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[ CAS No. 37888-03-2 ] {[proInfo.proName]}

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3d Animation Molecule Structure of 37888-03-2

Chemical Structure| 37888-03-2

Chemical Structure| 37888-03-2

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Quality Control of [ 37888-03-2 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 37888-03-2 ]

Product Details of [ 37888-03-2 ]

CAS No. :	37888-03-2	MDL No. :	MFCD00175518
Formula :	C₈H₆ClNO₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	183.59	Pubchem ID :	-
Synonyms :

Safety of [ 37888-03-2 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P280-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 37888-03-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 37888-03-2 ]
Downstream synthetic route of [ 37888-03-2 ]

[ 37888-03-2 ] Synthesis Path-Upstream 1~1

1
[ 37888-03-2 ]
[ 13078-79-0 ]

Reference： [1] European Journal of Medicinal Chemistry, 1983, vol. 18, # 4, p. 319 - 329

[ 37888-03-2 ] Synthesis Path-Downstream 1~9

1
[ 37888-03-2 ]
[ 170123-25-8 ]
(S)-1-tert-butyl 2-ethyl 2-((S)-1-(3-chlorophenyl)-2-nitroethyl)-3-oxopyrrolidine-1,2-dicarboxylate [ No CAS ]
(R)-1-tert-butyl 2-ethyl 2-((R)-1-(3-chlorophenyl)-2-nitroethyl)-3-oxopyrrolidine-1,2-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)urea; In toluene; at 20℃; for 24h;	General procedure: A mixture of N-Bocprotected 3-ketoproline1 (40.0 mg, 0.155 mmol)[1] and beta-nitrostyrene (52.0mg, 0.186 mmol) wasstirred in the presence of the catalyst (17.0 mg, 0.031 mmol) at 20Cwith anhydrous toluene (0.5 mL). The reaction progress was monitored using TLCand on completion, the solvent was evaporated in vacouand the crude product mixture purified by columnchromatography. [1]Rodrguez, I.;Calaza, M. I.; Jimnez, A. I.; Cativiela, C. Tetrahedron 2012, 68, 9582.

Reference： [1]Tetrahedron Letters,2015,vol. 56,p. 5172 - 5174

2
[ 6341-92-0 ]
[ 672-15-1 ]
[ 37888-03-2 ]
rac-(3S,3'S,4'S,5'S)-6-chloro-3'-(3-chlorophenyl)-5'-(2-hydroxyethyl)-4'-nitro-1,2-dihydrospiro[indole-3,2'-pyrrolidine]-2-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In methanol; for 0.666667h;Reflux;	6-Chloroisatin A-la (1.00 g, 5.4 mmol), 1-(3-chlorophenyl)-2-nitroethene (0.99 g, 5.4 mmol) and <strong>[672-15-1]L-homoserine</strong> (0.64 g, 5.4 mmol) are refluxed in MeOH for 40 min. The reaction mixture is concentrated in vacuo and purified by chromatography if necessary.

Reference： [1]Patent: US2015/291611,2015,A1 .Location in patent: Paragraph 0527; 0528

3
[ 37888-03-2 ]
[ 111836-35-2 ]
C₂₀H₁₉ClN₂O₄ [ No CAS ]

Reference： [1]Chemistry - A European Journal,2015,vol. 21,p. 19048 - 19057

4
[ 37888-03-2 ]
[ 111836-35-2 ]
C₂₀H₁₉ClN₂O₄ [ No CAS ]

Reference： [1]Chemistry - A European Journal,2015,vol. 21,p. 19048 - 19057

5
[ 6341-92-0 ]
[ 1187-84-4 ]
[ 37888-03-2 ]
rac-(3S,3'S,4'S,5'R)-6-chloro-3'-(3-chlorophenyl)-5'-[(methylsulfanyl)methyl]-4'-nitro-1,2-dihydrospiro[indole-3,2'-pyrrolidine]-2-one [ No CAS ]
rac-(3R,3'R,4'S,5'R)-6-chloro-4'-(3-chlorophenyl)-5'-[(methylsulfanyl)methyl]-3'-nitro-1,2-dihydrospiro[indole-3,2'-pyrrolidine]-2-one [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2016,vol. 59,p. 10147 - 10162

6
[ 6341-92-0 ]
[ 672-15-1 ]
[ 37888-03-2 ]
rac-(3S,3'S,4'S,5'S)-6-chloro-3'-(3-chlorophenyl)-5'-(2-hydroxyethyl)-4'-nitro-1,2-dihydrospiro[indole-3,2'-pyrrolidine]-2-one [ No CAS ]
rac-(3R,3'R,4'S,5'S)-6-chloro-4'-(3-chlorophenyl)-5'-(2-hydroxyethyl)-3'-nitro-1,2-dihydrospiro[indole-3,2'-pyrrolidine]-2-one [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2016,vol. 59,p. 10147 - 10162

7
[ 13099-95-1 ]
[ 37888-03-2 ]
ethyl 2-(1-(3-chlorophenyl)-2-nitroethyl)-3-oxo-2,3-dihydrobenzofuran-2-carboxylate [ No CAS ]

Reference： [1]European Journal of Organic Chemistry,2018,vol. 2018,p. 99 - 103

8
[ 13228-40-5 ]
[ 37888-03-2 ]
(3-chlorophenyl)(2-(pyridin-2-yl)-1H-indol-3-yl)methanone [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
82.21%	With cerium(III) chloride heptahydrate; In ethanol; at 120℃; for 12h;	In a thick-walled pressure reaction tube, CeCl 3 ·7H 2 O (7.5 mg, 0.02 mmol) was added in order.Reactant A (38.8 mg, 0.2 mmol), Reactant B (57.7 mg, 0.3 mmol);After the addition of solvent ethanol 2ml, placed in a 120 C oil bath reaction 12h.After the reaction was completed by TLC, it was purified by column chromatography.The developing agent was petroleum ether:ethyl acetate=4:1 and the isolation yield was 82.21%

Reference： [1]Patent: CN104945376,2017,B .Location in patent: Paragraph 0041; 0042; 0043; 0044

9
[ 100643-27-4 ]
[ 37888-03-2 ]
C₁₂H₁₀ClN₅O₃ [ No CAS ]

Reference： [1]RSC Advances,2019,vol. 9,p. 9770 - 9776

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Ghs Precautionary Statements

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P103	Read label before use
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Code	Phrase
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P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
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P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
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P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
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H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
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Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
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H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere