There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
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CAS No. : | 4146-30-9 | MDL No. : | MFCD00144873 |
Formula : | C23H52N6O25S3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 908.88 | Pubchem ID : | - |
Synonyms : |
Neomycin B sulfate;Fradiomycin B sulfate;Framycetin sulphate
|
Signal Word: | Danger | Class: | 6.1 |
Precautionary Statements: | P261-P280-P284-P304+P340-P333+P313-P342+P311 | UN#: | 2811 |
Hazard Statements: | H317-H334 | Packing Group: | Ⅲ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With 5'-GGA CUG GGC GAG AAG UUU AGU CC-3'; In aq. phosphate buffer; at 20℃; for 24h; | 10114] A volume of 900 tL of a 5.54 mM RNA aptamer solution (4.98 tmol) in 10mM sodium phosphate buffer (pH 6.8) was heated to 85° C. for 10 mm and was afterwards kept at room temperature for 15 mm. 684 tL of a 4.8 mM solution of neomycin B sulphate (3.28 tmol) in 10mM sodium phosphate buffer (pH 7.4) was added and the mixture was allowed to stand for 30 mm at room temperature. Then, 15 equiv. activated ester, acetyl sulfo-NHS ester 4 or STP-ester 5 (49.2 tmol) 500 jiL 10mM sodium phosphate buffer (pH 7.4), or 5 equiv. 2-iminothiolane hydrochloride (16.4 tmol) dissolved in 42 IL 10 mM sodium phosphate buffer (pH 7.4) were added and the reaction mixture was allowed to react for 24 hours at room temperature. Afier addition of 180 tL of a 7 wt.percent ethylamine water solution and thrther incubation for 30mm at room temperature, 486 tl of a 2 M sodium hydroxidesolution were added and the crude mixture was heated to 90°C. for 30 mm. After cooling to room temperature each 50 tLfraction was purified by HPLC using a Waters Spherisorb ODS-2C18 analytic colunm (water/acetone 1:0.81 containing 16.9mM HFBA) at a flow rate of 1 ml/min at 40° C. to afford the antibiotic derivatives 10 and 14. Afier evaporation of acetone and freeze-drying of collected fractions the product was taken up in 150 IL of D20 for NMR-studies. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With 5'-GGA CUG GGC GAG AAG UUU AGU CC-3'; In aq. phosphate buffer; at 20℃; for 24h; | General procedure: 10114] A volume of 900 tL of a 5.54 mM RNA aptamer solution (4.98 tmol) in 10mM sodium phosphate buffer (pH 6.8) was heated to 85 C. for 10 mm and was afterwards kept at room temperature for 15 mm. 684 tL of a 4.8 mM solution of neomycin B sulphate (3.28 tmol) in 10mM sodium phosphate buffer (pH 7.4) was added and the mixture was allowed to stand for 30 mm at room temperature. Then, 15 equiv. activated ester, acetyl sulfo-NHS ester 4 or STP-ester 5 (49.2 tmol) 500 jiL 10mM sodium phosphate buffer (pH 7.4), or 5 equiv. <strong>[4781-83-3]2-<strong>[4781-83-3]iminothiolane hydrochloride</strong></strong> (16.4 tmol) dissolved in 42 IL 10 mM sodium phosphate buffer (pH 7.4) were added and the reaction mixture was allowed to react for 24 hours at room temperature. Afier addition of 180 tL of a 7 wt.% ethylamine water solution and thrther incubation for 30mm at room temperature, 486 tl of a 2 M sodium hydroxidesolution were added and the crude mixture was heated to 90C. for 30 mm. After cooling to room temperature each 50 tLfraction was purified by HPLC using a Waters Spherisorb ODS-2C18 analytic colunm (water/acetone 1:0.81 containing 16.9mM HFBA) at a flow rate of 1 ml/min at 40 C. to afford the antibiotic derivatives 10 and 14. Afier evaporation of acetone and freeze-drying of collected fractions the product was taken up in 150 IL of D20 for NMR-studies. |