Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 230299-21-5 | MDL No. : | MFCD06246008 |
Formula : | C12H24B2O4 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | UEBSWKNVDRJVHN-UHFFFAOYSA-N |
M.W : | 253.94 | Pubchem ID : | 2734616 |
Synonyms : |
|
Num. heavy atoms : | 18 |
Num. arom. heavy atoms : | 0 |
Fraction Csp3 : | 1.0 |
Num. rotatable bonds : | 1 |
Num. H-bond acceptors : | 4.0 |
Num. H-bond donors : | 0.0 |
Molar Refractivity : | 73.61 |
TPSA : | 36.92 Ų |
GI absorption : | High |
BBB permeant : | Yes |
P-gp substrate : | No |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | Yes |
Log Kp (skin permeation) : | -6.0 cm/s |
Log Po/w (iLOGP) : | 0.0 |
Log Po/w (XLOGP3) : | 2.61 |
Log Po/w (WLOGP) : | 2.25 |
Log Po/w (MLOGP) : | 0.36 |
Log Po/w (SILICOS-IT) : | -0.24 |
Consensus Log Po/w : | 1.0 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 0.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -2.99 |
Solubility : | 0.258 mg/ml ; 0.00102 mol/l |
Class : | Soluble |
Log S (Ali) : | -3.03 |
Solubility : | 0.234 mg/ml ; 0.000923 mol/l |
Class : | Soluble |
Log S (SILICOS-IT) : | -2.43 |
Solubility : | 0.948 mg/ml ; 0.00373 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 1.0 alert |
Leadlikeness : | 0.0 |
Synthetic accessibility : | 4.26 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
98.6% | With tetrakis(dimethylamido)diborane In toluene at 20 - 100℃; for 1.25 h; | HEXYLENEGLYCOL (2-methyl-2,4-pentanediol) (FW: 118. 18. 12.0 g, 101. 6 mmol) in toluene (40 mL) was treated with tetrakis (dimethylamino) diboron (FW: 197.926 ; 9.9 g, 50 mmol) at room temperature and the reaction mixture stirred. The temperature was raised to 100 C within 10 minutes while the release of dimethylamine started to occur after about 5 minutes. The temperature was maintained at 100 C. for 60 minutes at which time for 30 minutes the evolution of dimethylamine occurred. Toluene was removed to give a solid (99.6percent pure by GC). The solid was recrystallised from toluene: petroleum (80 C-100 C) (1: 9) to give a colourless solid of bis (hexylene glycolato) diboron (MF: C12H24B204 ; FW : 253.94) : 8. 83 g, second crop: 3.69 g, combined yield 12.52 g, 98. 6percent; 99.6percent pure by GC. mp 99-101. 6 C. 8 (CDC13, 200 MHz) 1.21 (d, J= 7Hz, 6H); 1.28 (s, 12H); 1.47 (dd, J=12,14 Hz, 2H); 1.70 (dd, J=14,3 Hz; 2H) 4.14 (dm, 2H) ppm. 13C 8 (CDCL3, 50 MHz) 23.1 ; 28.3 ; 31.2 ; 46. 2 ; 64.1 ; 70.3 ppm. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
65% | With C25H36FeN2Si In toluene for 15 h; Inert atmosphere; Reflux | The first step: nitrogen protection, in the 5L reaction bottle, 0.4LBH3-Me2S (10M) and 2.0L dichloromethane, stirring evenly, the temperature to -10 to 0 deg C, slowly dropping 460g2-methyl -2,4-pentanediol (3.9 mol) was dissolved in 0.5 L of dichloromethane. Attention to control the process of dropping the bubble in the reactor, the exhaust gas then sodium hypochlorite solution absorption, the reaction process of the release of dimethyl sulfide absorption into dimethyl sulfoxide. After the completion of the dropwise addition, the reaction was stirred for 3-5 hours. When the GC reaction was not changed, the methylene chloride was distilled off at atmospheric pressure. After adding 3 g of 2,6-di-tert-butyl-4-methylphenol, the reaction temperature was raised Distillation gave 409 g of 2-methyl-2,4-pentanediol borane as a colorless oily liquid, GC: 98.0percent, yield 82percent.(R = Me), 55 g of cyclooctene and 550 mL of toluene were mixed under nitrogen atmosphere, and the temperature was maintained until the system was weakly refluxed. 128 g of 2-methyl-2,4-pentanedi Alcohol borane (1mol), drop finished, continue to reflux stirring reaction 15 hours. After the reaction was complete, the reaction mixture was cooled down, filtered through Celite, evaporated to dryness, and 220 mL of n-hexane solvent was added. The mixture was stirred at -10 ° C to -5 ° C for 1 to 2 hours and filtered to give 82.6 g of white crystalline bidentate -2,4-pentanediol, GC: 98.4percent, yield 65percent. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
98.6% | With tetrakis(dimethylamido)diborane; In toluene; at 20 - 100℃; for 1.25h; | HEXYLENEGLYCOL (2-methyl-2,4-pentanediol) (FW: 118. 18. 12.0 g, 101. 6 mmol) in toluene (40 mL) was treated with tetrakis (dimethylamino) diboron (FW: 197.926 ; 9.9 g, 50 mmol) at room temperature and the reaction mixture stirred. The temperature was raised to 100 C within 10 minutes while the release of dimethylamine started to occur after about 5 minutes. The temperature was maintained at 100 C. for 60 minutes at which time for 30 minutes the evolution of dimethylamine occurred. Toluene was removed to give a solid (99.6percent pure by GC). The solid was recrystallised from toluene: petroleum (80 C-100 C) (1: 9) to give a colourless solid of bis (hexylene glycolato) diboron (MF: C12H24B204 ; FW : 253.94) : 8. 83 g, second crop: 3.69 g, combined yield 12.52 g, 98. 6percent; 99.6percent pure by GC. mp 99-101. 6 C. 8 (CDC13, 200 MHz) 1.21 (d, J= 7Hz, 6H); 1.28 (s, 12H); 1.47 (dd, J=12,14 Hz, 2H); 1.70 (dd, J=14,3 Hz; 2H) 4.14 (dm, 2H) ppm. 13C 8 (CDCL3, 50 MHz) 23.1 ; 28.3 ; 31.2 ; 46. 2 ; 64.1 ; 70.3 ppm. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
71% | Example 16 4,4,4',4',6,6'-Hexamethyl-2,2'-bi-1,3,2-dioxaborinane This diboronic ester is prepared following general procedure A using 2-methyl-2,4-pentanediol. Yield, 71percent. 1H-nmr (CDCl3, 200 MHz): delta 1.18-1.32 (multiplet, 18H; 6*CH3), 1.44-1.56 (multiplet, 2H; 2*HCHC), 1.69-1.78 (multiplet, 2H; 2*HCHC) and 4.07-4.22 (multiplet, 2H; 2*OCH). F.W.: calc. for C12H24B2O4=253.94, found m/z 255 (M+1). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
83% | With bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; at 60℃; for 12h; | General procedure: A solution of triarylantimony diacetate (1: 0.5mmol), tetra(alkoxo)diboron (11: 1.5mmol), and dichlorobis(triphenylphosphine)palladium (II) (0.005mmol) in DME (5mL) was stirred at 60 °C for 12h under air atmosphere. After dilution with CH2Cl2 (30mL) and water (20mL), the reaction mixture was separated and the aqueous layer was extracted with CH2Cl2 (30mL×2). The combined organic layer was washed with brine, dried over anhydrous MgSO4 and concentrated under reduced pressure. The residue was purified by column chromatograph on silica gel to give arylboronates (12, 14?23). The products were confirmed by comparison of NMR data and MS spectra with that in the literature. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
93% | With (2,2,2-trifluoroethoxy)trimethylsilane; cesium fluoride; dichlorobis(trimethylphosphine)nickel; In tetrahydrofuran; at 100℃; for 2h;Inert atmosphere; Sealed tube; | Under an argon atmosphere,To the reaction vessel, 7.0 mg (0.025 mmol) of dichlorobis (trimethylphosphine) nickel,70.2 mg (0.5 mmol) of 4-chloroanisole,152 mg (1.0 mmol) of cesium fluoride,4,4,6,4 ', 4', 6'-hexamethyl-2,2'-bi (1,3,2-dioxaborolinalyl)140 mg (0.55 mmol),180 mg (1.05 mmol) of trimethyl (2,2,2-trifluoroethoxy) silane and 0.5 mL of tetrahydrofuran were added and sealed,Followed by stirring at 100 ° C. for 2 hours.After the reaction vessel was cooled to room temperature, 1 mL of a saturated aqueous solution of ammonium chloride was added, and the mixture was extracted three times with 8 mL of ethyl acetate, and the obtained organic phases were combined.The solvent was distilled off under reduced pressure, and the residue was purified using silica gel column chromatography (hexane: chloroform: ethyl acetate = 16: 4: 0 to 16: 4: 1)107 mg (colorless liquid, yield 93percent) of 2- (4-methoxyphenyl) -4,4,6-trimethyl-1,3,2-dioxaborinan was obtained. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
65% | With C25H36FeN2Si; In toluene; for 15h;Inert atmosphere; Reflux; | The first step: nitrogen protection, in the 5L reaction bottle, 0.4LBH3-Me2S (10M) and 2.0L dichloromethane, stirring evenly, the temperature to -10 to 0 deg C, slowly dropping 460g2-methyl -2,4-pentanediol (3.9 mol) was dissolved in 0.5 L of dichloromethane. Attention to control the process of dropping the bubble in the reactor, the exhaust gas then sodium hypochlorite solution absorption, the reaction process of the release of dimethyl sulfide absorption into dimethyl sulfoxide. After the completion of the dropwise addition, the reaction was stirred for 3-5 hours. When the GC reaction was not changed, the methylene chloride was distilled off at atmospheric pressure. After adding 3 g of 2,6-di-tert-butyl-4-methylphenol, the reaction temperature was raised Distillation gave 409 g of 2-methyl-2,4-pentanediol borane as a colorless oily liquid, GC: 98.0percent, yield 82percent.(R = Me), 55 g of cyclooctene and 550 mL of toluene were mixed under nitrogen atmosphere, and the temperature was maintained until the system was weakly refluxed. 128 g of 2-methyl-2,4-pentanedi Alcohol borane (1mol), drop finished, continue to reflux stirring reaction 15 hours. After the reaction was complete, the reaction mixture was cooled down, filtered through Celite, evaporated to dryness, and 220 mL of n-hexane solvent was added. The mixture was stirred at -10 ° C to -5 ° C for 1 to 2 hours and filtered to give 82.6 g of white crystalline bidentate -2,4-pentanediol, GC: 98.4percent, yield 65percent. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
32% | With 4,4'-bipyridine; In tetrahydrofuran; at 60℃; for 14h;Inert atmosphere; Sealed tube; | Reaction of 7a: In a glove box, a glass tube having PTFE stopcock (J. Young),equipped with a magnetic stirring bar, was charged with 9e (1.5 mg, 0.010 mmol), 11 (58 mg,0.22 mmol), THF (0.4 mL), and 7a (29 mg, 0.20 mmol). The tube was sealed by the stopcockand was taken out from the glove box. The mixture was heated at 60 °C with stirring for 14 h.After cooling to room temperature, the volatiles were removed from the reaction mixture underreduced pressure. The residue was purified by column chromatography on silica gel(CHROMATOREX DIOL, eluent: hexane:CHCl3 = 7:1) to afford (E)-12a (27 mg, 32percent) as awhite solid. Geometry of the carbon?carbon double bond was assigned on the analogy of that of (E)-8a. Dimethyl 2,3-bis(4,4,6-trimethyl-1,3,2-dioxaborinan-2-yl)fumarate [(E)-12a] 1H NMR (400 MHz, CDCl3) delta 4.20-4.34 (m, 2H), 3.75 (s, 6H), 1.65-1.80 (m, 4H), 1.34 (s, 6H),1.27 (s, 6H), 1.23 (d, J = 6.0 Hz, 6H). 13C NMR (101 MHz, CDCl3) delta 169.4, 71.4, 65.4, 52.3,45.7, 31.2, 27.61 (either meso or racemate), 27.59 (either meso or racamate), 23.1. The boron-bound carbon was not detected due to quadrupolar relaxation. 11B NMR (128 MHz,CDCl3) delta 25.1. HRMS (APCI, positive) m/z calcd for C18H31B2O8+ [M + H]+: 397.2200, found:397.2190. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
63% | With 4,4'-bipyridine; In tetrahydrofuran; at 60℃; for 14h;Inert atmosphere; Sealed tube; | In a glove box, a glass tube having PTFE stopcock (J. Young),equipped with a magnetic stirring bar, was charged with 9e (1.7 mg, 0.010 mmol), 11 (58 mg,0.23 mmol), THF (0.2 mL), and 7a (34 mg, 0.20 mmol). The tube was sealed by the stopcock and was taken out from the glove box. The mixture was heated at 60 °C with stirring for 14 h.After cooling to room temperature, the volatiles were removed from the reaction mixture under reduced pressure. The residue was purified by column chromatography on silica gel(CHROMATOREX DIOL, eluent: hexane:CHCl3 = 5:1) to afford (E)-12b (54 mg, 63percent) as awhite solid. Geometry of the carbon?carbon double bond was assigned on the analogy of that of (E)-8a. Diethyl 2,3-bis(4,4,6-trimethyl-1,3,2-dioxaborinan-2-yl)fumarate [(E)-12b]1H NMR (400 MHz, CDCl3) delta 4.11-4.32 (m, 6H), 1.62-1.79 (m, 4H), 1.34 (s, 6H), 1.27 (t, J =6.8 Hz, 6H), 1.26 (s, 6H), 1.22 (d, J = 6.4 Hz, 6H). 13C NMR (101 MHz, CDCl3) delta 168.9, 150.3(broad, C?B), 71.2, 65.3, 61.0, 45.8, 31.2, 27.54 (either meso or racemate), 27.52 (either mesoor racemate), 23.1, 14.2. 11B NMR (128 MHz, CDCl3) delta 26.1. HRMS (ESI, positive) m/z calcdfor C20H34B2O8Na+ [M + Na]+: 447.2332, found: 447.2332. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
General procedure: The reaction formula of this embodiment is as follows: 1) Under air, IMesCuCl (3 molpercent),Potassium carbonate (1.1 eq), bis(pinacolato)diboron (1 eq) was added to a pressure-resistant sealed reaction tube containing a magnetic particle. After filling with acetylene,3 mL of tetrahydrofuran was added to the reaction tube.Stir at room temperature for 20 minutes,Then add triisopropylsilyl bromoacetylene (0.25 mmol) to the reaction solution,The reaction was stirred in a 30 ° C oil bath for 12 hours.(2) The material obtained in the step (1) is cooled to room temperature, and thoroughly mixed with ethyl acetate. After filtering off the solid residue with a short silica gel column, the organic phase was retained.(3) spinning the solvent in the organic phase obtained in the step (2) to obtain a crude product.The crude product was then purified on a silica gel column. The eluent is a mixed solution of petroleum ether and ethyl acetate.And the ratio of petroleum ether to ethyl acetate is 50:1. The isolated yield was 78percent.The product was 99percent pure. The prepared product was subjected to structural characterization, and the results are shown in Table 1. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
86% | With copper(II) propionate; In tetrahydrofuran; at 0℃; for 48.5h;Inert atmosphere; Large scale; | Add in a 20 liter reactor(R)-2-methyl-N-(3-methylbutylidene)propane-2-sulfinamide 1.89 kg (10 mol),Then add 4 liters of t-butyl methyl ether, stir and mix.In a nitrogen-protected atmosphere,Join separatelyNeopentyl glycol diborate2.72 kg (12 mol),30 minutesAdd 329 multiple times internallyCopper trifluorosulfonate(1mol),Plus,The reaction solution was allowed to react at room temperature for 18 hours.TLC monitors the progress of the reaction,After the reaction is completed,2 liters of ethyl acetate dispersion reaction solution was added, and then washed with 3 liters of 1 N NaHCO 3 aqueous solution.Upper levelThe organic phase was washed three times with saturated brine.Discard the water and discard it,The organic phase was stirred and dried with 200 g of anhydrous sodium sulfate for at least 2 hours.The organic phase is concentrated under reduced pressure to obtain a compoundR-N-(R-tert-butylsulfinyl)-1-amino-3-methylbutane-1-boronic acid neopentyl glycol ester (2.66 kg,Yield 88percent,De value > 98: 2). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
81% | With (tBuPNN)CoCl2; In tetrahydrofuran; diethyl ether; at 25℃; under 11251.1 Torr; for 9h;Autoclave; | General procedure: In a N2 filled glovebox, NaBHEt3 (5 muL, 1M in THF, 5 mumol, 0.02 mol%) was added to a mixture of diboron compound (25 mmol) and complex 1 (1.1 mg, 2.5 mumol, 0.01 mol%) in Et2O (10 mL) at 25 C in a 100 mL tube equipped with a magnetic stir bar. After the mixture was stirred for minutes, the color was changed from colorless to purple. The reaction tube was then placed in an autoclave. The autoclave was closed, purged three times with hydrogen (less than the pressure needed). The reaction mixture was stirred at 25 C under H2 atmosphere (15 bar) for 9 h. After part of hydrogen was released, the autoclave was opened in a N2 filled glovebox. The reaction mixture was transferred to a 100 mL flask equipped with a magnetic stir bar. The Et2O solvent was removed via distillation under 1 atm of argon and the desired hydroborane was obtained by vacuum transfer as a clear, colorless liquid into an oven-dried, 50mL flask. |
Tags: 230299-21-5 synthesis path| 230299-21-5 SDS| 230299-21-5 COA| 230299-21-5 purity| 230299-21-5 application| 230299-21-5 NMR| 230299-21-5 COA| 230299-21-5 structure
[ 73183-34-3 ]
4,4,4',4',5,5,5',5'-Octamethyl-2,2'-bi(1,3,2-dioxaborolane)
Similarity: 0.81
[ 201733-56-4 ]
5,5,5',5'-Tetramethyl-2,2'-bi(1,3,2-dioxaborinane)
Similarity: 0.72
[ 1195-66-0 ]
2-Methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Similarity: 0.54
[ 61676-62-8 ]
2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Similarity: 0.54
[ 201733-56-4 ]
5,5,5',5'-Tetramethyl-2,2'-bi(1,3,2-dioxaborinane)
Similarity: 0.72
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
Home
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :