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Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
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Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
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* Storage: {[proInfo.prStorage]}
CAS No. : | 63-45-6 | MDL No. : | MFCD00013166 |
Formula : | C15H27N3O9P2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | GJOHLWZHWQUKAU-UHFFFAOYSA-N |
M.W : | 455.34 | Pubchem ID : | 6135 |
Synonyms : |
Primaquine phosphate;Primaquine bisphosphate;Phosphate, Primaquine;Diphosphate, Primaquine;Boucher and Muir Brand of Primaquine Phosphate;Primaquine bis(phosphate);Primaquine (Diphosphate);NSC 149765;Primaquine (phosphate)
|
Num. heavy atoms : | 29 |
Num. arom. heavy atoms : | 10 |
Fraction Csp3 : | 0.4 |
Num. rotatable bonds : | 6 |
Num. H-bond acceptors : | 11.0 |
Num. H-bond donors : | 8.0 |
Molar Refractivity : | 108.0 |
TPSA : | 235.31 Ų |
GI absorption : | Low |
BBB permeant : | No |
P-gp substrate : | No |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -12.08 cm/s |
Log Po/w (iLOGP) : | 0.64 |
Log Po/w (XLOGP3) : | -4.23 |
Log Po/w (WLOGP) : | 0.73 |
Log Po/w (MLOGP) : | -1.82 |
Log Po/w (SILICOS-IT) : | 2.55 |
Consensus Log Po/w : | -0.42 |
Lipinski : | 2.0 |
Ghose : | None |
Veber : | 1.0 |
Egan : | 1.0 |
Muegge : | 4.0 |
Bioavailability Score : | 0.17 |
Log S (ESOL) : | 0.14 |
Solubility : | 632.0 mg/ml ; 1.39 mol/l |
Class : | Highly soluble |
Log S (Ali) : | -0.1 |
Solubility : | 359.0 mg/ml ; 0.788 mol/l |
Class : | Very soluble |
Log S (SILICOS-IT) : | -5.17 |
Solubility : | 0.00305 mg/ml ; 0.0000067 mol/l |
Class : | Moderately soluble |
PAINS : | 0.0 alert |
Brenk : | 1.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 3.47 |
Signal Word: | Danger | Class: | 6.1 |
Precautionary Statements: | P301+P310 | UN#: | 2811 |
Hazard Statements: | H301 | Packing Group: | Ⅲ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
86% | With sodium hydroxide In water at 20℃; for 2 h; Darkness | Primaquine diphosphate (4 mmol) was dissolved in the minimum of distilled water with constant magnetic stirring. Covered with aluminum foil, was added slowly an aqueous solution of 10percent sodium hydroxide until the reaction medium reached the pH = 10. Reaction was left under stirring and shielding the light at room temperature for 2hours. The mixture was extracted with dichloromethane, dried over anhydrous sodium sulphate to give brown oil. Yield: 86percent. GC/MS (m/z): 259.1 (19percent); 201.1 (100percent); 186.0(21percent); 176.0 (26percent); 175.0 (26percent). 1H NMR (400 MHz, MeOD, δ in ppm): 1.28 (3H, d, CHCH3);1.67 (4H, m, CH2CH2); 2.73 (2H, m, CH2NH2);3.65 (1H, m, CHCH3); 3.85 (3H, s, OMe); 6.31 (1H, d, J = 2.4 Hz, H7); 6.44 (1H, d, J = 2.4 Hz, H5); 7.34 (1H, dd, J = 4.2; 8.3 Hz, H3); 8.01 (1H, dd, J = 1.6; 8.3 Hz, H4); 8.48 (1H, dd, J = 1.6; 4.2 Hz, H2). IR (KBr, cm-1):3383; 2943; 2872; 1749; 1616; 1595; 1577; 1519; 1454; 1386; 1219; 1161; 1097;1051; 1016; 925; 875; 8 23. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
86% | With sodium hydroxide; In water; at 20℃; for 2h;pH 10.0;Darkness; | Primaquine diphosphate (4 mmol) was dissolved in the minimum of distilled water with constant magnetic stirring. Covered with aluminum foil, was added slowly an aqueous solution of 10% sodium hydroxide until the reaction medium reached the pH = 10. Reaction was left under stirring and shielding the light at room temperature for 2hours. The mixture was extracted with dichloromethane, dried over anhydrous sodium sulphate to give brown oil. Yield: 86%. GC/MS (m/z): 259.1 (19%); 201.1 (100%); 186.0(21%); 176.0 (26%); 175.0 (26%). 1H NMR (400 MHz, MeOD, delta in ppm): 1.28 (3H, d, CHCH3);1.67 (4H, m, CH2CH2); 2.73 (2H, m, CH2NH2);3.65 (1H, m, CHCH3); 3.85 (3H, s, OMe); 6.31 (1H, d, J = 2.4 Hz, H7); 6.44 (1H, d, J = 2.4 Hz, H5); 7.34 (1H, dd, J = 4.2; 8.3 Hz, H3); 8.01 (1H, dd, J = 1.6; 8.3 Hz, H4); 8.48 (1H, dd, J = 1.6; 4.2 Hz, H2). IR (KBr, cm-1):3383; 2943; 2872; 1749; 1616; 1595; 1577; 1519; 1454; 1386; 1219; 1161; 1097;1051; 1016; 925; 875; 8 23. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Trifluoroethanol (0.07 mL, 1 mmol) in dried tetrahydrofuran (5 mL) was slowly added to a solution of carbonyl diimidazole (0.162 g, 1 mmol) in dried tetrahydrofuran (5 mL). After stirring for 1 h at room temperature, a solution of primaquine free base (0.263 g, 1 mmol; obtained by treating an aqueous solution of <strong>[63-45-6]primaquine diphosphate</strong> with an excess of Na2CO3 and then extracting with dichloromethane, followed by drying and evaporation of the solvent) in dried tetrahydrofuran (5 mL) was added to reaction mixture. After overnight at room temperature the reaction mixture was filtered and the solvent was evaporated under reduce pressure. The residue was re-dissolved in dichloromethane (50 mL) and the organic phase was washed (satd NaHCO3, water), dried (anhydrous MgSO4) and evaporated to dryness. The residue was further purified by dry column chromatography (silica gel; ether/light petroleum, 7:3) to give 4c as brown oil in 43% yield. IR (cm-1) numax 3360, 1737; 1H NMR (CDCl3): delta 1.23 (3H, d, J = 6.4), 1.58-1.68 (4H, m), 3.15-3.23 (2H, m), 3.51-3.60 (1H, m), 3.81 (3H, s), 4.36 (2H, q, J = 9.0), 4.89 (1H, br s), 5.92 (1H, d, J = 8.4), 6.20 (1H, d, J = 2.5), 6.27 (1H, d, J = 2.5), 7.23 (1H, dd, J = 8.2, 4.2), 7.85 (1H, dd, J = 8.2, 1.5), 8.45 (1H, dd, J = 4.2, 1.5); 13C NMR (CDCl3): delta 20.7, 26.6, 33.8, 41.4, 47.8, 55.3, 74.5, 91.8, 96.9, 121.9, 124.9, 130.0, 134.9, 135.6, 144.4, 144.9, 154.6, 159.5; FAB-MS, m/z (%) 386 (48, MH+), 201 (100), 175 (60). Anal. Calcd for C18H22F3N3O3: C, 56.10; H, 5.75; N, 10.90. Found: C, 56.36; H, 5.59; N, 10.77. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
General procedure: Trifluoroethanol (0.07 mL, 1 mmol) in dried tetrahydrofuran (5 mL) was slowly added to a solution of carbonyl diimidazole (0.162 g, 1 mmol) in dried tetrahydrofuran (5 mL). After stirring for 1 h at room temperature, a solution of primaquine free base (0.263 g, 1 mmol; obtained by treating an aqueous solution of <strong>[63-45-6]primaquine diphosphate</strong> with an excess of Na2CO3 and then extracting with dichloromethane, followed by drying and evaporation of the solvent) in dried tetrahydrofuran (5 mL) was added to reaction mixture. After overnight at room temperature the reaction mixture was filtered and the solvent was evaporated under reduce pressure. The residue was re-dissolved in dichloromethane (50 mL) and the organic phase was washed (satd NaHCO3, water), dried (anhydrous MgSO4) and evaporated to dryness. The residue was further purified by dry column chromatography (silica gel; ether/light petroleum, 7:3) to give 4c as brown oil in 43% yield. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
42% | With triethylamine; In tetrahydrofuran; at -10 - 20℃; for 2h; | General procedure: Ethyl chloroformate (0.19 mL, 2 mmol) was added to a suspension containing <strong>[63-45-6]primaquine diphosphate</strong> (0.911 g, 2 mmol) and triethylamine (3 mol equiv) in tetrahydrofuran (5 mL) at -10 C. The mixture was stirred at -10 C for 30 min and then left at room temperature for 90 min. The reaction mixture was filtered and the filtrate evaporated. The residue was re-dissolved in dichloromethane and the organic layers were washed (satd NaHCO3, water), dried (anhydrous MgSO4) and evaporated to dryness to yield an oily residue that was subjected to column chromatography on silica gel (ether/light petroleum, 7:3) to give 4a as a brown oil in 53% yield. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
36% | With triethylamine; In tetrahydrofuran; at -10 - 20℃; for 2h; | General procedure: Ethyl chloroformate (0.19 mL, 2 mmol) was added to a suspension containing <strong>[63-45-6]primaquine diphosphate</strong> (0.911 g, 2 mmol) and triethylamine (3 mol equiv) in tetrahydrofuran (5 mL) at -10 C. The mixture was stirred at -10 C for 30 min and then left at room temperature for 90 min. The reaction mixture was filtered and the filtrate evaporated. The residue was re-dissolved in dichloromethane and the organic layers were washed (satd NaHCO3, water), dried (anhydrous MgSO4) and evaporated to dryness to yield an oily residue that was subjected to column chromatography on silica gel (ether/light petroleum, 7:3) to give 4a as a brown oil in 53% yield. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
49% | With triethylamine; In tetrahydrofuran; at -10 - 20℃; for 2h; | General procedure: Ethyl chloroformate (0.19 mL, 2 mmol) was added to a suspension containing primaquine diphosphate (0.911 g, 2 mmol) and triethylamine (3 mol equiv) in tetrahydrofuran (5 mL) at -10 C. The mixture was stirred at -10 C for 30 min and then left at room temperature for 90 min. The reaction mixture was filtered and the filtrate evaporated. The residue was re-dissolved in dichloromethane and the organic layers were washed (satd NaHCO3, water), dried (anhydrous MgSO4) and evaporated to dryness to yield an oily residue that was subjected to column chromatography on silica gel (ether/light petroleum, 7:3) to give 4a as a brown oil in 53% yield. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
53% | With triethylamine; In tetrahydrofuran; at -10 - 20℃; for 2h; | Ethyl chloroformate (0.19 mL, 2 mmol) was added to a suspension containing <strong>[63-45-6]primaquine diphosphate</strong> (0.911 g, 2 mmol) and triethylamine (3 mol equiv) in tetrahydrofuran (5 mL) at -10 C. The mixture was stirred at -10 C for 30 min and then left at room temperature for 90 min. The reaction mixture was filtered and the filtrate evaporated. The residue was re-dissolved in dichloromethane and the organic layers were washed (satd NaHCO3, water), dried (anhydrous MgSO4) and evaporated to dryness to yield an oily residue that was subjected to column chromatography on silica gel (ether/light petroleum, 7:3) to give 4a as a brown oil in 53% yield. 1H NMR (CDCl3): delta 1.15 (3H, t, J = 7.1), 1.23 (3H, d, J = 6.4), 1.51-1.61 (4H, m), 3.11-3.20 (2H, m), 3.52-3.58 (1H, m), 3.81 (3H, s), 4.02 (2H, q, J = 7.1), 4.61 (1H, br s), 5.93 (1H, d, J = 8.2), 6.20 (1H, d, J = 2.5), 6.26 (1H, d, J = 2.5), 7.23 (1H, dd, J = 8.2, 4.2), 7.85 (1H, dd, J = 8.2, 1.6), 8.45 (1H, dd, J = 4.2, 1.6); 13C NMR (CDCl3): delta 14.7, 20.9, 26.9, 34.0, 41.0, 47.9, 55.3, 60.7, 91.7, 96.8, 121.9, 130.0, 134.9, 135.4, 144.4, 145.0, 156.8, 159.5; FAB-MS, m/z (%) 332 (75, MH+), 201 (100), 175 (37). Anal. Calcd for C18H25N3O3: C, 65.23; H, 7.60; N, 12.68. Found: C, 65.17; H, 7.91; N, 12.51. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
10% | With triethylamine; In tetrahydrofuran; at -10 - 20℃; for 2h; | General procedure: Ethyl chloroformate (0.19 mL, 2 mmol) was added to a suspension containing <strong>[63-45-6]primaquine diphosphate</strong> (0.911 g, 2 mmol) and triethylamine (3 mol equiv) in tetrahydrofuran (5 mL) at -10 C. The mixture was stirred at -10 C for 30 min and then left at room temperature for 90 min. The reaction mixture was filtered and the filtrate evaporated. The residue was re-dissolved in dichloromethane and the organic layers were washed (satd NaHCO3, water), dried (anhydrous MgSO4) and evaporated to dryness to yield an oily residue that was subjected to column chromatography on silica gel (ether/light petroleum, 7:3) to give 4a as a brown oil in 53% yield. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
42% | With triethylamine; In tetrahydrofuran; at -10 - 20℃; for 2h; | General procedure: Ethyl chloroformate (0.19 mL, 2 mmol) was added to a suspension containing <strong>[63-45-6]primaquine diphosphate</strong> (0.911 g, 2 mmol) and triethylamine (3 mol equiv) in tetrahydrofuran (5 mL) at -10 C. The mixture was stirred at -10 C for 30 min and then left at room temperature for 90 min. The reaction mixture was filtered and the filtrate evaporated. The residue was re-dissolved in dichloromethane and the organic layers were washed (satd NaHCO3, water), dried (anhydrous MgSO4) and evaporated to dryness to yield an oily residue that was subjected to column chromatography on silica gel (ether/light petroleum, 7:3) to give 4a as a brown oil in 53% yield. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
82% | A reaction mixture of primaquine diphosphate (402.4mg, 0.88mmol, 2eq.) and NEt3 (245muL, 1.76mmol, 4eq.) in dry methanol (6ml) was stirred for 30min at room temperature under nitrogen atmosphere before addition of <strong>[2892-62-8]3,4-dibutoxy-3-cyclobutene-1,2-dione</strong> (96muL, 0.44mmol). After heating at reflux for 48h the solvent was removed under reduced pressure; water was added, and the product was extracted with ethyl acetate (3×). The combined organic extracts were washed with brine, dried over anhydrous Na2SO4, and the solvent was removed under reduced pressure. The residue was purified by flash chromatography on silica gel using as eluent n-hexane/EtOAc (1:1) to EtOAc (100%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
89% | A reaction mixture of primaquine diphosphate (402.4mg, 0.88mmol, 2eq.) and NEt3 (368muL, 2.64mmol, 6eq.) in dry methanol (6ml) was stirred for 30min at room temperature under nitrogen atmosphere before addition of <strong>[2892-62-8]3,4-dibutoxy-3-cyclobutene-1,2-dione</strong> (96muL, 0.44mmol). After heating at reflux for 48h the solvent was removed under reduced pressure; water was added, and the product was extracted with EtOAc (3×). The combined organic extracts were washed with brine, dried over anhydrous Na2SO4, and the solvent was removed under reduced pressure. The residue was purified by flash chromatography on silica gel using as eluent n-hexane/EtOAc (1:1) to EtOAc (100%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
95% | With triethylamine; In N,N-dimethyl-formamide; at 20℃; for 48.0h;Inert atmosphere; | General procedure: To the stirred solution of primaquine biphosphate 2 (0.87 mmol)and triethylamine (2.6 mmol) in dry DMF (10 ml) nitrogen atmosphere,a solution of appropriate 2-chloropyrimidine 7 (0.87 mmol)in dry DMF (5 ml) was added. The reaction mixture was strirred atroom temerature for 48 h under nitrogen atmosphere. The reactionmixture was concenterated under vacuum and the residue waspurified by column chromatography using hexane/ethyl acetate aseluent to obtain corresponding 8, which was then recrystallizedfrom DCM/hexane to obtain yellow solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
61% | General procedure: A reaction mixture of primaquine diphosphate (1.2 equiv), andNEt3 (2.4 equiv) in dry solvent (1 mL/3-cyclobutene-1,2-dionederivative 8) was stirred for 30 min at room temperature undernitrogen atmosphere, before addition of 3-cyclobutene-1,2-dionederivative 8 (1.0 equiv). After heating at reflux for 12-48 h, the solventwas removed under reduced pressure and the residueobtained dissolved in EtOAc. The mixture was then washed withwater (2) and dried over anhydrous Na2SO4. The crude productwas purified by flash chromatography on silica gel using as eluenta gradient from n-hexane (100%) to n-hexane/EtOAc (1:2), followedby preparative TLC (n-Hexane/EtOAC 2:1). |
A116308[ 90-34-6 ]
8-(4-Amino-1-methylbutylamino)-6-methoxyquinoline
Reason: Free-salt
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
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P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
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P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
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P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
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P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
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P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
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P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
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P362 | Take off contaminated clothing and wash before reuse. |
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P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
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P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
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P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
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P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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