Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 55268-74-1 | MDL No. : | MFCD00058531 |
Formula : | C19H24N2O2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | FSVJFNAIGNNGKK-UHFFFAOYSA-N |
M.W : | 312.41 | Pubchem ID : | 4891 |
Synonyms : |
Embay 8440;(±)-Praziquantel;Traziquantel;Praziquantel, (S)-Isomer;Praziquantel, (R)-Isomer;Praziquantel, (+-)-Isomer;Pyquiton;Cesol;Droncit;Biltricide
|
Num. heavy atoms : | 23 |
Num. arom. heavy atoms : | 6 |
Fraction Csp3 : | 0.58 |
Num. rotatable bonds : | 2 |
Num. H-bond acceptors : | 2.0 |
Num. H-bond donors : | 0.0 |
Molar Refractivity : | 96.93 |
TPSA : | 40.62 Ų |
GI absorption : | High |
BBB permeant : | Yes |
P-gp substrate : | Yes |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | Yes |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | Yes |
CYP3A4 inhibitor : | Yes |
Log Kp (skin permeation) : | -6.31 cm/s |
Log Po/w (iLOGP) : | 3.01 |
Log Po/w (XLOGP3) : | 2.67 |
Log Po/w (WLOGP) : | 1.45 |
Log Po/w (MLOGP) : | 2.4 |
Log Po/w (SILICOS-IT) : | 2.47 |
Consensus Log Po/w : | 2.4 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 0.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -3.52 |
Solubility : | 0.0943 mg/ml ; 0.000302 mol/l |
Class : | Soluble |
Log S (Ali) : | -3.17 |
Solubility : | 0.209 mg/ml ; 0.000669 mol/l |
Class : | Soluble |
Log S (SILICOS-IT) : | -3.76 |
Solubility : | 0.0547 mg/ml ; 0.000175 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 0.0 alert |
Leadlikeness : | 0.0 |
Synthetic accessibility : | 2.9 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P280-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H332-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
81% | General procedure: To the DCM solution of diamine (0.27 g, 1 mmol, 1.0 equ.) was added 50% NaOH solution (0.48 mL, 6mmol) followed by chloroacetyl chloride and allowed to stir for 30 min. Then TEBAC (0.1 mmol, 0.1equ.) was added and refluxed for 2 h. It was then cooled to rt, diluted with water (2 mL) and extracted with DCM (10 mL X 2). The combined organic phase was then washed with 5% HCl and again with water, dried over Na2SO4, concentrated and purified by column chromatography (CHCl3/MeOH 98:2) to get the pure product. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
3.0 g (95%) | With sulfuric acid; | EXAMPLE 7 (+-)-2-cyclohexanecarbonyl-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline (I; R1 =cyclohexanecarbonyl, R2 =R3 =H) 3.3 g of 1-(2-phenyl)ethyl-4-cyclohexanecarbonyl-2-hydroxypiperazine-6-one (V; R2 =R3 =H, R1 =cyclohexanecarbonyl) was slowly added to 5 ml of concentrated sulfuric acid. The mixture was stirred at room temperature for 3 hours. The reaction mixture was poured into ice-water and neutralized with aqueous alkali. The resultant mixture was extracted with dichloromethane, and then the extract was concentrated. The residue was recrystallized with ethyl acetate to give 3.0 g (95%) of the product, m.p. 132~134 C. |
170.1 g | With sulfuric acid; In dichloromethane; at 0 - 5℃; for 4h; | General procedure: To asolution of conc. H2SO4 (600 mL) was added dropwise the above solution of 13 in CH2Cl2 at 0-5 C for 2h. After stirring at 0-5 C for 2 h, the reaction mixture was poured into cold water (5.0 L), and extractedwith CH2Cl2 (2 × 350 mL). The organic layer was washed with sequentially the saturated solution ofsodium bicarbonate (2 × 300 mL) and water (2 × 300 mL), dried over anhydrous MgSO4, andconcentrated at reduced pressure to afford crude 1 (195.5 g) as a off-white solid. The crude material wassuspended in 55% EtOH (950 mL) and heated at 60 C for 1 h. The mixture was cooled down to -6 Cand stirred for 8 h. The solids were collected by filtration, washed with cold 45% EtOH (3 × 100 mL) anddried under vacuum at 40 C for 12 h to provide 1 (170.1 g, 85% yield from compound 11) with 99.8% area purity by HPLC; a white solid; mp 138.4-139.2 C (EtOH-H2O) (lit.,3a 136-139 C); IR 3444, 2929,2853, 1649, 1628, 1447, 1421, 1357, 1326, 1300, 1245, 1211, 1177, 1126, 1088, 997, 894, 764, 693, 621cm-1; 1H NMR (400 MHz, CDCl3) delta 7.27 - 7.10 (m, 4 H), 5.16 (dd, J = 13.2, 2.4 Hz, 1 H), 4.83 - 4.74 (m,2 H), 4.47 (d, J = 17.4 Hz, 1 H), 4.08 (d, J = 17.4 Hz, 1 H), 2.99 - 2.76 (m, 4 H), 2.47 (m, 1 H), 1.82 -1.16 (m, 10 H); 13C NMR (CDCl3) delta 174.79, 164.44, 134.80, 132.86, 129.33, 127.49, 127.02, 125.51,55.00, 49.09, 45.22, 40.84, 39.15, 29.29, 29.07, 28.78, 25.77; MS m/z 313.1 (M+, 100). HRMS m/z [M +H]+ calcd for C19H24N2O2: 313.1911; found: 313.1910. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
58.6% | With sodium hydrogencarbonate; In dichloromethane; at 0 - 30℃; for 5h; | 60.67 g (0.30 mol) of intermediate III and 30.24 g (0.36 mol) of NaHCO3 were added to 240 gIn dichloromethane,Turn on the agitation,Cool down to 0 ~ 10 C,48.38 g (0.33 mol) of cyclohexylcarbonyl chloride was added dropwise.After the addition is completed, the temperature is controlled at 20 to 30 C.Stir the reaction for 5 h,Then 150 g of water was added to the reaction flask.Divide the organic phase,Concentrated to give a crude white praziquantel,Recrystallized from 95% ethanol,Obtained 80.2 g of a white solid.The yield is 85.6%.Purity (HPLC): 99.7%.The total yield from beta-phenethylamine to praziquantel was 60.8%. |
Prazole-5 (0.72 kg), dichloromethane (4.32 L) and sodium carbonate (0.4 kg) were stirred at 25-30 C. for 15 mm, cooled to 0-5 C. Cyclohexanoyl chloride (0.54 kg) was added dropwise, allow the reaction mass to attain 25-30 C. under stirring for 2 irs. After completion of reaction, reaction mass was quenched to DM water below 30 C., maintain the pH in the range 8-8.5, stirred. Two layers were separated. Aqueous layer was extracted with dichloromethane. Combined organic layers were washed with 1% lye, DM water, dried. Acetone was added, carbon treatment was given to organic layer, stirred for 1 hr at 40-45 C., filtered. Acetone was distilled. Crude material was crystallized by acetone andwater, and wash with chilled acetone. | ||
at 50℃; | The praziquantel synthesis process of this example comprises the following steps:(1) condensation reaction of beta-phenylethylamine and aminoacetic acid halide hydrochloride to form intermediate A: N-beta-phenethylaminoacetamide, the condensation reaction temperature is 60 ;(2) The resulting intermediate A and the haloacetal are condensed under basic conditions to form an intermediate B: N- (2-phenyl) ethyl-2 - [(2,2-dimethyl Oxyethyl) amino] acetamide, the condensation reaction temperature is 120 ;(3) The resulting intermediate B was cyclized under acid catalysis to give intermediate C: 4-carbonyl-1,2,3,6,7,11b-hexahydro-4H-pyrazinyl [2,1-a] Isoquinoline with cyclization temperature of -20C;(4) Intermediate C was reacted with cyclohexanecarbonyl chloride at 50 C to form the target product praziquantel. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
91.2% | With hydrogenchloride; In water;Reflux; | A mixture of PZQ (10 g, 32 mmol) and 2 N HCl (50 mL) was refluxed overnight. After PZQ was consumed, the reaction solution was cooled to room temperature, neutralized with Na2CO3 (aq.) and then extracted with DCM (100 mL*3). The organic layer was washed with water and brine, dried with anhydrous Na2SO4 and concentrated to get the product as a yellow solid (yield: 91.2%). |
77% | With hydrogenchloride; In ethanol; water; for 27h;Inert atmosphere; Reflux; | A 1 N HCl solution (600 mL) was added to a 2 L round bottom flask containing 20 g PZQ in EtOH (150 mL). The reaction mixture was refluxed for 27 h and then stirred overnight at room temperature. The solution was washed with 30 mL ethyl acetate. The aqueous layer was then ice-cooled and 5 M NaOH solution was added to adjust the pH of solution to the range of 12-14. The aqueous layer was extracted with 500 mL dichloromethane. The organic layer was washed with brine, dried over anhydrous MgSO4 and concentrated to obtain a pale yellow crude solid. The crude residue was purified by flash column chromatography using dichloromethane/methanol (0 to 20 % gradient) to obtain (rac)-PZQamine (10 g, 77 %). M.P. = 116-118 C; 1H NMR (400 MHz, Chloroform-d) delta 7.30 - 6.95 (m, 4H), 4.89 - 4.65 (m, 2H), 3.73 - 3.63 (m, 1H), 3.61 (d, J= 16 Hz, 1H), 3.47 (d, J= 16 Hz, 1H), 3.03 - 2.59 (m, 4H), 1.83 (bs, 1H); Mass Analysis: M+1 = 203.94 (observed), 203.11 (calculated); 2M+1 = 405.04 (observed), 404.22 (calculated). |
75% | With hydrogenchloride; In ethanol; water; for 48h;Reflux; | A 250 ml flask was charged with 15 g of praziquantel,80 ml of 2 mol / L HCl, 30 ml of ethanol,Heated to reflux for 48 hours, the solvent was recovered,The pH was adjusted to 12 with 20% sodium hydroxide,Dichloromethane 200ml extraction twice,The combined dichloromethane was washed twice with water,The methylene chloride layer was dried over anhydrous sodium sulfate,Activated carbon decolorization, filtration,After recovering methylene chloride, 7 g of a light yellow solid was obtained,75% yield. |
62% | With hydrogenchloride; In water;Inert atmosphere; Reflux; | A mixture of PZQ (10 g, 32 mmol) and 2 N HCl (50 mL) was refluxed overnight. After PZQ was consumed, the reaction solution was cooled to room temperature, neutralized with NaHCO3 (aq.) and then extracted with DCM/MeOH (V/V 10/1, 100 mL × 3). The organic layer was washed with water and brine, dried with anhydrous Na2SO4 and concentrated to get the crude product. The crude product was washed with petroleum ether/EtOAc (V/V 10/1) to yield compound 1 (4 g, 62%) as a yellow solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
There are obtained analogously: (-)-2-cyclohexylcarbonyl-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline, m.p. 107-108; [alpha]=-149.4 (from (-)-1-cyclohexylcarboxamidomethyl-2-chloroacetyl-TIS); (+)-2-cyclohexylcarbonyl-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline, m.p. 107-108; [alpha]=+148.2 (from (+)-1-cyclohexylcarboxamidomethyl-2-chloroacetyl-TIS); 2-(3-cyclohexenyl-carbonyl)-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline, m.p. 126 (from 1-(3-cyclohexenylcarboxamidomethyl)-2-chloroacetyl-TIS). | ||
EXAMPLE 192 To 1 g. (-)-1-cyclohexylcarboxamidomethyl-2-chloroacetyl-TIS in 50 ml. absolute tetrahydrofuran is added at 20 1.5 ml. of a 20% butyl lithium solution in hexane. The mixture is stirred for 2 hours at 20, boiled for 6 hours, hydrolyzed with water and the solvent evaporated off. The residue is taken up in chloroform and washed with water. After drying over magnesium sulfate and evaporation of the solvent, there is obtained (-)-2-cyclohexylcarbonyl-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline, m.p. 107-108 (from acetone/diethyl ether); [alpha]=-149.4. | ||
1.9 g (61%) | EXAMPLE 3 (+-)-2-cyclohexanecarbonyl-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline (I; R1 =cyclohexanecarbonyl, R2 =R3 =H) 3.76 g (0.01 mol) of N-(2-phenyl)ethyl-alpha-[N-(2,2-dimethoxy)ethyl-N-cyclohexanecarbonyl]glycine amide (II; R1 =cyclohexanecarbonyl, R2 =R3 =H, R5 =methyl) was added to 20 ml of methanesulfonic acid and the resultant mixture was stirred at room temperature for 8 hours. The reaction mixture was concentrated in vacuo, and then the residue was diluted with water and neutralized with ~10% aqueous sodium hydroxide solution. The neutralized solution was extracted with dichloromethane, and the extract was concentrated. The residue was recrystallized with ethyl acetate to give 1.9 g (61%) of the product, m.p. 133~134 C. |
The total yield of praziquantel, starting from iminodiacetonitrile, starting compound of the PREPARATION, is 35%. | ||
In tetrahydrofuran; | EXAMPLE 5 Synthesis of (R)-Praziquantel (Compound 12) The compound 11 (8.72 g, 25 mmol) and tetrahydrofuran (30 mL) were added to a rector and stirred evenly, and sodium hydride (80% of weight content, 0.9 g, 30 mmol) was added in batches into the reaction mixture, after the addition the reaction solution was stirred at room temperature for 3-4 hours, and then the solution was heated to 80 C. and stirred for further 6 hours. When HPLC analysis indicated the completion of the reaction, the resulting solution was poured into saturated salt water (100 ml) to quench the reaction and separate out the product, and the solid crude product was obtained by filtering. The crude product was recrystallized with anhydrous ethanol to get 7.03 g of pure (R)-praziquantel, wherein the yield was 90%, the melt point was 113-115 C. and the ee value was more than 99%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With triethylamine; In hexane; dichloromethane; | Example 6-3 Synthesis of (R)-praziquantel To a reactor the intermediate R-(-)-praziquantel amine (5.05 g, 25 mmol, 1 eq.), triethylamine (3.78 g, 5.22 mL, 37.5 mmol, 1.5 eq.) and dichloromethane (124 mL) were added and cooled in ice bath to 0 C. Cyclohexanecarboxylic acid chloride (4.05 g, 3.69 mL, 27.47 mmol, 1.1 eq.) was added dropwise to the mixture under stirring and the temperature was kept at 0 C. during addition. After the addition, the resulting mixture was stirred at 20-25 C. for 16 hours. When HPLC analysis indicated the completion of the reaction, the reaction was quenched with water (16 mL), and the solution was stirred for further 30 mins. The organic layer was separated and washed with saturated sodium carbonate, 0.5 N HCl and salt water, dried over anhydrous sodium sulfate and concentrated to get the residue. The residue was recrystallized with the mixed solvent of acetone/n-hexane (55 mL, l/l, v/v) to get 7.42 g colorless crystal of (R)-praziquantel, wherein the yield of (R)-praziquantel was 95%, the purity was 99.2% and the melt point was 113-115 C. The NMR data of (R)-praziquantel was as follows: 1H NMR (DMSO-d6, 400 MHz, delta ppm): 1.21-1.96 (m, 10H, 5*CH2), 2.45-2.50 (m, 1H, CH), 2.78-3.05 (m, 4H, CH2), 4.10 (d, 1H, CH2), 4.48 (d, 1H, CH2), 4.79-4.85 (m, 2H, CH2), 5.20 (d, 1H, CH), 7.12-7.30 (m, 4H, Ar-H). MS (ESI, +ve): m/z: 313.1 [M+H]+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
95% | In 12N-hydrochloric acid; | (c) 2-(cyclohexylcarbonyl)-1,3,4,6,7,11b-hexahydro-2H-pyrazino-(2,1-a)-4-isoquinoleinone (PRAZIQUANTEL) 12.25 g (0.037 mol) of 4-(cyclohexylcarbonyl)-2-hydroxy-6-oxo-1-phenethyl piperazine are added in portions to 12N-hydrochloric acid, previously cooled to 0 C., and left overnight at ambient temperature. The reaction mixture is poured into iced water and extracted with dichloromethane. The organic phase, dried over dry sodium sulphate and evaporated to dryness, leaves an oil which crystallises slowly at rest. The praziquantel crystals are thus obtained are recrystallized from a mixture of petroleum ether and acetone. White crystals. M.p.=138-140 C., yield: 95%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
140 mg | With sodium tetrahydroborate; at 60 - 70℃; for 12h;Inert atmosphere; | General procedure: To a solution of compound 1 (305 mg, 1.5 mmol) in methanol (10 mL), cyclohexanecarbaldehyde (186 muL, 1.5 mmol) was added at 0 C, followed by acetic acid (170 L, 3.0 mmol) addition. The mixture was thus maintained at 0 C for 1 h. Then it was heated at 60 C for 2 h. After cooled to 0 C, NaBH4 (0.45 g, 12.0 mmol) was added by portions. The reaction mixture was stirred at 60-70 C for 12 h, followed by evaporation to remove methanol. The residue was diluted with water (30 mL) and extracted with ethyl acetate (30 mL × 3). The organic phases were then processed in the usual way and chromatographed (2:1 petroleum ether/EtOAc) to afforded compound 13 (140 mg, 32%) as a white solid. |
Tags: 55268-74-1 synthesis path| 55268-74-1 SDS| 55268-74-1 COA| 55268-74-1 purity| 55268-74-1 application| 55268-74-1 NMR| 55268-74-1 COA| 55268-74-1 structure
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
Home
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :