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CAS No. : | 4546-54-7 | MDL No. : | MFCD00037992 |
Formula : | C10H13N5O4 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 267.24 | Pubchem ID : | - |
Synonyms : |
9-Pentofuranosyl-9H-purin-2-amine
|
Signal Word: | Warning | Class: | |
Precautionary Statements: | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | UN#: | |
Hazard Statements: | H315-H319 | Packing Group: | |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With palladium hydroxide, 20 wt% on carbon; ammonium formate; In 1,4-dioxane; methanol; for 1h;Reflux; | <strong>[2004-07-1]2-Amino-6-chloropurine riboside</strong> (877 mg, 2.91 mmol) was dissolved in15 cm3 methanol:dioxane (1:1) and 612 mg palladium hydroxideon carbon (20 wt% loading, 0.872 mmol) and 1835 mgammonium formate (29.1 mmol) were added. The mixturewas refluxed for 1 h, cooled to room temperature, and filteredthrough a Celite pad. The solvents were evaporated and theproduct was dried under high vacuum. No further purificationwas performed and a white solid was obtained in quantitativeyield. HR-ESI-MS: m/z calculated for [C10H14N5O4]+([M+H]+): 268.1040, found 268.1025; 1H NMR (400 MHz,DMSO-d6): delta = 3.51-3.56 (m, 1H, HbC(5?)), 3.60-3.66 (m,1H, HaC(5?)), 3.89-3.92 (m, 1H, HC(4?)), 4.11-4.14 (m, 1H,HC(3?)), 4.48-4.53 (m, 1H, HC(2?)), 5.06 (t, 1H, HO(5?)), 5.16(d, 1H, HO(3?)), 5.44 (d, 1H, HO(2?)), 5.83 (d, 1H, HC(1?)),6.55 (2H, H2N(2)), 8.30 (1H, HC(8)), 8.59 (1H, HC(6)) ppm;13C NMR (100 MHz, DMSO-d6): delta = 61.83 (C(5?)), 70.87(C(3?)), 73.90 (C(2?)), 85.78 (C(4?)), 86.66 (C(1?)), 141.27(C(8)), 149.74 (C(8)) ppm. |