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[ CAS No. 356783-27-2 ] {[proInfo.proName]}

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Chemical Structure| 356783-27-2
Chemical Structure| 356783-27-2
Structure of 356783-27-2 * Storage: {[proInfo.prStorage]}
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Product Details of [ 356783-27-2 ]

CAS No. :356783-27-2 MDL No. :MFCD29049445
Formula : C6H5FN2O3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 172.11 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 356783-27-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 356783-27-2 ]

[ 356783-27-2 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 356783-26-1 ]
  • [ 356783-27-2 ]
YieldReaction ConditionsOperation in experiment
With sodium chloride; sodium acetate; In water; ethyl acetate; N,N-dimethyl-formamide; EXAMPLE II-2 In 3.0 mL of N,N-dimethylformamide was dissolved 0.3 g of <strong>[356783-26-1]methyl 3,6-difluoro-2-pyrazinecarboxylate</strong>. After adding 0.16 g of sodium acetate at an ice-cooled temperature, the mixture thus obtained was stirred at 50 C. for 2.5 hours. The reaction mixture was poured into a mixture of 50 mL of ethyl acetate and 30 mL of water, and the organic layer was separated. The remaining aqueous phase was extracted with three 25 mL portions of ethyl acetate. The organic layers were united, washed successively with 15 mL of water and 15 ml of saturated aqueous solution of sodium chloride and dried on anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. The residue was purified by silica gel chromatography [eluent: n-hexane:ethyl acetate=1:2] to obtain 0.03 g of methyl 6-fluoro-3-oxo-3,4-dihydro-2-pyrazinecarboxylate as a colorless solid product.
  • 2
  • [ 356783-27-2 ]
  • [ 259793-96-9 ]
YieldReaction ConditionsOperation in experiment
With sodium bicarbonate; sodium chloride; ammonia; In methanol; water; ethyl acetate; PRODUCTION EXAMPLE 1 In 3.0 mL of methanol was dissolved 0.12 g of methyl 6-fluoro-3-oxo-3,4-dihydro-2-pyrazinecarboxylate. Then, gaseous ammonia was introduced into the solution at an ice-cooled temperature for a period of 10 minutes, after which the mixture thus obtained was allowed to stand at room temperature for 2 days. The solvent was removed under reduced pressure, the residue thus obtained was added to a mixture of 30 mL of ethyl acetate and 30 ml of water, pH was adjusted to 7.5 with saturated aqueous solution of sodium hydrogen carbonate, and the organic layer was separated. After adding 30 mL of ethyl acetate to the remaining aqueous layer, pH was adjusted to 1.0 with 1 mol/L hydrochloric acid, and the whole mixture was extracted with two 15 mL portions of ethyl acetate. The organic layers thus obtained were united, washed successively with 15 mL of water and 15 mL of saturated aqueous solution of sodium chloride and dried on anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. The solid product thus obtained was washed with diisopropyl ether to obtain 0.015 g of 6-fluoro-3-hydroxy-2-pyrazinecarboxamide as a yellow-colored solid product. IR (KBr) cm-1: 1685, 1671, 1655 1H-NMR (DMSO-d6) delta: 8.46(1H,brs), 8.50(1H,d,J=7.8 Hz), 8.70(1H,brs), 13.39(1H,s)
  • 3
  • C6H5FN2O3 [ No CAS ]
  • [ 259793-96-9 ]
YieldReaction ConditionsOperation in experiment
92.3% With ammonium carbonate; Room temperature to 500 ml reaction flask add 22.5g VII, ammonium carbonate 62g, 50 C the left and the right insulation instead on invitation 10h to the raw basic reaction end. System for various 220 ml EA extraction 2 time, combined with the organic phase, sodium sulfate drying. Filtered, concentrated dry solvent to obtain 19g yellow solid I, yield 92.3%.
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