[ CAS No. 640297-84-3 ] {[proInfo.proName]}

Name: 640297-84-3|3,8-Diethynyl-1,10-phenanthroline|98%
Brand: Ambeed
SKU: A1195667
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Quality Control of [ 640297-84-3 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 640297-84-3 ]

Product Details of [ 640297-84-3 ]

CAS No. :	640297-84-3	MDL No. :	MFCD32643325
Formula :	C₁₆H₈N₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	ZCPVSKKKVVMMPV-UHFFFAOYSA-N
M.W :	228.25	Pubchem ID :	15826907
Synonyms :

Safety of [ 640297-84-3 ]

Signal Word:	Warning	Class:
Precautionary Statements:	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313	UN#:
Hazard Statements:	H315-H319	Packing Group:
GHS Pictogram:

Application In Synthesis of [ 640297-84-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 640297-84-3 ]

[ 640297-84-3 ] Synthesis Path-Downstream 1~25

1
[ 14548-49-3 ]
[ 640297-84-3 ]
3,8-bis(4-(isonicotinoyl)phenylethynyl)-1,10-phenanthroline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
32%	With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine In N,N-dimethyl-formamide for 24h; Heating;

Reference： [1]Yang, Jinhua; Oh, Woon Su; Elder, Ian A.; Leventis, Nicholas; Sotiriou-Leventis, Chariklia [Synthetic Communications, 2003, vol. 33, # 19, p. 3317 - 3325]

2
[ 15854-87-2 ]
[ 640297-84-3 ]
3,8-bis[2-(4-pyridinyl)ethynyl]-1,10-phenanthroline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
85%	With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine In tetrahydrofuran at 60℃; for 6h;
85%	Stage #1: 4-iodopyridine; 3,8-bis(ethynyl)-1,10-phenanthroline With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ In tetrahydrofuran; triethylamine at 60℃; for 7h; Inert atmosphere; Stage #2: With potassium cyanide In methanol; dichloromethane; water for 1h; Inert atmosphere; Sonication;	General procedure: A flask was charged with 3,8-diethynylphenanthroline(229 mg, 1.0 mmol) and 3-iodopyridine(472 mg, 2.3 mmol), and dissolved with a solvent mixture of dry THF (90 ml) and triethylamine (9 ml). The Pd(PPh3)4 (116 mg, 0.10 mmol) and CuI (30 mg,0.16 mmol) were added to the flask. After the mixture was stirred at 60 C for 7 h, THF and triethylamine were removed by reduced pressure. The residue was dissolved with CH2Cl2-MeOH (95-5 ml) and added to an aqueous solution of KCN (1.0 g in 50 ml). After the solution was treated with ultrasonic irradiation for 1 h, the organic phase was separated and removed by rotary evaporation. The residue was further purified by SiO2 column chromatographywith CH2Cl2-MeOH (95:5-90:10, gradually) as eluent.
84%	With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 60℃; for 48h;

84%

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 60℃; for 48h;

Reference： [1]Resendiz, Marino J. E.; Noveron, Juan C.; Disteldorf, Hendrick; Fischer, Sonja; Stang, Peter J. [Organic Letters, 2004, vol. 6, # 5, p. 651 - 653]
[2]Shiotsuka, Michito; Ueno, Yusuke; Asano, Daiki; Matsuoka, Tomoya; Sako, Katsuya [Transition Metal Chemistry, 2015, vol. 40, # 6, p. 673 - 679]
[3]Ponce, Julia; Arroyo, Carlos R.; Tatay, Sergio; Frisenda, Riccardo; Gaviña, Pablo; Aravena, Daniel; Ruiz, Eliseo; Van Der Zant, Herre S. J.; Coronado, Eugenio [Journal of the American Chemical Society, 2014, vol. 136, # 23, p. 8314 - 8322]
[4]Ponce, Julia; Aragó, Juan; Vayá, Ignacio; Magenti, Jorge Gómez; Tatay, Sergio; Ortí, Enrique; Coronado, Eugenio [European Journal of Inorganic Chemistry, 2016, vol. 2016, # 12, p. 1851 - 1859]

3
[ 320573-10-2 ]
[ 640297-84-3 ]

Yield	Reaction Conditions	Operation in experiment
97%	With alkali metal carbonate In methanol
97%	With methanol; potassium carbonate at 20℃; for 1h;
95%	With potassium carbonate In methanol at 20℃;

92%	With potassium fluoride In methanol at 20℃;
78%	With potassium hydroxide In tetrahydrofuran; methanol for 22h;
67%	With tetrabutyl ammonium fluoride In tetrahydrofuran for 0.333333h;

Reference： [1]Ponce, Julia; Arroyo, Carlos R.; Tatay, Sergio; Frisenda, Riccardo; Gaviña, Pablo; Aravena, Daniel; Ruiz, Eliseo; Van Der Zant, Herre S. J.; Coronado, Eugenio [Journal of the American Chemical Society, 2014, vol. 136, # 23, p. 8314 - 8322]
[2]Ponce, Julia; Aragó, Juan; Vayá, Ignacio; Magenti, Jorge Gómez; Tatay, Sergio; Ortí, Enrique; Coronado, Eugenio [European Journal of Inorganic Chemistry, 2016, vol. 2016, # 12, p. 1851 - 1859]
[3]Resendiz, Marino J. E.; Noveron, Juan C.; Disteldorf, Hendrick; Fischer, Sonja; Stang, Peter J. [Organic Letters, 2004, vol. 6, # 5, p. 651 - 653]
[4]Ziessel, Raymond; Stroh, Christophe [Tetrahedron Letters, 2004, vol. 45, # 21, p. 4051 - 4055]
[5]Schmittel, Michael; Michel, Christoph; Wiegrefe, Andreas [Synthesis, 2005, # 3, p. 367 - 373]
[6]Ciszek, Jacob W.; Tour, James M. [Tetrahedron Letters, 2004, vol. 45, # 13, p. 2801 - 2803]

4
[ 1714-29-0 ]
[ 640297-84-3 ]
3,8-bis-pyren-1-ylethynyl-[1,10]phenanthroline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
20%	With diisopropylamine In benzene at 80℃;

Reference： [1]Ziessel, Raymond; Stroh, Christophe [Tetrahedron Letters, 2004, vol. 45, # 21, p. 4051 - 4055]

5
[ 69746-43-6 ]
[ 640297-84-3 ]
3,8-bis-(4-ethynyl(thioacetal)benzene)-1,10-phenanthroline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
40%	With copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾ In tetrahydrofuran at 60℃; for 72h; Inert atmosphere;
40%	With copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾ In tetrahydrofuran at 60℃; for 72h; Inert atmosphere;
21%	With copper(l) iodide; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 90℃; for 24h;

6
[ 134653-69-3 ]
[ 640297-84-3 ]
C₄₆H₂₆N₈ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
15%	With diisopropylamine In benzene at 80℃;

Reference： [1]Ziessel, Raymond; Stroh, Christophe [Tetrahedron Letters, 2004, vol. 45, # 21, p. 4051 - 4055]

7
[ 681184-51-0 ]
[ 640297-84-3 ]

Yield	Reaction Conditions	Operation in experiment
58%	With potassium hydroxide In toluene at 100℃;

Reference： [1]Ziessel, Raymond; Stroh, Christophe [Tetrahedron Letters, 2004, vol. 45, # 21, p. 4051 - 4055]

8
[ 3268-21-1 ]
[ 640297-84-3 ]
[ 850374-68-4 ]

Reference： [1]Synthesis,2005,p. 367 - 373

9
3-(2,5-bis-dodecyloxy-4-iodo-phenylethynyl)-[1,10]phenanthroline [ No CAS ]
[ 640297-84-3 ]
[ 691408-56-7 ]

Yield	Reaction Conditions	Operation in experiment
30%	With copper(l) iodide; triethylamine In benzene at 80℃; for 24h;

Reference： [1]Schmittel, Michael; Michel, Christoph; Wiegrefe, Andreas [Synthesis, 2005, # 3, p. 367 - 373]

10
[ 100125-12-0 ]
[ 640297-84-3 ]

Reference： [1]Synthesis,2005,p. 367 - 373
[2]Tetrahedron Letters,2004,vol. 45,p. 2801 - 2803
[3]Tetrahedron Letters,2004,vol. 45,p. 4051 - 4055
[4]Tetrahedron Letters,2004,vol. 45,p. 4051 - 4055
[5]Organic Letters,2004,vol. 6,p. 651 - 653
[6]Journal of the American Chemical Society,2014,vol. 136,p. 8314 - 8322
[7]European Journal of Inorganic Chemistry,2016,vol. 2016,p. 1851 - 1859

11
[ 66-71-7 ]
[ 640297-84-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 57 percent / sulfur monochloride; bromine; pyridine / various solvent(s) / 13 h / Heating 2: 100 percent / diisopropylethylamine; CuI / PdCl₂(PPh₃)2 / benzene / 40 h / 95 °C 3: 67 percent / TBAF / tetrahydrofuran / 0.33 h

Reference： [1]Ciszek, Jacob W.; Tour, James M. [Tetrahedron Letters, 2004, vol. 45, # 13, p. 2801 - 2803]

12
ammonium hexafluorophosphate [ No CAS ]
cis-bis(2,2′-bipyridine)dichloroosmium(II) dihydrate [ No CAS ]
[ 640297-84-3 ]
[Os(bpy)(3,8-bis(ethynyl)-1,10-phenanthroline)](PF₆)2 [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In 2-methoxy-ethanol refluxing bpy-complex and substituted phenanthroline (in dark), evapn., chromy., treatment with aq. NH4PF6;

Reference： [1]Connors Jr., Patrick J.; Tzalis, Dimitrios; Dunnick, Alejandro L.; Tor, Yitzhak [Inorganic Chemistry, 1998, vol. 37, # 5, p. 1121 - 1123]

13
[ 14243-64-2 ]
[ 7732-18-5 ]
[ 640297-84-3 ]
(triphenylphosphine)Au(3,8-bis(ethynyl)-1,10-phenanthrolinato)Au(triphenylphosphine) * 2H₂O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
88%	With potassium hydroxide In tetrahydrofuran; methanol (Ar); a MeOH soln. of ligand added to a THF soln. of Au complex, stirredat room temp., a MeOH soln. of KOH added dropwise, reacted for 10 min; filtered, washed (MeOH, H2O and ether), dried at 30°C (vac.) for 5 h; elem. anal.;

Reference： [1]Yamamoto, Youhei; Shiotsuka, Michito; Onaka, Satoru [Journal of Organometallic Chemistry, 2004, vol. 689, # 18, p. 2905 - 2911]

14
[ 17084-13-8 ]
[ 741692-64-8 ]
[ 640297-84-3 ]
(C₁₅H₁₁N₃RuC₁₅H₁₀N₃C₂)2C₁₂H₆N₂⁽⁴⁺⁾*4PF₆^(1-)=(C₁₅H₁₁N₃RuC₁₅H₁₀N₃C₂)2C₁₂H₆N₂(PF₆)4 [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
51%	In further solvent(s) a degassed soln. in (i-Pr)2NH was stirred at room temp. for 6 days, 4 equiv of KPF6 in water was added; solvent was removed , chromd. on alumina (CH3CN/H2O), crystd. from CH3CN-diethyl ether; elem. anal.;

Reference： [1]Ziessel, Raymond; Grosshenny, Vincent; Hissler, Muriel; Stroh, Christophe [Inorganic Chemistry, 2004, vol. 43, # 14, p. 4262 - 4271]

15
[ 14099-01-5 ]
[ 640297-84-3 ]
[ 763130-47-8 ]

Yield	Reaction Conditions	Operation in experiment
90%	In benzene (Ar); heated at 60°C for hours; concd., n-pentane added, filtered off, dried (vac.);

Reference： [1]Yamamoto, Youhei; Shiotsuka, Michito; Onaka, Satoru [Journal of Organometallic Chemistry, 2004, vol. 689, # 18, p. 2905 - 2911]

16
[ 14243-64-2 ]
[ 640297-84-3 ]
[ 686778-01-8 ]

Yield	Reaction Conditions	Operation in experiment
	With KOH or NaOCH₃ In not given synthesised by reacting Au(triphenylphosphine)Cl with 3,8-bis(ethynyl)-1,10-phenanthroline (2/1 ratio, with an excess KOH or NaOCH3);

Reference： [1]Yamamoto, Youhei; Shiotsuka, Michito; Okuno, Sigeru; Onaka, Satoru [Chemistry Letters, 2004, vol. 33, # 3, p. 210 - 211]

17
ammonium hexafluorophosphate [ No CAS ]
[ 15746-57-3 ]
[ 640297-84-3 ]
[Ru(bpy)(3,8-bis(ethynyl)-1,10-phenanthroline)](PF₆)2 [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In 2-methoxy-ethanol refluxing bpy-complex and substituted phenanthroline (in dark), evapn., chromy., treatment with aq. NH4PF6;

Reference： [1]Connors Jr., Patrick J.; Tzalis, Dimitrios; Dunnick, Alejandro L.; Tor, Yitzhak [Inorganic Chemistry, 1998, vol. 37, # 5, p. 1121 - 1123]

18
[ 69746-43-6 ]
[ 640297-84-3 ]
[ 1417191-53-7 ]
3,8-bis-(4-ethynyl(thioacetal)benzene)-1,10-phenanthroline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1: 21% 2: 18%	With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 45℃; for 18h; Inert atmosphere;

Reference： [1]Shiotsuka, Michito; Kondo, Hiroshi; Inomata, Tomohiko; Sako, Katsuya; Masuda, Hideki [Chemistry Letters, 2012, vol. 41, # 11, p. 1417 - 1419]

19
[ 640297-84-3 ]
C₆₄H₅₀CuN₄O₇S₂⁽¹⁺⁾*F₆P^(1-) [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: copper(l) iodide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; triphenylphosphine; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 72 h / 60 °C / Inert atmosphere 2.1: dichloromethane; acetonitrile / 0.5 h / Inert atmosphere 2.2: 3 h / Inert atmosphere

20
[ 1120-90-7 ]
[ 640297-84-3 ]
3,8-bis[2-(3-pyridinyl)ethynyl]-1,10-phenanthroline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
83%	Stage #1: 3-iodopyridine; 3,8-bis(ethynyl)-1,10-phenanthroline With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ In tetrahydrofuran; triethylamine at 60℃; for 7h; Inert atmosphere; Stage #2: With potassium cyanide In methanol; dichloromethane; water for 1h; Inert atmosphere; Sonication;	General procedure: A flask was charged with 3,8-diethynylphenanthroline(229 mg, 1.0 mmol) and 3-iodopyridine(472 mg, 2.3 mmol), and dissolved with a solvent mixture of dry THF (90 ml) and triethylamine (9 ml). The Pd(PPh3)4 (116 mg, 0.10 mmol) and CuI (30 mg,0.16 mmol) were added to the flask. After the mixture was stirred at 60 C for 7 h, THF and triethylamine were removed by reduced pressure. The residue was dissolved with CH2Cl2-MeOH (95-5 ml) and added to an aqueous solution of KCN (1.0 g in 50 ml). After the solution was treated with ultrasonic irradiation for 1 h, the organic phase was separated and removed by rotary evaporation. The residue was further purified by SiO2 column chromatographywith CH2Cl2-MeOH (95:5-90:10, gradually) as eluent.

Reference： [1]Shiotsuka, Michito; Ueno, Yusuke; Asano, Daiki; Matsuoka, Tomoya; Sako, Katsuya [Transition Metal Chemistry, 2015, vol. 40, # 6, p. 673 - 679]

21
[ 1120-90-7 ]
[ 640297-84-3 ]
[Pt(3,8-bis[2-(3-pyridinyl)ethynyl]-1,10-phenanthroline)(-CC-C₆H₅CH₃)2]*0.5H₂O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / tetrahydrofuran; triethylamine / 7 h / 60 °C / Inert atmosphere 1.2: 1 h / Inert atmosphere; Sonication 2.1: dichloromethane; acetonitrile / 4 h / 35 °C / Inert atmosphere

Reference： [1]Shiotsuka, Michito; Ueno, Yusuke; Asano, Daiki; Matsuoka, Tomoya; Sako, Katsuya [Transition Metal Chemistry, 2015, vol. 40, # 6, p. 673 - 679]

22
[ 120491-89-6 ]
[ 640297-84-3 ]
C₇₈H₁₀₆N₈O₁₆ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
82%	With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine In N,N-dimethyl-formamide at 80℃; Inert atmosphere; Schlenk technique;

Reference： [1]Jana, Atanu; Crowston, Bethany J.; Shewring, Jonathan R.; McKenzie, Luke K.; Bryant, Helen E.; Botchway, Stanley W.; Ward, Andrew D.; Amoroso, Angelo J.; Baggaley, Elizabeth; Ward, Michael D. [Inorganic Chemistry, 2016, vol. 55, # 11, p. 5623 - 5633]

23
silver nitrate [ No CAS ]
[ 640297-84-3 ]
Ag2(3,8-diethynyl-1,10-phenanthroline)·6(silver nitrate) [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
30%	In water for 0.333333h;

Reference： [1]Zhu, Jin-Jin; Hu, Peng; Zhou, Ke-Ke; Li, Bao; Zhang, Tianle [Dalton Transactions, 2017, vol. 46, # 20, p. 6663 - 6669]

24
trans-Pt(PBu<SUB>3</SUB>)<SUB>2</SUB>(1-ethynyl-4-methylbenzene)Cl [ No CAS ]
[ 640297-84-3 ]
C₈₂H₁₂₈N₂P₄Pt₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
68%	With copper(l) iodide; diisopropylamine In tetrahydrofuran at 35℃; for 18h; Inert atmosphere; Darkness;	Preparation of platinum dimer (tol-≡-){Pt(PBt3)2}(-≡-phen-≡-){Pt(PBt3)2}(-≡-tol) (D1) The L1 (35.6 mg, 0.16 mmol) and ClPt(PBu3)2(ETol)(293 mg, 0.39 mmol) were dissolved in THF (20 ml) underAr. To the solution was added DIPA (2 ml) and CuI (4 mg,0.020 mmol), the mixture was stirred at 35 °C for 18 hin the dark. To the solution was added MeOH (5 ml) andconcentrated by evaporation with evaporator. The crudeproduct was dissolved with a solvent mixture (110 ml) ofCH2Cl2-MeOH (10:1) and added KCN aq. (150 mg in100 ml) and extracted to remove copper ion. The organic layer was dried over anhydrous MgSO4and concentratedby evaporation with evaporator. The residue was purifiedby SiO2column chromatography with CH2Cl2-MeOH(97:3) as eluent, and a yellow compound was obtained.Yield: 175 mg (68%).Anal. Calcd for C82H128N2Pt2P4:C, 59.5; H, 7.8; N,1.7. Found: C, 59.5; H, 7.8; N, 1.7%. FT-IR (KBr, cm-1)ν(C≡C): 2098. UV/VIS (CH2Cl2): λabs nm (ε × 10-4) 390(10.4), 365 (7.3), 316 (3.9), 284 (6.4), 268 (6.7). 1H-NMR(CD2Cl2, 400 MHz, 5.320 ppm): δ = 8.95 (d, J = 2.0 Hz,2H, Phen-H2 and -H9), 7.98 (d, J = 2.0 Hz, 2H,Phen-H4 and -H7), 7.63 (s, 2H, Phen-H5 and -H6), 7.15(d, J = 8.0 Hz, 4H, Tolyl-H2 and -H6), 7.03 (d, J = 8.0 Hz,4H, Tolyl-H3 and -H5), 2.29 (s, 6H, Tolyl-CH3), 2.17 (m,24H, P-CH2 α), 1.65 (m, 24H, P-CH2 β), 1.48 (m, 24H,P-CH2 γ), 0.95 (t, J = 7.5 Hz, 36H, -CH3). 31P{1H} NMR(CD2Cl2): δ (ppm) = 3.27 (J(Pt-P) = 2340 Hz). GPC (THF):Mn = 1260 g·mol-1, Mw = 1350 g·mol-1, Mw/Mn = 1.07.

Reference： [1]Shiotsuka, Michito; Hashimoto, Takuto; Matsubara, Kenta; Sako, Katsuya [Transition Metal Chemistry, 2018, vol. 43, # 8, p. 693 - 703]

25
[ 134856-58-9 ]
[ 640297-84-3 ]
[ 1612886-54-0 ]

Yield	Reaction Conditions	Operation in experiment
64%	With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diisopropylamine In tetrahydrofuran at 40℃; for 22h; Inert atmosphere;	Preparation of 3,8-bis-(4-trimethylsilylethynyl-phenylethynyl)-1,10-phenanthroline 1-iodo-4-trimethylsilylethynyl-benzene (991 mg,3.3 mmol) and dissolved with THF (75 ml). Diisopropylamine(DIPA) (7.5 ml), Pd(PPh3)4 (87 mg,0.075 mmol), and CuI (14 mg, 0.075 mmol) were thenadded. After the mixture was stirred at 40 °C for 22 h,THF and DIPA were removed by reduced pressure. Theresidue was dissolved with a solvent mixture (88 ml)of CH2Cl2-MeOH (10:1). The solution was added to anaqueous solution (80 ml) of KCN (560 mg) and sonicated organic layer was washed with H2O(50 ml × 3) and driedover anhydrous MgSO4.The solvents were removed byevaporation with evaporator, and the residue was purifiedon SiO2column chromatography with CH2Cl2-MeOH(97:3) as eluent. A yellow powder was obtained and driedat 50 °C under vacuum for 3 h. Yield: 550 mg (64%).Anal. Calcd for C38H32N2Si2·1/2H2O: C, 78.4; H, 5.7; N,4.8. Found: C, 78.7; H, 5.5; N, 4.8. IR (cm-1) ν(C≡C): 2210,2099. 1H NMR (CDCl3): 9.26 (d, J = 2.0 Hz, 2H, Phen-H2and -H9), 8.35 (d, J = 2.0 Hz, 2H, Phen-H4 and -H7), 7.79(s, 2H, Phen-H5 and -H6), 7.55 (d, J = 8.8 Hz, 4H, Phenyl-H2 and -H6), 7.48 (d, J = 8.8 Hz, 4H, Phenyl-H3 and-H5), 0.27 (s, 18H, -Si(CH3)3).

Reference： [1]Shiotsuka, Michito; Hashimoto, Takuto; Matsubara, Kenta; Sako, Katsuya [Transition Metal Chemistry, 2018, vol. 43, # 8, p. 693 - 703]

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P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 640297-84-3 ] {[proInfo.proName]}

Quality Control of [ 640297-84-3 ]

Related Doc. of [ 640297-84-3 ]

Product Details of [ 640297-84-3 ]

Safety of [ 640297-84-3 ]

Application In Synthesis of [ 640297-84-3 ]

[ 640297-84-3 ] Synthesis Path-Downstream 1~25

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry