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Pharmaceutical Intermediate
Blood Glucose Regulators
Lacosamide
Diethoxy-triphenylphosphane
Pharmaceutical Intermediate
Blood Glucose Regulators
Anticonvulsants
Lacosamide

[ CAS No. 18509-25-6 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

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Chemical Structure| 18509-25-6
Chemical Structure| 18509-25-6
Structure of 18509-25-6 * Storage: {[proInfo.prStorage]}
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Quality Control of [ 18509-25-6 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification
Alternatived Products of [ 18509-25-6 ]

Product Details of [ 18509-25-6 ]

CAS No. :18509-25-6 MDL No. :MFCD09033742
Formula : C22H25O2P Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 352.41 Pubchem ID :-
Synonyms :

Safety of [ 18509-25-6 ]

Signal Word:Danger Class:6.1
Precautionary Statements:P273-P280-P301+P310+P330-P302+P352-P305+P351+P338-P314 UN#:3464
Hazard Statements:H301-H317-H319-H373-H411 Packing Group:Ⅲ
GHS Pictogram:

Application In Synthesis of [ 18509-25-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 18509-25-6 ]

[ 18509-25-6 ] Synthesis Path-Downstream   1~9

  • 1
  • [ 628-37-5 ]
  • [ 603-35-0 ]
  • [ 18509-25-6 ]
YieldReaction ConditionsOperation in experiment
In dichloromethane
In toluene at 75℃; for 48h; Yield given;
In toluene at 70℃; for 48h;
Reference： [1]Denney,D.B. et al. [Tetrahedron Letters, 1968, p. 85 - 89] Robinson, Philip L.; Kelly, Jeffery W.; Evans, Slayton A. [Phosphorus and Sulfur and the Related Elements, 1986, vol. 26, p. 15 - 24]
[2]Denney,D.B. et al. [Journal of the American Chemical Society, 1969, vol. 91, p. 5243 - 5246]
[3]Robinson, Philip L.; Barry, Carey N.; Kelly, Jeffery W.; Evans, Slayton A. [Journal of the American Chemical Society, 1985, vol. 107, # 18, p. 5210 - 5219]
[4]Kelly,J.W.; Evans,S.A. [Journal of the American Chemical Society, 1986, vol. 108, p. 7681] Kuyl-Yeheskiely, E.; Dreef-Tromp, C. M.; Marel, G. A. van der; Boom, J. H. van [Recueil des Travaux Chimiques des Pays-Bas, 1989, vol. 108, # 9, p. 314 - 316]
  • 2
  • [ 76-09-5 ]
  • [ 18509-25-6 ]
  • [ 49595-63-3 ]
YieldReaction ConditionsOperation in experiment
In benzene-d6 at 60℃; for 24h;
In benzene-d6; toluene -78 deg C -> 25 deg C;
Reference： [1]Robinson, Philip L.; Barry, Carey N.; Kelly, Jeffery W.; Evans, Slayton A. [Journal of the American Chemical Society, 1985, vol. 107, # 18, p. 5210 - 5219]
[2]Kelly,J.W.; Evans,S.A. [Journal of the American Chemical Society, 1986, vol. 108, p. 7681]
  • 3
  • [ 629-11-8 ]
  • [ 18509-25-6 ]
  • [ 592-90-5 ]
  • [ 40868-73-3 ]
YieldReaction ConditionsOperation in experiment
50% In dichloromethane Heating; Yields of byproduct given;
1: 6 % Spectr. 2: 50 % Spectr. In dichloromethane Heating;
Reference： [1]Robinson, Philip L.; Barry, Carey N.; Kelly, Jeffery W.; Evans, Slayton A. [Journal of the American Chemical Society, 1985, vol. 107, # 18, p. 5210 - 5219]
[2]Robinson, Philip L.; Kelly, Jeffery W.; Evans, Slayton A. [Phosphorus and Sulfur and the Related Elements, 1986, vol. 26, p. 15 - 24]
  • 4
  • [ 31558-25-5 ]
  • [ 18509-25-6 ]
  • [ 1564-98-3 ]
YieldReaction ConditionsOperation in experiment
85% -78 deg C -> 25 deg C;
Reference： [1]Kelly,J.W.; Evans,S.A. [Journal of the American Chemical Society, 1986, vol. 108, p. 7681]
  • 5
  • [ 5396-58-7 ]
  • [ 18509-25-6 ]
  • [ 118831-85-9 ]
  • [ 791-28-6 ]
YieldReaction ConditionsOperation in experiment
In toluene for 6h; Ambient temperature; Title compound not separated from byproducts;
Reference： [1]Murray, William T.; Evans, Slayton A. [Journal of Organic Chemistry, 1989, vol. 54, # 10, p. 2440 - 2446]
  • 6
  • [ 34300-94-2 ]
  • [ 18509-25-6 ]
  • [ 55022-72-5 ]
  • 4-ethylthio-4-methylbutanol [ No CAS ]
YieldReaction ConditionsOperation in experiment
1: 56 % Spectr. 2: 44 % Spectr. In toluene at 25℃;
Reference： [1]Robinson, Philip L.; Kelly, Jeffery W.; Slayton, A. Evans [Phosphorus and Sulfur and the Related Elements, 1987, vol. 31, p. 59 - 70]
  • 7
  • [ 27489-62-9 ]
  • [ 86852-11-1 ]
  • [ 27514-07-4 ]
  • [ 116350-36-8 ]
Reference： [1]Journal of the American Chemical Society,1989,vol. 111,p. 1776 - 1781
  • 8
  • [ 64-17-5 ]
  • [ 603-35-0 ]
  • [ 18509-25-6 ]
YieldReaction ConditionsOperation in experiment
94% With di-isopropyl azodicarboxylate In tetrahydrofuran
71% Stage #1: triphenylphosphine With di-isopropyl azodicarboxylate In tetrahydrofuran at -30 - 20℃; for 1h; Inert atmosphere; Stage #2: ethanol In tetrahydrofuran at 20℃; for 1h; 40.D (D) To a cooled (-30 °C) solution of triphenylphosphine (80 g, 305.0 mmol) in THF (1 L) under nitrogen was added DIAD (61.7 g, 305.1 mmol) in dropwise fashion. After stirring at rt for 1 h, EtOH (28g, 607.8 mmol) was added and stirring was continued at rt for 1 h. The mixture was then concentrated under reduced pressure and the mixture was diluted with hexane (1 L). The resulting precipitate was filtered, and the filtrate was concentrated under reduced pressure to provide diethyl triphenylphosphonite (76 g, 71%) as a colorless oil. 31P NMR (C6D6) G -41.6.
71% Stage #1: triphenylphosphine With di-isopropyl azodicarboxylate In tetrahydrofuran at -30 - 20℃; for 1h; Inert atmosphere; Stage #2: ethanol In tetrahydrofuran at 20℃; for 1h; Inert atmosphere; 40.D (D) To a cooled (-30° C.) solution of triphenylphosphine (80 g, 305.0 mmol) in THF (1 L) under nitrogen was added DIAD (61.7 g, 305.1 mmol) in dropwise fashion. After stirring at rt for 1 h, EtOH (28 g, 607.8 mmol) was added and stirring was continued at rt for 1 h. The mixture was then concentrated under reduced pressure and the mixture was diluted with hexane (1 L). The resulting precipitate was filtered, and the filtrate was concentrated under reduced pressure to provide diethyl triphenylphosphonite (76 g, 71%) as a colorless oil. 31P NMR (C6D6) 6-41.6.
Reference： [1]Mathieu-Pelta, Isabel; Evans, Slayton A. [Journal of Organic Chemistry, 1994, vol. 59, # 8, p. 2234 - 2237]
[2]Current Patent Assignee: JOHNSON & JOHNSON INC - WO2016/57731, 2016, A1 Location in patent: Page/Page column 151-152
[3]Current Patent Assignee: JOHNSON & JOHNSON INC - US2017/290800, 2017, A1 Location in patent: Paragraph 0656
  • 9
  • [ 18509-25-6 ]
  • [ 504-63-2 ]
  • [ 503-30-0 ]
  • [ 111-35-3 ]
YieldReaction ConditionsOperation in experiment
In dichloromethane at 45℃; Yield given. Yields of byproduct given;
1: 3 % Spectr. 2: 97 % Spectr. In dichloromethane Heating;
Reference： [1]Robinson, Philip L.; Barry, Carey N.; Kelly, Jeffery W.; Evans, Slayton A. [Journal of the American Chemical Society, 1985, vol. 107, # 18, p. 5210 - 5219]
[2]Robinson, Philip L.; Kelly, Jeffery W.; Evans, Slayton A. [Phosphorus and Sulfur and the Related Elements, 1986, vol. 26, p. 15 - 24]

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