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[ CAS No. 35340-49-9 ] {[proInfo.proName]}

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Chemical Structure| 35340-49-9
Chemical Structure| 35340-49-9
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Product Details of [ 35340-49-9 ]

CAS No. :35340-49-9 MDL No. :MFCD00005056
Formula : C24H18O7 Boiling Point : -
Linear Structure Formula :- InChI Key :YKSJJXGQHSESKB-UHFFFAOYSA-N
M.W : 418.40 Pubchem ID :629056
Synonyms :

Safety of [ 35340-49-9 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 35340-49-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 35340-49-9 ]

[ 35340-49-9 ] Synthesis Path-Downstream   1~33

  • 1
  • [ 518-44-5 ]
  • [ 108-24-7 ]
  • [ 35340-49-9 ]
YieldReaction ConditionsOperation in experiment
94% In pyridine Ambient temperature;
With pyridine Ambient temperature; Yield given;
  • 2
  • [ 54-04-6 ]
  • [ 35340-49-9 ]
  • diacetyldihydrofluorescein amide of mescaline [ No CAS ]
YieldReaction ConditionsOperation in experiment
28% With dmap; dicyclohexyl-carbodiimide In dichloromethane for 2h; Ambient temperature;
  • 3
  • [ 3476-50-4 ]
  • [ 35340-49-9 ]
  • [ 89759-27-3 ]
YieldReaction ConditionsOperation in experiment
65% With dmap; dicyclohexyl-carbodiimide In dichloromethane for 2h; Ambient temperature; with other alkohols and amines, also with codein, quinin, mescalin;
65% With dmap; dicyclohexyl-carbodiimide In dichloromethane for 2h; Ambient temperature;
  • 4
  • [ 35340-49-9 ]
  • [ 74515-40-5 ]
  • [ 89759-28-4 ]
YieldReaction ConditionsOperation in experiment
77% With dmap; dicyclohexyl-carbodiimide In dichloromethane for 2h; Ambient temperature;
  • 5
  • [ 35340-49-9 ]
  • α-deoxydihydroartemisinin [ No CAS ]
  • C39H40O10 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With dmap; dicyclohexyl-carbodiimide In dichloromethane Ambient temperature;
  • 6
  • [ 35340-49-9 ]
  • (3R,5aS,6R,8aS,9R,10R,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-ol [ No CAS ]
  • diacetyldihydrofluorescyl dihydroqinghaosu [ No CAS ]
YieldReaction ConditionsOperation in experiment
69.4% With dmap; dicyclohexyl-carbodiimide In dichloromethane Ambient temperature;
  • 7
  • [ 35340-49-9 ]
  • quinine [ No CAS ]
  • diacetyldihydrofluorescein ester of quinine [ No CAS ]
YieldReaction ConditionsOperation in experiment
46% With dmap; dicyclohexyl-carbodiimide In dichloromethane for 2h; Ambient temperature;
  • 8
  • [ 35340-49-9 ]
  • codein [ No CAS ]
  • diacetyldihydrofluorescein ester of codeine [ No CAS ]
YieldReaction ConditionsOperation in experiment
38% With dmap; dicyclohexyl-carbodiimide In dichloromethane for 2h; Ambient temperature;
  • 10
  • [ 108-24-7 ]
  • [ 35340-49-9 ]
YieldReaction ConditionsOperation in experiment
With sodium acetate
  • 12
  • [ 35340-49-9 ]
  • [ 518-39-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: 77 percent / DCC, 4-(dimethylamino)pyridine / CH2Cl2 / 2 h / Ambient temperature 2: 29 percent / 1.) NH3 vapor, 2.) iodine vapor / 1.) 15 min, 2.) 15 min 3: 2N NaOH / methanol / 2 h / Ambient temperature
  • 13
  • [ 35340-49-9 ]
  • [ 89759-30-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: 77 percent / DCC, 4-(dimethylamino)pyridine / CH2Cl2 / 2 h / Ambient temperature 2: 29 percent / 1.) NH3 vapor, 2.) iodine vapor / 1.) 15 min, 2.) 15 min
  • 14
  • fluorescein [ No CAS ]
  • [ 35340-49-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: 3.4 g / Zn / ethanol / Heating 2: 94 percent / pyridine / Ambient temperature
  • 15
  • [ 97744-44-0 ]
  • [ 35340-49-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: H2 / Pd(OH)2/C / ethanol / 0.5 h / Ambient temperature 2: pyridine / Ambient temperature
  • 16
  • [ 518-45-6 ]
  • [ 35340-49-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: 81 percent / K2CO3 / dimethylformamide / 24 h / 80 °C 2: H2 / Pd(OH)2/C / ethanol / 0.5 h / Ambient temperature 3: pyridine / Ambient temperature
  • 17
  • [ 596-09-8 ]
  • [ 35340-49-9 ]
YieldReaction ConditionsOperation in experiment
85% With palladium 10% on activated carbon; hydrogen In ethyl acetate at 20℃; for 18h; 2.1.2 2.1.2 Synthesis of compound M-4 Compound M-3 (153 mg, 0.367 mmol) was dissolved in 15 mL of ethyl acetate, 10% palladium/carbon (15 mg) was added, hydrogen was passed through, the reaction was carried out at room temperature for 18 h, suction filtered, and the filtrate was concentrated under reduced pressure to obtain the crude product. The crude product was purified by column chromatography (DCM:MeOH, 30:1 v/v) to give 130 mg of white solid in 85% yield.
74% With glacial acetic acid; zinc In tetrahydrofuran at 85℃; for 0.25h; Microwave irradiation; Flu-ester General procedure: To a solution of 2 (50 mg, 0.14 mmol) in THF (2 mL) and acetic acid (0.2 mL) was added Zn powder (50 mg). The reaction mixture was irradiated at 30 W and 85 °C in microwave reactor (CEM Discover, Dynamic mode, cooling air) for 15 min. The reaction mixture was filtered and the filter cake was washed with THF (10 mL 3). The filtrate was concentrated and purified by column chromatography (hexane:ethyl acetate = 2:1, v/v) to yield the desired product (35.8 mg, 0.10 mmol, yield 71%).
With palladium 10% on activated carbon; hydrogen In ethyl acetate at 20℃; for 18h;
With glacial acetic acid; zinc Microwave irradiation;

  • 18
  • [ 35340-49-9 ]
  • C29H24O7 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 18 h / 20 °C / Inert atmosphere 2: ammonium bicarbonate / tetrahydrofuran; methanol; water / 60 h / 20 °C / Inert atmosphere; Darkness
  • 19
  • [ 35340-49-9 ]
  • C35H32O7 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 18 h / 20 °C / Inert atmosphere 2: ammonium bicarbonate / tetrahydrofuran; methanol; water / 60 h / 20 °C / Inert atmosphere; Darkness 3: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate / dichloromethane; water / 18 h / 20 °C / Inert atmosphere; Darkness
  • 20
  • [ 35340-49-9 ]
  • [ 855751-82-5 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 18 h / 20 °C / Inert atmosphere 2: ammonium bicarbonate / tetrahydrofuran; methanol; water / 60 h / 20 °C / Inert atmosphere; Darkness 3: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate / dichloromethane; water / 18 h / 20 °C / Inert atmosphere; Darkness 4: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 18 h / 20 °C / Inert atmosphere; Darkness
  • 21
  • [ 7314-44-5 ]
  • [ 35340-49-9 ]
  • C33H28O9 [ No CAS ]
YieldReaction ConditionsOperation in experiment
207.3 mg With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 18h; Inert atmosphere;
  • 22
  • [ 35340-49-9 ]
  • [ 146651-75-4 ]
  • C31H28N2O6 [ No CAS ]
YieldReaction ConditionsOperation in experiment
90% Stage #1: dihydrofluorescein diacetate With thionyl chloride Inert atmosphere; Stage #2: tert–butyl (2–aminophenyl)carbamate With triethylamine In acetonitrile at 20℃; for 1h; Stage #3: With lithium hydroxide In tetrahydrofuran; water at 20℃; for 4h;
  • 23
  • [ 35340-49-9 ]
  • C40H28N2O5S2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: thionyl chloride / Inert atmosphere 1.2: 1 h / 20 °C 1.3: 4 h / 20 °C 2.1: borane solution / tetrahydrofuran / 4 h / Inert atmosphere; Reflux 2.2: 2 h / 20 °C 3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 3 h / 20 °C 4.1: hydrogenchloride / dichloromethane / 1 h / 20 °C 4.2: 1 h / 0 - 20 °C
  • 24
  • [ 35340-49-9 ]
  • C26H17N3O3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: thionyl chloride / Inert atmosphere 1.2: 1 h / 20 °C 1.3: 4 h / 20 °C 2.1: borane solution / tetrahydrofuran / 4 h / Inert atmosphere; Reflux 2.2: 2 h / 20 °C 3.1: hydrogenchloride / tetrahydrofuran / 1 h / 20 °C 3.2: 3 h / 0 - 20 °C
Multi-step reaction with 5 steps 1.1: thionyl chloride / Inert atmosphere 1.2: 1 h / 20 °C 1.3: 4 h / 20 °C 2.1: borane solution / tetrahydrofuran / 4 h / Inert atmosphere; Reflux 2.2: 2 h / 20 °C 3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 3 h / 20 °C 4.1: hydrogenchloride / dichloromethane / 1 h / 20 °C 4.2: 1 h / 0 - 20 °C 5.1: S-Nitrosoglutathione; sodium sulfide / tetrahydrofuran; aq. phosphate buffer / 0.5 h / pH 7.4 / Darkness; Inert atmosphere
  • 25
  • [ 35340-49-9 ]
  • C31H28N2O5 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: dichlorosulfoxide / Inert atmosphere 1.2: 1 h / 20 °C 1.3: 4 h / 20 °C 2.1: borane solution / tetrahydrofuran / 4 h / Inert atmosphere; Reflux 2.2: 2 h / 20 °C
Multi-step reaction with 4 steps 1.1: dichlorosulfoxide / 12 h / Reflux; Inert atmosphere 2.1: triethylamine / acetonitrile / 3.5 h / 0 - 20 °C / Reflux; Inert atmosphere 3.1: lithium hydroxide monohydrate; lithium hydroxide monohydrate / tetrahydrofuran / 4 h / 20 °C 4.1: borane-THF / tetrahydrofuran / 4 h / Reflux; Inert atmosphere 4.2: 2 h / 20 °C
  • 26
  • [ 35340-49-9 ]
  • C55H42N4O7S4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: thionyl chloride / Inert atmosphere 1.2: 1 h / 20 °C 1.3: 4 h / 20 °C 2.1: borane solution / tetrahydrofuran / 4 h / Inert atmosphere; Reflux 2.2: 2 h / 20 °C 3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 3 h / 20 °C
  • 27
  • [ 2321-07-5 ]
  • [ 35340-49-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: pyridine 2: glacial acetic acid; zinc / tetrahydrofuran / 0.25 h / 85 °C / Microwave irradiation
Multi-step reaction with 2 steps 1: pyridine 2: glacial acetic acid; zinc / Microwave irradiation
Multi-step reaction with 2 steps 1: Reflux 2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h / 20 °C
  • 28
  • [ 35340-49-9 ]
  • [ 74-89-5 ]
  • C25H21NO6 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Stage #1: dihydrofluorescein diacetate With O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran Stage #2: methylamine In tetrahydrofuran
  • 29
  • [ 35340-49-9 ]
  • C40H30N4O7 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1.1: dichlorosulfoxide / 12 h / Reflux; Inert atmosphere 2.1: triethylamine / acetonitrile / 3.5 h / 0 - 20 °C / Reflux; Inert atmosphere 3.1: lithium hydroxide monohydrate; lithium hydroxide monohydrate / tetrahydrofuran / 4 h / 20 °C 4.1: borane-THF / tetrahydrofuran / 4 h / Reflux; Inert atmosphere 4.2: 2 h / 20 °C 5.1: N,N-dimethyl-formamide / 0.25 h / Inert atmosphere 5.2: 6 h / 20 °C / Inert atmosphere 6.1: hydrogenchloride / dichloromethane; lithium hydroxide monohydrate / 2 h / 20 °C
  • 30
  • [ 35340-49-9 ]
  • C45H38N4O9 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1.1: dichlorosulfoxide / 12 h / Reflux; Inert atmosphere 2.1: triethylamine / acetonitrile / 3.5 h / 0 - 20 °C / Reflux; Inert atmosphere 3.1: lithium hydroxide monohydrate; lithium hydroxide monohydrate / tetrahydrofuran / 4 h / 20 °C 4.1: borane-THF / tetrahydrofuran / 4 h / Reflux; Inert atmosphere 4.2: 2 h / 20 °C 5.1: N,N-dimethyl-formamide / 0.25 h / Inert atmosphere 5.2: 6 h / 20 °C / Inert atmosphere
  • 31
  • [ 35340-49-9 ]
  • C31H28N2O6 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: dichlorosulfoxide / 12 h / Reflux; Inert atmosphere 2: triethylamine / acetonitrile / 3.5 h / 0 - 20 °C / Reflux; Inert atmosphere 3: lithium hydroxide monohydrate; lithium hydroxide monohydrate / tetrahydrofuran / 4 h / 20 °C
  • 32
  • [ 35340-49-9 ]
  • C35H32N2O8 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: dichlorosulfoxide / 12 h / Reflux; Inert atmosphere 2: triethylamine / acetonitrile / 3.5 h / 0 - 20 °C / Reflux; Inert atmosphere
  • 33
  • [ 35340-49-9 ]
  • C24H17ClO6 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With dichlorosulfoxide for 12h; Reflux; Inert atmosphere; 2.1.3 2.1.3 Synthesis of compound M-5 Compound M-4 (418 mg, 1 mmol) was dissolved in SOCl2 (3 mL), and the reaction was refluxed for 2 h under nitrogen protection. After the reaction was completed, it was cooled to room temperature, and SOCl2 was removed under reduced pressure. The concentrated residue was dissolved in anhydrous CH3CN (20 mL), and added to a mixed solution of Et3N (405 mg, 4 mmol) and N-Boc-1,2-phenylenediamine (140 mg, 0.67 mmol). The resulting mixture was reacted at 0°C for 0.5 h and then at room temperature for 3 h. Water (100 mL) was added to the above reaction solution to quench the reaction and extracted with ethyl acetate (3 x 30 mL). The organic phase was dried with anhydrous Na2SO4,Concentrate under reduced pressure.
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