[ CAS No. 352-97-6 ] {[proInfo.proName]}

Name: 352-97-6|2-Guanidinoacetic acid|95%
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2D 3D

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Quality Control of [ 352-97-6 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 352-97-6 ]

SDS Specification

Alternatived Products of [ 352-97-6 ]

Product Details of [ 352-97-6 ]

CAS No. :	352-97-6	MDL No. :	MFCD00004278
Formula :	C₃H₇N₃O₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	BPMFZUMJYQTVII-UHFFFAOYSA-N
M.W :	117.11	Pubchem ID :	763
Synonyms :	Guanidinoacetic acid;GAA;AI3-17119;NSC 26360;NSC 227847;NSC 1901;Guanidinoacetate

Calculated chemistry of [ 352-97-6 ]

Physicochemical Properties

Num. heavy atoms :	8
Num. arom. heavy atoms :	0
Fraction Csp3 :	0.33
Num. rotatable bonds :	3
Num. H-bond acceptors :	3.0
Num. H-bond donors :	4.0
Molar Refractivity :	27.41
TPSA :	99.2 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	No
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-7.97 cm/s

Lipophilicity

Log Po/w (iLOGP) :	-0.59
Log Po/w (XLOGP3) :	-1.35
Log Po/w (WLOGP) :	-1.45
Log Po/w (MLOGP) :	-3.63
Log Po/w (SILICOS-IT) :	-1.58
Consensus Log Po/w :	-1.72

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	2.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	0.48
Solubility :	356.0 mg/ml ; 3.04 mol/l
Class :	Highly soluble
Log S (Ali) :	-0.23
Solubility :	68.4 mg/ml ; 0.584 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	0.61
Solubility :	475.0 mg/ml ; 4.06 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	2.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.81

Safety of [ 352-97-6 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P264-P302+P352-P304+P340-P305+P351+P338-P332+P313-P337+P313-P501	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 352-97-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 352-97-6 ]

[ 352-97-6 ] Synthesis Path-Downstream 1~88

1
[ 609-14-3 ]
[ 352-97-6 ]
(2-amino-4,5-dimethyl-6-oxo-6H-pyrimidin-1-yl)-acetic acid [ No CAS ]

Reference： [1]Zhurnal Obshchei Khimii,1955,vol. 25,p. 1218,1221;engl.Ausg.S.1165

2
[ 812-00-0 ]
[ 352-97-6 ]
[ 57-00-1 ]

Reference： [1]Journal of Biological Chemistry,1949,vol. 180,p. 971 - 974
[2]Journal of Biological Chemistry,1949,vol. 180,p. 971 - 974

3
[ 6779-78-8 ]
[ 352-97-6 ]

Reference： [1]Justus Liebigs Annalen der Chemie,1925,vol. 442,p. 144,147
Justus Liebigs Annalen der Chemie,1926,vol. 447,p. 259

4
[ 64-17-5 ]
[ 352-97-6 ]
N-carbamimidoyl-glycine ethyl ester [ No CAS ]

Reference： [1]Canadian Journal of Chemistry,1954,vol. 32,p. 1012,1014

5
[ 63-68-3 ]
[ 352-97-6 ]
[ 57-00-1 ]

Reference： [1]Journal of Biological Chemistry,1941,vol. 140,p. 643,650
[2]Biochemische Zeitschrift,1942,vol. 310,p. 350
[3]Acta Physiologica Scandinavica,1947,vol. 14,p. 340
[4]Hoppe-Seyler's Zeitschrift fur Physiologische Chemie,1948,vol. 283,p. 96

6
[ 62-49-7 ]
[ 352-97-6 ]
[ 57-00-1 ]

Reference： [1]Hoppe-Seyler's Zeitschrift fur Physiologische Chemie,1948,vol. 283,p. 96
[2]Journal of Biological Chemistry,1941,vol. 140,p. 643,650

7
[ 861321-98-4 ]
[ 352-97-6 ]

Reference： [1]Justus Liebigs Annalen der Chemie,1925,vol. 442,p. 144,147
Justus Liebigs Annalen der Chemie,1926,vol. 447,p. 259

8
[ 543-83-9 ]
[ 352-97-6 ]

Reference： [1]Biochemical Journal,1923,vol. 17,p. 831

9
[ 352-97-6 ]
[ 6829-41-0 ]
N-(5-hydroxyimino-4,6-dioxo-1,4,5,6-tetrahydro-pyrimidin-2-yl)-glycine [ No CAS ]

Reference： [1]Patent: US2635960,1950,

10
[ 352-97-6 ]
[ 503-86-6 ]

Yield	Reaction Conditions	Operation in experiment
49%	With hydrogenchloride; In water; at 120℃; for 22h;Heating;	The synthesis of polyandrocarpamines A & B (PAC1 and PAC2) was performed from corresponding benzaldehyde derivatives, n-propylamine and 2-aminoimidazolin-4-one, the preparation of which was previously described in literature [53] (Figure 5). Guanidine (2.95 mmol, 1eq) and HClaq 6N (9 mL) were heated at 120 C for 22 h. Water was removed under vacuum and the crude product was solubilized in hot ethanol (9 mL). Diethylether (6 mL) was added, then the mixture was cooled to 0 C. After 6 h, filtration was performed and the 2-aminoimidazolin-4-one was isolated as a white powder with a 49% yield. RMN 1H (D2O): delta 4.18 (s, 2H, H-1); RMN 13C (D2O):delta 48.5 (C-1); 174.9 (C=O); [M - HCl]+ = 99.0427 (99.0433 C3H5N3O); F = 200-202 C. PAC1 and PAC2 were then produced by mixing the corresponding benzaldehyde (vanillin or catechaldehyde 1.48mmol, 1 eq) with n-propylamine (2.95 mmol, 2 eq). The imine formation was performed under microwave irradiation at 60 C for 30 min (maximized authorized power 60 W). Acetonitrile was added to the crude imine with 2-aminoimidazolin-4-one (1.48 mmol, 1 eq), and the mixture was stirred at reflux for 63 h. The solvent was removed under reduced pressure.

Reference： [1]Marine Drugs,2017,vol. 15
[2]Archiv der Pharmazie,1913,vol. 251,p. 558
Chemisches Zentralblatt,1912,vol. 83,p. 247
[3]Journal of the American Chemical Society,1953,vol. 75,p. 3138

11
[ 352-97-6 ]
[ 5115-19-5 ]

Reference： [1]Journal of Biological Chemistry,1946,vol. 165,p. 100
[2]Biochimica et Biophysica Acta - Proteins and Proteomics,2011,vol. 1814,p. 1219 - 1225

12
[ 352-97-6 ]
[ 57-00-1 ]

Reference： [1]Die biogenen Amine,4.Aufl.<Basel 1951> S.362-364,
[2]Hoppe-Seyler's Zeitschrift fur Physiologische Chemie,1906,vol. 48,p. 438

13
[ 352-97-6 ]
[ 141-97-9 ]
[ 53854-17-4 ]
[ 53854-15-2 ]

Reference： [1]Doklady Akademii Nauk SSSR,1952,vol. 87,p. 783
Chem.Abstr.,1954,p. 169

14
[ 2986-19-8 ]
[ 56-40-6 ]
[ 352-97-6 ]

Reference： [1]Journal of the Chemical Society,1930,p. 2376

15
[ 113-00-8 ]
[ 79-11-8 ]
[ 352-97-6 ]

Reference： [1]Chemische Berichte,1908,vol. 41,p. 4392
[2]Patent: US2766282,1952,
[3]Chemische Berichte,1908,vol. 41,p. 4392

16
[ 352-97-6 ]
[ 18133-26-1 ]
[ 538-75-0 ]
[ 6166-89-8 ]

Reference： [1]Journal of the American Chemical Society,1957,vol. 79,p. 1266

17
[ 352-97-6 ]
[ 133-13-1 ]
(5-ethyl-2-amino-4,6-dioxo-5,6-dihydro-4H-pyrimidin-1-yl)-acetic acid [ No CAS ]

Reference： [1]Zhurnal Obshchei Khimii,1955,vol. 25,p. 1218,1221;engl.Ausg.S.1165

18
[ 57-13-6 ]
[ 56-40-6 ]
[ 352-97-6 ]

Reference： [1]Enzymology,1940,vol. 8,p. 241,247

19
[ 57-13-6 ]
[ 352-97-6 ]

Reference： [1]Patent: US2820822,1956,

20
[ 2440-60-0 ]
[ 56-40-6 ]
[ 352-97-6 ]

Reference： [1]Hoppe-Seyler's Zeitschrift fur Physiologische Chemie,1934,vol. 225,p. 7

21
[ 74-79-3 ]
[ 56-40-6 ]
[ 352-97-6 ]

Reference： [1]Journal of Biological Chemistry,1941,vol. 138,p. 391,397
[2]Journal of Biological Chemistry,1941,vol. 140,p. 191
[3]Journal of the American Chemical Society,2012,vol. 134,p. 17797 - 17806
[4]Methods in Enzymology, Bd.5<New York 1962> S.844,

22
[ 420-04-2 ]
[ 56-40-6 ]
[ 352-97-6 ]

Yield	Reaction Conditions	Operation in experiment
94.6%	With ammonia; In water; at 60℃; for 4h;pH 11.0;	To a 250 mL four-necked flask equipped with a reflux condenser, a dropping funnel, and a thermometer, 27.0 g (0.36 mol) of glycine and 40.5 g of water were added, stirred and dissolved, and adjusted to pH 11 by addition of liquid ammonia. The temperature was increased to 60 C, (0.327 mol) of 50% aqueous solution of cyanamide, stirred for 4 h, filtered and washed with the filtrate. In a separate kettle, crude guanidine acetate and 4 times the mass of DMF were added,Heated to 40 C stirring 0.5h and then cooled to 0 C, by suction filtration, DMF washing filter cake,Finally, 39.93 g of guanidinoacetic acid was obtained with a yield of 94.6% and a content of 99.8%.

Reference： [1]Patent: CN105503659,2016,A .Location in patent: Paragraph 0016
[2]Enzymology,1940,vol. 8,p. 241,247
[3]Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences,1861,vol. 52,p. 1212
Jahresbericht ueber die Fortschritte der Chemie und Verwandter Theile Anderer Wissenschaften,1861,p. 530
[4]Patent: US2654779,1950,
[5]Patent: US2654779,1950,

23
[ 1184-90-3 ]
[ 56-40-6 ]
[ 352-97-6 ]

Reference： [1]Synthesis,1986,p. 777 - 779
[2]Angewandte Chemie,1955,vol. 67,p. 275

24
[ 53114-57-1 ]
[ 56-40-6 ]
[ 352-97-6 ]

Reference： [1]Journal of the Chemical Society,1930,p. 2376

25
[ 1071-37-0 ]
[ 56-40-6 ]
[ 352-97-6 ]

Reference： [1]<1955>441,

26
[ 56-40-6 ]
[ 352-97-6 ]

Reference： [1]Advances in Protein Chemistry,1954,vol. 9,p. 63

27
[ 352-97-6 ]
[ 607-97-6 ]
(5-ethyl-2-amino-4-methyl-6-oxo-6H-pyrimidin-1-yl)-acetic acid [ No CAS ]

Reference： [1]Zhurnal Obshchei Khimii,1955,vol. 25,p. 1218,1221;engl.Ausg.S.1165

28
[ 352-97-6 ]
[ 100-51-6 ]
[ 132624-67-0 ]

Reference： [1]Chemische Berichte,1959,vol. 92,p. 392,396

29
[ 352-97-6 ]
Nitroguanidinoessigsaeure [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1974,vol. 17,p. 431 - 433

30
[ 5329-33-9 ]
[ 56-40-6 ]
[ 352-97-6 ]

Reference： [1]Chemische Berichte,1962,vol. 95,p. 1670 - 1682

31
[ 867-44-7 ]
[ 56-40-6 ]
[ 352-97-6 ]

Reference： [1]Hoppe-Seyler's Zeitschrift fur Physiologische Chemie,1964,vol. 335,p. 272 - 274

32
[ 32521-19-0 ]
[ 352-97-6 ]
[ 130747-59-0 ]

Reference： [1]Journal of Heterocyclic Chemistry,1990,vol. 27,p. 1181 - 1184

33
[ 352-97-6 ]
[ 144455-11-8 ]
[ 144454-93-3 ]

Reference： [1]Il Farmaco,1992,vol. 47,p. 171 - 190

34
[ 352-97-6 ]
[ 119-53-9 ]
(4,5-Diphenyl-1H-imidazol-2-ylamino)-acetic acid [ No CAS ]

Reference： [1]Chemical and pharmaceutical bulletin,1981,vol. 29,p. 1115 - 1120

35
[ 352-97-6 ]
[ 98-59-9 ]
[ 124233-36-9 ]

Reference： [1]Collection of Czechoslovak Chemical Communications,1989,vol. 54,p. 533 - 535

36
[ 487-89-8 ]
[ 352-97-6 ]
[ 108-24-7 ]
3-<(2'-acetamido-5'-acetoxy-4'-imidazolinylidene)methyl>-1H-indole [ No CAS ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1994,vol. 33,p. 4 - 9

37
[ 877-03-2 ]
[ 352-97-6 ]
[ 108-24-7 ]
3-<(2'-acetamido-5'-acetoxy-4'-imidazolinylidene)methyl>-5-bromo-1H-indole [ No CAS ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1994,vol. 33,p. 10 - 16

38
[ 50562-79-3 ]
[ 352-97-6 ]
[ 108-24-7 ]
3-<(2'-acetamido-5'-acetoxy-4'-imidazolinylidene)methyl>-1-(p-toluenesulphonyl)-1H-indole [ No CAS ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1994,vol. 33,p. 4 - 9

39
[ 352-97-6 ]
[ 108-24-7 ]
[ 27092-42-8 ]
3-<(2'-acetamido-5'-acetoxy-4'-imidazolidinylidene)methylene>-1-benzoyl-1H-indole [ No CAS ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1994,vol. 33,p. 4 - 9
[2]Journal of the Indian Chemical Society,1994,vol. 71,p. 329 - 340

40
[ 352-97-6 ]
[ 108-24-7 ]
[ 158991-80-1 ]
[ 158991-84-5 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1994,vol. 33,p. 10 - 16

41
[ 352-97-6 ]
[ 108-24-7 ]
[ 158991-81-2 ]
[ 158991-85-6 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1994,vol. 33,p. 10 - 16

42
[ 352-97-6 ]
[ 108-24-7 ]
[ 10511-51-0 ]
3-<(2'-acetamido-5'-acetoxy-4'-imidazolinylidene)methyl>-1-benzyl-1H-indole [ No CAS ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1994,vol. 33,p. 4 - 9

43
[ 487-89-8 ]
[ 352-97-6 ]
[ 108-24-7 ]
[ 155859-47-5 ]

Reference： [1]Journal of the Indian Chemical Society,1994,vol. 71,p. 329 - 340

44
[ 50562-79-3 ]
[ 352-97-6 ]
[ 108-24-7 ]
[ 155859-38-4 ]

Reference： [1]Journal of the Indian Chemical Society,1994,vol. 71,p. 329 - 340

45
[ 352-97-6 ]
[ 108-24-7 ]
[ 10511-51-0 ]
[ 155859-44-2 ]

Reference： [1]Journal of the Indian Chemical Society,1994,vol. 71,p. 329 - 340

46
[ 352-97-6 ]
[ 90-15-3 ]
2-Brom-naphthochinon-(1,4)-4-<4-carboxymethyl-semicarbazon> [ No CAS ]

Reference： [1]Chemische Berichte,1963,vol. 96,p. 2170 - 2172

47
[ 7732-18-5 ]
[ 113-00-8 ]
[ 79-11-8 ]
[ 352-97-6 ]

Reference： [1]Chemische Berichte,1908,vol. 41,p. 4392
[2]Chemische Berichte,1908,vol. 41,p. 4392

48
[ 124-46-9 ]
[ 7732-18-5 ]
[ 56-40-6 ]
[ 352-97-6 ]

Reference： [1]Journal fur praktische Chemie (Leipzig 1954),1878,vol. <2>17,p. 477

49
[ 420-04-2 ]
[ 7664-41-7 ]
[ 7732-18-5 ]
[ 56-40-6 ]
[ 352-97-6 ]

Reference： [1]Jahresbericht ueber die Fortschritte der Chemie und Verwandter Theile Anderer Wissenschaften,1861,p. 531

50
ammonium hydroxide [ No CAS ]
[ 1758-73-2 ]
[ 56-40-6 ]
[ 352-97-6 ]

Reference： [1]Angewandte Chemie,1955,vol. 67,p. 275

51
[ 352-97-6 ]
S-adenosyl-L-methionine [ No CAS ]
[ 57-00-1 ]

Reference： [1]Comparative Biochemistry,Bd.1<New York 1960>S.226,

Yield	Reaction Conditions	Operation in experiment
		Among the compounds of formula (III), mention may be made especially of the following particularly preferred compounds: ... creatine monohydrate creatinine hydrochloride agmatine agmatine sulfate guanidinoacetic acid guanidinosuccinic acid 3-guanidinopropionic acid beta-N-methylguanidinopropionic acid ...

56
[ 124-38-9 ]
[ 79-11-8 ]
[ 352-97-6 ]

Reference： [1]Patent: US2620354,1951,

57
[ 6779-78-8 ]
aq. barium hydroxide solution [ No CAS ]
[ 352-97-6 ]

Reference： [1]Justus Liebigs Annalen der Chemie,1925,vol. 442,p. 144,147
Justus Liebigs Annalen der Chemie,1926,vol. 447,p. 259

58
bis-<S-methyl-thiuronium >-sulfate [ No CAS ]
[ 352-97-6 ]

Reference： [1]Justus Liebigs Annalen der Chemie,1953,vol. 583,p. 129,145

59
[ 113-00-8 ]
carbonate glycine [ No CAS ]
[ 352-97-6 ]

Reference： [1]Journal fur praktische Chemie (Leipzig 1954),1878,vol. <2>17,p. 477

60
compound C₆H₁₄O₄N₆ [ No CAS ]
[ 352-97-6 ]

Reference： [1]Chemische Berichte,1909,vol. 42,p. 4533

61
[ 19981-17-0 ]
glycine hydrochloride [ No CAS ]
[ 352-97-6 ]

Reference： [1]Justus Liebigs Annalen der Chemie,1925,vol. 442,p. 144,147
Justus Liebigs Annalen der Chemie,1926,vol. 447,p. 259

62
[ 56-40-6 ]
hydriodide of S-methyl-isothiourea [ No CAS ]
[ 352-97-6 ]

Reference： [1]American Chemical Journal,1903,vol. 29,p. 491

63
[ 352-97-6 ]
liver-extract [ No CAS ]
[ 57-13-6 ]

Reference： [1]Hoppe-Seyler's Zeitschrift fur Physiologische Chemie,1938,vol. 255,p. 137,142

64
[ 352-97-6 ]
pseudomonas ovalis [ No CAS ]
[ 57-13-6 ]

Reference： [1]Biochimica et Biophysica Acta,1948,vol. 2,p. 419

65
[ 352-97-6 ]
aq. barium hydroxide solution [ No CAS ]
[ 462-60-2 ]
[ 124-38-9 ]
[ 7664-41-7 ]
[ 56-40-6 ]

Reference： [1]Archiv der Pharmazie,1904,vol. 242,p. 634

66
[ 7664-93-9 ]
[ 14279-86-8 ]
barium permanganate [ No CAS ]
[ 352-97-6 ]
[ 67-64-1 ]

Reference： [1]Biochemical Journal,1923,vol. 17,p. 831

67
[ 1758-73-2 ]
[ 56-40-6 ]
[ 352-97-6 ]

Reference： [1]Synthesis,2000,p. 1656 - 1658

68
[ 352-97-6 ]
[ 372-31-6 ]
(4-hydroxy-6-trifluoromethyl-pyrimidin-2-ylamino)-acetic acid [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2004,vol. 14,p. 4449 - 4452

69
[ 1012335-55-5 ]
[ 352-97-6 ]
[6-cyano-6-(4-methoxydibenzo[b,d]furan-1-yl)-5,6,7,8-tetrahydroquinazolin-2-yl]amino}acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
52.45%		Example 18; [6-Cyano-6-(4-methoxydibenzo[ft,rf]furan-l-yl)-5,6,7,8-tetrahydroquinazolin-2-yl] amino} acetic acid; A mixture of the compound obtained in example 6 (lOOmg, 0.267mmol), guanidine acetic acid and sodium hydroxide (54mg, l mol) in 10 ml of methanol was stirred at 60-700C for 8 hrs. Methanol was evaporated under <n="45"/>vacuum and the reaction mass was diluted with 10 ml of water. The aqueous layer was washed with ether, acidified with 0.1 N HCl to pH 2 and extracted with ethyl acetate. The organic layer was washed with water followed by brine, and concentrated under vacuum. The crude product was crystallized form hexane to give 60mg (52.45% yields) of a yellow colored solid.1H-NMR (300MHz, DMSO-d6); 8.24 (d, J=6.4, IH); 8.2 (s, IH); 7.85 (d, J=8.1, IH); 7.63 (t, J=7.6, IH); 7.53 (t, J=7.4, IH); 7.38 (d, J=8.5, IH); 7.25 (d, J=8.5, IH); 6.67 (s, IH); 4.1 (s, 3H); 3.7 (s, 2H); 3.7-3.5 (m, 2H); 3- 3.2 (m, 2H); 2.9-2.8 (m, 2H)

Reference： [1]Patent: WO2008/32171,2008,A1 .Location in patent: Page/Page column 43-44

Yield	Reaction Conditions	Operation in experiment
		EXAMPLE 1 Guanidinoacetyl-L-histidine.H2 O (n=1) was prepared from glycyl-L-histidine and S-ethylisothiourea.H2 SO4. Solutions of 1.50 g. of S-ethylisothiourea.H2 SO4 in 5 ml of H2 O and 1.74 g. of Gly-His.HCl in 3 ml of H2 O were adjusted to pH 8-9 with 4 N NaOH. They were then mixed and kept at room temperature for a week. The cloudy suspension was filtered and the filtrate concentrated to dryness in vacuo. The residue, after addition of a small amount of EtOH, was dried in vacuo. A small amount of H2 O was added to dissolve the dry residue and resulting solution was poured onto the column (2.5 cm i.d. * 30 cm Amberlite CG-120, 200-400 mesh, pyridine form). H2 O, 1.0 M pyridine, 2.0 M pyridine, and 1.0 M pyridine--0.5 M NH4 OH were used as the effluent solutions. Each fraction was tested for ninhydrin, Pauli, and Sakaguchi reactions. The fractions containing guanidinoacetyl-L-histidine were pooled and concentrated to dryness in vacuo. Cryst from H2 O--EtOH; yield, 69.2%; mp, 108-111 C., decomp. Hydrolysis (6 N HCl, 110, 24 hours.) gave guanidinoacetic acid and histidine, as confirmed be tlc. (thin layer chromatography).

71
1H-1,2,4-triazole-1-carboximidamide monohydrochloride [ No CAS ]
[ 352-97-6 ]

Yield	Reaction Conditions	Operation in experiment
79%	With sodium carbonate; In water; glycine;	Example 2 In a 100 ml flask were added 5 g of glycine, 9,83 mg of 1-amidino-1,2,4-triazol-hydrochloride and 7.06 g of sodium carbonate, dissolved in 166 ml of water. The reaction suspension was stirred at rt over night. The precipitate was filtered, washed with methanol and dried at rt under vacuum to give 8.08 g of amidinoglycine (79% yield), m.p. 279-283C (dec.).

Reference： [1]Patent: EP684227,1995,A2

72
[ 352-97-6 ]
[ 84817-80-1 ]
[ 1034818-68-2 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,2007,vol. 46,p. 1297 - 1302

73
[ 1041182-97-1 ]
[ 352-97-6 ]
[ 1041183-02-1 ]

Reference： [1]Journal of Heterocyclic Chemistry,2008,vol. 45,p. 745 - 749

74
[ 352-97-6 ]
silver nitrate [ No CAS ]
2Ag⁽¹⁺⁾*H₂NC(NH)NCH₂COO^(2-) = {Ag₂C₃H₅N₃O₂} [ No CAS ]

Reference： [1]Bulletin de la Societe Chimique de France,1875,vol. 24,p. 272 - 278
[2]Gmelin Handbuch der Anorganischen Chemie,Gmelin Handbook: Ag: MVol.B6, 1.18.6, page 337 - 339

75
nickel(II) chloride hexahydrate [ No CAS ]
[ 352-97-6 ]
[ 368863-36-9 ]
[ 368863-37-0 ]