[ CAS No. 5086-74-8 ] {[proInfo.proName]}

Name: 5086-74-8|6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride|98%
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SKU: A167438
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Quality Control of [ 5086-74-8 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 5086-74-8 ]

Product Details of [ 5086-74-8 ]

CAS No. :	5086-74-8	MDL No. :	MFCD00005536
Formula :	C₁₁H₁₃ClN₂S	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	LAZPBGZRMVRFKY-UHFFFAOYSA-N
M.W :	240.75	Pubchem ID :	68628
Synonyms :	DL-Tetramisole Hydrochloride;(±)-Tetramisole hydrochloride;R-829;Tetramisole hydrochloride

Calculated chemistry of [ 5086-74-8 ]

Physicochemical Properties

Num. heavy atoms :	15
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.36
Num. rotatable bonds :	1
Num. H-bond acceptors :	1.0
Num. H-bond donors :	0.0
Molar Refractivity :	74.79
TPSA :	40.9 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	Yes
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.89 cm/s

Lipophilicity

Log Po/w (iLOGP) :	0.0
Log Po/w (XLOGP3) :	2.64
Log Po/w (WLOGP) :	1.86
Log Po/w (MLOGP) :	2.47
Log Po/w (SILICOS-IT) :	2.75
Consensus Log Po/w :	1.94

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-3.23
Solubility :	0.143 mg/ml ; 0.000594 mol/l
Class :	Soluble
Log S (Ali) :	-3.15
Solubility :	0.171 mg/ml ; 0.000709 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-3.03
Solubility :	0.223 mg/ml ; 0.000927 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	3.53

Safety of [ 5086-74-8 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 5086-74-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 5086-74-8 ]
Downstream synthetic route of [ 5086-74-8 ]

[ 5086-74-8 ] Synthesis Path-Upstream 1~8

1
[ 65329-72-8 ]
[ 5086-74-8 ]

Reference： [1] Patent: US4087611, 1978, A,
[2] Patent: US4090025, 1978, A,

2
[ 65329-70-6 ]
[ 5086-74-8 ]

Reference： [1] Patent: US4087611, 1978, A,
[2] Patent: US4090025, 1978, A,

3
[ 7440-44-0 ]
[ 65329-73-9 ]
[ 5086-74-8 ]

Reference： [1] Patent: US4087611, 1978, A,
[2] Patent: US4090025, 1978, A,

4
[ 65329-69-3 ]
[ 5086-74-8 ]

Reference： [1] Patent: US4090025, 1978, A,
[2] Patent: US4090025, 1978, A,

5
[ 65329-69-3 ]
[ 5086-74-8 ]

Reference： [1] Patent: US4087611, 1978, A,

6
[ 69510-65-2 ]
[ 5086-74-8 ]

Reference： [1] Patent: US4179460, 1979, A,

7
[ 70-11-1 ]
[ 5086-74-8 ]

Reference： [1] Patent: US4090025, 1978, A,
[2] Patent: US4090025, 1978, A,

8
[ 65346-98-7 ]
[ 5086-74-8 ]

Reference： [1] Patent: US4090025, 1978, A,
[2] Patent: US4090025, 1978, A,

[ 5086-74-8 ] Synthesis Path-Downstream 1~15

1
[ 5086-74-8 ]
[ 20406-02-4 ]

Reference： [1]Australian Journal of Chemistry,1968,vol. 21,p. 1557 - 1570

Yield	Reaction Conditions	Operation in experiment
77%		EXAMPLE 4 40 g of basic l-tetramisole are dissolved in a flask in 200 ml of dimethylsulphoxide, and a separately prepared solution of 5 g of potassium hydroxide in 10 ml of methanol is added under energetic agitation. The temperature is raised to 60, and the mixture is kept under agitation for 2 hours. It is cooled to below 10 C., 200 ml of water and 200 ml of chloroform are added, and the mixture well shaken. Two phases separate on leaving the mixture to stand. The chloroform phase is washed with 200 ml of water, and after separation the organic phase is precipitated with hydrogen chloride gas. The raceme tetramisole hydrochloride obtained in this manner weighs 36.2 g, the yield is 77% and the purity exceeds 98%.
		A method according to claim 1, wherein the tablets comprise at least one agrochemically active compound selected from ... 1-(2-chloro-5-pyridylmethyl)-3,5-dimethyl-2-nitroimino-hexahydro-1,3,5-triazine, 1-(2-chloro-5-thiazolylmethyl)-3,5-dimethyl-2-nitroimino-hexahydro-1,3,5-triazine, 0,0-dimethyl O-3-methyl-4-(methylsulfinyl)-phenyl phosphorothioate, trans-1,4,5,6-tetrahydro-1-methyl-2-[2-(3-methyl-2-thienyl)-vinyl]-pyrimidine tartrate, (-)-(S)-2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b] thiazole hydrochloride, 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-2-butanone, all-rac-1-(biphenyl-4-yloxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)-butan-2-ol, 2-p-chlorophenyl-2-(1H-1,2,4-triazol-1-yl-methyl)-hexane nitrile, ...
		EXAMPLE 79 6-Phenyl-2,3,5,6-tetrahydroimidazo(2,1-b)thiazole hydrochloride STR92 The product from Example 78 was converted to the desired 6-phenyl-2,3,5,6-tetrahydroimidazo(2,1-b)thiazole hydrochloride and recrystallized as described in Example 75A. 168 g of substantially pure product, m.p. 255-6 C, was obtained. Examples 2, 38, 78 and 79 in sequence demonstrate a preferred sequence of processes to synthesise 6-phenyl-2,3,5,6-tetrahydroimidazo(2,1-b)thiazole hydrochloride.

		C. This material (18.6 g) was then reacted with thionyl chloride by the method of Example E. The intermediate chloro-compound was not purified but cyclised according to the method of Example 75A to yield purified 6-phenyl-2,3,5,6-tetrahydroimidazo(2,1-b)thiazole hydrochloride, 13.9 g (79% of theory based on 2-imino-3-(2'-hydroxy-2'-phenylethyl)thiazolidine hydrochloride, 29% based on styrene oxide).
		There was thus obtained tetramisole hydrochloride of m.p. 255-8 C.
		The organic extract was combined with the said organic phase, and tetramisole hydrochloride was isolated in the same manner as described in Example 1. It had m.p. 259-60 C.
		EXAMPLE 3 Concentrated hydrochloric acid (24.5 ml. of 12 N) and water (74 ml.) were added to IHPT p-toluenesulphonate (80 g.; containing ca. 5.6 g. of impurities) in a reaction vessel. This mixture was stirred and sulphuryl chloride (38 ml.) was added slowly from a pressure equalising dropping funnel, the temperature being maintained below 50 C. with cooling. The dropping funnel and reaction vessel together formed a sealed system. The reaction mixture was stirred and heated at 50-55 C. for 8 hours. The reaction mixture, which contained ICPT in salt form, was poured into a mixture of ice (350 g.), sodium hydroxide solution (120 ml. of 17.6 N), toluene (80 ml.) and n-butanol (30 ml.). The temperature of this reaction mixture was maintained at 50-55 C. by heating and at pH 9.2-9.4 by dropwise addition of sodium hydroxide solution (17.6 N). When the pH had remained steady for 2 minutes without further addition of sodium hydroxide solution, the mixture was separated, both the aqueous and organic phases being kept. The aqueous phase was extracted with a mixture of toluene (73 ml.) and n-butanol (27 ml.), and the organic extract was combined with the said organic phase. The procedure used in Example 2 was then followed to give tetramisole hydrochloride of m.p. 258-60 C.
		EXAMPLE 80 6-Phenyl-2,3,5,6-tetrahydroimidazo(2,1-b)thiazole hydrochloride STR93 2-Imino-3-(2'-hydroxy-2'-phenylethyl)thiazolidine hydrochloride (258.5 g) was suspended in 1000 ml of 1,2-dichloroethane (EDC). The mixture was heated to 40 C and with stirring thionyl chloride (132 g) was added over 10 minutes. Stirring was continued at 40 C until no more gas was evolved. Cold water (500 ml) was then added slowly, with stirring followed by a slow addition of solid sodium bicarbonate (520 g). The mixture was then heated to 60 C, with stirring, and held at this temperature until no more gas was evolved (11/2 hours). The reaction mixture was cooled to room temperature and the EDC layer separated and dried over soda ash. The soda ash was washed with two lots of 250 mls EDC. The aqueous layer was extracted with two lots of 250 ml EDC and the soda ash was further washed, successively, with these extracts. Dry HCl (40 g) was next passed into the EDC solution. The solution was heated to boiling and 50 ml of EDC distilled off. On cooling the required compound crystallized in high purity. Yield 226 g (94% of theory), m.p. 253-4 C.
		EXAMPLE 1 40 g of basic d-tetramisole are dissolved in 400 ml of dimethylsulphoxide at ambient temperature. 5 g of potassium hydroxide are dissolved separately in 10 ml of hot methanol. This second solution is added to the first, and the mixture is kept for four hours at 40 under agitation. It is then cooled to 10 C., and 400 ml of water and 400 ml of chloroform are added, and the mixture shaken for a few minutes. The chloroform phase is extracted again with a further 400 ml of water, and the tetramisole hydrochloride is precipitated from the chloroform solution by bubbling hydrogen chloride gas through it. The yield of raceme tetramisole hydrochloride is 38.6 g (82%), and the purity exceeds 98%.

3
phosphorous pentasulfide [ No CAS ]
[ 7440-44-0 ]
[ 65329-73-9 ]
[ 5086-74-8 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; sodium hydroxide; In ethanol; chloroform; toluene;	EXAMPLE 11 Preparation of tetramisole hydrochloride from 1-(2-acetoxyethyl)-4-phenyl-2-imidazolidone Approximately 5 g. of 1-(2-acetoxyethyl)-4-phenyl-2-imidazolidone and 1.8 g. of phosphorous pentasulfide is refluxed in 20 ml. of toluene for twenty hours. The solvent is distilled off under reduced pressure and the residue is dissolved in a solution of chloroform (100 ml.) and 20 percent sodium hydroxide (100 ml.). The organic layer is then separated, washed, dried over sodium sulfate treated with charcoal, filtered and concentrated to an oil. The oil is refluxed in a solution of concentrated hydrochloric acid (20 ml.) and ethanol (10 ml.) for 1 hour. The solution is concentrated to dryness and the residue triturated with ethanol (20 ml.) and then filtered to yield the title compound with a tan coloration; m.p. 258-260 C.
	With hydrogenchloride; sodium hydroxide; In ethanol; chloroform; toluene;	EXAMPLE 11 Preparation of tetramisole hydrochloride from 1-(2-acetoxyethyl)-4-phenyl-2-imidazolidone Approximately 5 g. of 1-(2-acetoxyethyl)-4-phenyl-2-imidazolidone and 1.8 g. of phosphorous pentasulfide is refluxed in 20 ml. of toluene for twenty hours. The solvent is distilled off under reduced pressure and the residue is dissolved in a solution of chloroform (100 ml.) and 20 percent sodium hydroxide (100 ml.). The organic layer is then separated, washed, dried over sodium sulfate treated with charcoal, filtered and concentrated to an oil. The oil is refluxed in a solution of concentrated hydrochloric acid (20 ml.) and ethanol (10 ml.) for one hour. The solution is concentrated to dryness and the residue triturated with ethanol (20 ml.) and then filtered to yield the title compound with a tan coloration; m.p. 258-260 C.

Reference： [1]Patent: US4087611,1978,A
[2]Patent: US4090025,1978,A

4
phosphorous pentasulfide [ No CAS ]
[ 65329-69-3 ]
[ 5086-74-8 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; sodium hydroxide; In ethanol; chloroform; toluene;	EXAMPLE 6 Preparation of tetramisole hydrochloride from 1-(2-methoxyethyl)-4-phenyl-2-imidazolidone Approximately 4.4 g. of 1-(2-methoxyethyl)-4-phenyl-2-imidazolidone and 2 g. of phosphorous pentasulfide are refluxed together in 200 ml. of toluene for 20 hours. The toluene is distilled off under reduced pressure and the residue is taken in 100 ml. of chloroform and washed with 50 ml. of 20 percent sodium hydroxide solution. The organic layer is washed with water, dried and the solvent removed to give a yellow oil. The oil is refluxed for one hour in a solution of 10 ml. of concentrated hydrochloric acid and 10 ml. of ethanol. The solution is concentrated to dryness, the residual semisolid triturated with ethanol (20 ml.), filtered and dried to yield the title compound; m.p. 260-262 C.

Reference： [1]Patent: US4087611,1978,A

5
phosphorous pentasulfide [ No CAS ]
[ 65329-72-8 ]
[ 5086-74-8 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; sodium hydroxide; In ethanol; chloroform; toluene;	EXAMPLE 9 Preparation of tetramisole hydrochloride from 1-(2-hydroxyethyl)-4-phenyl-2-imidazolidone A mixture of 1-(2-hydroxyethyl)-4-phenyl-2-imidazolidone (4.1 g.) and phosphorous pentasulfide (1.8 g) in toluene (25 ml.) is refluxed for twenty hours. The toluene is distilled off under reduced pressure and the residue is dissolved in a solution of chloroform (50 ml.) and 20 percent sodium hydroxide (50 ml). The organic layer is separated, washed, dried over sodium sulfate and concentrated to an oil. The oil is refluxed in a solution of ethanol (10 ml.) and concentrated hydrochloric acid (20 ml.) for one hour. The solution is concentrated to dryness, triturated with ethanol (20 ml.), and filtered to yield the title compound as a white solid; m.p. 260 C.
	With hydrogenchloride; sodium hydroxide; In ethanol; chloroform; toluene;	EXAMPLE 9 Preparation of tetramisole hydrochloride from 1-(2-hydroxyethyl)-4-phenyl-2-imidazolidone A mixture of 1-(2-hydroxyethyl)-4-phenyl-2-imidazolidone (4.1 g.) and phosphorous pentasulfide (1.8 g.) in toluene (25 ml.) is refluxed for twenty hours. The toluene is distilled off under reduced pressure and the residue is dissolved in a solution of chloroform (50 ml.) and 20 percent sodium hydroxide (50 ml). The organic layer is separated, washed, dried over sodium sulfate and concentrated to an oil. The oil is refluxed and a solution of ethanol (10 ml.) and concentrated hydrochloric acid (20 ml.) for one hour. The solution is concentrated to dryness, triturated with ethanol (20 ml.), and filtered to yield the title compound as a white solid; m.p. 260 C.

Reference： [1]Patent: US4087611,1978,A
[2]Patent: US4090025,1978,A

6
[ 65329-70-6 ]
[ 5086-74-8 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; In ethanol; acetone;	EXAMPLE 5 Preparation of tetramisole hydrochloride from 1-(2-methoxyethyl)-4-phenylimidazolidine-2-thione Approximately 236 mg. of 1-(2-methoxyethyl)-4-phenylimidazolidine-2-thione, 5 ml. of concentrated hydrochloric acid, and 5 ml. of acetone are refluxed together for one hour. The solution is then concentrated to dryness under reduced pressure and triturated with 2 ml. of ethanol. The white solid precipitate is filtered off to yield the title compound.
	With hydrogenchloride; In ethanol; acetone;	EXAMPLE 5 Preparation of tetramisole hydrochloride from 1-(2-methoxyethyl)-4-phenylimidazolidine-2-thione Approximately 236 mg. of 1-(2-methoxyethyl)-4-phenylimidazolidine-2-thione, 5 ml. of concentrated hydrochloric acid, and 5 ml. of acetone are refluxed together for one hour. The solution is then concentrated to dryness under reduced pressure and triturated with 2 ml. of ethanol. The white solid precipitate is filtered off to yield the title compound.

Reference： [1]Patent: US4087611,1978,A
[2]Patent: US4090025,1978,A

7
[ 65329-69-3 ]
[ 5086-74-8 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; diphosphorus pentasulfide; sodium hydroxide; In ethanol; chloroform; toluene;	EXAMPLE 6 Preparation of tetramisole hydrochloride from 1-(2-methoxyethyl)-4-phenyl-2-imidazolidone Approximately 4.4 g. of 1-(2-methoxyethyl)-4-phenyl-2-imidazolidone and 2 g. of phosphorus pentasulfide are refluxed together in 200 ml. of toluene for 20 hours. The toluene is distilled off under reduced pressure and the residue is taken in 100 ml. of chloroform and washed with 50 ml. of 20 percent sodium hydroxide solution. The organic layer is washed with water, dried and the solvent removed to give a yellow oil. The oil is refluxed for one hour in a solution of 10 ml. of concentrated hydrochloric acid and 10 ml. of ethanol. The solution is concentrated to dryness, the residual semisolid triturated with ethanol (20 ml.), filtered and dried to yield the title compound; m.p. 260-262 C.

Reference： [1]Patent: US4090025,1978,A
[2]Patent: US4090025,1978,A

8
[ 69510-65-2 ]
[ 5086-74-8 ]

Yield	Reaction Conditions	Operation in experiment
	In hydrogenchloride; isopropyl alcohol;	EXAMPLE 5. R,S-2,3,5,6-tetrahydro-6-phenyl-imidazo(2,1-b)-thiazole hydrochloride. (Cyclodehydration with hydrochloric acid). 11.2 g (0.05 moles) of R,S-1-(2-hydroxyethyl)-4-phenyl-imidazolidine-2-thione were dissolved on stirring in 100 ml of hydrochloric acid, the reaction mixture obtained was heated under reflux for three hours, and the solvent distilled under reduced pressure off. The crude material was suspended in 40 ml of isopropanol and filtered. The yield of R,S-2,3,5,6-tetrahydro-6-phenyl-imidazo(2, 1-b)-thiazole hydrochloride was 11.6 g; m.p. 256-258 C. Yield--quantitative.

Reference： [1]Patent: US4179460,1979,A

Yield	Reaction Conditions	Operation in experiment
		EXAMPLE 2 40 g of basic d-tetramisole are dissolved in 200 ml of dimethylsulphoxide at ambient temperature, and to this is added a solution of 5g of potassium hydroxide in 10 ml of methanol. The reaction temperature is 40 C., and the mixture is kept under agitation for 26 hours. After cooling to below 10 C., 200 ml of water and 200 ml of chloroform are added, and the mixture is shaken for a few minutes. After sedimentation and separation, the chloroform phase is again washed with 200 ml of water and separated. The tetramisole is separated by bubbling hydrogen chloride gas through, and the yield of raceme tetramisole hydrochloride is 38 g (81%), with a purity exceeding 98%.

10
[ 15243-33-1 ]
[ 5086-74-8 ]
[Ru3(μ-Cl)(μ-.eta(2)-levamisole-C,S)(CO)9] [ No CAS ]

Reference： [1]European Journal of Inorganic Chemistry,2002,p. 2561 - 2564

11
[ 70-11-1 ]
[ 5086-74-8 ]

Reference： [1]Patent: US4090025,1978,A
[2]Patent: US4090025,1978,A

12
[ 65346-98-7 ]
[ 5086-74-8 ]

Reference： [1]Patent: US4090025,1978,A
[2]Patent: US4090025,1978,A

13
[ 5086-74-8 ]
(+)-tetramisole*CSA [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2019,vol. 141,p. 9191 - 9196

14
[ 5086-74-8 ]
[ 14769-74-5 ]

Reference： [1]Journal of the American Chemical Society,2019,vol. 141,p. 9191 - 9196

15
[ 5086-74-8 ]
[ 5036-02-2 ]

Reference： [1]Journal of the American Chemical Society,2019,vol. 141,p. 9191 - 9196

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P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 5086-74-8 ] {[proInfo.proName]}

Quality Control of [ 5086-74-8 ]

Related Doc. of [ 5086-74-8 ]

Product Details of [ 5086-74-8 ]

Calculated chemistry of [ 5086-74-8 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 5086-74-8 ]

Application In Synthesis of [ 5086-74-8 ]

[ 5086-74-8 ] Synthesis Path-Upstream 1~8

[ 5086-74-8 ] Synthesis Path-Downstream 1~15

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry