[ CAS No. 2693-46-1 ] {[proInfo.proName]}

Name: 2693-46-1|Fluoranthen-3-amine|96%
Brand: Ambeed
SKU: A395252
Price: 14.0 USD
Availability: InStock
Rating: 96 (40 reviews)

,{[proInfo.pro_purity]}

Cat. No.: {[proInfo.prAm]}

2D 3D

Structure of 2693-46-1 * Storage: {[proInfo.prStorage]}

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

For Research Only 110K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 2693-46-1 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 2693-46-1 ]

SDS Specification

Alternatived Products of [ 2693-46-1 ]

Product Details of [ 2693-46-1 ]

CAS No. :	2693-46-1	MDL No. :	MFCD00001185
Formula :	C₁₆H₁₁N	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	VHGJAFIHUSTRGB-UHFFFAOYSA-N
M.W :	217.27	Pubchem ID :	17599
Synonyms :

Safety of [ 2693-46-1 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 2693-46-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 2693-46-1 ]

[ 2693-46-1 ] Synthesis Path-Downstream 1~50

1
[ 2693-46-1 ]
[ 17798-09-3 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride at 230℃;

Reference： [1]v. Braun; Manz [Justus Liebigs Annalen der Chemie, 1931, vol. 488, p. 111,115, 116][Justus Liebigs Annalen der Chemie, 1932, vol. 496, p. 170,191]

2
[ 2693-46-1 ]
[ 2969-60-0 ]

Yield	Reaction Conditions	Operation in experiment
	With bromine; acetic acid

Reference： [1]Current Patent Assignee: CARL ZEISS AG - DE711159, 1938, C [DRP/DRBP Org.Chem.][DRP/DRBP Org.Chem.]

3
[ 2693-46-1 ]
4,5,6,6a-tetrahydro-fluoranthen-3-ylamine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With sodium amalgam; ethanol; acetic acid

Reference： [1]v. Braun; Manz [Justus Liebigs Annalen der Chemie, 1931, vol. 488, p. 111,115, 116][Justus Liebigs Annalen der Chemie, 1932, vol. 496, p. 170,191]

4
[ 892-21-7 ]
[ 2693-46-1 ]

Yield	Reaction Conditions	Operation in experiment
96%	With hydrazine hydrate In ethanol for 2h; Heating;
	With hydrogenchloride; acetic acid; tin(ll) chloride
	With ethanol; platinum Hydrogenation;

	(reduction);
	With calcium chloride; zinc In ethanol
	With Salmonella typhimurium TA₉₈ In various solvent(s) at 37℃;
	With hydrogen In methanol at 20℃; for 1h; chemoselective reaction;
	With palladium 10% on activated carbon; hydrogen In ethanol for 20h;

Reference： [1]Haeringen, C. J. van; Aten, N. F.; Cornelisse, J.; Lugtenburg, J. [Recueil des Travaux Chimiques des Pays-Bas, 1992, vol. 111, # 7/8, p. 335 - 344]
[2]v. Braun; Manz [Justus Liebigs Annalen der Chemie, 1931, vol. 488, p. 111,115, 116][Justus Liebigs Annalen der Chemie, 1932, vol. 496, p. 170,191]
[3]Kloetzel et al. [Journal of the American Chemical Society, 1956, vol. 78, p. 1165,1167]
[4]Buu-Hoi,N.P. et al. [Journal of the Chemical Society, 1964, p. 3920 - 3924]
[5]Burmistrov,S.I. et al. [Journal of Organic Chemistry USSR (English Translation), 1965, vol. 1, p. 909 - 911][Zhurnal Organicheskoi Khimii, 1965, vol. 1, # 5, p. 904 - 906]
[6]Ball, L. M.; Stocking, L. M.; Kohan, M. J.; Warren, S. H.; Lewtas, J. [Mutagenesis, 1995, vol. 10, # 6, p. 497 - 504]
[7]Location in patent: scheme or table Pandarus, Valerica; Ciriminna, Rosaria; Beland, Francois; Pagliaro, Mario [Advanced Synthesis and Catalysis, 2011, vol. 353, # 8, p. 1306 - 1316]
[8]Okazaki, Takao; Adachi, Taisuke; Kitagawa, Toshikazu [Bulletin of the Chemical Society of Japan, 2013, vol. 86, # 4, p. 464 - 471]

5
[ 19361-41-2 ]
[ 2693-46-1 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride

Reference： [1]Campbell et al. [Journal of the Chemical Society, 1951, p. 1404]

6
[ 2693-46-1 ]
[ 541-41-3 ]
ethyl fluoranthen-3-ylcarbamate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
98%	With potassium carbonate In tetrahydrofuran; water at 20℃; for 12h;
	With pyridine; benzene

Reference： [1]Zhang, Xuan; Si, Weili; Bao, Ming; Asao, Naoki; Yamamoto, Yoshinori; Jin, Tienan [Organic Letters, 2014, vol. 16, # 18, p. 4830 - 4833]
[2]Kloetzel et al. [Journal of the American Chemical Society, 1956, vol. 78, p. 1165,1167]

7
[ 2693-46-1 ]
[ 108-24-7 ]
N-fluoranthen-3-yl-diacetamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With sulfuric acid

Reference： [1]Kloetzel et al. [Journal of the American Chemical Society, 1956, vol. 78, p. 1165,1167]

8
[ 2693-46-1 ]
[ 135-19-3 ]
[ 95952-91-3 ]

Yield	Reaction Conditions	Operation in experiment
	With iodine at 200 - 220℃;

Reference： [1]Buu-Hoi,N.P. et al. [Journal of the Chemical Society, 1964, p. 3920 - 3924]

9
[ 108-31-6 ]
[ 2693-46-1 ]
[ 60354-77-0 ]

Yield	Reaction Conditions	Operation in experiment
98%	With acetic acid for 2.5h;

Reference： [1]Reddy, Paidi Yella; Kondo, Satoru; Fujita, Satoshi; Toru, Takeshi [Synthesis, 1998, # 7, p. 999 - 1002]

10
[ 108-30-5 ]
[ 2693-46-1 ]
N-(3-fluoranthene)succinamic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In pyridine for 24h; Ambient temperature;

Reference： [1]Li, Kai; Chen, Rongliang; Zhao, Bitao; Liu, Mei; Karu, Alexander E.; Roberts, Victoria A.; Li, Qing X. [Analytical Chemistry, 1999, vol. 71, # 2, p. 302 - 309]

11
[ 356-42-3 ]
[ 2693-46-1 ]
C₁₆H₁₁N*C₆F₁₀O₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In ethyl acetate at 20℃; for 0.5h;

Reference： [1]Zwirner-Baier, Iris; Neumann, Hans-Guenter [Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 1999, vol. 441, # 1, p. 135 - 144]

12
[ 50-00-0 ]
[ 2693-46-1 ]
fluoranthen-3-yl-dimethyl-amine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
65 mg	With formic acid for 12h; Heating;

Reference： [1]Bucholtz, Ehren C.; Brown, Randal L.; Tropsha, Alexander; Booth, Raymond G.; Wyrick, Steven D. [Journal of Medicinal Chemistry, 1999, vol. 42, # 16, p. 3041 - 3054]

13
2,5-bis-[4-(5-oxo-2-trifluoromethyl-4,5-dihydro-oxazol-4-yl)-phenoxymethyl]-benzoyl chloride [ No CAS ]
[ 2693-46-1 ]
N-fluoranthen-3-yl-2,5-bis-[4-(5-oxo-2-trifluoromethyl-4,5-dihydro-oxazol-4-yl)-phenoxymethyl]-benzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In dichloromethane at 4℃;

Reference： [1]Chen, Yen Ting; Seto, Christopher T. [Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 12, p. 3289 - 3298]

14
[ 2693-46-1 ]
[ 55431-45-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: H₂SO₄ 2: aq. H₂SO₄ / 280 °C

Reference： [1]Shenbor,M.I.; Gudz',L.A. [Journal of Organic Chemistry USSR (English Translation), 1975, vol. 11, p. 2401 - 2404][Zhurnal Organicheskoi Khimii, 1975, vol. 11, # 11, p. 2356 - 2360]

15
[ 2693-46-1 ]
[ 55431-46-4 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: H₂SO₄ 2: aq. H₂SO₄ / 280 °C 3: OH^-

16
[ 2693-46-1 ]
[ 60354-76-9 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 98 percent / AcOH / 2.5 h 2: 86 percent / ZnBr₂, HMDS / benzene / 1.5 h / Heating

Reference： [1]Reddy, Paidi Yella; Kondo, Satoru; Fujita, Satoshi; Toru, Takeshi [Synthesis, 1998, # 7, p. 999 - 1002]

17
[ 206-44-0 ]
[ 2693-46-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 20 percent / ammonium nitrate, trifluoroacetic anhydride / acetonitrile / 3 h / Ambient temperature 2: 96 percent / hydrazine monohydrate / Raney Ni / ethanol / 2 h / Heating
	Multi-step reaction with 2 steps 1: aqueous HNO₃; glacial acetic acid 2: tin (II)-chloride; acetic acid; aqueous hydrochloric acid
	Multi-step reaction with 2 steps 1: aqueous HNO₃; glacial acetic acid 2: platinum; ethanol / Hydrogenation

	Multi-step reaction with 2 steps 1: HNO₃, H₂SO₄ / acetic acid 2: aq. CaCl₂, Zn / ethanol
	Multi-step reaction with 2 steps 1: nitric acid / dichloromethane; water / 2 h 2: hydrogen; palladium 10% on activated carbon / ethanol / 20 h

18
[ 2693-46-1 ]
1,4-dihydro-2H-indeno[2,1-f]quinoline-3,11-dione [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: aqueous ethanol; sodium-amalgam; acetic acid 3: sodium dichromate; water; acetic acid / und Erwaermen des Reaktionsprodukts mit aethanol. Alkalilauge

Reference： [1]v. Braun; Manz [Justus Liebigs Annalen der Chemie, 1931, vol. 488, p. 111,115, 116][Justus Liebigs Annalen der Chemie, 1932, vol. 496, p. 170,191]

19
[ 2693-46-1 ]
[ 35324-28-8 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: aqueous HCl / 230 °C 2: diluted aqueous alkaline solution; sodium-amalgam

Reference： [1]v. Braun; Manz [Justus Liebigs Annalen der Chemie, 1931, vol. 488, p. 111,115, 116][Justus Liebigs Annalen der Chemie, 1932, vol. 496, p. 170,191]

20
[ 2693-46-1 ]
N-(4,5,6,6a-tetrahydro-fluoranthen-3-yl)-acetamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: aqueous ethanol; sodium-amalgam; acetic acid

Reference： [1]v. Braun; Manz [Justus Liebigs Annalen der Chemie, 1931, vol. 488, p. 111,115, 116][Justus Liebigs Annalen der Chemie, 1932, vol. 496, p. 170,191]

21
[ 2693-46-1 ]
[ 102084-82-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: I₂ / 200 - 220 °C 2: AsCl₃ / 1,2-dichloro-benzene / 0.5 h / Heating

Reference： [1]Buu-Hoi,N.P. et al. [Journal of the Chemical Society, 1964, p. 3920 - 3924]

22
[ 2693-46-1 ]
[ 92167-38-9 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: (i) aq. HCl, (ii) aq. NaNO₂, (iii) CuCl, aq. HCl 2: Na₂Cr₂O₇, H₂SO₄ / acetic acid

Reference： [1]Sieglitz,A.; Troester,H. [Chemische Berichte, 1963, vol. 96, p. 2577 - 2594]

23
[ 2693-46-1 ]
[ 81-16-3 ]
C₂₆H₁₅N₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
51%		3-Aminofluoranthene, 10.85 g, 49.94 [MMOL,] is suspended in water, 50 ml, and HCI, 12 M, 10 [ML,] 0.12 mol, at [0C.] Sodium nitrite, 3.50 g, 50.7 [MMOL,] in water, 10 mi, is added dropwise over 15 minutes. After 30 minutes at [0C,] the red-brown solution is filtered. Tobias acid (2- [NAPHTHYLAMINE-1-SULFONIC] acid), 11.15 g, 49.96 [MMOL,] is dissolved in pyridine, 50 ml, and cooled to [0C.] The diazonium salt solution is then added dropwise over 30 minutes at [0C.] After 2 hours, the suspension is filtered, washed with water and dried in vacuo to give a purple-red solid. The material, 15.6 g, 42.0 [MMOL,] is heated in pyridine, 250 ml, to [60C] in a 1 I reactor. Copper [(IL)] sulfate pentahydrate, 26.4 g, 0.105 mol, in water, 100 mi, is added dropwise to the azo compound. The temperature is then raised to [90C] for 4 hours. The mixture is cooled to room temperature and filtered to give a pale brown solid. The compound is purified by crystallization. Yield, 7.9 g, 21.4 mmol, [51%. TM = 155C.] MS [(APCI)] : 370.1 (M+1). The material has a [XMAE] eMAHsion of 478 nm in solution.

Reference： [1]Patent: WO2003/105538,2003,A1 .Location in patent: Page 50

24
[ 2693-46-1 ]
[ 90-02-8 ]
2-((fluoranthen-3-ylimino)methyl)phenol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
45%	With acetic acid In ethanol at 20℃; for 2h;

Reference： [1]You, Youngmin; Huh, Hyun Sue; Kim, Kil Suk; Lee, Soon W.; Kim, Dongho; Park, Soo Young [Chemical Communications, 2008, # 34, p. 3998 - 4000]

25
[ 2693-46-1 ]
[ 92866-01-8 ]

Yield	Reaction Conditions	Operation in experiment
87.1%	With N-Bromosuccinimide In N,N-dimethyl-formamide at 0 - 20℃; for 1h; Inert atmosphere; Darkness;	1.1 (Example 1) Synthesis of Exemplified Compounds D1 and D2; Exemplified Compounds D1 and D2 were synthesized according to a synthesis method to be described below.; (1) Synthesis of Intermediate Compound M1; Under an argon atmosphere, the following reagent and solvent were loaded into a 2-L four-necked flask. 3-Aminofluoranthene:45.4 g (209 mmol) DMF:910 mL Next, the reaction solution was cooled to 0°C with an ice bath in a state where the inside of the reaction system was shielded from light. Next, NBS (37.2 g, 209 mmol) was added to the reaction solution. After that, the ice bath was removed, and then the temperature of the reaction solution was returned to room temperature. Next, the reaction solution was stirred at room temperature for 1 hour. Next, a crystal (yellowish green crystal) precipitated at the time of the injection of the reaction solution into 2 L of ice water was taken by filtration. Next, the crystal taken by filtration was dissolved in 4 L of ethyl acetate, and then the solution was sequentially passed through 50 g of magnesium sulfate and 500 g of Florisil so that the raw material substance was removed. Next, a slurry-like substance produced at the time of the concentration of the filtrate under reduced pressure was filtered. Thus, a crystal was obtained. Next, the resultant crystal was dried under reduced pressure. Thus, 54.0 g of 2-bromofluoranthene-3-amine were obtained (yield: 87.1%).
83%	With N-Bromosuccinimide In N,N-dimethyl-formamide at 20℃; for 4h;	1 Synthesis of Exemplary Compound A12; 5.08 g (29 mmol) of N-bromosuccinimide (NBS) was added to 5.9 g (27 mmol) of Y1 in 250 ml of N,N-dimethylformamide at room temperature. After agitation for four hours, 100 ml of toluene and 250 ml of water were added to the solution, which was then extracted with toluene. The extract was washed twice with 100 ml each of water. After the organic phase was dried over magnesium sulfate, the solution was filtered. The filtrate was concentrated and recrystallized in toluene, yielding 6.6 g (yield = 83%) of a brown solid Y2.
60%	With N-Bromosuccinimide In N,N-dimethyl-formamide at 0 - 20℃;	1 [0099] First, 10.5 g (48 mmol) of fluoranthene-3-amine (El) was mixed in 300 mL of dimethylformamide at 00C, and 8.2 g (48 mmol) of N-bromosuccinimide was added to the mixture. The temperature of the reaction mixture was returned to the room temperature, and the mixture was stirred for eight hours. The mixture was poured into water, and the precipitate was filtered and then recrystallized with ethanol . After the crystals were filtered, the crystals were washed with heptane, and then dried. As a result, 29 g of a brown solid E2 was obtained (yield: 60%) .

60%	With N-Bromosuccinimide In N,N-dimethyl-formamide at 0 - 20℃;	1 EXAMPLE 1 In 300 ml of dimethylformamide, 10.5 g (48 mmol) of fluoranthene-3-amine (E1) was mixed at 0°C, 8.2 g (48 mmol) of N-bromosuccimide was added thereto, and the resulting mixture was returned to room temperature and stirred for 8 hours. The mixture was discharged into water, precipitates were filtered, and recrystallization was conducted in ethanol. Crystals are filtered, washed with heptane, and dried. As a result, 29 g (yield: 60%) of dark brown solid E2 was obtained.
60%	With N-Bromosuccinimide In N,N-dimethyl-formamide at 0 - 20℃;	1 0088] First, 10.5 g (48 mmol) of fluoranthene-3-amine (E1) was mixed with 300 mL of dimethylformamide at 0 degrees (Celsius). Next, 8.2 g (48 mmol) of N-bromosuccinimide was added to the mixture. The temperature was returned to room temperature, and the reaction mixture was stirred for eight hours. The reaction mixture was poured into water, and a precipitate was filtered. The precipitate was then recrystallized with ethanol. The resulting crystals were filtered, washed with heptane, and then dried. Thus, 29 g of a brown solid E2 was obtained (yield: 60%). Subsequently, 10 g (34 mmol) of E2 was put in a 500-mL round-bottom flask, and the inside of the reaction system was replaced with argon. Next, 150 mL of methoxycyclopentane was put in the flask in an argon atmosphere, and the solution was cooled to -75 degrees (Celsius). Next, 64 mL of a 1.6 M solution of n-butyllithium was added dropwise thereto. After the dropwise addition, the temperature of the reaction mixture was returned to room temperature, and stirring was conducted for one hour. Subsequently, the reaction mixture was again cooled to -75 degrees (Celsius), and 15 g of finely crushed dry ice was added to the mixture. The temperature of the reaction mixture was gradually returned to room temperature. After the temperature was returned to room temperature, stirring was conducted for eight hours, and 1 M hydrochloric acid was then added to the reaction mixture to terminate the reaction. Subsequently, extraction was conducted with ethyl acetate. The organic layer was concentrated to obtain a brown liquid. The liquid was purified by column chromatography (ethyl acetate/heptane = 1:3), and recrystallized with chloroform/methanol. Thus, 2.5 g of E3 was obtained in the form of a brown powder (yield: 28%).
60%	With N-Bromosuccinimide In N,N-dimethyl-formamide at 0 - 20℃; for 8h;	1 Example 1; [Synthesis of A110 and A110-2]; [0130] An isomer of example compound A110 is expressed as "A110-2" .[0131][Chem. 25][0132] First, 10.5 g (48 mmol) of fluoranthene-3-amine (El) was added to 300 ml of dimethylformamide at 0°C. Next, 8.2 g (48 mmol) of N-bromosuccinimide was added to the mixture. The temperature was returned to room temperature, and the mixture was stirred for eight hours. The resultant precipitate was filtered in water and then recrystallized with ethanol. The crystal was filtered, washed with heptane, and then dried. Thus, 29 g of brown solid E2 was obtained (yield: 60%) .

Reference： [1]Current Patent Assignee: CANON INC. - EP2530071, 2012, A1 Location in patent: Page/Page column 23-24
[2]Current Patent Assignee: CANON INC. - WO2011/102102, 2011, A1 Location in patent: Page/Page column 23
[3]Current Patent Assignee: CANON INC. - WO2010/123153, 2010, A1 Location in patent: Page/Page column 55; 56
[4]Current Patent Assignee: CANON INC. - EP2243761, 2010, A1 Location in patent: Page/Page column 21
[5]Current Patent Assignee: CANON INC. - WO2011/121935, 2011, A1 Location in patent: Page/Page column 18-19
[6]Current Patent Assignee: CANON INC. - WO2011/136155, 2011, A1 Location in patent: Page/Page column 34; 50

26
[ 2693-46-1 ]
[ 1329425-04-8 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 4 h / 20 °C 2.1: sulfuric acid / ethanol / 0.5 h / 0 °C 2.2: 1 h / 0 °C 2.3: 5 h / Reflux 3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 4 h / 90 °C