[ CAS No. 548-61-8 ] {[proInfo.proName]}

Name: 548-61-8|4,4',4''-Methanetriyltrianiline|97%
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Quality Control of [ 548-61-8 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 548-61-8 ]

Product Details of [ 548-61-8 ]

CAS No. :	548-61-8	MDL No. :	MFCD00137820
Formula :	C₁₉H₁₉N₃	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	ADUMIBSPEHFSLA-UHFFFAOYSA-N
M.W :	289.37	Pubchem ID :	68356
Synonyms :	Leucopararosaniline

Safety of [ 548-61-8 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P501-P261-P273-P272-P280-P302+P352-P362+P364-P333+P313	UN#:	N/A
Hazard Statements:	H317-H412	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 548-61-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 548-61-8 ]

[ 548-61-8 ] Synthesis Path-Downstream 1~50

1
[ 603-49-6 ]
[ 548-61-8 ]

Yield	Reaction Conditions	Operation in experiment
	With acetic acid; zinc

Reference： [1]Shoesmith; Sosson; Hetherington [Journal of the Chemical Society, 1927, p. 2227] Fischer,E.; Fischer,O. [Justus Liebigs Annalen der Chemie, 1878, vol. 194, p. 290;][Chemische Berichte, 1880, vol. 13, p. 2204]

2
[ 603-45-2 ]
[ 548-61-8 ]

Yield	Reaction Conditions	Operation in experiment
	With ethanol; ammonia at 150℃;

Reference： [1]Fischer,E.; Fischer,O. [Chemische Berichte, 1878, vol. 11, p. 473] Dale; Schorlemmer [Chemische Berichte, 1877, vol. 10, p. 1123]

3
[ 467-62-9 ]
[ 548-61-8 ]

Yield	Reaction Conditions	Operation in experiment
79%	With hydrogen In tetrahydrofuran for 12h;
	With hydrogenchloride; zinc
	With ammonium sulfide

With ethanol; sodium hydrogensulfite; zinc in der Siedehitze;

Reference： [1]Touchard, François; Fache, Fabienne; Lemaire, Marc [European Journal of Organic Chemistry, 2000, # 22, p. 3787 - 3792]
[2]Fischer,E.; Fischer,O. [Justus Liebigs Annalen der Chemie, 1878, vol. 194, p. 290;][Chemische Berichte, 1880, vol. 13, p. 2204]
[3]Fischer,O.; Fritzen [Journal fur praktische Chemie (Leipzig 1954), 1909, vol. <2>79, p. 563]
[4]Fischer,O.; Fritzen [Journal fur praktische Chemie (Leipzig 1954), 1909, vol. <2>79, p. 563]

4
[ 548-61-8 ]
[ 467-62-9 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; mercury dichloride at 150℃;
	With pyridine; copper chloride; air at 100℃;

Reference： [1]Fischer,O.; Greiff [Chemische Berichte, 1880, vol. 13, p. 670]
[2]Current Patent Assignee: I.G. FARBENINDUSTRIE AG (historic) - DE492448, 1930, C [Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 16, p. 830][Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 16, p. 830]

5
[ 548-61-8 ]
[ 27575-78-6 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride Diazotization_.Behandeln der Diazoniumsalzloesung mit CuCl, NaCl und konz. Salzsaeure;

Reference： [1]Fischer,O.; Hess [Chemische Berichte, 1905, vol. 38, p. 337] Montagne [Recueil des Travaux Chimiques des Pays-Bas, 1905, vol. 24, p. 121][Recueil des Travaux Chimiques des Pays-Bas, 1906, vol. 25, p. 413]

6
[ 47334-87-2 ]
[ 548-61-8 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; zinc

Reference： [1]Fischer,O.; Greiff [Chemische Berichte, 1880, vol. 13, p. 670] Renouf [Chemische Berichte, 1883, vol. 16, p. 1307] Fischer,O. [Chemische Berichte, 1882, vol. 15, p. 678]

7
[ 548-61-8 ]
[ 118-75-2 ]
[ 467-62-9 ]

Yield	Reaction Conditions	Operation in experiment
	With ethanol

Reference： [1]Fischer,O.; Greiff [Chemische Berichte, 1880, vol. 13, p. 670] Current Patent Assignee: Hoechster Farbw. - DE11412, 1800, C [Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 1, p. 64][Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 1, p. 64]

8
[ 50-00-0 ]
[ 100-65-2 ]
[ 62-53-3 ]
[ 548-61-8 ]

Yield	Reaction Conditions	Operation in experiment
	With aniline hydrochloride at 100℃;

9
[ 27770-00-9 ]
[ 62-53-3 ]
[ 548-61-8 ]

Yield	Reaction Conditions	Operation in experiment
	With aniline hydrochloride at 170℃;

Reference： [1]Vongerichten; Bock [Chemisches Zentralblatt, 1903, vol. 74, # II, p. 442]

10
[ 142-04-1 ]
[ 62-53-3 ]
[ 103-70-8 ]
[ 548-61-8 ]

Yield	Reaction Conditions	Operation in experiment
	With zinc(II) chloride at 170℃;

Reference： [1]Giacalone [Gazzetta Chimica Italiana, 1933, vol. 63, p. 757,759]

11
[ 548-61-8 ]
[ 56-81-5 ]
tri-[6]quinolyl-methane [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With sulfuric acid; 2,4,6-Trinitrophenol at 140 - 150℃;

Reference： [1]Noelting; Schwartz [Chemische Berichte, 1891, vol. 24, p. 1606]

12
[ 623-11-0 ]
[ 548-61-8 ]
[ 128526-93-2 ]

Yield	Reaction Conditions	Operation in experiment
70%	With acetic acid In ethanol at 50℃; for 10h;

Reference： [1]Hellwinkel, Dieter; Fritsch, Helmut [Chemische Berichte, 1990, vol. 123, # 11, p. 2207 - 2226]

13
[ 932-98-9 ]
[ 548-61-8 ]
[ 128526-94-3 ]

Yield	Reaction Conditions	Operation in experiment
71%	With acetic acid In ethanol at 50℃; for 18h;

Reference： [1]Hellwinkel, Dieter; Fritsch, Helmut [Chemische Berichte, 1990, vol. 123, # 11, p. 2207 - 2226]

14
[ 548-61-8 ]
[ 20850-89-9 ]
[ 107960-51-0 ]

Yield	Reaction Conditions	Operation in experiment
31%	In dichloromethane Ambient temperature;

Reference： [1]Gotthardt, Hans; Pflaumbaum, Wolfgang [Chemische Berichte, 1987, vol. 120, p. 1017 - 1022]

15
[ 569-61-9 ]
[ 548-61-8 ]

Yield	Reaction Conditions	Operation in experiment
	With methanol; sodium tetrahydroborate; sodium hydroxide; at 20℃; for 1h;	EX 11 was prepared by reduction of pararosaniline hydrochloride. Specifically, 115.18 g of pararosaniline hydrochloride, 200 mL of methanol, 11.1 mL of SN Sodium hydroxide, and 1 .86 g Sodium Borohydride were stirred at room temperature for about 1 hour. Then the pH was adjusted to 7-9 and the product precipitated out. Filter to collect product.

Reference： [1]Chemische Berichte,1990,vol. 123,p. 2207 - 2226
[2]RSC Advances,2015,vol. 5,p. 78071 - 78080
[3]Bulletin of the Chemical Society of Japan,2009,vol. 82,p. 730 - 736
[4]Synlett,2015,vol. 26,p. 2659 - 2662
[5]Patent: WO2016/178668,2016,A1 .Location in patent: Page/Page column 70

16
[ 548-61-8 ]
[ 874-60-2 ]
[ 128527-46-8 ]

Yield	Reaction Conditions	Operation in experiment
75%	With pyridine at 80℃; for 10h;

Reference： [1]Hellwinkel, Dieter; Fritsch, Helmut [Chemische Berichte, 1990, vol. 123, # 11, p. 2207 - 2226]

17
[ 548-61-8 ]
[ 586-96-9 ]
[ 128526-92-1 ]

Yield	Reaction Conditions	Operation in experiment
35%	With acetic acid In ethanol at 70℃; for 24h;

Reference： [1]Hellwinkel, Dieter; Fritsch, Helmut [Chemische Berichte, 1990, vol. 123, # 11, p. 2207 - 2226]

18
[ 548-61-8 ]
[ 175791-98-7 ]
C₁₁₂H₁₀₃N₁₅O₉ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
45%	With pyridine; triphenyl phosphite at 100℃; for 12h;
43%	With pyridine; triphenyl phosphite at 90℃; for 12h;

Reference： [1]Osterod, Frank; Kraft, Arno [Chemical Communications, 1997, # 15, p. 1435 - 1436]
[2]Kraft, Arno; Osterod, Frank [Journal of the Chemical Society. Perkin transactions I, 1998, # 6, p. 1019 - 1025]

19
[ 201230-82-2 ]
[ 548-61-8 ]
[ 175791-96-5 ]
C₁₁₂H₁₀₃N₁₅O₉ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
31%	With 1,8-diazabicyclo[5.4.0]undec-7-ene In various solvent(s) at 100℃;
	With 1,8-diazabicyclo[5.4.0]undec-7-ene In various solvent(s) at 100℃; for 5h; Yield given;

20
[ 548-61-8 ]
4-(3,4,5-Tris-dodecyloxy-benzoylamino)-benzoic acid [ No CAS ]
C₁₆₉H₂₆₂N₆O₁₅ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
68%	With pyridine; triphenyl phosphite In various solvent(s) at 90℃; for 12h;

Reference： [1]Kraft, Arno; Osterod, Frank [Journal of the Chemical Society. Perkin transactions I, 1998, # 6, p. 1019 - 1025]

21
[ 548-61-8 ]
4-{3,5-Bis-[5-(4-tert-butyl-phenyl)-[1,3,4]oxadiazol-2-yl]-benzoylamino}-benzoic acid [ No CAS ]
C₁₃₃H₁₁₈N₁₈O₁₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
15%	With pyridine; triphenyl phosphite at 90℃; for 12h;

Reference： [1]Kraft, Arno; Osterod, Frank [Journal of the Chemical Society. Perkin transactions I, 1998, # 6, p. 1019 - 1025]

22
[ 142-04-1 ]
[ 548-61-8 ]

Yield	Reaction Conditions	Operation in experiment
	With zinc(II) chloride at 120 - 140℃;

Reference： [1]Current Patent Assignee: Fischer - DE16710, 1800, C [Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 1, p. 57][Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 1, p. 57]

23
[ 62-53-3 ]
[ 548-61-8 ]

Yield	Reaction Conditions	Operation in experiment
	With aniline hydrochloride
	With aniline hydrochloride

Reference： [1]Current Patent Assignee: Kalle & Co. - DE93699, C [Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 4, p. 180][Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 4, p. 180]
[2]Current Patent Assignee: Kalle & Co. - DE87972, 1800, C [Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 4, p. 49][Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 4, p. 49]

24
[ 62-53-3 ]
[ 548-61-8 ]

Yield	Reaction Conditions	Operation in experiment
	With aniline hydrochloride at 100 - 110℃;

25
[ 548-61-8 ]
[ 102368-13-8 ]
[ 322424-44-2 ]

Yield	Reaction Conditions	Operation in experiment
77%	In dichloromethane at 20℃;

Reference： [1]Touchard, François; Fache, Fabienne; Lemaire, Marc [European Journal of Organic Chemistry, 2000, # 22, p. 3787 - 3792]

26
[ 548-61-8 ]
[ 128143-89-5 ]
tris[4-(2,2':6',2''-terpyridin-4'-yl)aminophenyl]methane [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
62%	at 220℃; for 8h;

Reference： [1]Constable, Edwin C.; Housecroft, Catherine E.; Tao, Yaqiu [Synthesis, 2004, # 6, p. 869 - 874]

27
[ 548-61-8 ]
2-[2,6-Di-tert-butyl-5-(2,2-dimethyl-propionyl)-4-oxo-4H-[1,3]dioxin-2-yl]-4,4-dimethyl-pent-1-ene-1,3-dione [ No CAS ]
[ 693778-86-8 ]

Yield	Reaction Conditions	Operation in experiment
90%	In tetrahydrofuran; acetonitrile at 20℃; for 240h;

Reference： [1]Heilmayer, Werner; Smounig, Ralf; Gruber, Karl; Fabian, Walter M.F.; Reidlinger, Claudia; Kappe, C. Oliver; Wentrup, Curt; Kollenz, Gert [Tetrahedron, 2004, vol. 60, # 12, p. 2857 - 2867]

28
[ 548-61-8 ]
[ 128527-08-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 35 percent / glacial AcOH / ethanol / 24 h / 70 °C 2: 30 percent / 50percent HNO₃ / dioxane; H₂O / 20 h / 95 - 100 °C

Reference： [1]Hellwinkel, Dieter; Fritsch, Helmut [Chemische Berichte, 1990, vol. 123, # 11, p. 2207 - 2226]

29
[ 548-61-8 ]
[ 128527-09-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 70 percent / glacial AcOH / ethanol / 10 h / 50 °C 2: 23 percent / conc. HNO₃, NaNO₂ / dioxane; H₂O / 10 h / Heating

Reference： [1]Hellwinkel, Dieter; Fritsch, Helmut [Chemische Berichte, 1990, vol. 123, # 11, p. 2207 - 2226]

30
[ 548-61-8 ]
[ 128527-47-9 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 75 percent / pyridine / 10 h / 80 °C 2: 60 percent / CrO₃, glacial AcOH / H₂O / 5 h / 40 - 80 °C

Reference： [1]Hellwinkel, Dieter; Fritsch, Helmut [Chemische Berichte, 1990, vol. 123, # 11, p. 2207 - 2226]

31
[ 548-61-8 ]
tris-(4-benzylamino-phenyl)-methane [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 110 - 115 °C / auf dem Wasserbade 2: benzene; alcohol; sodium amalgam

Reference： [1]Fischer,O.; Fritzen [Journal fur praktische Chemie (Leipzig 1954), 1909, vol. <2>79, p. 563]

32
[ 555-16-8 ]
[ 548-61-8 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: ZnCl₂ 2: zinc; hydrochloric acid

Reference： [1]Fischer,O. [Chemische Berichte, 1882, vol. 15, p. 678]

33
sodium bicarbonate water [ No CAS ]
[ 548-61-8 ]
(2S)-4-(benzyloxycarbonyl)amino-2-(tert-butoxycarbonyl)aminobutyric acid [ No CAS ]
HATU [ No CAS ]
[ 378802-38-1 ]

Yield	Reaction Conditions	Operation in experiment
	With 4-methyl-morpholine In water; N,N-dimethyl-formamide	R.75 Synthesis of tris[4-(β-benzyloxycarbonylaminomethyl-L-alanyl) aminophenyl]methane hydrochloride Reference Example 75 Synthesis of tris[4-(β-benzyloxycarbonylaminomethyl-L-alanyl) aminophenyl]methane hydrochloride Tris(4-aminophenyl)methane (145 mg), β-benzyloxycarbonylaminomethyl-N-t-butoxycarbonyl-L-alanine (618 mg) and N-methylmorpholine (172 mg) were dissolved in N,N-dimethylformamide (3 ml), after which an N,N-dimethylformamide solution containing O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (0.825 M, 2 ml) was added while cooling on ice, the temperature was raised to room temperature, and the mixture was stirred for 14 hours. The reaction mixture was poured into water (20 mL) and shaken. This was then centrifuged, and the supernatant was removed. After adding saturated sodium bicarbonate water (20 mL) to the residue and stirring, the mixture was centrifuged and the supernatant was removed. The procedure of centrifugation and removal of the supernatant was then carried out once with saturated sodium bicarbonate water (20 mL) and twice with water (20 mL). The residue was dried under reduced pressure to obtain tris[4-(β-benzyloxycarbonylaminomethyl-N-t-butoxycarbonyl-L-alanyl)aminophenyl]methane.

Reference： [1]Current Patent Assignee: ROCHE HOLDING AG; Chugai Pharmaceutical (in: Roche) - US2003/162724, 2003, A1

34
[ 112-16-3 ]
[ 548-61-8 ]
[ 1174046-23-1 ]

Yield	Reaction Conditions	Operation in experiment
89%	With triethylamine In dichloromethane

Reference： [1]Location in patent: experimental part Houjou, Hirohiko; Koga, Tatsuya; Akiizumi, Midori; Yoshikawa, Isao; Araki, Koji [Bulletin of the Chemical Society of Japan, 2009, vol. 82, # 6, p. 730 - 736]

35
[ 764-85-2 ]
[ 548-61-8 ]
[ 1174046-20-8 ]

Yield	Reaction Conditions	Operation in experiment
85%	With triethylamine In dichloromethane

36
[ 17746-05-3 ]
[ 548-61-8 ]
[ 1174046-22-0 ]

Yield	Reaction Conditions	Operation in experiment
80%	With triethylamine In dichloromethane

37
[ 548-61-8 ]
[ 79-03-8 ]
[ 1174046-14-0 ]

Yield	Reaction Conditions	Operation in experiment
93%	With triethylamine In dichloromethane

38
[ 548-61-8 ]
[ 638-29-9 ]
[ 1174046-16-2 ]

Yield	Reaction Conditions	Operation in experiment
90%	With triethylamine In dichloromethane

39
[ 548-61-8 ]
[ 142-61-0 ]
[ 1174046-17-3 ]

Yield	Reaction Conditions	Operation in experiment
95%	With triethylamine In dichloromethane

40
[ 548-61-8 ]
[ 112-13-0 ]
[ 1174046-21-9 ]

Yield	Reaction Conditions	Operation in experiment
92%	With triethylamine In dichloromethane

41
[ 548-61-8 ]
[ 75-36-5 ]
[ 339288-99-2 ]

Yield	Reaction Conditions	Operation in experiment
77%	With triethylamine In dichloromethane

42
[ 548-61-8 ]
[ 141-75-3 ]
[ 1174046-15-1 ]

Yield	Reaction Conditions	Operation in experiment
79%	With triethylamine In dichloromethane

43
[ 548-61-8 ]
[ 2528-61-2 ]
[ 1174046-18-4 ]

Yield	Reaction Conditions	Operation in experiment
80%	With triethylamine In dichloromethane

44
[ 548-61-8 ]
[ 111-64-8 ]
[ 1174046-19-5 ]

Yield	Reaction Conditions	Operation in experiment
78%	With triethylamine In dichloromethane

45
[ 872679-70-4 ]
[ 548-61-8 ]
[ 1239678-32-0 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,p. 3772 - 3776

46
[ 548-61-8 ]
[ 619-66-9 ]
4,4′,4′′-[methanetriyltris(benzene-4,1-diyl)-tris(azanylylidene)]tris(methanylylidene)}tribenzoic Acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
89%	In ethanol at 20℃; for 168h; Inert atmosphere;	4,4',4''-[methanetriyltris(benzene-4,1-diyl)tris(azanylylidene)]tris(methanylylidene)}tribenzoic acid (4a) A solution of 4-formylbenzoic acid (189mg, 1.25 mmol) in absolute ethanol (15 mL) was addedinto a stirred solution of 4,4’,4’’-triaminotriphenylmethane 5 (110 mg, 0.38 mmol) inabsolute ethanol (40 mL), in a pre-dried 100 mL singleneckround-bottomed flask equipped with a magneticstirrer. The resulting mixture was stirred for seven daysat room temperature, under an atmosphere of drynitrogen. The reaction mixture was then filtered under suction on a sintered funnel to give a greyishpink solid which was washed with absolute ethanol (60 mL). Purification of the solid was performedby column chromatography on silica gel (9 : 1 : 0.15, CHCl3 : MeOH : Et3N) to afford product 4a as agrey solid (232 mg, 89%)

Reference： [1]Markoulides, Marios S.; Efthymiou, Constantinos G.; Tasiopoulos, Anastasios J.; Chronakis, Nikos [Synlett, 2015, vol. 26, # 19, p. 2659 - 2662]

47
[ 548-61-8 ]
[ 70916-98-2 ]
4′,4′′′,4′′′′′-[Methanetriyltris(benzene-4,1-diyl)tris(azanylylidene)]tris(methanylylidene)}tris(1,1′-biphenyl)-4′-carboxylic Acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
63%	In ethanol at 20℃; for 240h; Inert atmosphere;	4',4''',4'''''-[Methanetriyltris(benzene-4,1-diyl)tris(azanylylidene)]tris(methanylylidene)}tris(1,1'-biphenyl)-4'-carboxylicacid (4b) A solution of 4-(4-formylphenyl)benzoic acid 8 (203 mg, 0.89mmol) in absolute ethanol (15 mL) wasadded into a stirred solution of 4,4’,4’’-triaminotriphenylmethane 5 (78.6 mg, 0.27mmol) in absolute ethanol (35 mL), in a dry100 mL single-neck round-bottomed flask.The resulting mixture was stirred for tendays at room temperature, under an atmosphere of dry nitrogen. The reaction mixture was then filteredunder suction on a sintered funnel to give an off-white solid which was washed successively withEtOH, CHCl3, acetonitrile, THF and finally with ether. Residual solvent traces were removed underhigh vacuum to afford product 4b as an off-white solid (157 mg, 63%).

Reference： [1]Markoulides, Marios S.; Efthymiou, Constantinos G.; Tasiopoulos, Anastasios J.; Chronakis, Nikos [Synlett, 2015, vol. 26, # 19, p. 2659 - 2662]

48
[ 62940-38-9 ]
[ 548-61-8 ]
C₇₉H₅₅N₃O₃ [ No CAS ]

Reference： [1]Chemical Communications,2017,vol. 53,p. 428 - 431

49
[ 66-98-8 ]
[ 548-61-8 ]
C₆₁H₄₃N₃O₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With copper(ll) sulfate pentahydrate In tetrahydrofuran for 3h; Autoclave;

Reference： [1]Yue, Jie-Yu; Markoulides, Marios; Regan, Andrew C.; Li, Shu-Ying; Chronakis, Nikos; Gourdon, André; Chen, Ting; Yan, Hui-Juan; Wang, Dong [Chemical Communications, 2017, vol. 53, # 2, p. 428 - 431]

50
[ 548-61-8 ]
[ 98648-23-8 ]
C₅₈H₄₀N₆O₆ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With copper(ll) sulfate pentahydrate In tetrahydrofuran at 120℃; for 3h; Autoclave;

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Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 548-61-8 ] {[proInfo.proName]}

Quality Control of [ 548-61-8 ]

Related Doc. of [ 548-61-8 ]

Product Details of [ 548-61-8 ]

Safety of [ 548-61-8 ]

Application In Synthesis of [ 548-61-8 ]

[ 548-61-8 ] Synthesis Path-Downstream 1~50

Related Functional Groups of [ 548-61-8 ]

Aryls

Amines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

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[ 548-61-8 ]