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With scandium tris(trifluoromethanesulfonate); In 1,2-dichloro-ethane; for 24.0h;Reflux;
Compound 2-3 (118.5 mg, 0.29 mmol)And scandium triflate (Sc (OTf) 3) (72.7 mg, 0.148 mmol)Was added to 1,2-dichloroethane (2.7 mL)(0.11 mL) was added to the mixture, and the mixture was refluxed for 24 hours.Saturated sodium hydrogencarbonate solution was added to the reaction solution,The aqueous layer was extracted with dichloromethane.The combined organic layers were washed with brine and dried over sodium sulfate.After removal of the organic solvent under vacuum, the residue was chromatographed with ODS (30% acetonitrile) to give jacseosidine as a pale yellow solid.The resulting jasothocidin was dried under vacuum at room temperature for 30 minutes.The yield was 65.6 mg (yield was 67.1%)