[ CAS No. 6843-45-4 ] {[proInfo.proName]}

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Quality Control of [ 6843-45-4 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 6843-45-4 ]

Product Details of [ 6843-45-4 ]

CAS No. :	6843-45-4	MDL No. :	MFCD12755958
Formula :	C₄H₆N₂O₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	114.10	Pubchem ID :	-
Synonyms :

Safety of [ 6843-45-4 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 6843-45-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 6843-45-4 ]

[ 6843-45-4 ] Synthesis Path-Downstream 1~10

1
[ 56099-63-9 ]
[ 6843-45-4 ]

Yield	Reaction Conditions	Operation in experiment
	With trifluoroacetic acid for 1h; Heating;
	With sulfuric acid In water at 24.9℃; ΔH(excit); ΔS(excit). Various temperatures, reagents and pH;

Reference： [1]Gueler, Faruk; Moodie, Roy B. [Journal of the Chemical Society. Perkin transactions II, 1980, p. 1752 - 1756]
[2]Gueler, Faruk; Moodie, Roy B. [Journal of the Chemical Society. Perkin transactions II, 1980, p. 1752 - 1756]

Yield	Reaction Conditions	Operation in experiment
	at 0℃; sowie bei 25grad;

4
[ 461-72-3 ]
[ 18871-66-4 ]
[ 6843-45-4 ]

Yield	Reaction Conditions	Operation in experiment
73%	In toluene Heating;
68%	In toluene for 2h; Reflux;	10149] Preparation of 3-methylimidazolidine-2,4-dione To a solution of hydantoin (0.50 g, 5.0 mmol) in toluene(30 mE), i, i -dimethoxy-N,N-dimethylethanamine (i .3 g, i 0 mmol, 2 equiv) was added. The mixture was refluxed for 2 hours then allowed to cool down to room temperature. Direct crystallization from the toluene gives 3-methylimi- dazolidine-2,4-dione (i) as a white solid (0.39 g, 68% yield) without thrther purification. ‘H NMR (400 MHz, CD3OD):ö8.Oi (s, iH), 3.88 (s, iH), 2.8i (s, iH). ‘3C NMR (400 MHz, CD3OD): öi72.9, i58.9, 46.0, 23.2.
62%	In toluene for 3h; Heating;

50%	In toluene at 110℃; for 2h;	3 2,4-imidazolinedione (1.0 equiv) was dissolved in 40 ml of toluene,N, N-dimethylacetamide dimethyl acetal (N, N-dimethylacetamide dimethyl acetal) (3.0 equiv)The reaction solution was stirred at 110 ° C for 2 hours and then cooled to room temperature and cooled to 0 ° C for 15 minutes.Filter to get residue,The residue was washed five times with toluene and dried in vacuo to give 3-methylimidazolidine-2,4-dione (3-methyl-imidazoline-2,4-dione).Yield 50%.
	In toluene at 110℃; for 2h;	1.16 Hydantoin (19.0 g, 190 mmol, 1.0 eq) was suspended in toluene (700 ml) and N,N-dimethylacetamide dimethyl acetal (75.0 g, 563 mmol, 3.0 eq) was added. The resulting mixture was heated at 110 °C for two hours, cooled to ambient temperature and then cooled to 0° C for 15 minutes. The resulting precipitate was collected by filtration, washed with toluene (5 x 50 mL) and dried in vacuo to afford the titled compound as a pale yellow solid. NMR (400 MHz, CDC13) δ 6.09 (1 H, brs); 3.99 (1 H, s); 3.04 (1 H, s) ppm.
	In toluene for 3h; Reflux;

Reference： [1]Porter, Michael J.; White, Nicola J.; Howells, Garnet E.; Laffan, David D.P. [Tetrahedron Letters, 2004, vol. 45, # 35, p. 6541 - 6543]
[2]Current Patent Assignee: UNIVERSITY OF OTTAWA HEART INSTITUTE - US2016/324992, 2016, A1 Location in patent: Paragraph 0149
[3]Janin, Yves L.; Huel, Christiane; Flad, Genevieve; Thirot, Sylvie [European Journal of Organic Chemistry, 2002, # 11, p. 1763 - 1769]
[4]Current Patent Assignee: SICHUAN UNIVERSITY - CN106279132, 2017, A Location in patent: Paragraph 0081; 0082; 0083
[5]Current Patent Assignee: MERCK & CO INC - WO2012/151136, 2012, A1 Location in patent: Page/Page column 29
[6]Nie, Yu; Li, Jing; Yuan, Qianjia; Zhang, Wanbin [Chinese Journal of Chemistry, 2022, vol. 40, # 7, p. 819 - 824]

5
[ 6843-45-4 ]
[ 4771-50-0 ]
3-Methyl-5-[1-(7-methyl-1H-indol-3-yl)-meth-(Z)-ylidene]-imidazolidine-2,4-dione [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,p. 5039 - 5044

6
[ 6843-45-4 ]
[ 876-72-2 ]
5-[1-(4-Chloro-1H-indol-3-yl)-meth-(Z)-ylidene]-3-methyl-imidazolidine-2,4-dione [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,p. 5039 - 5044

7
[ 6843-45-4 ]
[ 1008-07-7 ]
5-[1-(7-Chloro-1H-indol-3-yl)-meth-(Z)-ylidene]-3-methyl-imidazolidine-2,4-dione [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With piperidine; at 110℃; for 4h;	We heated a mixture of (1-6) (1 mmol) and l-methylimidazol-255(l,3H)- dione (which we synthesized according to the method used by Janin et al., Eur. <n="126"/>J. Org. Chem. 2002:1763-1769, 2002) (250mg, 2.5 mmol) in piperidine (2 mL) at 1100C for four hours under an argon atmosphere. Then, we allowed the reaction mixture to cool in a refrigerator (~ 5C) with the addition of ether (2 mL). We filtered the precipitate and washed it with ether to give (1-7). 1H NMR (500 MHz, DMSO-d6): delta 12.15 (IH, br s), 10.26 (IH, br s), 8.23 (IH, s), 7.79 (IH, d, J = 8.0 Hz), 7.27 (IH, d, J = 8.0 Hz,), 7.13 (IH, t, J = 7.8 Hz), 6.82 (IH, s), 2.97 (3H, s).

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,p. 5039 - 5044
[2]Patent: WO2007/75772,2007,A2 .Location in patent: Page/Page column 124-125

8
[ 6843-45-4 ]
[ 92855-65-7 ]
5-[1-(7-Benzyloxy-1H-indol-3-yl)-meth-(Z)-ylidene]-3-methyl-imidazolidine-2,4-dione [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,p. 5039 - 5044

9
[ 6843-45-4 ]
[ 115666-21-2 ]
5-((7-bromo-1H-indol-3-yl)methylene)-3-methylimidazolidine-2,4-dione [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
73%	With piperidine at 110℃; for 6h; Sealed tube;	Preparation of 5-((7-bromo- iH-indol-3-yl)methyl-ene)-3-methylimidazolidine-2,4-dione (2). To a solution of 7-bromo-i H-indole-3-carbaldehyde (220 mg, i.0 mmol) in piperidine (2 mE) in a seal tube was added 3-methylimida- zolidine-2,4-dione (i) (230 mg, 2.0 mmol, 2 equiv). Thetube was sealed and the reaction mixture was heated for 6 hours at 1100 C. Afier cooling down to room temperature, the mixture was transferred to water (100 mL) using a pipet. The target compound was filtered out as yellow precipitate (234 mg, 73% yield) without further purification. ‘H NMR (300 MHz, DMSO-d6): ö 8.19 (s, 1H), 7.80 (dd, J=8.02, 0.80 Hz, 1H), 7.38 (dd, J=7.59, 0.74 Hz, 1H), 7.04 (t, J=7.78 Hz, 1H), 6.77 (d, J=0.53 Hz, 1H), 2.93 (s, 3H).
	With piperidine In ethanol at 90℃; for 16h;

Reference： [1]Current Patent Assignee: UNIVERSITY OF OTTAWA HEART INSTITUTE - US2016/324992, 2016, A1 Location in patent: Paragraph 0150
[2]Lan, Yu; Bai, Ping; Liu, Yan; Afshar, Sepideh; Striar, Robin; Rattray, Anna Kathryn; Meyer, Tyler Nicholas; Langan, Amelia G.; Posner, Alisa M.; Shen, Shiqian; Tanzi, Rudolph E.; Zhang, Can; Wang, Changning [Journal of Medicinal Chemistry, 2021, vol. 64, # 20, p. 15420 - 15428]

10
[ 875003-43-3 ]
[ 6843-45-4 ]
[ 109-77-3 ]
(cis-3,7a')-5'-amino-7-fluoro-1,2'-dimethyl-1',2,3'-trioxo-1',2',3',7a'-tetrahydrospiro[indoline-3,7'-pyrrolo[1,2-c]imidazole]-6'-carbonitrile [ No CAS ]

Reference： [1]ACS Combinatorial Science,2017,vol. 19,p. 455 - 463

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[ CAS No. 6843-45-4 ] {[proInfo.proName]}

Quality Control of [ 6843-45-4 ]

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Application In Synthesis of [ 6843-45-4 ]

[ 6843-45-4 ] Synthesis Path-Downstream 1~10

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