[ CAS No. 705-86-2 ] {[proInfo.proName]}

Name: 705-86-2|6-Pentyltetrahydro-2H-pyran-2-one|97%
Brand: Ambeed
SKU: A181647
Price: 5.0 USD
Availability: InStock
Rating: 96 (26 reviews)

,{[proInfo.pro_purity]}

Cat. No.: {[proInfo.prAm]}

DV 2D 3D

3d Animation Molecule Structure of 705-86-2

Structure of 705-86-2 * Storage: {[proInfo.prStorage]}

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

For Research Only 110K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 705-86-2 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 705-86-2 ]

SDS Specification

Alternatived Products of [ 705-86-2 ]

Product Details of [ 705-86-2 ]

CAS No. :	705-86-2	MDL No. :	MFCD00006649
Formula :	C₁₀H₁₈O₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	GHBSPIPJMLAMEP-UHFFFAOYSA-N
M.W :	170.25	Pubchem ID :	12810
Synonyms :		Chemical Name :	6-Pentyltetrahydro-2H-pyran-2-one

Calculated chemistry of [ 705-86-2 ]

Physicochemical Properties

Num. heavy atoms :	12
Num. arom. heavy atoms :	0
Fraction Csp3 :	0.9
Num. rotatable bonds :	4
Num. H-bond acceptors :	2.0
Num. H-bond donors :	0.0
Molar Refractivity :	49.35
TPSA :	26.3 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.54 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.53
Log Po/w (XLOGP3) :	2.54
Log Po/w (WLOGP) :	2.66
Log Po/w (MLOGP) :	2.19
Log Po/w (SILICOS-IT) :	2.85
Consensus Log Po/w :	2.55

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.23
Solubility :	0.998 mg/ml ; 0.00586 mol/l
Class :	Soluble
Log S (Ali) :	-2.74
Solubility :	0.31 mg/ml ; 0.00182 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-2.67
Solubility :	0.367 mg/ml ; 0.00215 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.44

Safety of [ 705-86-2 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 705-86-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 705-86-2 ]

[ 705-86-2 ] Synthesis Path-Downstream 1~88

1
[ 705-86-2 ]
[ 16425-13-1 ]

Reference： [1]Recueil des Travaux Chimiques des Pays-Bas,1967,vol. 86,p. 481 - 503

2
[ 705-86-2 ]
[ 16856-74-9 ]

Reference： [1]Recueil des Travaux Chimiques des Pays-Bas,1967,vol. 86,p. 481 - 503

3
[ 705-86-2 ]
[ 2319-29-1 ]

Reference： [1]Archiv der Pharmazie,1960,vol. 293 /65,p. 245 - 251

4
[ 67-56-1 ]
[ 705-86-2 ]
(2S,6R)-2-Methoxy-6-pentyl-tetrahydro-pyran [ No CAS ]
(2R,6R)-2-Methoxy-6-pentyl-tetrahydro-pyran [ No CAS ]

Reference： [1]Bioscience, Biotechnology and Biochemistry,1993,vol. 57,p. 422 - 426

5
[ 7677-24-9 ]
[ 705-86-2 ]
[ 143215-30-9 ]
[ 143215-30-9 ]

Reference： [1]Journal of the American Chemical Society,1992,vol. 114,p. 8375 - 8384

6
[ 705-86-2 ]
[ 108-98-5 ]
[ 143215-46-7 ]
[ 143215-46-7 ]

Reference： [1]Journal of the American Chemical Society,1992,vol. 114,p. 8375 - 8384

7
[ 705-86-2 ]
[ 479-27-6 ]
[ 109002-35-9 ]

Reference： [1]Journal fur praktische Chemie (Leipzig 1954),1986,vol. 328,p. 906 - 910

8
[ 705-86-2 ]
[ 149-73-5 ]
Methyl 4-methoxydecanoate [ No CAS ]

Reference： [1]Journal of Organic Chemistry,1994,vol. 59,p. 2253 - 2256

9
[ 705-86-2 ]
[ 138760-86-8 ]

Reference： [1]Tetrahedron Letters,1991,vol. 32,p. 6854 - 6856

10
[ 705-86-2 ]
[ 14309-57-0 ]
[ 6175-23-1 ]
[ 1038622-41-1 ]
[ 60-12-8 ]
[ 91525-87-0 ]
[ 66-25-1 ]

Reference： [1]Bioscience, Biotechnology and Biochemistry,1993,vol. 57,p. 2111 - 2115

11
[ 4203-48-9 ]
[ 705-86-2 ]

Reference： [1]Chemistry - A European Journal,2018,vol. 24,p. 4556 - 4561
[2]Journal of Organic Chemistry,1990,vol. 55,p. 462 - 466
[3]Journal of Organic Chemistry,1986,vol. 51,p. 155 - 161

12
[ 23866-95-7 ]
[ 705-86-2 ]

Reference： [1]Tetrahedron Letters,1990,vol. 31,p. 3767 - 3770

13
[ 705-86-2 ]
[ 197856-91-0 ]
[ 59285-67-5 ]

Reference： [1]Tetrahedron Letters,1988,vol. 29,p. 1915 - 1918

14
[ 100591-72-8 ]
[ 705-86-2 ]

Reference： [1]Tetrahedron Letters,1985,vol. 26,p. 2253 - 2256

15
[ 89701-69-9 ]
[ 705-86-2 ]

Reference： [1]Chemische Berichte,1984,vol. 117,p. 859 - 861

16
[ 89701-69-9 ]
[ 706-14-9 ]
[ 705-86-2 ]

Reference： [1]Chemische Berichte,1984,vol. 117,p. 859 - 861

17
[ 501-23-5 ]
[ 705-86-2 ]

Reference： [1]Chemistry Letters,1982,p. 5 - 6

18
[ 124-41-4 ]
[ 705-86-2 ]
[ 110-42-9 ]

Reference： [1]Journal of the American Oil Chemists' Society,1995,vol. 72,p. 199 - 204

19
[ 705-86-2 ]
[ 23866-95-7 ]

Reference： [1]Journal of Organic Chemistry,1997,vol. 62,p. 8522 - 8528
[2]Journal of the American Chemical Society,2008,vol. 130,p. 1136 - 1137
[3]Journal of the American Chemical Society,1995,vol. 117,p. 12641 - 12642
[4]Journal of Organic Chemistry,1998,vol. 63,p. 2360 - 2361
[5]Patent: WO2006/125550,2006,A1 .Location in patent: Page/Page column 16-17

20
[ 108-24-7 ]
[ 705-86-2 ]
Acetic acid (2S,6R)-6-pentyl-tetrahydro-pyran-2-yl ester [ No CAS ]

Reference： [1]Journal of Organic Chemistry,1996,vol. 61,p. 7648 - 7649

21
[ 705-86-2 ]
[ 882-33-7 ]
6-Pentyl-3-phenylsulfanyl-tetrahydro-pyran-2-one [ No CAS ]

Reference： [1]Journal of Organic Chemistry,1997,vol. 62,p. 2633 - 2635

22
[ 4819-67-4 ]
[ 705-86-2 ]

Reference： [1]Journal of Organic Chemistry,1997,vol. 62,p. 2633 - 2635
[2]Tetrahedron Letters,2004,vol. 45,p. 3681 - 3683
[3]Advanced Synthesis and Catalysis,2004,vol. 346,p. 257 - 262
[4]Russian Journal of Applied Chemistry,1997,vol. 70,p. 621 - 626
[5]Journal of Organic Chemistry,1997,vol. 62,p. 2633 - 2635
[6]Russian Journal of General Chemistry,2011,vol. 81,p. 1664 - 1670
[7]Journal of Fluorine Chemistry,2006,vol. 127,p. 592 - 596

23
[ 705-86-2 ]
δ-thiodecalactone [ No CAS ]

Reference： [1]Journal of Agricultural and Food Chemistry,1998,vol. 46,p. 668 - 672

24
[ 5932-79-6 ]
[ 201230-82-2 ]
[ 99978-13-9 ]
[ 705-86-2 ]

Reference： [1]Journal of the American Chemical Society,1998,vol. 120,p. 8692 - 8701

25
[ 626-89-1 ]
[ 201230-82-2 ]
[ 705-86-2 ]
[ 80114-09-6 ]

Reference： [1]Journal of the American Chemical Society,1998,vol. 120,p. 8692 - 8701

26
[ 705-86-2 ]
[ 4203-48-9 ]
[ 23866-95-7 ]

Reference： [1]Journal of Organic Chemistry,1999,vol. 64,p. 2582 - 2589

Yield	Reaction Conditions	Operation in experiment
	With potassium methanolate; hydrogen;trans, cis-[RuCl2(1-amino-2-diphenylphosphinoethane-N,P)2]; cis-RuCl2(Ph2P(CH2)2NH2)2; In toluene; at 100℃; under 22502.3 Torr; for 4h;Conversion of starting material;	Several others esters (see Table 3) were hydrogenated under identical conditions as reported in Table 4 with RuCl2(L-1)2. The reaction conditions were identical to those reported above for methyl benzoate.
	With N,N-bis-(2-hydroxyethyl)glycine; m-cresol purple; Geobacillus kaustophilus HTA426 phosphotriesterase-like lactonase; water; sodium chloride; In dimethyl sulfoxide; at 75℃;pH 8.3;Enzymatic reaction;Kinetics;	General procedure: The lactonase, phosphotriesterase, and esterase hydrolyses of GkaP were monitored by absorbance changes in a UV-2550 spectrophotometer (Shimadzu, Kyoto, Japan) at a constant temperature of 75C with 1 mL reaction volumes (path length = 1cm). Analysis of reaction samples for each substrate was performed at a constant enzyme concentration. The delta-decanolactone substrate was dissolved in dimethyl sulfoxide (DMSO), whereas the p-nitrophenylcaprylate and OP substrates in acetonitrile as stock solutions. For enzymatic kinetics assay, aliquots of the stock were added to the reaction buffer for defined concentrations. The hydrolysis of lactone was monitored using a pH-sensitive colorimetric assay [33]. Briefly, the reactions were performed in 2.5 mM Bicine (pH 8.3) containing 0.2MNaCl, 0.2 mM cresol purple, and 0.02-20 mM lactone substrate. Upon mixture of the substrate with the enzyme, the decrease inabsorbance was monitored at 577 nm (epsilon577 = 47300 M-1cm-1, 1%DMSO). The enzyme was diafiltrated with 10 mM bicine (pH 8.3), with a PD-10 column (GE Healthcare, Shanghai, China) before use. Kinetic measurements with p-nitrophenyl caprylate (pNPC8), and ethyl-paraoxon were performed in 50 mM phosphate buffer (pH 8.0). The reaction rates were monitored bythe release of p-nitrophenol (epsilon405 = 16000M-1cm-1, 2% acetonitrile). The initial rates were corrected for the background rate of spontaneous hydrolysis in the absence of enzymes, which were subtracted from the enzymatic rates. The kinetic parameters (kcat, Km) were obtained byfitting the data to the Michaelis-Menten equation [V = S×E×kcat/(S+Km)] or to the pseudo first-order form of it at S<<Km (V = S×E×kcat/Km) with GraphPad Prism software (Graphpad, San Diego, CA), where V is the initial velocity, E is the enzyme concentration, S is the substrate concentration. The final concentrations used in the assay to determine specific activities towardthe tested OP pesticides were 1mM, 1mM, 0.25 mM, and 0.25 mM for paraoxon, parathion, diazinon, and chlorpyrifos, respectively. The rate of paraoxon and parathion hydrolysis was measured at a wavelength of 405nm as described above. The rate of diazinon hydrolysis wasmeasured at a wavelength of 228nm (epsilon228 = 3300 M-1cm-1), and chlorpyrifos was measured at 276 nm (epsilon276 = 2790 M-1cm-1). Control reactions were performed in the absence of enzyme. One unit of enzymatic activity was defined as the amount of enzyme that catalyzed the hydrolysis of 1 mumol substrate per minute. All assays were performed at least in triplicate. Enzyme concentrations were determined using the Bio-Rad protein assay kit II (Bio-Rad, Richmond,CA).

Yield	Reaction Conditions	Operation in experiment
		Examples of lactones generated from the compounds of the present invention include: ... 4-methyl-5-pentyl-dihydro-2(3H)-furan-2-one; 5-hexyldihydro-5-methyl-2(3H)-furanone; dihydro-5-methyl-5-vinyl-2(3H)-furanone; octahydro-2H-1-benzopyran-2-one; tetrahydro-6-pentyl-2H-pyran-2-one; tetrahydro-6-hexyl-2H-pyran-2-one; tetrahydro-6-heptyl-2H-pyran-2-one; tetrahydro-6-(3-pentenyl)-(E)-2H-pyran-2-one; ...
		Trans,trans delta-damascone produced according to U.S. Pat. No. 4,211,242 Maltol; Ethyl maltol; Delta-undecalactone; Delta-decalactone; Amyl acetate; Ethyl butyrate; Ethyl valerate; 2,6-Dimethyl-2,6-undecadiene-10-one; 2-Methyl-5-isopropyl acetophenone; ...
		Examples of lactones derived from X substituted by -OH when R2=H in formula I include: ... 4-methyl-5-pentyl-dihydro-2(3H)-furan-2-one; 5-hexyldihydro-5-methyl-2(3H)-furanone; dihydro-5-methyl-5-vinyl-2(3H)-furanone; octahydro-2H-1-benzopyran-2-one; tetrahydro-6-pentyl-2H-pyran-2-one; tetrahydro-6-hexyl-2H-pyran-2-one; tetrahydro-6-heptyl-2H-pyran-2-one; tetrahydro-6-(3-pentenyl)-(E)-2H-pyran-2-one; ...

Compounds of formula I may generate the following lactones of formula HY ... 4-methyl-5-pentyl-dihydro-2(3H)-furan-2-one 5-hexyldihydro-5-methyl-2(3H)-furanone dihydro-5-methyl-5-vinyl-2(3H)-furanone octahydro-2H-1-benzopyran-2-one tetrahydro-6-pentyl-2H-pyran-2-one tetrahydro-6-hexyl-2H-pyran-2-one tetrahydro-6-heptyl-2H-pyran-2-one tetrahydro-6-(3-pentenyl)-(E)-2H-pyran-2-one ...

29
(-)-5-hydroxy-dec-2<i>c</i>-enoic acid lactone [ No CAS ]
[ 705-86-2 ]

Reference： [1]Recueil des Travaux Chimiques des Pays-Bas,1940,vol. 59,p. 191,195, 197
[2]Australian Journal of Chemistry,1968,vol. 21,p. 2819,2821

30
[ 2627-86-3 ]
[ 705-86-2 ]
[ 272439-66-4 ]

Reference： [1]Heterocycles,2000,vol. 52,p. 1359 - 1370

31
[ 3886-69-9 ]
[ 705-86-2 ]
[ 272439-68-6 ]

Reference： [1]Heterocycles,2000,vol. 52,p. 1359 - 1370

32
[ 3287-99-8 ]
[ 705-86-2 ]
N-benzyl-5-hydroxydecanamide [ No CAS ]

Reference： [1]Tetrahedron Letters,2001,vol. 42,p. 2439 - 2441

33
[ 705-86-2 ]
[ 4203-48-9 ]

Yield	Reaction Conditions	Operation in experiment
93%	With potassium methanolate; hydrogen;dichloro-bis-[2-(diphenylphosphino)ethylamine]ruthenium; In toluene; at 100℃; under 37503.8 Torr; for 4h;Product distribution / selectivity;	Several others esters (see Table 3) were hydrogenated under identical conditions as reported in Table 4 with RuCl2(L-I)2. The reaction conditions were identical to those reported above for methyl benzoate.Table 3: Structure and name of substrates used EPO <DP n="28"/>Table 4: Results obtained using the general conditions described above EPO <DP n="29"/>Conversion: (in %, analysed by GC after silylation) of ester to alcohol after 2h 30min. Reaction conditions: Substrate (20 mmol), H2 gas (50 bars), RuCl2(L-I)2 0.05 mol%, NaOMe 10 mol%, THF (14 mL) at 1000C during 2h 30min. J) Reaction run for 4h. EPO <DP n="30"/>2) Reaction run with KOMe (10 mol%) in THF during 5h at 1000C with H2 gas (30 bars).; 6) Reaction run with KOMe (10 mol%) in toluene during 4h at 1000C with H2 gas (50 bars).
86%	With hydrogen; sodium methylate;RuCl2(L-1); In tetrahydrofuran; at 100℃; under 37503.8 Torr; for 2.5h;Product distribution / selectivity;	Several other esters, whose structure and names are described in Table 3, were hydro genated under the conditions described above using preformed RuCl2(L-I). Isolated yield are given in Table 4.Table 3: Structure and names of substrates usedTable 4: Hydrogenation of esters using RuCl2(L-I) EPO <DP n="19"/>Sub.: Substrate as described in Table 3.Conv.: Conversion (in %, analysed by GC after silylation) of ester to alcohol after 2h30min.Reaction conditions: Substrate (20 mmol), H2 gas (50 bars), RuCl2(L-I) 0.05 mol%,NaOMe 10 mol%, THF (14 mL) at 1000C during 2h 30min.
76%	With 2-(N,N-dimethylamino)athanol; samarium diiodide; In tetrahydrofuran; at 25℃; for 24h;Glovebox;	To an oven dried round bottom flask containing a magnetic stir bar in a glove box, a desired amount of substrate along with 7 eq with respect to substrate of SmI2 and 42 eq of DMAE were added in that order. The reaction was left until the reaction mixture became colorless and a white precipitate formed (24h). The round bottom flask was then removed from the box and quenched with air and 0.1M HCl. Product was extracted using ethyl acetate and water. The organic layer was then treated with saturated aqueous sodium thiosulfate. The remaining solution was then dried with magnesium sulfate, filtered and then solvent was removed by rotary evaporation. The resulting substance was then placed under a high vacuum system to ensure complete removal of solvent.

Reference： [1]Organic and Biomolecular Chemistry,2012,vol. 10,p. 5820 - 5824
[2]Chemical Communications,2011,vol. 47,p. 10254 - 10256
[3]Journal of Natural Products,2001,vol. 64,p. 572 - 577
[4]Patent: WO2006/106483,2006,A1 .Location in patent: Page/Page column 26-29
[5]Angewandte Chemie - International Edition,2007,vol. 46,p. 7473 - 7476
[6]Organic and biomolecular chemistry,2020,vol. 18,p. 3585 - 3598
[7]Journal of the American Chemical Society,2008,vol. 130,p. 1136 - 1137
[8]Patent: WO2006/106484,2006,A1 .Location in patent: Page/Page column 17-18
[9]Organic Letters,2017,vol. 19,p. 290 - 293
[10]Organic Letters,2010,vol. 12,p. 4140 - 4143
[11]Journal of the American Chemical Society,2009,vol. 131,p. 15467 - 15473
[12]Tetrahedron Letters,2015,vol. 56,p. 3212 - 3215
[13]Angewandte Chemie - International Edition,2014,vol. 53,p. 8722 - 8726
Angew. Chem.,2014,vol. 126,p. 8867 - 8871,5
[14]Angewandte Chemie - International Edition,2013,vol. 52,p. 7237 - 7241
Angew. Chem.,2013,vol. 125,p. 7378 - 7382
[15]Journal of the American Chemical Society,2013,vol. 135,p. 15702 - 15705
[16]Journal of the American Chemical Society,2014,vol. 136,p. 8459 - 8466
[17]Chirality,2016,p. 623 - 627

34
[ 108-24-7 ]
[ 705-86-2 ]
[ 222315-65-3 ]

Reference： [1]Angewandte Chemie - International Edition,2003,vol. 42,p. 818 - 820

35
[ 705-86-2 ]
δ-thiodecalactone [ No CAS ]
6-pentyl-tetrahydro-pyran-2-thione [ No CAS ]
6-pentyl-tetrahydro-thiopyran-2-thione [ No CAS ]

Reference： [1]Tetrahedron Letters,2003,vol. 44,p. 6647 - 6650

36
[ 705-86-2 ]
trifluoroethyl trifluoroacetate [ No CAS ]
6-Pentyl-3-(2,2,2-trifluoro-acetyl)-tetrahydro-pyran-2-one [ No CAS ]

Reference： [1]Organic Letters,2004,vol. 6,p. 2619 - 2621

37
[ 705-86-2 ]
[ 504-63-2 ]
8-pentyl-1,5,7-trioxa-spiro[5.5]undecane [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2005,vol. 127,p. 528 - 529

38
[ 505-90-8 ]
[ 706-14-9 ]
[ 705-86-2 ]

Reference： [1]Synthetic Communications,2005,vol. 35,p. 153 - 160

39
[ 4203-48-9 ]
[ 859815-68-2 ]
[ 51856-98-5 ]
[ 705-86-2 ]

Reference： [1]Tetrahedron,2005,vol. 61,p. 8995 - 9000

40
[ 897381-05-4 ]
[ 705-86-2 ]
(S)-1-Furan-2-yl-9-hydroxy-1-trimethylsilanyloxy-tetradec-3-yn-5-one [ No CAS ]

Reference： [1]Tetrahedron Letters,2006,vol. 47,p. 3665 - 3668

41
[ 897381-06-5 ]
[ 705-86-2 ]
(S)-9-Hydroxy-1-(5-methyl-furan-2-yl)-1-trimethylsilanyloxy-tetradec-3-yn-5-one [ No CAS ]

Reference： [1]Tetrahedron Letters,2006,vol. 47,p. 3665 - 3668

42
[ 75-16-1 ]
[ 705-86-2 ]
(2S,6R)-2-Methyl-6-pentyl-tetrahydro-pyran-2-ol [ No CAS ]

Reference： [1]Organic Letters,2006,vol. 8,p. 4231 - 4234

43
6-pentyl-tetrahydro-pyran-2-thione [ No CAS ]
[ 705-86-2 ]
δ-thiodecalactone [ No CAS ]

Reference： [1]Tetrahedron Letters,2006,vol. 47,p. 6067 - 6070

44
[ 705-86-2 ]
5⁽⁶⁾-decenoic acid [ No CAS ]
[ 706-14-9 ]
[ 85392-04-7 ]
[ 26303-90-2 ]

Reference： [1]Bioscience, Biotechnology and Biochemistry,2005,vol. 69,p. 2416 - 2420

45
[ 4819-67-4 ]
[ 32821-72-0 ]
[ 705-86-2 ]

Yield	Reaction Conditions	Operation in experiment
	With dihydrogen peroxide;lithium hydroxide; In Ethyl propionate; at 100℃; for 6h;Heating / reflux;	In a three-necked 250 ml flask equipped with a magnetic stirrer and A reflux condenser were introduced 31G of 2-pentyl cyclopentanone (0.2 mole), 31g of anhydrous ethyl propionate, and 0.048g (1 mol%) of anhydrous lithium hydroxide. The mixture was brought to reflux at ca. 100C. Then 57. 5g (0.22 mole) of an anhydrous 13% w/w hydrogen peroxide solution in ethyl propionate, obtained from extraction of a 70% aqueous H202 solution by ethyl propionate, were slowly added over 4h in the reactor while maintaining the reflux 2h after the end of the introduction. The reaction mixture was then washed with 10 % water to remove the non converted H202, and finally distilled to recover the solvent. GC analysis of the residue revealed the presence of 18% non converted 2-pentyl cyclopentanone (82% conversion), 73% of lactones and 19% of by-products. Procedure B) : The reaction was carried out as in Procedure A), but using 0.22 mol of H202 in the form of 70% weight aqueous solution. The conversion was 53%, with 61% selectivity for the lactones. Procedure C) : In a three-necked 250 ml flask equipped with a magnetic stirrer and a DEAN-STARCK reflux condenser were introduced 61.6g of 2-pentyl cyclopentanone (0.4 mole), 100g of anhydrous ethyl propionate solvent, and O. lg (1 mol%) of anhydrous lithium hydroxide and the mixture was brought to reflux at ca. 110C. Then 21. 5g (0.44 mole) of 70 % w/w aqueous H202 solution were added over 4h in the reactor and under conditions such as incipient and formed water are removed as a 90: 10 ethyl propionate/water azeotropic mixture, ethyl propionate being resent to the reactor. The reaction mixture was then maintained to reflux for two hours, cooled to 30C, then washed with 10 % water to remove the non converted H202, and finally distilled to recover the solvent. GC analysis of the residue bulb-to-bulb distilled indicated the presence of 0.5% non converted 2-pentyl cyclopentanone (99.5% conversion) and 96% of lactones.Example 2 BAEYER-VILLIGER Oxidation ofpentyl cvclopentanone using various catalysts This example illustrates the influence of the catalyst USED IN THE BAEYER-VILLIGER OXIDATION of 2-pentyl cyclopentanone to lactones by 202. The reaction was carried out in the presence of 1 mol% catalyst in ethyl propionate as solvent at 110C in the same conditions as those reported in Example 1, Procedure C). The results are reported in Table 1.
	With dihydrogen peroxide;lithium hydroxide; In water; Ethyl propionate; at 110℃; for 6h;Heating / reflux;	In a three-necked 250 ml flask equipped with a magnetic stirrer and a DEAN-STARCK reflux condenser were introduced 61.6g of 2-pentyl cyclopentanone (0.4 mole), 100g of anhydrous ethyl propionate solvent, and O. lg (1 mol%) of anhydrous lithium hydroxide and the mixture was brought to reflux at ca. 110C. Then 21. 5g (0.44 mole) of 70 % w/w aqueous H202 solution were added over 4h in the reactor and under conditions such as incipient and formed water are removed as a 90: 10 ethyl propionate/water azeotropic mixture, ethyl propionate being resent to the reactor. The reaction mixture was then maintained to reflux for two hours, cooled to 30C, then washed with 10 % water to remove the non converted H202, and finally distilled to recover the solvent. GC analysis of the residue bulb-to-bulb distilled indicated the presence of 0.5% non converted 2-pentyl cyclopentanone (99.5% conversion) and 96% of lactones.
	With dihydrogen peroxide;sodium tert-pentoxide; In water; Ethyl propionate; at 110℃; for 6h;Heating / reflux;	This example illustrates the influence of the catalyst USED IN THE BAEYER-VILLIGER OXIDATION of 2-pentyl cyclopentanone to lactones by 202. The reaction was carried out in the presence of 1 mol% catalyst in ethyl propionate as solvent at 110C in the same conditions as those reported in Example 1, Procedure C). The results are reported in Table 1.

	With dihydrogen peroxide;lithium hydroxide; In tert-Amyl alcohol; water; at 110℃; for 6h;Heating / reflux;	This example illustrates the influence of the catalyst USED IN THE BAEYER-VILLIGER OXIDATION of 2-pentyl cyclopentanone to lactones by 202. The reaction was carried out in the presence of 1 mol% catalyst in ethyl propionate as solvent at 110C in the same conditions as those reported in Example 1, Procedure C). The results are reported in Table 1.When the reaction was carried out in the presence of 1 mol% catalyst in tert-amyl alcohol as solvent at reflux in the same conditions as those reported in Example 1, Procedure C), similar results, reported in Table LA, were obtained.
	With dihydrogen peroxide;sodium hydrogencarbonate; In water; Ethyl propionate; at 110℃; for 6h;Heating / reflux;	This example illustrates the influence of the catalyst USED IN THE BAEYER-VILLIGER OXIDATION of 2-pentyl cyclopentanone to lactones by 202. The reaction was carried out in the presence of 1 mol% catalyst in ethyl propionate as solvent at 110C in the same conditions as those reported in Example 1, Procedure C). The results are reported in Table 1.
	With dihydrogen peroxide;sodium hydrogencarbonate; In tert-Amyl alcohol; water; at 110℃; for 6h;Heating / reflux;	This example illustrates the influence of the catalyst USED IN THE BAEYER-VILLIGER OXIDATION of 2-pentyl cyclopentanone to lactones by 202. The reaction was carried out in the presence of 1 mol% catalyst in ethyl propionate as solvent at 110C in the same conditions as those reported in Example 1, Procedure C). The results are reported in Table 1.When the reaction was carried out in the presence of 1 mol% catalyst in tert-amyl alcohol as solvent at reflux in the same conditions as those reported in Example 1, Procedure C), similar results, reported in Table LA, were obtained.
	With dihydrogen peroxide;magnesium 2-ethylhexanoate; In water; Ethyl propionate; at 110℃; for 6h;Heating / reflux;	This example illustrates the influence of the catalyst USED IN THE BAEYER-VILLIGER OXIDATION of 2-pentyl cyclopentanone to lactones by 202. The reaction was carried out in the presence of 1 mol% catalyst in ethyl propionate as solvent at 110C in the same conditions as those reported in Example 1, Procedure C). The results are reported in Table 1.
	With dihydrogen peroxide;sodium hydroxide; In tert-Amyl alcohol; water; at 110℃; for 6h;Heating / reflux;	This example illustrates the influence of the catalyst USED IN THE BAEYER-VILLIGER OXIDATION of 2-pentyl cyclopentanone to lactones by 202. The reaction was carried out in the presence of 1 mol% catalyst in ethyl propionate as solvent at 110C in the same conditions as those reported in Example 1, Procedure C). The results are reported in Table 1.When the reaction was carried out in the presence of 1 mol% catalyst in tert-amyl alcohol as solvent at reflux in the same conditions as those reported in Example 1, Procedure C), similar results, reported in Table LA, were obtained.
	With dihydrogen peroxide;lithium bromide; In water; Ethyl propionate; at 110℃; for 6h;Heating / reflux;	This example illustrates the influence of the catalyst USED IN THE BAEYER-VILLIGER OXIDATION of 2-pentyl cyclopentanone to lactones by 202. The reaction was carried out in the presence of 1 mol% catalyst in ethyl propionate as solvent at 110C in the same conditions as those reported in Example 1, Procedure C). The results are reported in Table 1.
	With dihydrogen peroxide;potassium acetate; In water; Ethyl propionate; at 110℃; for 6h;Heating / reflux;	This example illustrates the influence of the catalyst USED IN THE BAEYER-VILLIGER OXIDATION of 2-pentyl cyclopentanone to lactones by 202. The reaction was carried out in the presence of 1 mol% catalyst in ethyl propionate as solvent at 110C in the same conditions as those reported in Example 1, Procedure C). The results are reported in Table 1.
	With dihydrogen peroxide;sodium 2,2,2-trifluoroacetate; In water; Ethyl propionate; at 110℃; for 6h;Heating / reflux;	This example illustrates the influence of the catalyst USED IN THE BAEYER-VILLIGER OXIDATION of 2-pentyl cyclopentanone to lactones by 202. The reaction was carried out in the presence of 1 mol% catalyst in ethyl propionate as solvent at 110C in the same conditions as those reported in Example 1, Procedure C). The results are reported in Table 1.
	With dihydrogen peroxide;sodium 2-ethylhexanoic acid; In water; Ethyl propionate; at 110℃; for 6h;Heating / reflux;	This example illustrates the influence of the catalyst USED IN THE BAEYER-VILLIGER OXIDATION of 2-pentyl cyclopentanone to lactones by 202. The reaction was carried out in the presence of 1 mol% catalyst in ethyl propionate as solvent at 110C in the same conditions as those reported in Example 1, Procedure C). The results are reported in Table 1.
	With dihydrogen peroxide;lithium acetate; In water; chlorobenzene; at 110℃; for 6h;Heating / reflux;Reactivity;	This example illustrates the influence of the solvent used in the Baeyer-Villiger oxidation of 2-pentyl cyclopentanone to lactones by 70 % w/w aqueous H202 solution at 110C and in the presence of 1 mol% lithium acetate. The reaction was carried out under the same conditions as those described in Example 1, Procedure C). The results are reported in Table 2.
	With dihydrogen peroxide;lithium acetate; In 1,4-dioxane; water; at 110℃; for 6h;Heating / reflux;Reactivity;	This example illustrates the influence of the solvent used in the Baeyer-Villiger oxidation of 2-pentyl cyclopentanone to lactones by 70 % w/w aqueous H202 solution at 110C and in the presence of 1 mol% lithium acetate. The reaction was carried out under the same conditions as those described in Example 1, Procedure C). The results are reported in Table 2.
	With dihydrogen peroxide;lithium acetate; In Isopropyl acetate; water; at 110℃; for 6h;Heating / reflux;Reactivity;	This example illustrates the influence of the solvent used in the Baeyer-Villiger oxidation of 2-pentyl cyclopentanone to lactones by 70 % w/w aqueous H202 solution at 110C and in the presence of 1 mol% lithium acetate. The reaction was carried out under the same conditions as those described in Example 1, Procedure C). The results are reported in Table 2.
	With dihydrogen peroxide;lithium acetate; In water; Ethyl propionate; at 110℃; for 6h;Heating / reflux;	This example illustrates the influence of the catalyst USED IN THE BAEYER-VILLIGER OXIDATION of 2-pentyl cyclopentanone to lactones by 202. The reaction was carried out in the presence of 1 mol% catalyst in ethyl propionate as solvent at 110C in the same conditions as those reported in Example 1, Procedure C). The results are reported in Table 1.Example 3 BAEYER-VILLIGER Oxidation of pentyl cyclopentanone using various solvents This example illustrates the influence of the solvent used in the Baeyer-Villiger oxidation of 2-pentyl cyclopentanone to lactones by 70 % w/w aqueous H202 solution at 110C and in the presence of 1 mol% lithium acetate. The reaction was carried out under the same conditions as those described in Example 1, Procedure C). The results are reported in Table 2.
	With dihydrogen peroxide;lithium acetate; In tert-Amyl methyl ether; water; at 110℃; for 6h;Heating / reflux;Reactivity;	This example illustrates the influence of the solvent used in the Baeyer-Villiger oxidation of 2-pentyl cyclopentanone to lactones by 70 % w/w aqueous H202 solution at 110C and in the presence of 1 mol% lithium acetate. The reaction was carried out under the same conditions as those described in Example 1, Procedure C). The results are reported in Table 2.
	With dihydrogen peroxide;calcium carbonate; In water; Ethyl propionate; at 110℃; for 6h;Heating / reflux;	This example illustrates the influence of the catalyst USED IN THE BAEYER-VILLIGER OXIDATION of 2-pentyl cyclopentanone to lactones by 202. The reaction was carried out in the presence of 1 mol% catalyst in ethyl propionate as solvent at 110C in the same conditions as those reported in Example 1, Procedure C). The results are reported in Table 1.
	With dihydrogen peroxide;sodium peroxide; In water; Ethyl propionate; at 110℃; for 6h;Heating / reflux;	This example illustrates the influence of the catalyst USED IN THE BAEYER-VILLIGER OXIDATION of 2-pentyl cyclopentanone to lactones by 202. The reaction was carried out in the presence of 1 mol% catalyst in ethyl propionate as solvent at 110C in the same conditions as those reported in Example 1, Procedure C). The results are reported in Table 1.
	With dihydrogen peroxide;Na(polyacrylate); In water; Ethyl propionate; at 110℃; for 6h;Heating / reflux;	This example illustrates the influence of the catalyst USED IN THE BAEYER-VILLIGER OXIDATION of 2-pentyl cyclopentanone to lactones by 202. The reaction was carried out in the presence of 1 mol% catalyst in ethyl propionate as solvent at 110C in the same conditions as those reported in Example 1, Procedure C). The results are reported in Table 1.
	With dihydrogen peroxide;lithium pentane-2,4-dionate; In water; Ethyl propionate; at 110℃; for 6h;Heating / reflux;	This example illustrates the influence of the catalyst USED IN THE BAEYER-VILLIGER OXIDATION of 2-pentyl cyclopentanone to lactones by 202. The reaction was carried out in the presence of 1 mol% catalyst in ethyl propionate as solvent at 110C in the same conditions as those reported in Example 1, Procedure C). The results are reported in Table 1.
	With dihydrogen peroxide;lithium carbonate; In water; Ethyl propionate; at 110℃; for 6h;Heating / reflux;	This example illustrates the influence of the catalyst USED IN THE BAEYER-VILLIGER OXIDATION of 2-pentyl cyclopentanone to lactones by 202. The reaction was carried out in the presence of 1 mol% catalyst in ethyl propionate as solvent at 110C in the same conditions as those reported in Example 1, Procedure C). The results are reported in Table 1.
	With dihydrogen peroxide;barium carbonate; In water; Ethyl propionate; at 110℃; for 6h;Heating / reflux;	This example illustrates the influence of the catalyst USED IN THE BAEYER-VILLIGER OXIDATION of 2-pentyl cyclopentanone to lactones by 202. The reaction was carried out in the presence of 1 mol% catalyst in ethyl propionate as solvent at 110C in the same conditions as those reported in Example 1, Procedure C). The results are reported in Table 1.

Reference： [1]Journal of Fluorine Chemistry,2006,vol. 127,p. 592 - 596
[2]Patent: WO2004/78738,2004,A1 .Location in patent: Page 10-11
[3]Patent: WO2004/78738,2004,A1 .Location in patent: Page 11
[4]Patent: WO2004/78738,2004,A1 .Location in patent: Page 11-12
[5]Patent: WO2004/78738,2004,A1 .Location in patent: Page 11-12
[6]Patent: WO2004/78738,2004,A1 .Location in patent: Page 11-12
[7]Patent: WO2004/78738,2004,A1 .Location in patent: Page 11-12
[8]Patent: WO2004/78738,2004,A1 .Location in patent: Page 11-12
[9]Patent: WO2004/78738,2004,A1 .Location in patent: Page 11-12
[10]Patent: WO2004/78738,2004,A1 .Location in patent: Page 11-12
[11]Patent: WO2004/78738,2004,A1 .Location in patent: Page 11-12
[12]Patent: WO2004/78738,2004,A1 .Location in patent: Page 11-12
[13]Patent: WO2004/78738,2004,A1 .Location in patent: Page 11-12
[14]Patent: WO2004/78738,2004,A1 .Location in patent: Page 12-13
[15]Patent: WO2004/78738,2004,A1 .Location in patent: Page 12-13
[16]Patent: WO2004/78738,2004,A1 .Location in patent: Page 12-13
[17]Patent: WO2004/78738,2004,A1 .Location in patent: Page 11-12
[18]Patent: WO2004/78738,2004,A1 .Location in patent: Page 12-13
[19]Patent: WO2004/78738,2004,A1 .Location in patent: Page 11-12
[20]Patent: WO2004/78738,2004,A1 .Location in patent: Page 11-12
[21]Patent: WO2004/78738,2004,A1 .Location in patent: Page 11-12
[22]Patent: WO2004/78738,2004,A1 .Location in patent: Page 11-12
[23]Patent: WO2004/78738,2004,A1 .Location in patent: Page 11-12
[24]Patent: WO2004/78738,2004,A1 .Location in patent: Page 11-12

46
[ 705-86-2 ]
(+/-)-(2S,6R)-2-methyl-6-pentyltetrahydropyran-2-carboxaldehyde [ No CAS ]

Reference： [1]Organic Letters,2006,vol. 8,p. 4231 - 4234

47
[ 705-86-2 ]
(+/-)-(2S,6R)-2-methoxy-2-methyl-6-pentyltetrahydropyran [ No CAS ]

Reference： [1]Organic Letters,2006,vol. 8,p. 4231 - 4234

48
[ 705-86-2 ]
(+/-)-(2S,6R)-2-methyl-6-pentyl-2-propa-1',2'-dienyltetrahydropyran [ No CAS ]

Reference： [1]Organic Letters,2006,vol. 8,p. 4231 - 4234

49
[ 705-86-2 ]
(+/-)-(2'S,6'R)-1-furan-2-yl-3-(2'-methyl-6'-pentyltetrahydropyran-2'-yl)propenone [ No CAS ]

Reference： [1]Organic Letters,2006,vol. 8,p. 4231 - 4234

50
[ 705-86-2 ]
(+/-)-(2'S,3'R,7'R)-1-furan-2-yl-2-(3'-hydroxy-3'-methyl-7'-pentyloxepan-2-yl)ethanone [ No CAS ]

Reference： [1]Organic Letters,2006,vol. 8,p. 4231 - 4234

51
[ 705-86-2 ]
(+/-)-(2'S,6'R,3R)-1-furan-2-yl-3-hydroxy-3-(2'-methyl-6'-pentyltetrahydropyran-2'-yl)propan-1-one [ No CAS ]

Reference： [1]Organic Letters,2006,vol. 8,p. 4231 - 4234

52
[ 705-86-2 ]
Methanesulfonic acid (R)-3-furan-2-yl-1-((2S,6R)-2-methyl-6-pentyl-tetrahydro-pyran-2-yl)-3-oxo-propyl ester [ No CAS ]

Reference： [1]Organic Letters,2006,vol. 8,p. 4231 - 4234

53
[ 705-86-2 ]
Chloro-methanesulfonic acid (R)-3-furan-2-yl-1-((2S,6R)-2-methyl-6-pentyl-tetrahydro-pyran-2-yl)-3-oxo-propyl ester [ No CAS ]

Reference： [1]Organic Letters,2006,vol. 8,p. 4231 - 4234

54
[ 705-86-2 ]
(5R,7S)-7-Pentyl-1,6-dioxa-spiro[4.5]decane [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2005,vol. 127,p. 528 - 529

55
[ 705-86-2 ]
(2S,6S)-2-(3-Chloro-propyl)-6-pentyl-tetrahydro-pyran-2-carbonitrile [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2005,vol. 127,p. 528 - 529

56
[ 705-86-2 ]
(2S,6S)-2-(3-Hydroxy-propyl)-6-pentyl-tetrahydro-pyran-2-carbonitrile [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2005,vol. 127,p. 528 - 529

57
[ 705-86-2 ]
trifluoroethyl trifluoroacetate [ No CAS ]
[ 544436-22-8 ]

Reference： [1]Angewandte Chemie - International Edition,2003,vol. 42,p. 818 - 820

58
[ 705-86-2 ]
trifluoroethyl trifluoroacetate [ No CAS ]
(R)-7-Pentyl-6-oxa-spiro[4.5]decane [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2003,vol. 42,p. 818 - 820
[2]Angewandte Chemie - International Edition,2003,vol. 42,p. 818 - 820

59
[ 705-86-2 ]
trifluoroethyl trifluoroacetate [ No CAS ]
(2S,6R)-2,6-Dipentyl-tetrahydro-pyran [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2003,vol. 42,p. 818 - 820

60
[ 705-86-2 ]
trifluoroethyl trifluoroacetate [ No CAS ]
(R)-2-Pentyl-1-oxa-spiro[5.5]undecane [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2003,vol. 42,p. 818 - 820

61
[ 705-86-2 ]
trifluoroethyl trifluoroacetate [ No CAS ]
(1S,5R,7S)-7-Pentyl-1-vinyl-6-oxa-spiro[4.5]decane [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2003,vol. 42,p. 818 - 820

62
[ 705-86-2 ]
trifluoroethyl trifluoroacetate [ No CAS ]
(2S,6S)-2-(4-Chloro-butyl)-6-pentyl-tetrahydro-pyran-2-carbonitrile [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2003,vol. 42,p. 818 - 820

63
[ 705-86-2 ]
trifluoroethyl trifluoroacetate [ No CAS ]
(1S,5R,7S)-1-Methyl-7-pentyl-1-vinyl-6-oxa-spiro[4.5]decane [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2003,vol. 42,p. 818 - 820

64
[ 705-86-2 ]
trifluoroethyl trifluoroacetate [ No CAS ]
(2R,6S)-2-Pent-4-enyl-6-pentyl-tetrahydro-pyran-2-carbonitrile [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2003,vol. 42,p. 818 - 820

65
[ 705-86-2 ]
trifluoroethyl trifluoroacetate [ No CAS ]
(2R,6S)-2-(5-Chloro-pentyl)-6-pentyl-tetrahydro-pyran-2-carbonitrile [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2003,vol. 42,p. 818 - 820

66
[ 705-86-2 ]
trifluoroethyl trifluoroacetate [ No CAS ]
(2R,6S)-2-((E)-6-Methoxy-hex-4-enyl)-6-pentyl-tetrahydro-pyran-2-carbonitrile [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2003,vol. 42,p. 818 - 820

67
[ 705-86-2 ]
trifluoroethyl trifluoroacetate [ No CAS ]
((1S,5R,7S)-7-Pentyl-6-oxa-spiro[4.5]dec-1-yl)-acetic acid methyl ester [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2003,vol. 42,p. 818 - 820

68
[ 705-86-2 ]
trifluoroethyl trifluoroacetate [ No CAS ]
((1S,5R,7S)-7-Pentyl-6-oxa-spiro[4.5]dec-1-yl)-acetic acid [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2003,vol. 42,p. 818 - 820

69
[ 705-86-2 ]
trifluoroethyl trifluoroacetate [ No CAS ]
Trimethyl-[(5R,7S)-7-pentyl-6-oxa-spiro[4.5]dec-(1E)-ylidenemethyl]-silane [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2003,vol. 42,p. 818 - 820

70
[ 705-86-2 ]
trifluoroethyl trifluoroacetate [ No CAS ]
(2R,6S)-2-((E)-6-Methoxy-4-methyl-hex-4-enyl)-6-pentyl-tetrahydro-pyran-2-carbonitrile [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2003,vol. 42,p. 818 - 820

71
[ 705-86-2 ]
trifluoroethyl trifluoroacetate [ No CAS ]
(2R,6S)-6-Pentyl-2-(5-trimethylsilanyl-pent-4-ynyl)-tetrahydro-pyran-2-carbonitrile [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2003,vol. 42,p. 818 - 820

72
[ 705-86-2 ]
trifluoroethyl trifluoroacetate [ No CAS ]
Phosphoric acid 4-((2R,6S)-2-cyano-6-pentyl-tetrahydro-pyran-2-yl)-butyl ester diethyl ester [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2003,vol. 42,p. 818 - 820

73
[ 705-86-2 ]
[ 102942-65-4 ]

Reference： [1]Journal of Natural Products,2001,vol. 64,p. 572 - 577

74
[ 705-86-2 ]
[ 345261-16-7 ]

Reference： [1]Journal of Natural Products,2001,vol. 64,p. 572 - 577

75
[ 705-86-2 ]
[ 345261-14-5 ]

Reference： [1]Journal of Natural Products,2001,vol. 64,p. 572 - 577

76
[ 705-86-2 ]
[ 345261-15-6 ]

Reference： [1]Journal of Natural Products,2001,vol. 64,p. 572 - 577

77
[ 705-86-2 ]
6-Acetamido-1,1,1-trichloroundecane [ No CAS ]

Reference： [1]Journal of Natural Products,2001,vol. 64,p. 572 - 577

78
[ 705-86-2 ]
[ 2825-91-4 ]

Reference： [1]Heterocycles,2000,vol. 52,p. 1359 - 1370
[2]Tetrahedron Letters,1988,vol. 29,p. 1915 - 1918
[3]Chirality,2016,p. 623 - 627

79
[ 705-86-2 ]
[ 197856-91-0 ]

Reference： [1]Heterocycles,2000,vol. 52,p. 1359 - 1370

80
[ 705-86-2 ]
[ 59285-67-5 ]

Reference： [1]Heterocycles,2000,vol. 52,p. 1359 - 1370

81
[ 705-86-2 ]
[ 134625-01-7 ]

Reference： [1]Heterocycles,2000,vol. 52,p. 1359 - 1370

82
[ 705-86-2 ]
[ 5270-42-8 ]

Reference： [1]Angewandte Chemie - International Edition,2015,vol. 54,p. 5196 - 5200
Angew. Chem.,2015,vol. 127,p. 5285 - 5289,5
[2]Journal of Organic Chemistry,1998,vol. 63,p. 2360 - 2361

83
[ 705-86-2 ]
[ 501-23-5 ]

Reference： [1]Journal of the American Chemical Society,2019,vol. 141,p. 5669 - 5674
[2]Journal of Organic Chemistry,1997,vol. 62,p. 2633 - 2635

84
[ 705-86-2 ]
[ 544436-22-8 ]

Reference： [1]Journal of Organic Chemistry,1996,vol. 61,p. 7648 - 7649

85
[ 705-86-2 ]
(2R,6R)-2-Allyl-6-pentyl-tetrahydro-pyran [ No CAS ]

Reference： [1]Journal of Organic Chemistry,1996,vol. 61,p. 7648 - 7649

86
[ 705-86-2 ]
Trimethyl-((2S,6R)-6-pentyl-tetrahydro-pyran-2-ylethynyl)-silane [ No CAS ]

Reference： [1]Journal of Organic Chemistry,1996,vol. 61,p. 7648 - 7649

87
[ 705-86-2 ]
(2S,6S)-2-Allyl-6-pentyl-tetrahydro-pyran-2-carbonitrile [ No CAS ]

Reference： [1]Journal of Organic Chemistry,1996,vol. 61,p. 7648 - 7649

88
[ 592-76-7 ]
carbon monoxide [ No CAS ]
[ 705-86-2 ]

Reference： [1]Chemische Berichte,1984,vol. 117,p. 859 - 861
[2]Chemische Berichte,1984,vol. 117,p. 859 - 861

Same Skeleton Products

Related Products

Historical Records

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]}	{[ getRatePrice(item.pr_usd, 1,1) ]}	Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]}	{[ item.pr_usastock ]}	Inquiry -	{[ item.pr_chinastock ]}	Inquiry -

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 705-86-2 ] {[proInfo.proName]}

Quality Control of [ 705-86-2 ]

Related Doc. of [ 705-86-2 ]

Product Details of [ 705-86-2 ]

Calculated chemistry of [ 705-86-2 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 705-86-2 ]

Application In Synthesis of [ 705-86-2 ]

[ 705-86-2 ] Synthesis Path-Downstream 1~88

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry