Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 7292-73-1 | MDL No. : | MFCD00066444 |
Formula : | C8H8FNO2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | JKFYKCYQEWQPTM-UHFFFAOYSA-N |
M.W : | 169.15 | Pubchem ID : | 98313 |
Synonyms : |
|
Num. heavy atoms : | 12 |
Num. arom. heavy atoms : | 6 |
Fraction Csp3 : | 0.12 |
Num. rotatable bonds : | 2 |
Num. H-bond acceptors : | 4.0 |
Num. H-bond donors : | 2.0 |
Molar Refractivity : | 40.65 |
TPSA : | 63.32 Ų |
GI absorption : | High |
BBB permeant : | Yes |
P-gp substrate : | No |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -8.47 cm/s |
Log Po/w (iLOGP) : | 1.1 |
Log Po/w (XLOGP3) : | -1.6 |
Log Po/w (WLOGP) : | 1.01 |
Log Po/w (MLOGP) : | -1.0 |
Log Po/w (SILICOS-IT) : | 0.95 |
Consensus Log Po/w : | 0.09 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 1.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -0.12 |
Solubility : | 129.0 mg/ml ; 0.761 mol/l |
Class : | Very soluble |
Log S (Ali) : | 0.78 |
Solubility : | 1020.0 mg/ml ; 6.02 mol/l |
Class : | Highly soluble |
Log S (SILICOS-IT) : | -1.73 |
Solubility : | 3.13 mg/ml ; 0.0185 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 0.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 1.7 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P264-P270-P301+P312-P330 | UN#: | N/A |
Hazard Statements: | H302-H315-H320-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
94.5% | Rac-1 (0.4?mol, 67.61?g) was dissolved in 4.0?M sodium hydroxide (500?mL) at ambient temperature with stirring for 20?min. Phenylacetyl chloride was added dropwise while the mixture was vigorously stirred at 0?C. After 10?h, the reaction mixture was extracted using dichloromethane to remove small amount of phenylacetic acid. Subsequently, the aqueous layer was acidified to pH 2.0 with hydrochloric acid (6.0?M). The precipitate was filtered, washed with ultrapure water three times. The filtered precipitate dried at 70?C for 12?h to afford the product 2. Yield: 94.5%, 108.54?g white powder. 1H NMR (500?MHz, D2O) delta 7.30 (dd, J?=?7.2, 4.5?Hz, 2H), 7.10 - 7.00 (m, 2H), 4.28 (s, 1H); 13C NMR (126?MHz, D2O) delta 181.00 (s), 162.87 (s), 160.94 (s), 138.15 (s), 128.61 (d, J?=?8.4?Hz), 115.47 (s), 115.30 (s), 59.86 (s); MS (ESI): m/z?=?285.7 [M?+?H]+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
87% | In tetrahydrofuran; | Step A: To a solution of 2-amino-2-(4-fluorophenyl)acetic acid (5 g, 29.5 mmol) in THF (50 mL) at 50 C. was added triphosgene (8.77 g, 29.5 mmol), then heating was continued for 3 h. The reaction mixture was then filtered and evaporated to a volume of about 10 mL, followed by addition of 150 mL of hexanes. The mixture was heated slightly, and then cooled to -20 C. for 1 hr. The crude slurry was filtered to give 4-(4-fluorophenyl)oxazolidine-2,5-dione (5.03 g, 87%) which was used without further purification. |
87% | In tetrahydrofuran; hexane; at -20 - 50℃; for 4h; | Example 6Preparation of (R,S)- 2-(Amino(4-fluorophenyl)methyl)-N-(5-methyl-lH-pyrazol-3-yl)quinolin-4-amine[00237] Step A: To a solution of 2-amino-2-(4-fluorophenyl)acetic acid (5 g, 29.5 mmol) in THF (50 mL) at 50 C was added triphosgene (8.77 g, 29.5 mmol), then heating was continued for 3 h. The reaction mixture was then filtered and evaporated to a volume of aboutlO mL, followed by addition of 150 mL of hexanes. The mixture was heated slightly, and then cooled to -20 C for 1 h. The crude slurry was filtered to give 4-(4-fluorophenyl)oxazolidine-2,5-dione (5.03 g, 87%) which was used without further purification. |
In tetrahydrofuran; at 50℃;Heating; | 00287] Step A: To a solution of 2-amino-2-(4-fluorophenyl)acetic acid (5 g, 29.5 mmol) in THF (50 mL) at 50 0C was added triphosgene (8.77 g, 29.5 mmol), then heating was continued for 3 h. The reaction mixture was then filtered and evaporated to a volume of aboutlO mL, followed by addition of 150 mL of hexanes. The mixture was heated slightly, and then cooled to -20 0C for 1 h. The crude slurry was filtered to give 4-(4-fluorophenyl)oxazolidine-2,5-dione (5.03 g, 87%) which was used without further purification. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With sodium hydroxide; In water; at 20℃; for 12h; | 4-Fluoro-phenyl glycine 1 (20 mg, 0.12 mmol) was dissolved in H2O (1 mL) containing equimolar amounts of NaOH (5 mg, 0.12 mmol). The solution was cooled to 0 C., then m-toluoyl chloride (16 muL, 0.12 mmol) was added dropwise under vigorous stirring. The mixture was allowed to warm to room temperature and stirred for approx. 12 h. After acidification with 1 M HCl (1 mL), the product was extracted from the reaction mixture with DCM (4 mL). The organic layer was separated and the solvent was removed in vacuo to yield (4-Fluoro-phenyl)-(3-methyl-benzoylamino)-acetic acid 2 (34 mg, 0.12 mmol, quant.) as a white solid: 1H-NMR (400 MHz, CD3OD) delta=7.67-7.08 (m, 8H), 5.66 (s, 1H), 2.38 (s, 3H). MS calcd. for C16H15FNO3 (M+H+) 288.10, found 288.4 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In N,N-dimethyl-formamide; at 20℃; | EXAMPLE 10; N-[4-(l-methyl-4,5-dihydro-lH-imidazol-2-yl)phenyl]-2-(4-fluorophenyl)-2-(4- chlorophenylaminocarbonylamino)-acetamide; EPO <DP n="59"/> [0314] To a solution of 4-fluorophenyl glycine (288 mg, 1.70 mmol) in DMF (5 mL), 4- chlorophenyl isocyanate (262 mg, 1.70 mmol) was added. The mixture was then stirred at room temperature overnight. It was concentrated in vacuo. The residue was purified by HPLC to give a powder (210 mg). MS 323.1 and 325.1 (M+H, Cl pattern).[0315] To a solution of the powder (52 mg, 0.16 mmol) and 4-(l-Methyl-4,5-dihydro-lH- imidazol-2-yl)-phenylamine (64 mg, 0.37 mmol) in DMF (3 mL) and H2O (1 mL), EDC (64 mg, 0.33 mmol) was added. After being stirred at room temperature for 2h, the mixture was concentrated in vacuo. The residue was purified by HPLC to give the titled compound as a white powder (28 mg). MS 480.1 and 482.1 (M+H, Cl pattern). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride; at 0 - 20℃; for 18h; | HCl (g) was bubbled into a solution of 4-fluoro-DL-phenylglycine (810 mg, 4.79 mmol") in methanol (20 mL) for 5 min at 0 0C. The reaction wanned to ambient temperature and stirred for 18 h. The mixture was concentrated to give the title compound (1 g). MS 183.9 (M+ 1) | |
With sulfuric acid;Reflux; | General procedure: The amino acid (1.0 mmol, 1.0 eq) was dispersed in MeOH (1.0 mL per 0.21 mmol of amino acid) with concd H2SO4 (1.8 eq). The mixture was refluxed overnight, at which point LC-MS analysis indicated complete conversion had taken place. The mixture was cooled then concentrated under reduced pressure. The resulting residue was basified with sat. NaHCO3(aq), then extracted with DCM. The combined organic layers were concentrated under reduced pressure. This was taken up into water and THF (5:1), before adding in Boc2O (1.05 eq), and stirring at room temperature overnight. The mixture was diluted with water, before extraction with DCM. Concentration of the combined organic layers gave the desired product. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
at 20℃; for 2h; | 4-Fluoro-phenyl glycine 1 (10 g, 66 mmol) was added to a 250 mL round bottomed flask that contained trifluoroacetic anhydride (30 mL) and stirred for 2 h at room temperature. Upon formation of oxazolinone 2, the excess TFAA and TFA were removed in vacuo as an azeotrope with toluene .The remaining yellow solid was dissolved in 750 mL dry toluene and benzylcyanoformate (11 mL, 1.1 equiv, 72 mmol) was added via syringe followed by the dropwise addition of tributylphosphine (17 mL, 1 equiv, 66 mmol). CO2 emission from the reaction was observed with an oil bubbler. The reaction was allowed to stir at room temperature for 12 h and then was concentrated to dryness under reduced pressure, dissolved in EtOAc, and washed with sodium bicarbonate, 1 M HC1, and brine. The crude mixture was purified by silica gel chromatography and eluted with a gradient of 0-60% EtOAc/Hex to give 7 g of the desired imidazole benzyl ester 3 (7.0g, 19.2 mmol) as an off-white solid. | |
at 20℃; for 2h; | General procedure: 3-Chlorophenylglycine (5.41 mmol, 1.0 g) was added toTFAA (3 mL) in a 25 mL round-bottomed flask. The mixture was stirred for 2 h at r.t. and excess TFAA was removed invacuo by means of azeotroping with toluene (5 × 10 mL) togive 1.32 g (93% yield) of a yellow solid product. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With acetic anhydride; for 5h; | To a solution of (4-fluorophenyl)glycine (1.9 g) in formic acid (20 ml) was added acetic anhydride (7 ml). After stirring for 5 h, the reaction was concentrated in vacuo to 10 ml. Water (25 ml) was added. After additional stirring for 30 min, the reaction mixture was concentrated in vacuo. The residue was triturated with water, filtered, and dried in vacuo, to provide white crystals.Yield: 1.7 g. Mp: 190-203 0C; 1H-NMR (DMSO -de) delta 5.40 (d, 1, CH), 8.97 (d, 1, NH),8.08 (s, 1, CHO), 7.22 and 7.43 (2 x m, 4, Ar(F)H), 13.10 (s, 1, COOH); 19 F-NMR (DMSO-dbeta) delta -114.97. | |
With acetic anhydride; for 5h; | (a). (4-Fluorophenyl)-formylamino acetic acid To a solution of (4-fluorophenyl)glycine (1.9 g) in formic acid (20 ml) was added acetic anhydride (7 ml). After stirring for 5 h, the reaction was concentrated in vacuo to 10 ml. Water (25 ml) was added. After additional stirring for 30 min, the reaction mixture was concentrated in vacuo. The residue was triturated with water, filtered, and dried in vacuo, to provide white crystals. Yield: 1.7 g. Mp: 190-203 C.; 1H-NMR (DMSO-d6) delta 5.40 (d, 1, CH), 8.97 (d, 1, NH), 8.08 (s, 1, CHO), 7.22 and 7.43 (2*m, 4, Ar(F)H), 13.10 (s, 1, COOH); 19F-NMR (DMSO-d6) delta -114.97. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
To a cooled solution of 2-amino-2-(4-fluorophenyl)acetic acid (1.0 g, 6.17 mmol) in ethanol was added con. H2SO4 (1 mL) over a period of 1 min. The reaction mixture was heated at reflux for 5 h. The solvent was evaporated under reduced pressure and the residue was diluted with ethyl acetate (20 mL). The organic solution was washed with aqueous saturated NaHCtheta3 (15 mL x 2), water (20 mL), brine solution (10 mL), dried over anhydrous Na2SO4 and evaporated under reduced pressure to give ethyl 2-amino-2- (4-fluorophenyl)acetate (0.75 g, 65%) as crude compound (oily liquid). The crude compound was taken to the next step without further purification. LC-MS (M+H20)+ = 198.0. 1H NMR (400 MHz, DMSO-d6): delta 7.44-7.40 (2H, m), 7.18-7.13 (2H, m), 4.51 (IH, s), 4.12-4.01 (2H, m), 2.26 (2H, s), 1.12 (3H, t, J= 8.0 Hz). | ||
With sulfuric acid; for 5.01667h;Cooling; Reflux; | Intermediate AI(1)ethyl 2-amino-2-(4-fluorophenyl)acetateTo a cooled solution of 2-amino-2-(4-fluorophenyl)acetic acid (1.0 g, 6.17 mmol) in ethanol was added con. H2SO4 (1 mL) over a period of 1 min. The reaction mixture was heated at reflux for 5 h. The solvent was evaporated under reduced pressure and the residue was diluted with ethyl acetate (20 mL). The organic solution was washed with aqueous saturated NaHCC (15 mL x 2), water (20 mL), brine solution (10 mL), dried over anhydrous Na2S04 and evaporated under reduced pressure to give ethyl 2-amino-2- (4-fluorophenyl)acetate (0.75 g, 65%) as crude compound (oily liquid). The crude compound was taken to the next step without further purification. LC-MS (Mu+]¾0)+ = 198.0. 'H NMR (400 MHz, DMSO-d6): delta 7.44-7.40 (2H, m), 7.18-7.13 (2H, m), 4.51 (1H, s), 4.12-4.01 (2H, m), 2.26 (2H, s), 1.12 (3H, t, J= 8.0 Hz). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
99% | With sodium hydroxide; In water; isopropyl alcohol; at 20℃; for 1h;Cooling with ice; | Step 1. [(tert-Butoxycarbonyl)amino](4-fluorophenyl)acetic acid To amino(4-fluorophenyl)acetic acid (from Acros, 3.0 g, 18 mmol) in 1.0 M sodium hydroxide in water (25.0 mL, 25.0 mmol), cooled in wet ice bath was added a solution of di-tert- butyldi carbonate (4.6 g, 21 mmol) in isopropyl alcohol (15.0 mL). The ice bath was removed and the resulting suspension was stirred at rt for 1 h. The volatile solvent was removed under reduced pressure and remaining solution was adjusted to pH = 3 with 4M HC1, and then extracted with Ethyl acetate. The organic fraction was washed with brine, dried over sodium sulfate, filtered and concentrated to give 4.75 g (99%) of the desired product, which was used in the next step without further purification. |
45% | To a solution of 2-amino-2-(4-fluorophenyl)acetic acid (1.00 g, 5.91 mmol) in acetone (50 ml) and 2N sodium hydroxide (50 ml, 100 mmol), di-tert-butyl dicarbonate (1.29 g, 5.91 mmol) was added and the reaction was stirred at RT for 3h. Acetone was evaporated, the aqueous phase was acidified with 37% HCl until pH 1. The product was extracted with EtOAc and the organic phase was washed with water and brine, dried over Na2SO4 and evaporated. The resulting oil was triturated with petroleum ether to give 2-(tert-butoxycarbonylamino)-2-(4-fluorophenyl)acetic acid (725 mg; 45% yield). | |
45% | With sodium hydroxide; In acetone; at 20℃; for 3h; | To a solution of 2-amino-2-(4-fluorophenyl)acetic acid (1.00 g, 5.91 mmol) in acetone (50 ml) and 2N sodium hydroxide (50 ml, 100 mmol), was added di-tert-butyl dicarbonate (1.29 g, 5.91 mmol), and the reaction was stirred at RT for 3 hours. Acetone was evaporated, the aqueous phase was acidified with 37% HCl until pH 1. The product was extracted with EtOAc, and the organic phase was washed with water and brine, dried over Na2SO4 and evaporated. The resulting oil was triturated with petroleum ether to give 2-(tert-butoxycarbonylamino)-2-(4-fluorophenyl)acetic acid (725 mg; 45% yield). |
With sodium hydrogencarbonate; In 1,4-dioxane; water; | 2-Amino-2-(4-fluorophenyl) acetic acid (1g, 5.73 mmol) was dissolved in a solution of water and dioxane (1:1, 140 mL), to which sodium bicarbonate (8.2 g, 97.4 mmol) was added slowly, followed by di-tert-butyl dicarbonate (2.7 g, 12.0 mmol) in one portion. The reaction mixture was stirred overnight and then diluted with water and extracted with ethyl ether (×3). The aqueous layer was adjusted to pH 3.4 with a solution of citric acid in EtOAc (20 mL), and the organic layers were separated. The organic layer was washed with water (×2), dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. The crude product was used in the next step without further purification. | |
With sodium hydroxide; In tetrahydrofuran; at 20℃; for 12h; | To a stirred solution of 2-amino-2-(4-fluorophenyl)acetic acid (EI, 2.5 g, 14.77 mmol) in THF (25mL), boc anhydride (3.54 g, 16.25 mmol) and NaOH (3N, 20 mL) were added and stirred at room temperature for 12 h. The progress of the reaction was monitored by TLC. After completion of the reaction, reaction mixture was quenched with 6N HC1 solution and extracted with EtOAc. The combined organic layer was washed with brine, dried over Na2S04 and concentrated under reduced pressure to afford compound EJ (2.2 g, crude) as a brown oil. LC-MS: m/z 269.23 [M+H]+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydroxide; at 0 - 20℃; for 3h; | General procedure: Phenylglycine (1.0 equiv, 6.60 mmol, 1.0 g) was added to2.0 M NaOH (20 mL) in a 100 mL round-bottomed flask.The solution was cooled to 0 C in an ice bath, and then 4-fluorobenzoylchloride (9, 1.0 equiv, 6.60 mmol, 0.78 mL)was added dropwise over 20 min. The reaction was allowedto warm to r.t. and stirred for 2 h. The solution was thenmade slightly acidic (pH 5-6) by dropwise addition of 2.0 MHCl and was extracted with EtOAc (5 × 75 mL). The organicphase was dried over MgSO4 and concentrated in vacuo toyield 8d as white solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
84% | With dipotassium peroxodisulfate; water; copper diacetate; palladium diacetate; In dimethyl sulfoxide; at 120℃; for 24h;Inert atmosphere; | General procedure: A mixture of 1 (0.5 mmol), 2 (0.6 mmol), DMSO (5% H2O aq, 5mL), Pd(OAc)2 (5 mol%), Cu(OAc)2 (10 mol%), and K2S2O8 (2equiv) was stirred at 120 C under Ar atmosphere for 24 h. Thereaction mixture was washed with H2O, and the aqueous phasewas extracted with EtOAc (3×). The combined organic layer waswashed with brine, dried over Na2SO4, and evaporated underreduced pressure. The crude product was purified by silica gelcolumn chromatography to give the corresponding products(3a-d,7b 3f-k,7b 3n-s7b). |
Tags: 7292-73-1 synthesis path| 7292-73-1 SDS| 7292-73-1 COA| 7292-73-1 purity| 7292-73-1 application| 7292-73-1 NMR| 7292-73-1 COA| 7292-73-1 structure
[ 93939-74-3 ]
(R)-2-Amino-2-(4-fluorophenyl)acetic acid
Similarity: 1.00
[ 19883-57-9 ]
(S)-2-Amino-2-(4-fluorophenyl)acetic acid
Similarity: 1.00
[ 144744-41-2 ]
(R)-2-Amino-2-(4-fluorophenyl)acetic acid hydrochloride
Similarity: 0.98
[ 7292-74-2 ]
2-Amino-2-(3-fluorophenyl)acetic acid
Similarity: 0.98
[ 1219399-79-7 ]
2-Amino-2-(4-fluorophenyl)acetic acid hydrochloride
Similarity: 0.98
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
Home
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :