Alternatived Products of [ 518-44-5 ]
Product Details of [ 518-44-5 ]
CAS No. : | 518-44-5 |
MDL No. : | MFCD00046931 |
Formula : |
C20H14O5
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
334.32
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Pubchem ID : | - |
Synonyms : |
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Application In Synthesis of [ 518-44-5 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 518-44-5 ]
- 1
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[ 2321-07-5 ]
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[ 518-44-5 ]
Yield | Reaction Conditions | Operation in experiment |
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With ammonium hydroxide; zinc |
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With acetic acid; zinc |
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With sodium hydroxide; zinc |
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With sodium tetrahydroborate at 20℃; for 2h; borate buffer; |
3
To 2 ml of a 1 mM solution of fluorescein (Sigma, prod. No. F-6377) in 0.1 M borate buffer, pH 8.5 was added approximately 5 mg of sodium borohydride. The mixture was shaken and left at room temperature for two hours. 40 microliters of the reduced solution was added to 960 //I of phosphate-buffered saline, pH 7.4. Figure 3A shows the spectrum of the reduced fluoroescein flourochrome, i.e. dihydrofluorescein (dotted line) which was recorded on a Hewlett-Packard diode array spectrophotometer. The spectrum of untreated fluorescein (solid line) was recorded by exactly the same procedure. The sample of diluted, reduced fluorochrome was gently oxidized in air and its spectrum recorded (dashed line). Figure 3B shows the formulas for fluorescein (fluorescent) and dihydrofluorescein (non-fluorescent). |
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Multi-step reaction with 3 steps
1: pyridine
2: acetic acid; zinc / Microwave irradiation
3: methanol; sodium hydroxide |
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Reference:
[1]v. Liebig
[Journal fur praktische Chemie (Leipzig 1954), 1912, vol. <2> 85, p. 255][Chemische Berichte, 1914, vol. 47, p. 2597]
[2]v. Liebig
[Journal fur praktische Chemie (Leipzig 1954), 1913, vol. <2> 88, p. 43]
[3]Baeyer
[Justus Liebigs Annalen der Chemie, 1876, vol. 183, p. 31][Justus Liebigs Annalen der Chemie, 1910, vol. 372, p. 109]
[4]Current Patent Assignee: GENERAL ELECTRIC CO - WO2006/65146, 2006, A2
Location in patent: Page/Page column 19-20
[5]Le, Hoa Thi; Nguyen, Dinh Phi Long; Shin, Hyo Seob; Jung, Woong; Kang, Chulhun; Kim, Tae Woo
[Free Radical Research, 2021, vol. 55, # 4, p. 461 - 468]
- 2
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[ 518-44-5 ]
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[ 108-24-7 ]
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[ 35340-49-9 ]
Yield | Reaction Conditions | Operation in experiment |
94% |
In pyridine Ambient temperature; |
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With pyridine Ambient temperature; Yield given; |
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Reference:
[1]Sharma, Padam N.; Brossi, Arnold
[Helvetica Chimica Acta, 1984, vol. <1> 67, # 35, p. 301 - 304]
[2]Tadic, Dragana; Brossi, Arnold
[Heterocycles, 1990, vol. 31, # 11, p. 1975 - 1982]
- 3
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[ 35340-49-9 ]
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[ 518-44-5 ]
Yield | Reaction Conditions | Operation in experiment |
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Alkaline hydrolysis; |
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With methanol; sodium hydroxide |
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Reference:
[1]Saengkhae, Chantarawan; Loetchutinat, Chatchanok; Garnier-Suillerot, Arlette
[Biochemical Pharmacology, 2003, vol. 65, # 6, p. 969 - 977]
[2]Le, Hoa Thi; Nguyen, Dinh Phi Long; Shin, Hyo Seob; Jung, Woong; Kang, Chulhun; Kim, Tae Woo
[Free Radical Research, 2021, vol. 55, # 4, p. 461 - 468]
- 4
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[ 518-44-5 ]
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[ 2513-33-9 ]
Yield | Reaction Conditions | Operation in experiment |
80% |
With potassium hydroxide In water for 5h; Reflux; |
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Reference:
[1]Ou, Pan; Zhang, Ruilong; Liu, Zhengjie; Tian, Xiaohe; Han, Guangmei; Liu, Bianhua; Hu, Zhangjun; Zhang, Zhongping
[Angewandte Chemie - International Edition, 2019, vol. 58, # 8, p. 2261 - 2265][Angew. Chem., 2019, vol. 131, # 8, p. 2283 - 2287,5]