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CAS No. : | 632-85-9 | MDL No. : | MFCD00017736 |
Formula : | C16H12O5 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | XLTFNNCXVBYBSX-UHFFFAOYSA-N |
M.W : | 284.26 | Pubchem ID : | 5281703 |
Synonyms : |
BRN 0287152;Vogonin
|
Num. heavy atoms : | 21 |
Num. arom. heavy atoms : | 16 |
Fraction Csp3 : | 0.06 |
Num. rotatable bonds : | 2 |
Num. H-bond acceptors : | 5.0 |
Num. H-bond donors : | 2.0 |
Molar Refractivity : | 78.46 |
TPSA : | 79.9 Ų |
GI absorption : | High |
BBB permeant : | No |
P-gp substrate : | No |
CYP1A2 inhibitor : | Yes |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | Yes |
CYP2D6 inhibitor : | Yes |
CYP3A4 inhibitor : | Yes |
Log Kp (skin permeation) : | -5.56 cm/s |
Log Po/w (iLOGP) : | 2.55 |
Log Po/w (XLOGP3) : | 3.49 |
Log Po/w (WLOGP) : | 2.88 |
Log Po/w (MLOGP) : | 0.77 |
Log Po/w (SILICOS-IT) : | 3.03 |
Consensus Log Po/w : | 2.54 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 0.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -4.23 |
Solubility : | 0.0166 mg/ml ; 0.0000585 mol/l |
Class : | Moderately soluble |
Log S (Ali) : | -4.85 |
Solubility : | 0.00401 mg/ml ; 0.0000141 mol/l |
Class : | Moderately soluble |
Log S (SILICOS-IT) : | -5.1 |
Solubility : | 0.00225 mg/ml ; 0.00000791 mol/l |
Class : | Moderately soluble |
PAINS : | 0.0 alert |
Brenk : | 0.0 alert |
Leadlikeness : | 0.0 |
Synthetic accessibility : | 3.15 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With aluminum (III) chloride; In acetonitrile; at -5 - 0℃; for 8h;Reflux; | General procedure: 18a-18g (15 mmol) was dissolved in acetonitrile (25 mL) and the solution was cooled to -5-0 C. Aluminiumtrichloride (120 mmol) was added to solution slowly while maintaining a batch temperature below 0 C. Theresulting mixture was then heated and refluxed for about 8 hours. After cooling to room temperature, thereaction solution was evaporated in vacuum. The residue was added 1 M HCl and stirred at room temperatureovernight. The resulting suspension was filtered, and the filter cake was further purified by recrystallizationfrom methanol (20 mL) to obtain pure product 19a-19g. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In methanol; at 55℃; for 4.5h; | Examples 14; Preparation of 5,7-dihydroxy-8-methoxy-2-phenyl-6-(piperidin-1-ylmethyl)-4H-chromen-4-one [Piperidine <strong>[632-85-9]Wogonin</strong>]; The mixture of <strong>[632-85-9]Wogonin</strong> (28.4 g), methanol (350 ml), 37% formaldehyde solution (8.1 ml), piperidine (8.5 g) was stirred under for 4.5 hours at 55 C., then precipitates were removed by filtration and washed several times with methanol, after drying under reduced pressure at 65 C. to get the product as yellow solid 35.3 g of purity 99.2%. MS: (API-ES) m/z 382.5[M+H]+, 404.5[M+Na]+; 1H NMR (DMSO-d6, 400 MHz) delta 8.058.06 (m, 2H, Ar-2',6'-H), 7.607.61 (m, 3H, Ar-3',4',5'-H), 6.89 (s, 1H, 3-H), 3.95 (s, 2H, CH2), 3.83 (s, 3H, 8-OCH3), 2.79 (s, 4H, CH2), 1.64 (m, 4H, CH2), 1.50 (m, 2H, CH2). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In methanol; at 55℃; for 4h; | Examples 12; Preparation of 5,7-dihydroxy-8-methoxy-6-(morpholinomethyl)-2-phenyl-4H-chromen-4-one [Morpholine <strong>[632-85-9]Wogonin</strong>]; The mixture of <strong>[632-85-9]Wogonin</strong> (28.4 g), methanol (350 ml), 37% formaldehyde solution (8.1 ml), morpholine (8.7 g) was stirred under for 4 hours at 55 C., then precipitates were removed by filtration and washed several times with methanol, after drying under reduced pressure at 65 C. to get the product as yellow solid 36.3 g of purity 99.1%. MS: (API-ES) m/z 384.5[M+H]+, 406.5[M+Na]+; 1H NMR (DMSO-d6, 400 MHz) delta 8.078.08 (m, 2H, Ar-2',6'-H), 7.617.63 (m, 3H, Ar-3',4',5'-H), 7.00 (s, 1H, 3-H), 3.87 (s, 3H, 8-OCH3), 3.82 (s, 2H, CH2), 3.65 (s, 4H, CH2), 2.60 (s, 4H, CH2). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In methanol; at 55℃; for 4h; | Examples 10; Preparation of 5,7-dihydroxy-8-methoxy-2-phenyl-6-(pyrrolidin-1-ylmethyl)-4H-chromen-4-one [Pyrrolidine <strong>[632-85-9]Wogonin</strong>]; The mixture of <strong>[632-85-9]Wogonin</strong> (28.4 g), methanol (350 ml), 37% formaldehyde solution (8.1 ml), pyrrolidine (7.1 g) was stirred under for 4 hours at 55 C., then precipitates were removed by filtration and washed several times with methanol, after drying under reduced pressure at 65 C. to get the product as orange red solid 35.4 g of purity 99.1%. MS: (API-ES) m/z 368.5[M+H]+, 390.5[M+Na]+; 1H NMR (DMSO-d6, 400 MHz) delta 8.038.04 (m, 2H, Ar-2',6'-H), 7.597.60 (m, 3H, Ar-3',4',5'-H), 6.79 (s, 1H, 3-H), 4.09 (s, 2H, CH2), 3.81 (s, 3H, 8-OCH3), 3.03 (s, 4H, CH2), 1.90 (s, 4H, CH2). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In methanol; at 51℃; for 4h; | Examples 5Preparation of 6-((4-methylpiperazin-1-yl)methyl)-<strong>[632-85-9]5,7-dihydroxy-8-methoxy-2-phenyl-4H-chromen-4-one</strong> [Methylpiperazine <strong>[632-85-9]Wogonin</strong>]; The mixture of <strong>[632-85-9]Wogonin</strong> (28.4 g), methanol (350 ml), 37% formaldehyde solution (8.04 ml), 4-N-methyl-piperazine (10.1 g) was stirred under for 4 hours at 51 C., then precipitates were removed by filtration and washed several times with methanol, after drying under reduced pressure at 55 C. to get the product as orange red solid 38.6 g of purity 99.7%. m.p.:179 C. MS: (API-ES) m/z 397.5 [M+H]+, 419.5 [M+Na]+, 1H NMR (DMSO-d6/CF3COOD, 400 MHz): delta 8.128.14 (m, 2H, Ar-2',6'-H), 7.647.66 (m, 3H, Ar-3',4',5'-H), 7.15 (s, 1H, 3-H), 4.44 (s, 2H, CH2), 3.96 (s, 3H, 8-OCH3), 3.43-3.74 (m, 8H, CH2), 2.93 (s, 3H, N-CH3). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In methanol; at 50℃; for 4h; | Examples 6; Preparation of 6-((4-(2-hydroxyethyl) piperazin-1-yl)methyl)-<strong>[632-85-9]5,7-dihydroxy-8-methoxy-2-phenyl-4H-chromen-4-one</strong>; [Hydroxyethylpiperazine <strong>[632-85-9]Wogonin</strong>]The mixture of <strong>[632-85-9]Wogonin</strong> (28.4 g), methanol (350 ml), 37% formaldehyde solution (8.04 ml), 4-N-hydroxyethyl-piperazine (13.1 g) was stirred under for 4 hours at 50 C., then precipitates were removed by filtration and washed several times with methanol, after drying under reduced pressure at 65 C. to get the product as yellow solid 41.7 g of purity 99.5%. MS: (API-ES) m/z 427.5[M+H]+, 449.5[M+Na]+; 1H NMR (DMSO-d6/CF3COOD, 400 MHz): delta 8.118.13 (m, 2H, Ar-2',6'-H), 7.627.67 (m, 3H, Ar-3',4',5'-H), 7.11 (s, 1H, 3-H), 4.45 (s, 2H, CH2), 3.98 (s, 3H, 8-OCH3), 3.78 (t, 2H, -CH2-OH), 3.49-3.69 (m, 8H, CH2), 3.36 (t, 2H, N-CH2). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In methanol; at 55℃; for 4h; | Examples 9; Preparation of 6-((dimethylamino)methyl)-<strong>[632-85-9]5,7-dihydroxy-8-methoxy-2-phenyl-4H-chromen-4-one</strong> [Dimethylamine <strong>[632-85-9]Wogonin</strong>]; The mixture of <strong>[632-85-9]Wogonin</strong> (28.4 g), methanol (350 ml), 37% formaldehyde solution (8.1 ml), 33% dimethylamine solution (13.6 g) was stirred under for 4 hours at 55 C., then precipitates were removed by filtration and washed several times with methanol, after drying under reduced pressure at 65 C. to get the product as yellow solid 32.7 g of purity 99.3%. MS: (API-ES) m/z 342.5[M+H]+; 1H NMR (DMSO-d6, 400 MHz) delta 8.038.04 (m, 2H, Ar-2',6'-H), 7.59-7.60 (m, 3H, Ar-3',4',5'-H), 6.81 (s, 1H, 3-H), 3.97 (s, 2H, CH2), 3.82 (s, 3H, 8-OCH3), 2.56 (s, 6H, CH3). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In methanol; at 55℃; for 4h; | Examples 13; Preparation of 5,7-dihydroxy-8-methoxy-2-phenyl-6-(thiomorpholinomethyl)-4H-chromen-4-one [Sulfurmorpholine <strong>[632-85-9]Wogonin</strong>]; The mixture of <strong>[632-85-9]Wogonin</strong> (28.4 g), methanol (350 ml), 37% formaldehyde solution (8.1 ml), sulfurmorpholine (10.3 g) was stirred under for 4 hours at 55 C., then precipitates were removed by filtration and washed several times with methanol, after drying under reduced pressure at 65 C. to get the product as yellow solid 37.6 g of purity 99.2%. MS: (API-ES) m/z 400.5[M+H]+, 422.5[M+Na]+; 1H NMR (DMSO-d6, 400 MHz)delta: 8.068.08 (m, 2H, Ar-2',6'-H), 7.617.63 (m, 3H, Ar-3',4',5'-H), 6.99 (s, 1H, 3-H), 3.87 (s, 3H, 8-OCH3), 3.84 (s, 2H, CH2), 2.86 (s, 4H, CH2), 2.71 (s, 4H, CH2). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In methanol; at 50℃; for 4h; | Examples 7; Preparation of 5,7-dihydroxy-6-((4-hydroxypiperidin-1-yl)methyl)-8-methoxy-2-phenyl-4H-chromen-4-one [Hydroxypiperidine <strong>[632-85-9]Wogonin</strong>]; The mixture of <strong>[632-85-9]Wogonin</strong> (28.4 g), methanol (350 ml), 37% formaldehyde solution (8.04 ml), 4-hydroxy-piperidine (10.2 g) was stirred under for 4 hours at 50 C., then precipitates were removed by filtration and washed several times with methanol, after drying under reduced pressure at 65 C. to get the product as orange red solid 38.5 g of purity 99.4%. MS:(API-ES) m/z 398.5 [M+H]+420.5 [M+Na]+; 1H NMR (DMSO-d6, 400 MHz): delta 8.058.06 (m, 2H, Ar-2',6'-H), 7.607.61 (m, 3H, Ar-3',4',5'-H), 6.90 (s, 1H, 3-H), 3.94 (s, 2H, CH2), 3.83 (s, 3H, 8-OCH3), 3.65-3.67 (m, 1H, CH), 2.62, 2.98 (m, 4H, CH2), 1.51, 1.83 (m, 4H, CH2). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In methanol; at 55℃; for 4h; | Examples 11; Preparation of 5,7-dihydroxy-8-methoxy-2-phenyl-6-(piperazin-1-ylmethyl)-4H-chromen-4-one [Piperazine <strong>[632-85-9]Wogonin</strong>]; The mixture of <strong>[632-85-9]Wogonin</strong> (28.4 g), methanol (350 ml), 37% formaldehyde solution (8.1 ml), piperazine (8.6 g) was stirred under for 4 hours at 55 C., then precipitates were removed by filtration and washed several times with methanol, after drying under reduced pressure at 65 C. to get the product as yellow solid 36.1 g of purity 99.1%. MS: (API-ES) m/z 383.5[M+H]+; 1H NMR (DMSO-d6, 400 MHz) delta 8.138.14 (m, 2H, Ar-2',6'-H), 7.647.66 (m, 3H, Ar-3',4',5'-H), 7.14 (s, 1H, 3-H), 4.43 (s, 2H, CH2), 3.98 (s, 3H, 8-OCH3), 3.36 (s, 4H, CH2), 3.56 (s, 4H, CH2), 1.25 (s, 1H, NH). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In methanol; at 55℃; for 4h; | Examples 8; Preparation of 6-((bis(2-hydroxyethyl)amino)methyl)-<strong>[632-85-9]5,7-dihydroxy-8-methoxy-2-phenyl-4H-chromen-4-one</strong> [Diethanolamin <strong>[632-85-9]Wogonin</strong>]; The mixture of <strong>[632-85-9]Wogonin</strong> (28.4 g), methanol (350 ml), 37% formaldehyde solution (8.04 ml), diethanolamine (10.5 g) was stirred under for 4 hours at 55 C., then precipitates were removed by filtration and washed several times with methanol, after drying under reduced pressure at 65 C. to get the product as yellow solid 39.3 g of purity 99.2%. MS: (API-ES) m/z 402.4[M+H]+, 424.4[M+Na]+; 1H NMR (DMSO-d6, 400 MHz): delta 8.058.06 (m, 2H, Ar-2',6'-H), 7.607.61 (m, 3H, Ar-3',4',5'-H), 6.90 (s, 1H, 3-H), 3.94 (s, 2H, CH2), 3.83 (s, 3H, 8-OCH3), 3.63 (m, 4H, O-CH2), 2.55 (m, 4H, N-CH2). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
at 20℃; for 1h;Ultrasonication; aq. phosphate buffer; | A 0.1 or 1 ml aliquot of the stock solution (1.0 x 10-4 mol/L) of Wo was transferred into a 10 ml volumetric burette, and an appropriate amount of 1.0 x 10-2 mol/L CDs (beta-CD and HP-beta-CD) was added. The solution was diluted to a final volume of 10 ml with distilled water. The mixed solution was diluted to the final volume with distilled water and ultrasonic handled for 30 min, equilibrated for 30 min at 20 +/- 1 C. The working solution was transferred into a 1 cm x 1 cm quartz cell to record fluorescence spectra. All measurements of fluorescence were made against a blank solution treated in the same way but without Wo in a 1.0 cm quartz cell. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
96% | With sulfuric acid; In ethanol; water; at 95℃; for 8.5h;Inert atmosphere; | General procedure: To a stirring mixture of glucuronide methyl ester (0.5 mmol) and sulfuric acid (1.1 mL) in ethanol (8 mL) was added water (1.1 mL), the reaction mixture was stirred at 95 C for the indicated time under a N2 atmosphere. After cooled down to the room temperature, the mixture was poured into water. Then the precipitate was filtered off, washed with water and recrystallized from methanol to obtain the desired products. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
85% | With potassium carbonate; In acetone;Reflux; Inert atmosphere; | 3-Bromopropanol (0.30 g, 2.16 mmol) was added to a mixtureof <strong>[632-85-9]wogonin</strong> (0.50 g, 1.76 mmol) and potassium carbonate (1.01 g,7.31 mmol) in acetone and stirred at refluxing under nitrogen for12 h. The reaction mixture was concentrated under reduced pressureand then 100 mL pure water was added. After it, the mixturewas filtered to get the yellow solid 2 (0.51 g, 85%). Melting point:198-201 C. ESI-MS: m/z [M+H]+ = 343.13. 1H NMR (300 MHz,DMSO-d6) d 1.92 (2H, m), 3.60 (2H, m), 3.86 (3H, d), 4.19 (2H,m), 4.59 (1H, s), 6.60 (1H, s), 7.02 (1H, s), 7.61-7.63 (3H, m),8.06-8.09 (2H, m), 12.61 (1H, s) ppm. 13C NMR (75 MHz, DMSOd6)d 31.99, 57.21, 61.16, 66.10, 96.74, 104.13, 105.07, 126.42,128.73, 129.34, 130.87, 132.26, 149.00, 156.69, 158.12, 163.41,182.37 ppm. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
95% | With palladium 10% on activated carbon; hydrogen; In methanol; ethyl acetate; at 15 - 25℃; | Compound 4-3 (900 mg, 2 mmol, 1.0 eq)Potassium carbonate (552 mg, 4 mmol, 2.0 eq) in 30 mL of acetone,The mixture was added dropwise with dimethyl sulfate (504 mg, 4 mmol, 2.0 eq) and stirred for 4 hours at 60 C. Acetone was distilled off, diluted with water, extracted three times with DCM, washed with brine, washed with water and dried over anhydrous sodium sulfate. The product (925 mg, 99%).The above methylation product, 10% palladium on carbon (106mg, 1mol, 0.5eq) placed in a reaction flask, 20mL of methanol and 10mL of ethyl acetate was added, hydrogen was replaced, stirred at room temperature to complete consumption of raw materials, filtered, Recrystallization (DCM / PE) gave the product as a yellow solid (540 mg, 95%). |
95% | With palladium 10% on activated carbon; hydrogen; In methanol; ethyl acetate; at 20℃; | Weighing the compound 4 - 3 (900 mg, 2 mmol, 1.0 eq), potassium carbonate (552 mg, 4 mmol, 2.0 eq) for 30 ml in acetone, into the dimethyl sulfate (504 mg, 4 mmol, 2.0 eq), heating to 60 C stirring 4 hours, evaporate acetone, diluted with water, DCM extraction three times, saturated salt water, washing, dried with anhydrous sodium sulfate, concentrated to obtain methylated product (925 mg, 99%). The above-mentioned methylation product, 10% palladium carbon (106 mg, 1 mol, 0.5 eq) is placed in the reaction bottle, add 20 ml methanol and 10 ml ethyl acetate, hydrogen after the replacement, stirring at the room temperature to the consumption of raw materials fully, filtration, concentration, crude product using re-crystallization (DCM/PE) to obtain the product a yellow solid (540 mg, 95%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
58% | In N,N-dimethyl-formamide; at 60 - 80℃; | General procedure: A mixture of <strong>[632-85-9]wogonin</strong> (1) (0.68mmol), 1~1.2 equiv of chloroheterocycle and 2~3 equiv base (potassiumcarbonate or sodium hydride) were dissolved in DMF (4mL) and stirred at 60 C ~80 C for 1 ~ 12 hours.After cooling to room temperature, the reaction was quenched with water (20 mL), extracted withdichloromethane (3 × 20 mL), and washed with brine (60 mL). The organic layer was dried over anhydroussodium sulfate, filtered and concentrated. The residue was purified by column chromatograph on silica gel togive 3p-3r. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
55% | In N,N-dimethyl-formamide; at 60 - 80℃; | General procedure: A mixture of <strong>[632-85-9]wogonin</strong> (1) (0.68mmol), 1~1.2 equiv of chloroheterocycle and 2~3 equiv base (potassiumcarbonate or sodium hydride) were dissolved in DMF (4mL) and stirred at 60 C ~80 C for 1 ~ 12 hours.After cooling to room temperature, the reaction was quenched with water (20 mL), extracted withdichloromethane (3 × 20 mL), and washed with brine (60 mL). The organic layer was dried over anhydroussodium sulfate, filtered and concentrated. The residue was purified by column chromatograph on silica gel togive 3p-3r. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
53% | In N,N-dimethyl-formamide; at 60 - 80℃; | General procedure: A mixture of <strong>[632-85-9]wogonin</strong> (1) (0.68mmol), 1~1.2 equiv of chloroheterocycle and 2~3 equiv base (potassiumcarbonate or sodium hydride) were dissolved in DMF (4mL) and stirred at 60 C ~80 C for 1 ~ 12 hours.After cooling to room temperature, the reaction was quenched with water (20 mL), extracted withdichloromethane (3 × 20 mL), and washed with brine (60 mL). The organic layer was dried over anhydroussodium sulfate, filtered and concentrated. The residue was purified by column chromatograph on silica gel togive 3p-3r. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium carbonate; In acetone; for 8h;Reflux; | General procedure: To a solution of <strong>[632-85-9]wogonin</strong> (1) (1.4 mmol) in acetone (50 mL) was added potassium carbonate (1.69 mmol) anddibromoalkane (1.69 mmol). The reaction mixture was refluxed for 8 hours and cooled to room temperature.The mixture was filtered, and the solvent was evaporated in vacuum. The residue was purified by columnchromatograph on silica gel to obtain intermediate (2). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium carbonate; In acetone; for 8h;Reflux; | General procedure: To a solution of <strong>[632-85-9]wogonin</strong> (1) (1.4 mmol) in acetone (50 mL) was added potassium carbonate (1.69 mmol) anddibromoalkane (1.69 mmol). The reaction mixture was refluxed for 8 hours and cooled to room temperature.The mixture was filtered, and the solvent was evaporated in vacuum. The residue was purified by columnchromatograph on silica gel to obtain intermediate (2). |
Tags: 632-85-9 synthesis path| 632-85-9 SDS| 632-85-9 COA| 632-85-9 purity| 632-85-9 application| 632-85-9 NMR| 632-85-9 COA| 632-85-9 structure
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
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P243 | Take precautionary measures against static discharge. |
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P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
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P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
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P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
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P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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