[ CAS No. 6683-19-8 ] {[proInfo.proName]}

Name: 6683-19-8|2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate)|98%
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Quality Control of [ 6683-19-8 ]

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Product Details of [ 6683-19-8 ]

CAS No. :	6683-19-8	MDL No. :	MFCD00059345
Formula :	C₇₃H₁₀₈O₁₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	BGYHLZZASRKEJE-UHFFFAOYSA-N
M.W :	1177.63	Pubchem ID :	64819
Synonyms :

Safety of [ 6683-19-8 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 6683-19-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 6683-19-8 ]
Downstream synthetic route of [ 6683-19-8 ]

[ 6683-19-8 ] Synthesis Path-Upstream 1~7

1
[ 67-56-1 ]
[ 6683-19-8 ]
[ 6386-38-5 ]

Reference： [1] Russian Chemical Bulletin, 2012, vol. 61, # 9, p. 1689 - 1693[2] Izv. Akad. Nauk, Ser. Khim., 2012, # 9, p. 1673 - 1677,5

2
[ 115-77-5 ]
[ 6386-38-5 ]
[ 6683-19-8 ]

Yield	Reaction Conditions	Operation in experiment
98%	With sodium montmorillonite In methanol at 130 - 140℃; for 7 h; Inert atmosphere	The 584gβ- (3,5- di-t-butyl-4-hydroxyphenyl) propionate,68 g of pentaerythritol,0.58 g of sodium montmorillonite,50 ml of methanol was added to the flask with mechanical stirring,Thermometer socket,In a 1000 ml four-necked flask equipped with a stirrer,Heating the material with a heating jacket,And stirring is started,The temperature reaches 130-140 ,Filled with nitrogen,The reaction system pressure was controlled at 3-4 MPa,7h after the end of the reaction,Cooling to 25 ,filter,drying,Pentaerythritol tetrakis [β - (3,5-di-tert-butyl-4-hydroxyphenyl) propionate]. The results of liquid chromatography, the results shown in Figure 1,The absorption peak at the retention time of 2.643 min belongs to 3.5 methyl ester with the content of 0.43percent.The absorption peak at the retention time of 3.29 min is attributed toPentaerythritol tris [β- (3,5-di-tert-butyl-4-hydroxyphenyl) propionate], content of 0.69percent;The absorption peak at 3.84 min was assigned to dealkylationPentaerythritol tetrakis [β- (3,5-di-tert-butyl-4-hydroxyphenyl) propionate] in 0.55percent;The absorption peak at the retention time of 4.747 min is attributed toPentaerythritol tetrakis [β- (3,5-di-tert-butyl-4-hydroxyphenyl) propionate] in 96.45percentTherefore, the synthesis of pentaerythritol tetrakis [[beta] - (3,5-di-tert-butyl-4-hydroxyphenyl) propionate] in the present method meets the industry standard of not less than 94percent. The yield of the product was 98percent.
96.7%	at 185℃; for 7 h;	Take pentaerythritol 6.8g, 3,5-methyl ester 65.8g and ionic liquid catalyst [Bmim] OH 0.34g added to fourBottle, the reaction pressure is -0.1MPa, reaction at 185 7h, after the reaction is hot (70 or so) was added 90ml solvent was allowed to standStratification, the upper organic phase, the lower ionic liquid phase, ionic liquid recycling recycling, organic phase recrystallization to give the productAntioxidant 1010. HPLC showed that the target product pentaerythritol tetrakis [β- (3,5-di-tert-butyl-4- hydroxyphenyl) propionate]The amount can reach 98.6percent, yield 96.7percent.

Reference： [1] Patent: CN106278894, 2017, A, . Location in patent: Paragraph 0017; 0018; 0019
[2] Patent: CN106748790, 2017, A, . Location in patent: Paragraph 0031; 0032; 0033; 0034; 0035; 0036; 0037-0050
[3] Russian Chemical Bulletin, 2012, vol. 61, # 9, p. 1689 - 1693[4] Izv. Akad. Nauk, Ser. Khim., 2012, # 9, p. 1673 - 1677,5
[5] Patent: WO2005/42463, 2005, A1, . Location in patent: Page/Page column 10
[6] Patent: WO2005/42463, 2005, A1, . Location in patent: Page/Page column 10
[7] Patent: WO2005/42463, 2005, A1, . Location in patent: Page/Page column 10
[8] Patent: WO2005/42463, 2005, A1, . Location in patent: Page/Page column 10
[9] Patent: WO2005/42463, 2005, A1, . Location in patent: Page/Page column 10
[10] Patent: WO2005/42463, 2005, A1, . Location in patent: Page/Page column 10
[11] Patent: WO2005/42463, 2005, A1, . Location in patent: Page/Page column 10
[12] Patent: WO2005/42463, 2005, A1, . Location in patent: Page/Page column 10
[13] Patent: WO2005/42463, 2005, A1, . Location in patent: Page/Page column 10
[14] Patent: WO2005/42463, 2005, A1, . Location in patent: Page/Page column 10
[15] Patent: WO2005/42463, 2005, A1, . Location in patent: Page/Page column 10
[16] Patent: WO2005/42463, 2005, A1, . Location in patent: Page/Page column 10
[17] Patent: WO2005/42463, 2005, A1, . Location in patent: Page/Page column 10
[18] Patent: WO2005/42463, 2005, A1, . Location in patent: Page/Page column 10
[19] Patent: WO2005/42463, 2005, A1, . Location in patent: Page/Page column 10
[20] Patent: WO2005/42463, 2005, A1, . Location in patent: Page/Page column 10
[21] Patent: WO2005/42463, 2005, A1, . Location in patent: Page/Page column 10
[22] Patent: US5136082, 1992, A,
[23] Patent: US5136082, 1992, A,
[24] Patent: US4618700, 1986, A,

3
[ 51590-67-1 ]
[ 856335-90-5 ]
[ 6386-38-5 ]
[ 6683-19-8 ]

Reference： [1] Patent: US5081280, 1992, A,

4
[ 115-77-5 ]
[ 6228-26-8 ]
[ 6386-38-5 ]
[ 9004-34-6 ]
[ 6683-19-8 ]

Reference： [1] Patent: US4883902, 1989, A,

5
[ 84633-54-5 ]
[ 6386-38-5 ]
[ 6683-19-8 ]

Reference： [1] Patent: WO2005/42463, 2005, A1, . Location in patent: Page/Page column 4-6
[2] Patent: WO2005/42463, 2005, A1, . Location in patent: Page/Page column 6-9
[3] Patent: WO2005/42463, 2005, A1, . Location in patent: Page/Page column 9-10

6
[ 463-84-3 ]
[ 6386-38-5 ]
[ 6683-19-8 ]

Reference： [1] Patent: WO2004/48312, 2004, A1, . Location in patent: Page 7

7
[ 57852-58-1 ]
[ 6683-19-8 ]

Reference： [1] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1985, vol. 34, p. 1833 - 1841[2] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1985, # 9, p. 1987 - 1996

[ 6683-19-8 ] Synthesis Path-Downstream 1~12

1
[ 57852-58-1 ]
[ 6683-19-8 ]
C₇₃H₁₀₆O₁₂ [ No CAS ]

Reference： [1]Bulletin of the Academy of Sciences of the USSR Division of Chemical Science,1985,vol. 34,p. 1833 - 1841
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya,1985,p. 1987 - 1996

Yield	Reaction Conditions	Operation in experiment
	In methanol; at 20℃; for 1h;Purification / work up;	1.2 Preparation of crystalline particles of IRGANOX1010 from methanol; An aqueous solution of 500 g methanol (93.0 weight%) is added to a 1.51 double jacketreaction vessel equipped with anchor agitator and stirred at 220 rpm at 20C. 500 g parti- cles of IRGANOX 1010 as obtained by Example 1.1 are added while agitating. The mix- ture is kept stirring at 20C for 60 min. The crystalline particles are filtered off with a suc- tion filter screen of 60 mesh and dried in an oven for 2 h at 35C and 2 h at 80C at lessthan 50 mbar. A particle fraction of 10% is smaller than 600 jj., 50% smaller than 900 \|j.and 90% smaller than 1400 n. The crystalline particles are characterised their heat of fu- sion: -45 J/g at 114.5C (Mettler-Toledo DSC 822, 40 jil vial, 10C/min) and a residualmoisture content of less than 10% at 150 times the gravitational acceleration.
	In ethanol; at 50℃; for 0.5h;Purification / work up;	2. Preparation of crystalline particles of IRGANOX 1010 from ethanol; An aqueous solution of 800 g ethanol (90.0 weight%) is added to a 1.51 double jacketreaction vessel equipped with anchor agitator and stirred at 220 rpm at 50C. 50 g parti- cles of IRGANOX 1010 as obtained by Example 1.1 are added while agitating. The mix- ture is stirred at,iOC for 30 min. The crystalline particles are filtered off with a suctionfilter screen of 60 mesh and dried in an oven for 2 h at 35C and 2 h at 80C at less than50 mbar. A particle fraction of 10% is smaller than 600 i, 50% smaller than 900 {i and90% smaller than 1400 jj,. The crystalline particles are characterised by their heat of fu- sion: -47 J/g at 114.1C (Mettler-Toledo DSC 822,40 i vial, 10C/min) and a residualmoisture content of less than 10% at 150 times the gravitational acceleration.

Yield	Reaction Conditions	Operation in experiment
		Further costabilizers can also be substituted phenols or hydroquinones, for example the following: 4-tert-butylpyrocatechol, methoxyhydroquinone, 2,6-di-tert-butyl-4-methylphenol, n-octadecyl-beta-(3,5-di-tert-butyl-4-hydroxyphenyl) propionate, 1,1,3-tris-(2-methyl-4-hydroxy-5-tert-butylphenyl)butane, 1,3,5-trimethyl-2,4,6-tris-(3,5-di-tert-butyl-4-hydroxybenzyl)-benzene, 1,3,5-tris-(3,5-di-tert-butyl-4-hydroxybenzyl) isocyanurate, 1,3,5-tris-[beta-(3,5-di-tert-butyl-4-hydroxyphenyl) propionyloxyethyl] isocyanurate, 1,3,5-tris-(2,6-dimethyl-3-hydroxy-4-tert-butylbenzyl) isocyanurate or pentaerythrityl tetrakis-[beta-(3,5-di-tert-butyl-4-hydroxyphenyl)-propionate].
		A process according to claim 1 wherein the compound of formula I is isooctyl 3,5-di-tert-butyl-4-hydroxyhydrocinnamate, n-octadecyl 3,5-di-tert-butyl-4-hydroxyhydrocinnamate, or pentaerythrityl tetrakis(3,5-di-tert-butyl-4-hydroxyhydrocinnamate).
		CONTROL EXAMPLE 1A The procedure and ingredients of Example 1 are used except for NMP, in other words, the reaction is neat. After 2.5 hours, 98% of tetrakis [3-(3,5-di-t-butyl-4-hydroxyphenyl)propionyloxymethyl]methane is obtained, based on the pentaerythritol.

		CONTROL EXAMPLE 2A The procedure and ingredients of Example 2 are used except for NMP, in other words, the reaction is neat. After 2.5 hours, 92% of tetrakis [3-(3,5-di-t-butyl-4-hydroxyphenyl)propionyloxymethyl]methane is obtained, based on the pentaerythritol.
		The compound numbers I-1, I-4, I-6 and I-7 correspond to those of the present compounds given in Table 1; the compound numbers from AO-1 to AO-6 represent the following compounds: AO-1: Tris[beta-(3,5-di-t-butyl-4-hydroxyphenyl)propionyloxy]ethyl isocyanurate AO-2: Pentaerythritol tetrakis[beta-(3,5-di-t-butyl-4-hydroxyphenyl)propionate] AO-3: Dilauryl 3,3'-thiodipropionate AO-4: Distearyl 3,3'-thiodipropionate AO-5: Pentaerythritol tetrakis(beta-hexylthiopropionate) AO-6: Pentaerythritol tetrakis(beta-laurylthiopropionate)
		In Examples, the following compounds were used for comparison. A0-1 2,6-Di-t-butyl-4-methylphenol A0-2 n-Octadecyl 3-(3,5-di-t-butyl-4-hydroxyphenyl)propionate A0-3 Pentaerythritol tetrakis[3-(3,5-di-t-butyl-4-hydroxyphenyl)propionate] A0-4 1,3,5-Trimethyl-2,4,6-tris(3,5-di-t-butyl-4-hydroxybenzyl)benzene
		Compounds of Formula III 1,1,1-trimethylol-propane-{3-(3',5'-di-t-butyl-4'-hydroxyphenyl)-propionate} pentaerythritol tetrakis-{3-(2'-methyl-5'-t-butyl-4'-hydroxyphenyl)-propionate} pentaerythritol tetrakis-{3-(3',5'-di-t-butyl-4'-hydroxyphenyl)-propionate}.
		C. Vacuum was applied and the pressure was reduced to 8 to 20 mm Hg. while heating the mixture in 2.5 hours 155 C. and holding it at that temperature for nine hours. The vacuum was released with nitrogen. The reaction mixture was cooled to 110 C. and acidified with 3.0 g of glacial acetic acid. The resultant melt was dissolved in 500 ml of ethyl alcohol, and the solution was clarified into a 2000 ml flask. 445 ml of ethyl alcohol were added to the filtrate and the solution was seeded with 0.5 g of pentaerythritol tetrakis-{3-(3',5'-di-t-butyl-4-hydroxypheny)propionate} at 40 C. The reaction product crystallized, and the slurry was allowed to cool overnight. The reaction product was then isolated on a Buchner funnel, washed with ethyl alcohol, sucked dry and dried in a vacuum oven at 60 C. to a constant weight. 114 g of dry pentaerythritol tetrakis-{3-(3',5'-di-t-butyl-4-hydroxyphenyl)propionate} of the above formula were obtained.

4
[ 6683-19-8 ]
[ 32687-77-7 ]

Reference： [1]Russian Journal of General Chemistry,2001,vol. 71,p. 931 - 933

5
[ 463-84-3 ]
[ 6386-38-5 ]
[ 6683-19-8 ]

Yield	Reaction Conditions	Operation in experiment
	Neat (no solvent);	IRGANOX 1010 is obtained without the presence of a solvent by catalytic transesterification of methyl 3- (3, 5-DI-TERT-BUTYL-4-HYDROXYPHENYL)-PROPIONATE with pentae- rythritol and subsequent distillation of the melt in the vacuum at elevated temperatures.

Reference： [1]Patent: WO2004/48312,2004,A1 .Location in patent: Page 7

6
[ 115-77-5 ]
[ 6386-38-5 ]
[ 6683-19-8 ]

Yield	Reaction Conditions	Operation in experiment
98%	With sodium montmorillonite; In methanol; at 130 - 140℃; under 22502.3 - 30003 Torr; for 7h;Inert atmosphere;	The 584gbeta- (3,5- di-t-butyl-4-hydroxyphenyl) propionate,68 g of pentaerythritol,0.58 g of sodium montmorillonite,50 ml of methanol was added to the flask with mechanical stirring,Thermometer socket,In a 1000 ml four-necked flask equipped with a stirrer,Heating the material with a heating jacket,And stirring is started,The temperature reaches 130-140 ,Filled with nitrogen,The reaction system pressure was controlled at 3-4 MPa,7h after the end of the reaction,Cooling to 25 ,filter,drying,Pentaerythritol tetrakis [beta - (3,5-di-tert-butyl-4-hydroxyphenyl) propionate]. The results of liquid chromatography, the results shown in Figure 1,The absorption peak at the retention time of 2.643 min belongs to 3.5 methyl ester with the content of 0.43%.The absorption peak at the retention time of 3.29 min is attributed toPentaerythritol tris [beta- (3,5-di-tert-butyl-4-hydroxyphenyl) propionate], content of 0.69%;The absorption peak at 3.84 min was assigned to dealkylationPentaerythritol tetrakis [beta- (3,5-di-tert-butyl-4-hydroxyphenyl) propionate] in 0.55%;The absorption peak at the retention time of 4.747 min is attributed toPentaerythritol tetrakis [beta- (3,5-di-tert-butyl-4-hydroxyphenyl) propionate] in 96.45%Therefore, the synthesis of pentaerythritol tetrakis [[beta] - (3,5-di-tert-butyl-4-hydroxyphenyl) propionate] in the present method meets the industry standard of not less than 94%. The yield of the product was 98%.
96.7%	With 1-butyl-3-methylimidazolium hydroxide; at 185℃; for 7h;	Take pentaerythritol 6.8g, 3,5-methyl ester 65.8g and ionic liquid catalyst [Bmim] OH 0.34g added to fourBottle, the reaction pressure is -0.1MPa, reaction at 185 7h, after the reaction is hot (70 or so) was added 90ml solvent was allowed to standStratification, the upper organic phase, the lower ionic liquid phase, ionic liquid recycling recycling, organic phase recrystallization to give the productAntioxidant 1010. HPLC showed that the target product pentaerythritol tetrakis [beta- (3,5-di-tert-butyl-4- hydroxyphenyl) propionate]The amount can reach 98.6%, yield 96.7%.
	lithium hydroxide; at 180℃; for 20h;Product distribution / selectivity;	A Radleys Carousel 6 Place Reaction Station, with 250ml flasks connected to water- pump vacuum in order to facilitate methanol removal was used to screen different catalysts for the reaction of pentaerythritol (2.8g) and PP Base (27. 2g, 13% excess) at a reaction temperature of 180C. Catalysts were used at a total loading of 3mol%/PP Base (where two catalysts were used, each was added at 1. 5mol% loading). Where two catalysts were used, the 2nd catalyst was added after 4h. Anox 20 content is given by HPLC area% of the final product mixture. The results obtained are summarised in the following table

	lithium methanolate; zinc stearate; at 180℃; for 17h;Product distribution / selectivity;	A Radleys Carousel 6 Place Reaction Station, with 250ml flasks connected to water- pump vacuum in order to facilitate methanol removal was used to screen different catalysts for the reaction of pentaerythritol (2.8g) and PP Base (27. 2g, 13% excess) at a reaction temperature of 180C. Catalysts were used at a total loading of 3mol%/PP Base (where two catalysts were used, each was added at 1. 5mol% loading). Where two catalysts were used, the 2nd catalyst was added after 4h. Anox 20 content is given by HPLC area% of the final product mixture. The results obtained are summarised in the following table
	lithium acetate; zinc stearate; at 180℃; for 24h;Product distribution / selectivity;	A Radleys Carousel 6 Place Reaction Station, with 250ml flasks connected to water- pump vacuum in order to facilitate methanol removal was used to screen different catalysts for the reaction of pentaerythritol (2.8g) and PP Base (27. 2g, 13% excess) at a reaction temperature of 180C. Catalysts were used at a total loading of 3mol%/PP Base (where two catalysts were used, each was added at 1. 5mol% loading). Where two catalysts were used, the 2nd catalyst was added after 4h. Anox 20 content is given by HPLC area% of the final product mixture. The results obtained are summarised in the following table
	lithium acetate; zinc(II) tosylate; at 180℃; for 24h;Product distribution / selectivity;	A Radleys Carousel 6 Place Reaction Station, with 250ml flasks connected to water- pump vacuum in order to facilitate methanol removal was used to screen different catalysts for the reaction of pentaerythritol (2.8g) and PP Base (27. 2g, 13% excess) at a reaction temperature of 180C. Catalysts were used at a total loading of 3mol%/PP Base (where two catalysts were used, each was added at 1. 5mol% loading). Where two catalysts were used, the 2nd catalyst was added after 4h. Anox 20 content is given by HPLC area% of the final product mixture. The results obtained are summarised in the following table
	lithium hydroxide; zinc(II) octanoate; at 180℃; for 24h;Product distribution / selectivity;	A Radleys Carousel 6 Place Reaction Station, with 250ml flasks connected to water- pump vacuum in order to facilitate methanol removal was used to screen different catalysts for the reaction of pentaerythritol (2.8g) and PP Base (27. 2g, 13% excess) at a reaction temperature of 180C. Catalysts were used at a total loading of 3mol%/PP Base (where two catalysts were used, each was added at 1. 5mol% loading). Where two catalysts were used, the 2nd catalyst was added after 4h. Anox 20 content is given by HPLC area% of the final product mixture. The results obtained are summarised in the following table
	lithium acetate; manganese(II) acetate; at 180℃; for 24h;Product distribution / selectivity;	A Radleys Carousel 6 Place Reaction Station, with 250ml flasks connected to water- pump vacuum in order to facilitate methanol removal was used to screen different catalysts for the reaction of pentaerythritol (2.8g) and PP Base (27. 2g, 13% excess) at a reaction temperature of 180C. Catalysts were used at a total loading of 3mol%/PP Base (where two catalysts were used, each was added at 1. 5mol% loading). Where two catalysts were used, the 2nd catalyst was added after 4h. Anox 20 content is given by HPLC area% of the final product mixture. The results obtained are summarised in the following table
	lithium acetate; zinc diethyldithiocarbamate; at 180℃; for 22h;Product distribution / selectivity;	A Radleys Carousel 6 Place Reaction Station, with 250ml flasks connected to water- pump vacuum in order to facilitate methanol removal was used to screen different catalysts for the reaction of pentaerythritol (2.8g) and PP Base (27. 2g, 13% excess) at a reaction temperature of 180C. Catalysts were used at a total loading of 3mol%/PP Base (where two catalysts were used, each was added at 1. 5mol% loading). Where two catalysts were used, the 2nd catalyst was added after 4h. Anox 20 content is given by HPLC area% of the final product mixture. The results obtained are summarised in the following table
	lithium methanolate; zinc diacetate; at 180℃; for 20h;Product distribution / selectivity;	A Radleys Carousel 6 Place Reaction Station, with 250ml flasks connected to water- pump vacuum in order to facilitate methanol removal was used to screen different catalysts for the reaction of pentaerythritol (2.8g) and PP Base (27. 2g, 13% excess) at a reaction temperature of 180C. Catalysts were used at a total loading of 3mol%/PP Base (where two catalysts were used, each was added at 1. 5mol% loading). Where two catalysts were used, the 2nd catalyst was added after 4h. Anox 20 content is given by HPLC area% of the final product mixture. The results obtained are summarised in the following table
	lithium methanolate; at 180℃; for 20h;Product distribution / selectivity;	A Radleys Carousel 6 Place Reaction Station, with 250ml flasks connected to water- pump vacuum in order to facilitate methanol removal was used to screen different catalysts for the reaction of pentaerythritol (2.8g) and PP Base (27. 2g, 13% excess) at a reaction temperature of 180C. Catalysts were used at a total loading of 3mol%/PP Base (where two catalysts were used, each was added at 1. 5mol% loading). Where two catalysts were used, the 2nd catalyst was added after 4h. Anox 20 content is given by HPLC area% of the final product mixture. The results obtained are summarised in the following table
	zinc diacetate; lithium; at 180℃; for 22h;Product distribution / selectivity;	A Radleys Carousel 6 Place Reaction Station, with 250ml flasks connected to water- pump vacuum in order to facilitate methanol removal was used to screen different catalysts for the reaction of pentaerythritol (2.8g) and PP Base (27. 2g, 13% excess) at a reaction temperature of 180C. Catalysts were used at a total loading of 3mol%/PP Base (where two catalysts were used, each was added at 1. 5mol% loading). Where two catalysts were used, the 2nd catalyst was added after 4h. Anox 20 content is given by HPLC area% of the final product mixture. The results obtained are summarised in the following table
	zinc diacetate; lithium acetate; at 180℃; for 20h;Product distribution / selectivity;	A Radleys Carousel 6 Place Reaction Station, with 250ml flasks connected to water- pump vacuum in order to facilitate methanol removal was used to screen different catalysts for the reaction of pentaerythritol (2.8g) and PP Base (27. 2g, 13% excess) at a reaction temperature of 180C. Catalysts were used at a total loading of 3mol%/PP Base (where two catalysts were used, each was added at 1. 5mol% loading). Where two catalysts were used, the 2nd catalyst was added after 4h. Anox 20 content is given by HPLC area% of the final product mixture. The results obtained are summarised in the following table
	calcium hydride; gallium(III) acetylacetonate; at 180℃; for 24h;Product distribution / selectivity;	A Radleys Carousel 6 Place Reaction Station, with 250ml flasks connected to water- pump vacuum in order to facilitate methanol removal was used to screen different catalysts for the reaction of pentaerythritol (2.8g) and PP Base (27. 2g, 13% excess) at a reaction temperature of 180C. Catalysts were used at a total loading of 3mol%/PP Base (where two catalysts were used, each was added at 1. 5mol% loading). Where two catalysts were used, the 2nd catalyst was added after 4h. Anox 20 content is given by HPLC area% of the final product mixture. The results obtained are summarised in the following table
	calcium hydride; at 180℃; for 24h;Product distribution / selectivity;	A Radleys Carousel 6 Place Reaction Station, with 250ml flasks connected to water- pump vacuum in order to facilitate methanol removal was used to screen different catalysts for the reaction of pentaerythritol (2.8g) and PP Base (27. 2g, 13% excess) at a reaction temperature of 180C. Catalysts were used at a total loading of 3mol%/PP Base (where two catalysts were used, each was added at 1. 5mol% loading). Where two catalysts were used, the 2nd catalyst was added after 4h. Anox 20 content is given by HPLC area% of the final product mixture. The results obtained are summarised in the following table
	lithium acetate; zinc(II) octanoate; at 180℃; for 24h;Product distribution / selectivity;	A Radleys Carousel 6 Place Reaction Station, with 250ml flasks connected to water- pump vacuum in order to facilitate methanol removal was used to screen different catalysts for the reaction of pentaerythritol (2.8g) and PP Base (27. 2g, 13% excess) at a reaction temperature of 180C. Catalysts were used at a total loading of 3mol%/PP Base (where two catalysts were used, each was added at 1. 5mol% loading). Where two catalysts were used, the 2nd catalyst was added after 4h. Anox 20 content is given by HPLC area% of the final product mixture. The results obtained are summarised in the following table
	lithium acetate; La(acetylacetonate)3; at 180℃; for 24h;Product distribution / selectivity;	A Radleys Carousel 6 Place Reaction Station, with 250ml flasks connected to water- pump vacuum in order to facilitate methanol removal was used to screen different catalysts for the reaction of pentaerythritol (2.8g) and PP Base (27. 2g, 13% excess) at a reaction temperature of 180C. Catalysts were used at a total loading of 3mol%/PP Base (where two catalysts were used, each was added at 1. 5mol% loading). Where two catalysts were used, the 2nd catalyst was added after 4h. Anox 20 content is given by HPLC area% of the final product mixture. The results obtained are summarised in the following table
	lithium acetate; at 180℃; for 20 - 24h;Product distribution / selectivity;	A Radleys Carousel 6 Place Reaction Station, with 250ml flasks connected to water- pump vacuum in order to facilitate methanol removal was used to screen different catalysts for the reaction of pentaerythritol (2.8g) and PP Base (27. 2g, 13% excess) at a reaction temperature of 180C. Catalysts were used at a total loading of 3mol%/PP Base (where two catalysts were used, each was added at 1. 5mol% loading). Where two catalysts were used, the 2nd catalyst was added after 4h. Anox 20 content is given by HPLC area% of the final product mixture. The results obtained are summarised in the following table
	gallium(III) acetylacetonate; at 180℃; for 24h;Product distribution / selectivity;	A Radleys Carousel 6 Place Reaction Station, with 250ml flasks connected to water- pump vacuum in order to facilitate methanol removal was used to screen different catalysts for the reaction of pentaerythritol (2.8g) and PP Base (27. 2g, 13% excess) at a reaction temperature of 180C. Catalysts were used at a total loading of 3mol%/PP Base (where two catalysts were used, each was added at 1. 5mol% loading). Where two catalysts were used, the 2nd catalyst was added after 4h. Anox 20 content is given by HPLC area% of the final product mixture. The results obtained are summarised in the following table
	With 1-methyl-pyrrolidin-2-one;	EXAMPLE 1 To a reaction vessel equipped with a mechanical stirrer, thermometer, condenser, a trap and nitrogen sparge tube are added 94.5 g (60 mole % excess) methyl 3-(3,5-di-t-butyl-4-hydroxyphenyl)propionate, 6.8 g pentaerythritol and 13 ml N-methylpyrrolidone (NMP) and heated to 120 C. Then 0.083 g lithium amide is added with agitation and the reaction mixture is heated to 140 C. at atmosperhic pressure while continuously sparging with nitrogen gas at a rate of 1 L/min. for 1.5 hours. Analysis by high pressure liquid chromatography indicated that 99% of tetrakis [3-(3,5-di-t-butyl-4-hydroxyphenyl)propionyloxymethyl]methane is obtained, based on the pentaerythritol.
	In N,N-dimethyl acetamide;	EXAMPLE 4 To a reaction vessel equipped with a condenser, a thermometer, a trap and a mechanical stirrer are added 76 g (30 mole % excess) of methyl 3-(3,5-di-t-butyl-4-hydroxyphenyl) propionate, 6.8 g of pentaerythritol and 8 ml of N,N-dimethylacetamide (DMAC) and heated to 120 C. Then 0.85 g of lithium amide is added to the reaction mixture. With agitation and under a vacuum of 90 mmHg, the reaction mixture is heated to 140 C. and the DMAC is refluxed. After 2.5 hours, analysis by high pressure liquid chromatography indicated that 96% of tetrakis [3-(3,5-di-t-butyl-4hydroxyphenyl)propionyloxymethyl]methane is obtained, based on the pentaerythritol.
	In methanol;	EXAMPLE 1 A 6300 liter vessel is charged with 5010 kg (17.15 kmol=30 mol %, based on pentaerythritol) of methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate (abbreviated hereinafter to methyl ester) as a melt of about 80 C., 450 kg (3.3 kmol) of pentaerythritol and 3 kg (0.13 kmol=4 mol %, based on pentaerythritol) of lithium amide. With stirring, the mixture is heated to 150 C. over 100 minutes under a pressure of about 200 mbar. At 120-125 C. methanol begins to distill into a receiver vessel. As soon as about 380 liters of methanol are distilled off, full vacuum is applied and the batch is heated to about 200 C. Methyl ester begins to boil under reflux at about 175 C. and 80 mbar. A vacuum of 7 to 10 mbar and a temperature of 198 C. is then gradually attained, while methanol is removed through the vacuum pump. The methyl ester reflux is maintained for 1/2 hour and then excess methyl ester is distilled off into a receiver vessel. At the conclusion of the distillation, i.e. after about 8 hours, the vacuum is 3 to 5 mbar, the temperature is 200 C. and the amount of methyl ester is 1080 kg. The methyl ester which has distilled off is re-used for another batch. The hot reaction melt is clarified by filtration at 180-200 C. and then crystallized by charging it into methanol which is slightly acidified with acetic acid. Yield: 3700 kg (95.0% of theory) of crystalline pentaerythrityl tetrakis-[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate] with a melting point of 118-119 C.

Reference： [1]Patent: CN106278894,2017,A .Location in patent: Paragraph 0017; 0018; 0019
[2]Patent: CN106748790,2017,A .Location in patent: Paragraph 0031; 0032; 0033; 0034; 0035; 0036; 0037-0050
[3]Russian Chemical Bulletin,2012,vol. 61,p. 1689 - 1693
Izv. Akad. Nauk, Ser. Khim.,2012,p. 1673 - 1677,5
[4]Patent: WO2005/42463,2005,A1 .Location in patent: Page/Page column 10
[5]Patent: WO2005/42463,2005,A1 .Location in patent: Page/Page column 10
[6]Patent: WO2005/42463,2005,A1 .Location in patent: Page/Page column 10
[7]Patent: WO2005/42463,2005,A1 .Location in patent: Page/Page column 10
[8]Patent: WO2005/42463,2005,A1 .Location in patent: Page/Page column 10
[9]Patent: WO2005/42463,2005,A1 .Location in patent: Page/Page column 10
[10]Patent: WO2005/42463,2005,A1 .Location in patent: Page/Page column 10
[11]Patent: WO2005/42463,2005,A1 .Location in patent: Page/Page column 10
[12]Patent: WO2005/42463,2005,A1 .Location in patent: Page/Page column 10
[13]Patent: WO2005/42463,2005,A1 .Location in patent: Page/Page column 10
[14]Patent: WO2005/42463,2005,A1 .Location in patent: Page/Page column 10
[15]Patent: WO2005/42463,2005,A1 .Location in patent: Page/Page column 10
[16]Patent: WO2005/42463,2005,A1 .Location in patent: Page/Page column 10
[17]Patent: WO2005/42463,2005,A1 .Location in patent: Page/Page column 10
[18]Patent: WO2005/42463,2005,A1 .Location in patent: Page/Page column 10
[19]Patent: WO2005/42463,2005,A1 .Location in patent: Page/Page column 10
[20]Patent: WO2005/42463,2005,A1 .Location in patent: Page/Page column 10
[21]Patent: US5136082,1992,A
[22]Patent: US5136082,1992,A
[23]Patent: US4618700,1986,A

7
[ 84633-54-5 ]
[ 6386-38-5 ]
[ 6683-19-8 ]

Yield	Reaction Conditions	Operation in experiment
	lithium hydroxide; zinc(II) octanoate; at 175℃; for 3 - 27h;Product distribution / selectivity;	PP Base (277g, 15% excess), pentaerythritol (28g) and lithium hydroxide monohydrate (0. 15g, 1. 7mol%/Penta) were charged to 500ml litre 4-necked flask equipped with a stirrer, thermometer, pump inlet and distillation head fitted to a condenser, which in turn goes to a liquid-liquid exchanger containing water and cyclohexane. A pump is used to circulate the cyclohexane from the exchanger back into the reactor at a rate of about 0.4g cyclohexane/PP Base g per hour, thus allowing continual distillation of cyclohexane + by-product methanol (the latter being extracted into water by the exchanger). The reaction mass was heated to 175C with distillation of cyclohexane and methanol. Two shots of zinc octanoate (0.448g, 0. 6mol%/Penta) were added after 5 and 12h. Samples were taken at regular intervals and analysed by HPLC, with results given in area% in the Table below. Time (hrs) PP Acid Disub Tris Anox 20 PP Base 3 0. 4 7. 9 31. 2 27. 3 32. 7 5 0. 4 5. 0 27. 5 38. 6 28. 0 7 0. 4 1. 9 19. 7 56. 2 21. 5 9 0. 4 0. 9 13. 1 66. 8 18. 4 12oui0. 6 7. 8 74. 2 16. 1 14 0_5 03 4. 9 78. 8 15. 0 16 0_5 0. 3 3. 7 80. 2 14. 7 After purification (dilution with cyclohexane, washing, separation of the aqueous layer, drying and crystallisation from cyclohexane), the colour of the Anox 20 final product was found to be APHA 6. Example la Example 1 was repeated but with a reduced excess of PP Base (260g, 8% excess), and with just one shot of zinc octanoate (0.9g, 1. 2mol%/Penta) after 5h. The results are provided in the Table below. Time (hrs) PP Acid Disub Tris Anox 20 PP Base 3 0.4 5.8 29.5 39.4 24.0 5 0. 4 4. 7 27. 2 45. 4 21. 5 7 0.4 2. 2 22. 0 56. 8 17. 6 9 0.4 1. 4 16. 9 65. 1 15. 5 12 0. 5 0. 8 11. 7 73. 5 12. 7 14 0. 6 0. 5 8. 5 77. 9 11. 6 19 0. 7 0. 3 5 80. 0 10. 9 After purification, the colour of the Anox 20 final product was found to be APHA 5 Comparative Example 1 Example 1 was repeated but with lithium hydroxide monohydrate (0.44g, 5mol%/Penta) dosed in eight 0. 055g shots at 2h intervals. The time taken to reach a level of 5% Tris (the point at which the reaction is regarded as complete, and ready to go into the purification stage) was found to be 21h. After purification, the colour of the Anox 20 final product was found to be APHA 14 Comparative Example la Comparative Example 1 was repeated but with lithium hydroxide monohydrate (0.44g, 5mol%/Penta) added all at the beginning of the reaction. The time taken to reach a level of 5% Tris was found to be 28h. After purification, the colour of the Anox 20 final product was found to be APHA 20 Comparative Example lb Comparative example lwas repeated but with lithium hydroxide monohydrate (0. 15g, 1.7 mol%/Penta) and zinc octanoate (0.9g, 1. 2mol%/Penta) added together at the start. The time taken to reach a level of 5% Tris was found to be 27h. After purification, the colour of the Anox 20 final product was found to be APHA 16 These results are summarised in the following Table to illustrate the benefits of the inventive catalyst system
	zinc diacetate; lithium acetate; at 180℃; for 1 - 23.5h;Product distribution / selectivity;	PP Base (247g, 15% excess), pentaerythritol (25g) and lithium acetate (0.75g, 3mol%/PE) were charged to 500ml litre 4-necked flask equipped with a stirrer, thermometer, pump inlet and distillation head fitted to a condenser, which in turn goes to a liquid-liquid exchanger containing water and cyclohexane. A pump is used to circulate the cyclohexane from the exchanger back into the reactor at a rate of about 1.6g/min, thus allowing continual distillation of cyclohexane + by-product methanol (the latter being extracted into water by the exchanger). The reaction mass was heated to 180C with distillation of cyclohexane and methanol. Samples were taken at regular intervals and analysed by HPLC, with results given in area % in the Table below. Time (hrs) PP Acid Disub Tris De-butyl A20 PP Base 2 0. 37 10. 29 29. 95 0. 09 16. 36 40.86 4 0.39 5. 2 28. 38 0. 2 32. 67 31.54 6 0. 41 2. 83 23. 81 0. 41 44. 49 26.43 23 0. 44 0. 33 9. 54 0. 66 68. 83 18.34 47 0. 47 0. 08 4. 98 0. 92 75. 39 16.02 Comparative Example 3 As Comparative Example 2, but instead zinc octanoate (2.9g, 3mol%/PE) was used as catalyst with the following results. Time (hrs) PP Acid Disub Tris De-butyl A20 PP Base 1 0. 02 4. 10 0. 62 0. 00 0. 17 89.61 2 0. 00 10. 77 3. 36 0. 01 0. 15 77.15 3 0. 00 15. 63 7. 05 0. 02 0. 40 68. 47 4 0. 00 18. 25 11. 95 0. 01 0. 88 62.05 5 0. 00 18. 28 16. 29 0. 02 1. 52 58. 33 22. 8 0. 00 3. 90 30. 64 0. 71 28. 69 33.22 Example 2 As Comparative Example 2, but with lithium acetate (0.75g, 3mol%/PE) added at the beginning, and zinc acetate (1.43g, 3mol%/PE) added after 4h at 180C, with the following results. Time (hrs) PP Acid Disub Tris De-butyl A20 PP Base 1 0. 28 16. 88 18. 49 0. 04 3. 39 55.53 2 0. 40 10. 44 30. 22 0. 40 15. 32 40.53 3 0. 47 6. 96 30.02 0. 55 24. 96 34.75 4 0. 47 5. 34 28.65 0. 63 30. 51 32.08 5 0. 55 2. 92 24. 74 0. 77 40. 26 28.03 6 0. 66 1. 83 20. 54 0.87 47. 36 25.65 22. 3 02. 21 0.02 2. 07 1. 29 74. 53 15.27 Example 3 As Example 2, but with a reduced amount of PP Base (227.4g, 8% excess) used. Time (hrs) PP Acid Disub Tris De-butyl A20 PP Base 1 0. 30 17. 88 21. 13 0. 05 4. 42 50. 82 2 0.41 12. 02 31. 63 0. 41 15. 92 36.66 3 0.60 6. 72 29. 12 0. 75 33. 28 27.04 4 0. 67 6. 44 29. 06 0. 84 36. 25 26.24 5 0.81 3. 48 26. 25 0. 94 43. 25 22.47 6 0. 89 2. 36 22. 82 1. 09 49. 23 20. 30 7 1. 06 1. 61 19. 69 1. 22 55. 20 17.47 23. 3 2. 78 0. 08 4. 58 1. 67 76. 42 8. 86 Example 4 As Example 2, but with a lower amount of zinc acetate (0.72g, 1. 5mol%/PE) used. Time (hrs) PP Acid Disub Tris De-butyl A20 PP Base 1 0. 24 15. 87 22. 86 0. 07 5. 41 51.39 2 0.37 9. 59 30. 26 0. 41 17. 29 39.67 3 0.40 6.75 29.66 0.51 25. 16 35. 31 4 0.38 5. 15 28. 12 0.58 30. 92 32.63 5 0.52 3.18 24.96 0.69 39.20 28.99 6 0.61 1.90 20.72 0.80 46. 75 26.54 23.3 1.64 0.02 2.47 1.23 74. 42 15.68 Example 5 As Example 4, but with a lower amount of lithium acetate (0.38g, 1. 5mol%/PE) used. Time (hrs) PP Acid Disub Tris De-butyl A20 PP Base 1OH16. 39 14. 710032. 32 60.52 2 0. 14 12. 51 28. 61 0. 13 11. 81 43.90 3 0. 21 9. 02 30. 41 0. 24 19. 56 38.24 4 0. 23 6. 94 29. 83 0. 47 25. 34 35.01 50294. 48 28. 2105632. 66 31.46 6 0.30 2.97 25.29 0.66 40.88 27.33 22.5 1.03 0.01 1.84 1.16 75. 42 16.66
	zinc(II) acetylacetonate; lithium acetate; for 4 - 10h;Product distribution / selectivity;	As Example 2, but with lithium acetate (0.2g, 1. 5mol%/l ? P base) added at the beginning and zinc acetylacetonate (0.73g, 1. 5mol%/PP base) added after 4h, with the following results obtained. Time (hrs) PP Acid Disub Tris De-butyl A20 PP Base 3 0. 3 5. 0 27. 0 0. 6 28. 7 35. 8 4 0. 3 2. 9 23. 4 0. 7 39. 3 31. 0 6 0. 4 0. 5 10. 9 1. 0 61. 7 20. 9 10 0. 4 0 1. 4 1. 1 75. 1 18.

Reference： [1]Patent: WO2005/42463,2005,A1 .Location in patent: Page/Page column 4-6
[2]Patent: WO2005/42463,2005,A1 .Location in patent: Page/Page column 6-9
[3]Patent: WO2005/42463,2005,A1 .Location in patent: Page/Page column 9-10

Yield	Reaction Conditions	Operation in experiment
	In methanol; at 30℃; for 6h;Purification / work up;	3. Preparation of crystalline particles of IRGANOX B 225 (1:1 mixture IRGANOX 1010 andIRGAFOS 168) from methanol; An aqueous solution of 500 g methanol (93 weight%) is added to a 1.51 double jacketreaction vessel equipped with an anchor agitator) and stirred at 220 rpm at 30C. 5 gIRGANOX 1010 particles as obtained by Example 1.1 and 500 g solidified particles ofIRGANOX B 225 as obtained in essentially the same manner as in Example 1.1 areadded while agitating. The mixture is kept stirring at 30C for 360 min. The crystallineparticles are filtered off with a suction filter screen of 60 mesh and dried in an oven for2 h at 35C and 2 h at 80C at less than 50 mbar. A particle fraction of 10% is smallerthan 600 p., 50% smaller than 900 n and 90% smaller than 1400 p.. The crystalline parti- cles are characterised by their heat of fusion: -20 J/g at 114.1 C (Mettler-ToledoDSC 822,40 pi vial, 10C/min) and a residual moisture content of less than 10% at 150times the gravitational acceleration.

9
[ 51590-67-1 ]
[ 856335-90-5 ]
[ 6386-38-5 ]
[ 6683-19-8 ]

Yield	Reaction Conditions	Operation in experiment
	With nitrogen; In water;	(1) In a 500-ml four-necked flask fitted with a stirrer, a condenser, a thermometer, and a nitrogen introducing tube, 182.7 g (0.625 mole) of methyl 3-(3,5-di-tert-butyl-4-hydroxy-phenyl)propionate, 18.9 g (0.139 mole) of pentaerithritol and 0.73 g (0.0035 mole) of monobutyltin oxide were placed and allowed to react at 185 C. for 1 hour. The resulting methanol was distilled off. The reaction was further continued for 13 hours under a reduced pressure of 60-70 mmHg by bubbling nitrogen gas into the solution (2NL/HR) and completed. Upon completion of the reaction, unesterified trisubstitute (A) in the mixture was less than 5% HPLC(s/s). Excess methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)-propionate was distilled off by thin-film distillation at 150-185 C. under 0.5-0.1 mmHg for 1 hour. The distillate was 19.5 g and the rate of distillation was 97%. This can be reused, as it is, for the next reaction. After the reaction mixture was cooled to 115 C., nitrogen gas was admitted to it to return its pressure to atmospheric pressure, and the reaction mixture was dissolved homogeneously by toluene. The toluene solution above (tin content: 700 ppm) was washed with 400 g (0.16 mole) of 5% oxalic acid water and then with 40 g of water twice at 60 C. to partition the solution to two layers. The toluene layer was concentrated at 125 C. under 30 mmHg for 1 hour to give a pale yellow tacky substance. When recrystallized from methanol, the pale yellow tacky substance so obtained afforded 147.8 g of tetra-kis [3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionyloxymethyl]-methane in white crystals as intended. yield: 87%, residual tin content: 1 ppm, (removal rate: more than 99.9% by atomic absorption spectrophotometry), transmittance: 98% (spectrophotometry at 425 nm).

Reference： [1]Patent: US5081280,1992,A

10
[ 115-77-5 ]
[ 6228-26-8 ]
[ 6386-38-5 ]
[ 9004-34-6 ]
[ 6683-19-8 ]

Yield	Reaction Conditions	Operation in experiment
	With oxalic acid; di(n-butyl)tin oxide; In toluene;	EXAMPLE 1 A one-liter four-necked flask equipped with a stirrer, a reflux condenser, a thermometer and a nitrogen gas inlet tube was charged with 300 g of toluene, 20 g of dibutyltin oxide, 44.2 g of pentaerythritol, 420 g of methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate (at least 99% pure) and 0.11 g of bis[2,2,2-tris(hydroxymethyl)ethoxy]methane, and the contents were heated with stirring at 170-175 C. for 12 hours, while the byproduct methanol was distilled off with toluene. Thereafter, 300 g of toluene, 2.0 g of oxalic acid and 12 g of powdered cellulose (Solka Floc) were added and the mixture was heated under reflux for dehydration. The oxalate salt of dibutyltin oxide, insoluble in toluene, and the Solka floc were filtered off, and the toluene was distilled off under reduced pressure to give 420 g of a light-yellow syrupy substance. Analysis of this syrupy substance revealed that the yield of tetrakis[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionyloxymethyl]methane was 97.0% of the theoretical on the pentaerythritol basis and that of the byproduct 2.8% of the theoretical on the pentaerythritol basis.

Reference： [1]Patent: US4883902,1989,A

11
[ 67-56-1 ]
[ 6683-19-8 ]
[ 6386-38-5 ]

Reference： [1]Russian Chemical Bulletin,2012,vol. 61,p. 1689 - 1693
Izv. Akad. Nauk, Ser. Khim.,2012,p. 1673 - 1677,5

12
[ 24424-99-5 ]
[ 6683-19-8 ]
C₉₃H₁₄₀O₂₀ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With pyridine; dmap; at 60℃; for 3h;Inert atmosphere;	General procedure: 0.01 mol of a phenol compound, 0.05 mol of di-tert-butyl dicarbonate, and 30 g of pyridine were mixed to obtain a mixture, and 0.025 mol of 4-dhnethylaminopyridine was added to the mixture at room temperature in a nitrogen atmosphere. The mixture was stirred at 60 C. for 3 hours. After cooling to room temperature, the reaction mixture was poured into 150 g of ion-exchanged water, and 200 g of chloroform was added thereto to carry out oil-water separation. The organic layer was dried over anhydrous sodium sulfate, and the solvent was removed by evaporation. The residue was crystallized from 100 g of methanol. The resulting white powder crystals were dried under reduced pressure at 60 C. for 3 hours to give a desired product. The resulting white powder crystals were identified to be the desired product by 1H-NMR and IR analyses. The melting point of the product was measured. The results obtained are shown in Tables 1 through 3 below.

Reference： [1]Patent: US9777138,2017,B2 .Location in patent: Page/Page column 95

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P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 6683-19-8 ] {[proInfo.proName]}

Quality Control of [ 6683-19-8 ]

Related Doc. of [ 6683-19-8 ]

Product Details of [ 6683-19-8 ]

Safety of [ 6683-19-8 ]

Application In Synthesis of [ 6683-19-8 ]

[ 6683-19-8 ] Synthesis Path-Upstream 1~7

[ 6683-19-8 ] Synthesis Path-Downstream 1~12

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry