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[ CAS No. 630067-06-0 ] {[proInfo.proName]}

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Quality Control of [ 630067-06-0 ]

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Product Details of [ 630067-06-0 ]

CAS No. :	630067-06-0	MDL No. :	MFCD06255104
Formula :	C₁₃H₈N₂O₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	UCJSMIWAXWPDOJ-UHFFFAOYSA-N
M.W :	224.21	Pubchem ID :	3446446
Synonyms :

Safety of [ 630067-06-0 ]

Signal Word:	Warning	Class:
Precautionary Statements:	P261-P305+P351+P338	UN#:
Hazard Statements:	H302-H315-H319-H335	Packing Group:
GHS Pictogram:

Application In Synthesis of [ 630067-06-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 630067-06-0 ]
Downstream synthetic route of [ 630067-06-0 ]

[ 630067-06-0 ] Synthesis Path-Upstream 1~1

1
[ 630067-06-0 ]
[ 4199-88-6 ]

Reference： [1] Journal of Organic Chemistry, 2015, vol. 80, # 21, p. 10498 - 10504

[ 630067-06-0 ] Synthesis Path-Downstream 1~23

1
[ 630067-06-0 ]
cis-[Ru(3,4,7,8-tetramethyl-1,10-phenanthroline)2Cl₂] [ No CAS ]
sodium perchlorate [ No CAS ]
[Ru(3,4,7,8-tetramethyl-1,10-phenanthroline)2(5-carboxy-1,10-phenanthroline)](ClO₄)2 [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
50%	In ethanol; water Ru complex and ligand (3 equiv.) in H2O-EtOH refluxed for 6.5 h; monitored by TLC; solvent stripped; dissolved in min. hot H2O; slowly dripped into satd. NaClO4 soln. with stirring; ppt. collected by suction filtration; purified by column chromy. (neutral alumina, MeCN to MeCN-MeOH); most copious fraction collected; elem. anal.;

Reference： [1]Higgins, Bernadette; DeGraff; Demas [Inorganic Chemistry, 2005, vol. 44, # 19, p. 6662 - 6669]

2
[ 14099-01-5 ]
[ 630067-06-0 ]
Re(5-carboxy-1,10-phenanthroline)(CO)3Cl [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In toluene Re complex and ligand (1.1 equiv.) in toluene refluxed for 2 h; recrystd. from MeOH;

Reference： [1]Higgins, Bernadette; DeGraff; Demas [Inorganic Chemistry, 2005, vol. 44, # 19, p. 6662 - 6669]

3
ruthenium trichloride hydrate [ No CAS ]
[ 630067-06-0 ]
sodium perchlorate [ No CAS ]
[Ru(5-carboxy-1,10-phenanthroline)3](ClO₄)2 [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In ethanol; water RuCl3*nH2O and ligand (5 equiv.) in H2O-EtOH refluxed for ca. 6 h; monitored by TLC; solvent stripped; triturated with MeOH; concd.; dripped into satd. NaClO4 soln.; ppt. collected; purified by column chromy. (neutral alumina, MeOH to MeOH-H2O); last fraction collected; elem. anal.;

Reference： [1]Higgins, Bernadette; DeGraff; Demas [Inorganic Chemistry, 2005, vol. 44, # 19, p. 6662 - 6669]

4
potassium cyanide [ No CAS ]
ruthenium trichloride hydrate [ No CAS ]
[ 630067-06-0 ]
[ 867253-46-1 ]

Yield	Reaction Conditions	Operation in experiment
	In N,N-dimethyl-formamide RuCl3*nH2O and ligand (2 equiv.) in DMF stirred at reflux for 4.75 h; monitored by TLC; solvent stripped; small amt. of H2O added; ppt. isolatedbu suction filtration; washed (H2O, acetone); mixed with KCN in H2O; re fluxed for 6.5 h; solvent stripped; triturated with MeOH; sepd. by column chromy. (neutralalumina, MeOH to MeOH-H2O); most copious fraction collected; elem. anal .; three isomers obtained;

Reference： [1]Higgins, Bernadette; DeGraff; Demas [Inorganic Chemistry, 2005, vol. 44, # 19, p. 6662 - 6669]

5
cis-bis-(2,2′-bipyridine) dichlororuthenium(II) dihydrate [ No CAS ]
[ 630067-06-0 ]
sodium perchlorate [ No CAS ]
[Ru(2,2'-bipyridine)2(5-carboxy-1,10-phenanthroline)](ClO₄)2 [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In ethanol; water Ru complex and ligand (2 equiv.) in H2O-EtOH refluxed for ca. 4-6 h; monitored by TLC; solvent vol. reduced; dripped into stirred satd. NaClO4 soln.; ppt. collected by suction filtration; washed with cold H2O; dried; purified by column chromy. (neutral alumina, acetone, acetone-MeOH, MeOH, MeOH-H2O); last band collected; elem. anal.;

Reference： [1]Higgins, Bernadette; DeGraff; Demas [Inorganic Chemistry, 2005, vol. 44, # 19, p. 6662 - 6669]

6
[ 630067-06-0 ]
[ 867253-49-4 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: toluene 2: AgClO₄*H₂O / tetrahydrofuran

Reference： [1]Higgins, Bernadette; DeGraff; Demas [Inorganic Chemistry, 2005, vol. 44, # 19, p. 6662 - 6669]

7
[ 630067-06-0 ]
[ 867253-48-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: toluene 2: tetrahydrofuran

Reference： [1]Higgins, Bernadette; DeGraff; Demas [Inorganic Chemistry, 2005, vol. 44, # 19, p. 6662 - 6669]

8
[ 630067-06-0 ]
[ 4199-88-6 ]

Yield	Reaction Conditions	Operation in experiment
81%	With nitronium tetrafluoborate; silver carbonate In N,N-dimethyl acetamide at 90℃; for 12h; Inert atmosphere; Schlenk technique; regioselective reaction;

Reference： [1]Natarajan, Palani; Chaudhary, Renu; Venugopalan, Paloth [Journal of Organic Chemistry, 2015, vol. 80, # 21, p. 10498 - 10504]

9
[ 630067-06-0 ]
[ 14691-88-4 ]
4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl-1,10-phenanthroline-5-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 4-amino-2,2,6,6-tetramethyl-1-piperidine-1-oxyl With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine In dichloromethane Stage #2: 1,10-phenanthroline-5-carboxylic acid With dicyclohexyl-carbodiimide In dichloromethane at 48℃; for 20h;

Reference： [1]Yang, Jing; Cao, Qian; Hu, Wei-Liang; Ye, Rui-Rong; He, Liang; Ji, Liang-Nian; Qin, Peter Z.; Mao, Zong-Wan [Dalton Transactions, 2017, vol. 46, # 2, p. 445 - 454]

10
[ 630067-06-0 ]
[ 48167-07-3 ]
4-(2-(1,10-phenanthroline-5-carboxamido)ethyl)-1,2-phenylene diacetate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
62%	With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In dichloromethane at 0℃; for 25h;

Reference： [1]Vellaisamy, Kasipandi; Li, Guodong; Ko, Chung-Nga; Zhong, Hai-Jing; Fatima, Sarwat; Kwan, Hiu-Yee; Wong, Chun-Yuen; Kwong, Wai-Jing; Tan, Weihong; Leung, Chung-Hang; Ma, Dik-Lung [Chemical Science, 2018, vol. 9, # 5, p. 1119 - 1125]

11
[ 630067-06-0 ]
C₃₉H₅₄N₇O₁₁Pol [ No CAS ]
C₅₂H₆₁N₉O₁₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 1,10-phenanthroline-5-carboxylic acid With benzotriazol-1-ol; diisopropyl-carbodiimide In dimethyl sulfoxide; N,N-dimethyl-formamide for 0.166667h; Stage #2: C₃₉H₅₄N₇O₁₁Pol In dimethyl sulfoxide; N,N-dimethyl-formamide Stage #3: With chlorotriisopropylsilane; trifluoroacetic acid In water for 3h;

Reference： [1]Laws, Kristine; Bineva-Todd, Ganka; Eskandari, Arvin; Lu, Chunxin; O'Reilly, Nicola; Suntharalingam, Kogularamanan [Angewandte Chemie - International Edition, 2018, vol. 57, # 1, p. 287 - 291][Angew. Chem., 2018, vol. 130, # 1, p. 293 - 297,5]

12
[ 630067-06-0 ]
C₃₁H₅₉N₁₀O₇Pol [ No CAS ]
C₄₄H₆₆N₁₂O₈ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 1,10-phenanthroline-5-carboxylic acid With benzotriazol-1-ol; diisopropyl-carbodiimide In dimethyl sulfoxide; N,N-dimethyl-formamide for 0.166667h; Stage #2: C₃₁H₅₉N₁₀O₇Pol In dimethyl sulfoxide; N,N-dimethyl-formamide Stage #3: With chlorotriisopropylsilane; trifluoroacetic acid In water for 3h;

Reference： [1]Laws, Kristine; Bineva-Todd, Ganka; Eskandari, Arvin; Lu, Chunxin; O'Reilly, Nicola; Suntharalingam, Kogularamanan [Angewandte Chemie - International Edition, 2018, vol. 57, # 1, p. 287 - 291][Angew. Chem., 2018, vol. 130, # 1, p. 293 - 297,5]

13
[ 630067-06-0 ]
C₅₁H₉₅N₂₀O₇Pol [ No CAS ]
C₆₄H₁₀₂N₂₂O₈ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 1,10-phenanthroline-5-carboxylic acid With benzotriazol-1-ol; diisopropyl-carbodiimide In dimethyl sulfoxide; N,N-dimethyl-formamide for 0.166667h; Stage #2: C₅₁H₉₅N₂₀O₇Pol In dimethyl sulfoxide; N,N-dimethyl-formamide Stage #3: With chlorotriisopropylsilane; trifluoroacetic acid In water for 3h;

Reference： [1]Laws, Kristine; Bineva-Todd, Ganka; Eskandari, Arvin; Lu, Chunxin; O'Reilly, Nicola; Suntharalingam, Kogularamanan [Angewandte Chemie - International Edition, 2018, vol. 57, # 1, p. 287 - 291][Angew. Chem., 2018, vol. 130, # 1, p. 293 - 297,5]

14
[ 630067-06-0 ]
C₅₂H₉₁N₂₄O₁₃Pol [ No CAS ]
C₆₅H₉₈N₂₆O₁₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 1,10-phenanthroline-5-carboxylic acid With benzotriazol-1-ol; diisopropyl-carbodiimide In dimethyl sulfoxide; N,N-dimethyl-formamide for 0.166667h; Stage #2: C₅₂H₉₁N₂₄O₁₃Pol In dimethyl sulfoxide; N,N-dimethyl-formamide Stage #3: With chlorotriisopropylsilane; trifluoroacetic acid In water for 3h;

Reference： [1]Laws, Kristine; Bineva-Todd, Ganka; Eskandari, Arvin; Lu, Chunxin; O'Reilly, Nicola; Suntharalingam, Kogularamanan [Angewandte Chemie - International Edition, 2018, vol. 57, # 1, p. 287 - 291][Angew. Chem., 2018, vol. 130, # 1, p. 293 - 297,5]

15
bis[μ-chloro-bis(2-phenylisoquinolinato-C²,N)iridium(III)] [ No CAS ]
ammonium hexafluorophosphate [ No CAS ]
[ 630067-06-0 ]
C₄₃H₂₈IrN₄O₂⁽¹⁺⁾*F₆P^(1-) [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
48%	Stage #1: bis[μ-chloro-bis(2-phenylisoquinolinato-C²,N)iridium(III)]; 1,10-phenanthroline-5-carboxylic acid In methanol; dichloromethane at 20℃; for 10h; Stage #2: ammonium hexafluorophosphate In methanol; dichloromethane for 0.333333h;

Reference： [1]Wu, Chun; Wu, Ke-Jia; Liu, Jin-Biao; Zhou, Xiao-Ming; Leung, Chung-Hang; Ma, Dik-Lung [Chemical Communications, 2019, vol. 55, # 45, p. 6353 - 6356]

16
[iridium(III)(μ-chloro)(2-phenylpyridine)2]2 [ No CAS ]
ammonium hexafluorophosphate [ No CAS ]
[ 630067-06-0 ]
C₃₅H₂₄IrN₄O₂⁽¹⁺⁾*F₆P^(1-) [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: [iridium(III)(μ-chloro)(2-phenylpyridine)2]2; 1,10-phenanthroline-5-carboxylic acid In methanol; dichloromethane at 20℃; for 10h; Stage #2: ammonium hexafluorophosphate In methanol; dichloromethane for 0.333333h;

Reference： [1]Wu, Chun; Wu, Ke-Jia; Liu, Jin-Biao; Zhou, Xiao-Ming; Leung, Chung-Hang; Ma, Dik-Lung [Chemical Communications, 2019, vol. 55, # 45, p. 6353 - 6356]

17
[ 630067-06-0 ]
[ 204255-11-8 ]
C₂₉H₃₄N₄O₅ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
15%	With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride

Reference： [1]Wu, Chun; Wu, Ke-Jia; Liu, Jin-Biao; Zhou, Xiao-Ming; Leung, Chung-Hang; Ma, Dik-Lung [Chemical Communications, 2019, vol. 55, # 45, p. 6353 - 6356]

18
[ 14099-01-5 ]
[ 630067-06-0 ]
C₁₆H₈ClN₂O₅Re [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
84%	In ethanol Reflux;	3.3. Preparation of Re(5-COOH-phen)(CO)3Cl (4) Re(CO)5Cl (0.26 g, 0.72 mmol) and 5-COOH-phen (0.16 g, 0.72 mmol) were added along with 25 mL ethanol and a magneticstir bar to a 100 mL round-bottom flask. The solution was refluxedovernight during which time the solution turned yellow-orange. Atthe end of the reaction, a dark orange precipitate was present. Theprecipitate was collected by vacuum filtration on a fine-frit glassfunnel.Color: Yellow, 84.0% yield. Anal. Calcd. for ReC16H8O5N2Cl: C,36.27; H, 1.52; N, 5.29. Found. C, 34.65; H, 1.50; N, 5.02. IR (KBrpellet, cm1): (CO) 3300 (broad), 2014 sh,1907 sh, 1H NMR (DMSO):d ppm 8.14 (dd, 1H, J 5.2, 2.4 Hz), 8.18 (dd, 1H, J 5.2, 2.4 Hz), 9.04(s, 1H), 9.02 (dd, 1H, J 8.4, 1.6 Hz), 9.50 (m, 2H), 9.70 (dd, 1H,J 8.8, 1.2 Hz).

Reference： [1]Ensz, Kevin; Komreddy, Venugopal; Moore, Curtis E.; Nguyen, Huy; Rillema, D. Paul [Journal of Molecular Structure, 2020, vol. 1223]

19
[ 1082-21-9 ]
[ 630067-06-0 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hydroxide In water Reflux;

Reference： [1]Current Patent Assignee: UNIVERSITY OF LONDON - WO2021/69913, 2021, A1 Location in patent: Page/Page column 11

20
[ 630067-06-0 ]
C₇₉H₁₃₀N₁₇O₁₉Pol [ No CAS ]
C₉₂H₁₃₆N₁₉O₂₀Pol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With benzotriazol-1-ol; diisopropyl-carbodiimide In dimethyl sulfoxide; N,N-dimethyl-formamide

Reference： [1]Current Patent Assignee: UNIVERSITY OF LONDON - WO2021/69913, 2021, A1 Location in patent: Page/Page column 11

21
[ 2038-03-1 ]
[ 630067-06-0 ]
N‑(2‑morpholinoethyl)‑1,10‑phenanthroline‑5‑carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
72%	Stage #1: 1,10-phenanthroline-5-carboxylic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 1h; Stage #2: 4-(2-AMINOETHYL)MORPHOLINE In N,N-dimethyl-formamide for 72h; Inert atmosphere;	Synthesis of ligand N-(2-morpholinoethyl)-1,10-phenanthroline-5-carboxamide(ligand PhAEM) 1,10-Phenanthroline-5-carboxylic acid (1 equiv.; 0.89 mmol)was solubilized in 5 mL of DMF with HATU (1.2 equiv.,1.07 mmol) and DIPEA (3 equiv., 2.67 mmol), and themixture was stirred for 1 h at room temperature until thesolution turned dark brown. 4-(2-Aminoethyl)morpholine(1.2 equiv., 1.07 mmol) was then added to the reaction andstirred overnight. DMF was evaporated under vacuum andthe residue washed with 100 mL H2O.The white residuewas filtered through a glass wool plug with cold Et2O,andvacuum-dried to afford the desired product with 72% yield.1H NMR (400 MHz, DMSO-d6): δ (ppm) 9.18-9.15 (Hab,dd; 2H), 9.06-9.03 (NH, t, 1H), 8.81-8.78 (Hd, dd, 1H),8.60-8.58 (Hc, dd, 1H), 8.22 (He, s, 1H), 7.89-7.82 (Hfg,mult, 2H), 3.78-3.73 (O-CH2, mult, 4H), 8H morpholine inHDO d 13C NMR (101 MHz, DMSO-D6): δ (ppm) 167.69,151.21, 150.15, 145.45, 137.14, 134.67, 132.20, 126.93,126.51, 125.67, 124.09, 123.50, 63.58, 55.27, 51.57, 34.12.IR (cm-1): 3414, 1654-1651, 1548 ESI-MS (positive mode)for C19H20N4O2[M-H]+, calculated 337.1659 m/z; found337.1661 [M-H]+ (0.52 ppm).

Reference： [1]Berger, Gilles; Debaille, Vinciane; Dufrasne, François; Gelbcke, Michel; Inam, Haider; Marloye, Mickaël; Meyer, Franck; Moore, Connor J.; Pritchard, Justin R. [Journal of Biological Inorganic Chemistry, 2021, vol. 26, # 5, p. 535 - 549]

22
[ 630067-06-0 ]
[ 106451-92-7 ]
1,10‑phenanthroline‑5‑hexanoate‑biotinamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
52%	Stage #1: 1,10-phenanthroline-5-carboxylic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 1h; Stage #2: 6-N-Biotinylaminohexanol In N,N-dimethyl-formamide	Synthesis of 1,10-phenanthroline-5-hexanoate-biotinamide(ligand PhBio) 1,10-Phenanthroline-5-carboxylic acid (1 equiv.; 0.30 mmol)was solubilized in 5 mL of DMF with HBTU (1.2 equiv.,0.35 mmol) and DIPEA (3 equiv., 0.90 mmol) and the mixturestirred for 1 h at room temperature until the solutionturned dark brown. N-(Hexanol)biotinamide (1.2 equiv.,0.35 mmol) was then added to the reaction and stirred overnight.DMF was evaporated under vacuum and the residuewashed with 100 mL H2O.The white residue was filteredthrough a glass wool plug with cold Et2O,and vacuumdriedto afford the desired product in 52% yield. 1H NMR(400 MHz, DMSO-d6): δ (ppm) 9.23-9.22 (Ha, d; 1H,J = 1.8 Hz), 9.21-9.20 (Hb, d, 1H, J = 1.9 Hz), 9.16-9.15(Hd, dd, 1H, J1 = 1.8 Hz, J2 = 4.3 Hz), 8.72-8.69 (Hc, dd,1H, J1 = 1.8 Hz, J2 = 8 Hz), 8.70 (He, s, 1H, J = 1.5 Hz),7.87-7.83 (Hfg, mult, 2H), 7.76-7.73 (NH, t, 1H,J = 5.9 Hz), 6.40 (NH, s, 1H), 6.34 (NH, s, 1H) 4.44-4.41(Hh, t, 2H, J = 6.6 Hz), 4.29-4.26 (Hm, mult, 1H), 4.11-4.08(Hn, mult, 1H), 3.09-3.01 (Hki, massif, 3H), 2.80-2.76 (Hl,dd, 1H, J1 = 7.4 Hz, J2 = 13.8 Hz), 2.55-2.53 (Hl, d, 1H,J = 11.2 Hz), 2.05-2.01 (Hj, t, 2H, J = 7.4 Hz), 1.84-1.77(Hi, quint, 2H, J = 7.1 Hz), 1.63-1.21 (H aliphatic, massif,14H), 13C NMR (101 MHz, DMSO-d6): δ (ppm) 172.37,166.38, 163.22, 152.84, 150.70, 147.32, 146.13, 138.29,134.57, 132.21, 127.10, 126.29, 126.19, 124.52, 124.23,65.90, 61.57, 59.71, 55.96, 38.74, 35.76, 29.56, 28.74,28.67, 28.57, 26.58, 25.87, 25.74. IR (cm-1): 3300, 3205,2936, 2855, 1731, 1674, 1634. ESI-MS (positive mode)for C29H35N5O4S[M-H]+, calculated m/z 550.2483; found550.2482 [M-H]+ (0.05 ppm).

Reference： [1]Berger, Gilles; Debaille, Vinciane; Dufrasne, François; Gelbcke, Michel; Inam, Haider; Marloye, Mickaël; Meyer, Franck; Moore, Connor J.; Pritchard, Justin R. [Journal of Biological Inorganic Chemistry, 2021, vol. 26, # 5, p. 535 - 549]

23
[ 630067-06-0 ]
(6-aminohexyl)triphenylphosphonium bromide [ No CAS ]
HATU [ No CAS ]
(6-(1,10-phenanthroline-5-carboxamido)hexyl)triphenylphosphonium bromide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
74.3%	With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;

Reference： [1]Wang, Wen-Jin; Mu, Xia; Tan, Cai-Ping; Wang, Yu-Jian; Zhang, Yuebin; Li, Guohui; Mao, Zong-Wan [Journal of the American Chemical Society, 2021, vol. 143, # 30, p. 11370 - 11381]

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P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Ghs Hazard Statements

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere