3.77 (m, 10H, 5 CH2 ) , 3.87-3.90 (m, 2H, CH2), 3.93-3.95 (m, 2H, CH2),4.09-4.11 (m, 2H, CH2), 4.19-4.24 (m, 4H, 2 CH2), 6.93 (d, J 8.0 Hz, 1H, H60), 7.13 (d,J 2.0 Hz, 1H, H30), 7.18 (dd, J 8.2 and 2.0 Hz, 1H, H50), 7.67 (d, J 8.2 Hz, 2H, H3 and H5),7.89 (d, J 8.2 Hz, 2H, H2 and H6), 10.00 (s, 1H, CHO) ppm. 13C NMR (100.6 MHz, CDCl3): 68.65 (CH2), 68.77 (CH2), 68.83 (CH2), 68.92 (CH2), 69.16 (CH2), 69.26 (CH2), 69.30 (CH2),69.36 (CH2), 70.47 (CH2), 70.54 (CH2), 112.84 (C30), 113.62 (C60), 120.35 (C50), 127.05 (C3and C5), 130.14 (C2 and C6), 132.65 (C40), 134.65 (C1), 146.72 (C4), 148.95 (C10), 149.44 (C20),191.76 (CHO) ppm. FTIR (neat): 2916, 1659, 1630, 1594, 1456, 1347, 1253, 1123, 958, 867,799 cm1. MS (ESI) m/z (%): 417 (M++1, 62), 416 (M+, 45).

Reference： [1]Kotha, Sambasivarao; Kashinath, Dhurke [Synthesis, 2005, # 6, p. 971 - 976]
[2]Batista, Patrícia M. R.; Martins, Cátia D. F.; Raposo, M. Manuela M.; Costa, Susana P. G. [Molecules, 2023, vol. 28, # 8]

12
[ 14047-29-1 ]
[ 75460-28-5 ]
[ 854520-13-1 ]

Yield	Reaction Conditions	Operation in experiment
39%	With sodium carbonate In tetrahydrofuran; toluene at 80℃;

Reference： [1]Kotha, Sambasivarao; Kashinath, Dhurke [Synthesis, 2005, # 6, p. 971 - 976]

13
[ 75460-28-5 ]
[ 149104-90-5 ]
[ 854520-12-0 ]

Yield	Reaction Conditions	Operation in experiment
62%	With sodium carbonate In tetrahydrofuran; toluene at 80℃;

Reference： [1]Kotha, Sambasivarao; Kashinath, Dhurke [Synthesis, 2005, # 6, p. 971 - 976]

14
[ 676-83-5 ]
[ 75460-28-5 ]
[ 865700-06-7 ]

Yield	Reaction Conditions	Operation in experiment
65%	Stage #1: 18-bromo-2,3,5,6,8,9,11,12,14,15-decahydrobenzo[b][1,4,7,10,13,16]Hexaoxacyclotetradecene With n-butyllithium In tetrahydrofuran; hexane at -95 - -92℃; for 1.5h; Stage #2: methyldichlorophosphane In tetrahydrofuran; hexane at -90 - 20℃;

Reference： [1]Fresneda, Jorge; De Jesús, Ernesto; Gómez-Sal, Pilar; Mardomingo, Carmen López [European Journal of Inorganic Chemistry, 2005, vol. 8, p. 1468 - 1476]

15
[ 75460-28-5 ]
[ 644-97-3 ]
[ 865700-07-8 ]

Yield	Reaction Conditions	Operation in experiment
83%	Stage #1: 18-bromo-2,3,5,6,8,9,11,12,14,15-decahydrobenzo[b][1,4,7,10,13,16]Hexaoxacyclotetradecene With n-butyllithium In tetrahydrofuran; hexane at -95 - -92℃; for 1.5h; Stage #2: Dichlorophenylphosphine In tetrahydrofuran; hexane at -90 - 20℃;

Reference： [1]Fresneda, Jorge; De Jesús, Ernesto; Gómez-Sal, Pilar; Mardomingo, Carmen López [European Journal of Inorganic Chemistry, 2005, vol. 8, p. 1468 - 1476]

16
[ 75460-28-5 ]
[ 766-97-2 ]
[ 879874-11-0 ]

Yield	Reaction Conditions	Operation in experiment
60%	With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide In various solvent(s) at 80℃; for 12h;

Reference： [1]Hennrich, Gunther; Rurack, Knut; Spieles, Monika [European Journal of Organic Chemistry, 2006, # 2, p. 516 - 521]

17
[ 75460-28-5 ]
[ 100-01-6 ]
[ 2095155-24-9 ]

Yield	Reaction Conditions	Operation in experiment
90%	With copper(l) iodide; caesium carbonate; <i>L</i>-proline In N,N-dimethyl-formamide at 130℃; for 168h; Inert atmosphere;

Reference： [1]Schneider, Susanne; Licsandru, Erol-Dan; Kocsis, Istvan; Gilles, Arnaud; Dumitru, Florina; Moulin, Emilie; Tan, Junjun; Lehn, Jean-Marie; Giuseppone, Nicolas; Barboiu, Mihail [Journal of the American Chemical Society, 2017, vol. 139, # 10, p. 3721 - 3727]

18
[ 2257422-15-2 ]
[ 75460-28-5 ]
[ 2257422-16-3 ]

Yield	Reaction Conditions	Operation in experiment
222 mg	With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate In 1,2-dimethoxyethane; water at 90℃; for 8h; Inert atmosphere;	1-[(3,4-benzo-18-crown-6-ether-1-yl)]-1'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ferrocene 1,1'-ferrocene diboronic acid 275 mg (1.01 mmol) and pinacol 121 mg (1.00 mmol) were dissolved in a mixed solvent of 2.24 mL of 3 M cesium carbonate aqueous solution and 6.72 mL of 1,2-dimethoxyethane (DME) and stirred for 20 minutes under nitrogen. Then 4-bromobenzo-18-crown-6-ether 400 mg (1.02 mmol) and [1,1'-bis(diphenylphosphino)ferrocene] dichloropalladium (II) 122 mg (167 mmol) were added and the solution refluxed at 90 °C for 8 hours. Completion of the reaction was indicated by thin layer chromatography (TLC) (silica gel; chloroform: methanol = 9: 1), with the appearance of a new spot (Rf = 0.6). After cooling to room temperature, the reaction solution was added to ice-water. After extraction with ethyl acetate (3 x 30 mL), the obtained organic layer was neutralized with 100 mL of ammonium chloride aqueous solution adjusted to pH 6, then washed with 100 mL of saturated sodium chloride aqueous solution and then 100 mL of distilled water. Anhydrous sodium sulfate was then added to the organic layer, the mixture filtered and the solvent removed under reduced pressure. The crude product was purified by silica gel column chromatography (gradient: chloroform only to chloroform:methanol = 98:2) to obtain a brown viscous solid (222 mg, yield 38%). 1H NMR (400 MHz, CD3CN) δ 1.33 (s, 12H, protecting group), 3.56-4.25 (m, 20H, crown ether), 4.10 (t, 2H, ferrocenyl-H), 4.24 (t, 4H, ferrocenyl-H), 4.58 (t, 2 H, ferrocenyl-H), 6.85 (d, J=8.5Hz, 1H, ph-H), 7.03 (dd, J=8.5 Hz, J=1.8 Hz, 1H, ph-H), 7.13 (d, J=1.8 Hz, 1H, ph-H). 13C NMR (100 MHz, CDCl3) δ 25.04 (protecting group), 66.82 (ferrocenyl-C), 69.11(ferrocenyl-C), 69.38-70.85 (10 carbon signals), 70.99 (ferrocenyl-C), 70.91 (ferrocenyl-C), 74.17 (ferrocenyl-C), 75.29 (ferrocenyl-C), 83.26 (protecting group), 113.30 (ph-C), 114.43 (ph-C), 119.49 (ph-C), 132.07 (ph-C), 147.79 (ph-C), 148.9 (ph-C). ESI-Mass (CH3CN, m/z), calculated for C32H43BFeO8Na [=M+Na+]: 645.22981; found: 645.22667.

Reference： [1]Miyaji, Hidekazu; Komada, Haruka; Goto, Keisuke; Fujimoto, Junko; Kiriyama, Naoaki; Tucker, James H.R. [Tetrahedron Letters, 2018, vol. 59, # 43, p. 3853 - 3857]

19
[ 75460-28-5 ]
[ 121207-31-6 ]
C₃₀H₃₉BF₂N₂O₆ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
37%	With palladium diacetate; potassium carbonate; triphenylphosphine; In 1,4-dioxane; at 100℃; for 15h;Sealed tube; Inert atmosphere;	1. Add 8-methyl BODIPY (0.2 mmol, 54 mg) to a 15 ml sealed bottle.with18-Bromo-2,3,5,6,8,9,11,12,14,15-decahydrobenzo[b][1,4,7,10,13,16]Hexaoxacyclotetradecene (0.24 mmol, 94 mg),Fix the sealed bottle to the thermostat mixer,Add 2ml 1,4-dioxane(about 20mmol, 1730mg),Then put a suitable magnetic stirrer in the bottle, and the tube of the argon bottle is connected to a needle.The needle is immersed, the argon valve is opened to blast the argon gas, and the dissolved oxygen and water in the solution are discharged. After 15 minutes, the argon gas is stopped and the needle is removed.Connect the argon cylinder from the side interface and purge with argon for 15 min.Subsequently, Pd(OAc) 2 (0.01 mmol, the molar ratio to the raw material BODIPY is 1:20),PPh3 (0.02 mmol) and K2CO3 (0.2 mmol). then,The mixture was stirred with heating (300 rpm) at 100 C for 15 hours.2. Next, the crude mixture is poured into CH2Cl2 (80-120 ml) to quench the reaction.It was washed three times with water (100 ml), dried over MgSO 4 and filtered.Evaporate to dryness on a rotary evaporator.Obtained by column chromatography [silica; heptane/dichloromethane; 1:2 (v/v)]It was an orange solid (41.7 mg, 37%).

Reference： [1]Patent: CN109912635,2019,A .Location in patent: Paragraph 0026-0032; 0049-0079

20
[ 75460-28-5 ]
[ 73183-34-3 ]
[ 2363048-23-9 ]

Yield	Reaction Conditions	Operation in experiment
61%	With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In N,N-dimethyl-formamide at 80℃; for 12h; Inert atmosphere;
61%	With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In N,N-dimethyl-formamide at 80℃; for 3h; Inert atmosphere;	1 Synthesis of compound 4 Add 3 (400mg, 1.03mmol) to a 50mL two-necked bottle in turn, bis(pinacolato)diboron (313mg, 1.23mmol), PdCl2(dppf) (75mg, 0.103mmol, 10%), KOAc (221mg, 2.25mmol, 3eq.), pump and ventilate three times under the protection of Ar gas, add anhydrous DMF (freeze deoxygenation) (20 mL), heat to 80°C, react for 3 hours, and stop the reaction. After cooling to room temperature, CH2Cl2 extraction (50mL×3), combine the organic phases, wash with distilled water (50mL×3), dry the organic phase with anhydrous magnesium sulfate, filter to remove magnesium sulfate, the solvent was removed by rotary evaporation, and the residue was purified with a silica gel chromatography column (eluent: dichloromethane: methanol = 20:1) to obtain a light yellow oil: 200.41 mg, with a yield of 61%.
	Stage #1: 18-bromo-2,3,5,6,8,9,11,12,14,15-decahydrobenzo[b][1,4,7,10,13,16]Hexaoxacyclotetradecene With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium acetate; barium carbonate In toluene for 0.0833333h; Schlenk technique; Inert atmosphere; Stage #2: bis(pinacol)diborane In toluene at 100℃; for 15h; Schlenk technique; Inert atmosphere; Sealed tube;

Reference： [1]Zeng, Wang; Zhang, Wei; Li, Xianying; Jin, Wusong; Zhang, Dengqing [Chemistry - A European Journal, 2019, vol. 25, # 72, p. 16692 - 16698]
[2]Current Patent Assignee: DONGHUA UNIVERSITY - CN109456301, 2021, B Location in patent: Paragraph 0037-0040
[3]Capocasa, Giorgio; Di Berto Mancini, Marika; Di Stefano, Stefano; Frateloreto, Federico; Lanzalunga, Osvaldo; Olivo, Giorgio [European Journal of Organic Chemistry, 2020]

21
[ 75460-28-5 ]
[ 14098-24-9 ]

Reference： [1]Advanced Synthesis and Catalysis,2020,vol. 362,p. 166 - 176

22
[ 1332748-00-1 ]
[ 75460-28-5 ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
80%	With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate In ethanol; water; toluene at 80℃; for 48h; Inert atmosphere;

Reference： [1]Fathalla, Maher [Journal of Porphyrins and Phthalocyanines, 2021, vol. 25, # 2, p. 95 - 101]

23
[ 75460-28-5 ]
[ 4347-33-5 ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
93 %	With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate In 1,2-dimethoxyethane; water at 80℃; Inert atmosphere;	3.2. Synthesis of Formyl Crown Ethers 1c-e by Suzuki Coupling General procedure: General method for Suzuki coupling: In a round bottom flask under nitrogen atmosphere,40-bromobenzo-18-crown-6 ether (150 mg, 0.38 mmol) was dissolved in a mixtureof 1,2-dimethoxyethane (6 mL) and deionized water (2 mL) at room temperature andboronic acid (0.46 mmol), tetrakis(triphenylphosphine)palladium(0) (27 mg, 0.023 mmol),and potassium carbonate (315 mg, 2.28 mmol) were added. The mixture was heated at80 C for about 24 h until the disappearance of the halide (checked by TLC). After coolingto room temperature, the mixture was transferred to an extraction funnel and saturatedNaCl solution (10 mL) was added, followed by extraction with ethyl acetate (3 15 mL).The organic extracts were combined and washed with water (20 mL) and 10% aqueousNaOH (20 mL). The organic extract was dried over anhydrous magnesium sulfate, filtered,and evaporated to dryness. The crude extract was purified by column chromatographyon silica gel using dichloromethane and mixtures of increasing polarity with methanol(up to DCM/MeOH, 9:1) as the eluent. The fractions containing the pure compound werecombined and evaporated to dryness.

Reference： [1]Batista, Patrícia M. R.; Martins, Cátia D. F.; Raposo, M. Manuela M.; Costa, Susana P. G. [Molecules, 2023, vol. 28, # 8]

24
[ 27329-70-0 ]
[ 75460-28-5 ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
90 %	With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate In 1,2-dimethoxyethane; water at 80℃; Inert atmosphere;	3.2. Synthesis of Formyl Crown Ethers 1c-e by Suzuki Coupling General procedure: General method for Suzuki coupling: In a round bottom flask under nitrogen atmosphere,40-bromobenzo-18-crown-6 ether (150 mg, 0.38 mmol) was dissolved in a mixtureof 1,2-dimethoxyethane (6 mL) and deionized water (2 mL) at room temperature andboronic acid (0.46 mmol), tetrakis(triphenylphosphine)palladium(0) (27 mg, 0.023 mmol),and potassium carbonate (315 mg, 2.28 mmol) were added. The mixture was heated at80 C for about 24 h until the disappearance of the halide (checked by TLC). After coolingto room temperature, the mixture was transferred to an extraction funnel and saturatedNaCl solution (10 mL) was added, followed by extraction with ethyl acetate (3 15 mL).The organic extracts were combined and washed with water (20 mL) and 10% aqueousNaOH (20 mL). The organic extract was dried over anhydrous magnesium sulfate, filtered,and evaporated to dryness. The crude extract was purified by column chromatographyon silica gel using dichloromethane and mixtures of increasing polarity with methanol(up to DCM/MeOH, 9:1) as the eluent. The fractions containing the pure compound werecombined and evaporated to dryness.

Reference： [1]Batista, Patrícia M. R.; Martins, Cátia D. F.; Raposo, M. Manuela M.; Costa, Susana P. G. [Molecules, 2023, vol. 28, # 8]

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P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 75460-28-5 ] {[proInfo.proName]}

Quality Control of [ 75460-28-5 ]

Related Doc. of [ 75460-28-5 ]

Product Details of [ 75460-28-5 ]

Safety of [ 75460-28-5 ]

Application In Synthesis of [ 75460-28-5 ]

[ 75460-28-5 ] Synthesis Path-Downstream 1~24

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry