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[ CAS No. 4146-30-9 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
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Inaccessible (Haz class 6.1), International USD 150+
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Chemical Structure| 4146-30-9
Chemical Structure| 4146-30-9
Structure of 4146-30-9 * Storage: {[proInfo.prStorage]}
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Product Details of [ 4146-30-9 ]

CAS No. :4146-30-9 MDL No. :MFCD00144873
Formula : C23H52N6O25S3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 908.88 Pubchem ID :-
Synonyms :
Neomycin B sulfate;Fradiomycin B sulfate;Framycetin sulphate

Safety of [ 4146-30-9 ]

Signal Word:Danger Class:6.1
Precautionary Statements:P261-P280-P284-P304+P340-P333+P313-P342+P311 UN#:2811
Hazard Statements:H317-H334 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 4146-30-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 4146-30-9 ]

[ 4146-30-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 14464-29-0 ]
  • [ 4146-30-9 ]
  • [ 1393446-89-3 ]
YieldReaction ConditionsOperation in experiment
With 5'-GGA CUG GGC GAG AAG UUU AGU CC-3'; In aq. phosphate buffer; at 20℃; for 24h; 10114] A volume of 900 tL of a 5.54 mM RNA aptamer solution (4.98 tmol) in 10mM sodium phosphate buffer (pH 6.8) was heated to 85° C. for 10 mm and was afterwards kept at room temperature for 15 mm. 684 tL of a 4.8 mM solution of neomycin B sulphate (3.28 tmol) in 10mM sodium phosphate buffer (pH 7.4) was added and the mixture was allowed to stand for 30 mm at room temperature. Then, 15 equiv. activated ester, acetyl sulfo-NHS ester 4 or STP-ester 5 (49.2 tmol) 500 jiL 10mM sodium phosphate buffer (pH 7.4), or 5 equiv. 2-iminothiolane hydrochloride (16.4 tmol) dissolved in 42 IL 10 mM sodium phosphate buffer (pH 7.4) were added and the reaction mixture was allowed to react for 24 hours at room temperature. Afier addition of 180 tL of a 7 wt.percent ethylamine water solution and thrther incubation for 30mm at room temperature, 486 tl of a 2 M sodium hydroxidesolution were added and the crude mixture was heated to 90°C. for 30 mm. After cooling to room temperature each 50 tLfraction was purified by HPLC using a Waters Spherisorb ODS-2C18 analytic colunm (water/acetone 1:0.81 containing 16.9mM HFBA) at a flow rate of 1 ml/min at 40° C. to afford the antibiotic derivatives 10 and 14. Afier evaporation of acetone and freeze-drying of collected fractions the product was taken up in 150 IL of D20 for NMR-studies.
  • 2
  • [ 4781-83-3 ]
  • [ 4146-30-9 ]
  • C27H52N6O14S [ No CAS ]
YieldReaction ConditionsOperation in experiment
With 5'-GGA CUG GGC GAG AAG UUU AGU CC-3'; In aq. phosphate buffer; at 20℃; for 24h; General procedure: 10114] A volume of 900 tL of a 5.54 mM RNA aptamer solution (4.98 tmol) in 10mM sodium phosphate buffer (pH 6.8) was heated to 85 C. for 10 mm and was afterwards kept at room temperature for 15 mm. 684 tL of a 4.8 mM solution of neomycin B sulphate (3.28 tmol) in 10mM sodium phosphate buffer (pH 7.4) was added and the mixture was allowed to stand for 30 mm at room temperature. Then, 15 equiv. activated ester, acetyl sulfo-NHS ester 4 or STP-ester 5 (49.2 tmol) 500 jiL 10mM sodium phosphate buffer (pH 7.4), or 5 equiv. <strong>[4781-83-3]2-<strong>[4781-83-3]iminothiolane hydrochloride</strong></strong> (16.4 tmol) dissolved in 42 IL 10 mM sodium phosphate buffer (pH 7.4) were added and the reaction mixture was allowed to react for 24 hours at room temperature. Afier addition of 180 tL of a 7 wt.% ethylamine water solution and thrther incubation for 30mm at room temperature, 486 tl of a 2 M sodium hydroxidesolution were added and the crude mixture was heated to 90C. for 30 mm. After cooling to room temperature each 50 tLfraction was purified by HPLC using a Waters Spherisorb ODS-2C18 analytic colunm (water/acetone 1:0.81 containing 16.9mM HFBA) at a flow rate of 1 ml/min at 40 C. to afford the antibiotic derivatives 10 and 14. Afier evaporation of acetone and freeze-drying of collected fractions the product was taken up in 150 IL of D20 for NMR-studies.
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