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CAS No. : | 623142-96-1 | MDL No. : | MFCD12024693 |
Formula : | C24H24N4O5S | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | SHPFDGWALWEPGS-UHFFFAOYSA-N |
M.W : | 480.54 | Pubchem ID : | 9869779 |
Synonyms : |
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Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
72% | Example 74: N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-methoxyphenyl}-N'-[1-(1,3-thiazol-2-yl)ethyl]urea 4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-methoxyaniline (816 mg) was dissolved in chloroform (40 ml) and triethylamine (2.0 ml) to prepare a solution. A solution of triphosgene (368 mg) in chloroform (1.0 ml) was then added to the solution, and the mixture was stirred at room temperature for one hr. Next, a solution of <strong>[432047-36-4]1-(1,3-thiazol-2-yl)-1-ethylamine</strong> (352 mg) in chloroform (1.0 ml) was added thereto, and the mixture was stirred at room temperature overnight. Water (40 ml) was added thereto, and the mixture was stirred for 10 min, followed by extraction with chloroform. The organic layer was washed with saturated brine and was dried over sodium sulfate. The solvent was removed by evaporation, and the residue was purified by chromatography on silica gel using chloroform/acetone for development to give the title compound (860 mg, 72%). 1H-NMR (CDCl3, 400 MHz): delta 1.69 (d, J = 6.8 Hz, 3H), 3.83 (s, 3H), 4.06 (s, 3H), 4.07 (s, 3H), 5.37 - 5.45 (m, 1H), 5.67 (d, J = 7.3 Hz, 1H), 6.51 (d, J = 5.4 Hz, 1H), 6.70 (d, J = 2.4 Hz, 1H), 6.79 (dd, J = 2.4, 8.8 Hz, 1H), 7.02 (s, 1H), 7.30 (d, J = 3.4 Hz, 1H), 7.53 (s, 1H), 7.57 (s, 1H), 7.73 (d, J = 3.4 Hz, 1H), 8.19 (d, J = 8.8 Hz, 1H), 8.47 (d, J = 5.4 Hz, 1H) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1.1: pyridine; hydroxylamine hydrochloride / ethanol / 20 °C 2.1: ammonium chloride; zinc / methanol / 2 h / Heating / reflux 3.1: triethylamine / chloroform / 1 h / 20 °C 3.2: 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1.1: ammonium chloride; zinc / methanol / 2 h / Heating / reflux 2.1: triethylamine / chloroform / 1 h / 20 °C 2.2: 20 °C |