* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Stage #1: With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium In tert-butyl methyl ether; cyclohexane at 6 - 10℃; Stage #2: at 20℃; for 14 h; Stage #3: at 10 - 20℃; for 5.16667 h;
Example 2A Preparation of 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene, Xantphos To a 5L round bottom flask (RBF) are added MTBE (2.5 L), 9,9-dimethylxanthene (131.4 g, 0.60 mole) and TMEDA (155 g, 1.32 mole). After degassing the solution, s-BuLi (1.11 L, 1.3 M in cyclohexane, 1.44 mole) is cannulated into a dropping funnel and then slowly added over 60 min while maintaining the batch temperature at 6-10° C. The mixture is then aged for 14 h at room temperature. Ph2PCl is added slowly via a dropping funnel while maintain the mildly exothermic reaction at 10-20° C. ~60percent of the Ph2PCl (175 mL, 0.93 mole) is added in 0.5 hour. The mixture is aged for 10 minutes before addition of the remaining Ph2PCl (120 mL, 0.63 mole). After aged for 5 h at room temperature, the reaction is quenched with MeOH (9.9 mL, 0.24 mole). The product is filtered and the slightly yellow solid is washed consecutively with MTBE (250 mL), MeOH (2*250 mL), water (2*300 mL), MeOH (2*250 mL) and MTBE (250 mL) and dried to give an off-white solid as product (304.2 g, 88percent yield).
77%
Stage #1: With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium In tert-butyl methyl ether; cyclohexane at 10 - 20℃; for 16 h; Stage #2: at 20℃; for 5.75 h;
Example 2 Preparation of 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene, Xantphos To a 1L round bottom flask (RBF) are added MTBE (500 mL), 9,9-dimethylxanthene (26.65 g) and TMEDA (30.6 g). After degassing the solution, s-BuLi (155 g, 1.3 M in cyclohexane) is cannulated into a dropping funnel and then slowly added over 30 min while maintaining the batch temperature at 10-20° C. The mixture is then aged for 16 h at room temperature. Ph2PCl is added slowly via a dropping funnel while maintain the mildly exothermic reaction at 10-20° C. ~60percent of the Ph2PCl (30 mL) is added in 0.5 hour. The mixture is aged for 15 minutes before addition of the remaining Ph2PCl. After aged for 5.5 h at room temperature, the reaction is quenched with MeOH (2.0 mL). The product is filtered and the slightly yellow solid is washed consecutively with MeOH (200 mL), water (200 mL), MeOH (200 mL) and MTBE (200 mL) and dried to give an off-white solid as product (54.8 g, 77percent yield).
<i>N</i>-{5-[(3-dimethylamino-propylimino)-methyl]-9,9-dimethyl-9<i>H</i>-xanthen-4-ylmethylene}-<i>N</i>',<i>N</i>'-dimethyl-propane-1,3-diamine[ No CAS ]
<i>N</i>-{5-[(3-dimethylamino-propylamino)-methyl]-9,9-dimethyl-9<i>H</i>-xanthen-4-ylmethyl}-<i>N</i>',<i>N</i>'-dimethyl-propane-1,3-diamine[ No CAS ]
To a 1L RBF are added MTBE (500 mL), <strong>[19814-75-6]9,9-dimethylxanthene</strong> (26.65 g) and TMEDA (30.6 g). After degassing the solution, s-BuLi (155 g, 1.3 M in cyclohexane) is cannulated into a dropping funnel and then slowly added over 30 min while maintaining the batch temperature at 10-20 C. The mixture is then aged for 16 h at room temperature. Ph2PCl is added slowly via a dropping funnel while maintain the mildly exothermic reaction at 10-20 C. [0225] Approximately 60% of the Ph2PCl (30mL) is added in 0.5 hour. The mixture is aged for 15 minutes before addition of the remaining Ph2PCl. After aged for 5.5 h at room temperature, the reaction is quenched with MeOH (2.0 mL). The product is filtered and the slightly yellow solid is washed consecutively with MeOH (200 mL), water (2000 mL), MeOH (200 mL) and MTBE (200 mL) and dried to give an off-white solid as product.
Chemistry
Pharmaceutical Intermediates
Inhibitors/Agonists
Material Science
For Research Only
110K+ Compounds
Competitive Price
1-2 Day Shipping
