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[ CAS No. 153631-19-7 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
Chemical Structure| 153631-19-7
Chemical Structure| 153631-19-7
Structure of 153631-19-7 * Storage: {[proInfo.prStorage]}
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Product Details of [ 153631-19-7 ]

CAS No. :153631-19-7 MDL No. :MFCD01631071
Formula : C32H34N2O8 Boiling Point : -
Linear Structure Formula :- InChI Key :VFLOXJCZWDDILQ-NODMTMHWSA-N
M.W : 574.62 Pubchem ID :10438068
Synonyms :

Calculated chemistry of [ 153631-19-7 ]

Physicochemical Properties

Num. heavy atoms : 42
Num. arom. heavy atoms : 24
Fraction Csp3 : 0.31
Num. rotatable bonds : 10
Num. H-bond acceptors : 8.0
Num. H-bond donors : 2.0
Molar Refractivity : 155.02
TPSA : 121.24 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : No
P-gp substrate : Yes
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : Yes
CYP2D6 inhibitor : Yes
CYP3A4 inhibitor : Yes
Log Kp (skin permeation) : -7.53 cm/s

Lipophilicity

Log Po/w (iLOGP) : 4.23
Log Po/w (XLOGP3) : 3.21
Log Po/w (WLOGP) : 2.71
Log Po/w (MLOGP) : 1.38
Log Po/w (SILICOS-IT) : 4.25
Consensus Log Po/w : 3.15

Druglikeness

Lipinski : 1.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 0.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -5.19
Solubility : 0.00373 mg/ml ; 0.00000649 mol/l
Class : Moderately soluble
Log S (Ali) : -5.43
Solubility : 0.00214 mg/ml ; 0.00000373 mol/l
Class : Moderately soluble
Log S (SILICOS-IT) : -8.24
Solubility : 0.00000331 mg/ml ; 0.0000000057 mol/l
Class : Poorly soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 2.0
Synthetic accessibility : 5.57

Safety of [ 153631-19-7 ]

Signal Word:Warning Class:
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 UN#:
Hazard Statements:H315-H319 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 153631-19-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 153631-19-7 ]

[ 153631-19-7 ] Synthesis Path-Downstream   1~50

  • 1
  • [ 124482-92-4 ]
  • [ 153631-19-7 ]
  • [ 168611-18-5 ]
YieldReaction ConditionsOperation in experiment
75% With N-ethyl-N,N-diisopropylamine In tetrahydrofuran for 4.5h;
  • 3
  • [ 153631-18-6 ]
  • [ 153631-19-7 ]
YieldReaction ConditionsOperation in experiment
71% With potassium <i>tert</i>-butylate In dichloromethane for 1.5h; Ambient temperature;
  • 5
  • [ 102691-36-1 ]
  • [ 153631-19-7 ]
  • [ 168611-18-5 ]
YieldReaction ConditionsOperation in experiment
96% With N,N-diisopropylamine tetrazolide In dichloromethane Ambient temperature;
  • 6
  • [ 153631-19-7 ]
  • 3-tert-butylphenyl chlorothionoformate [ No CAS ]
  • [ 199581-44-7 ]
YieldReaction ConditionsOperation in experiment
With dmap In dichloromethane at 0 - 20℃; for 18h; Yield given;
  • 7
  • [ 108-24-7 ]
  • [ 153631-19-7 ]
  • Acetic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
100% With pyridine at 20℃;
With pyridine at 20℃;
  • 8
  • magnesium methanolate [ No CAS ]
  • [ 817623-11-3 ]
  • [ 153631-19-7 ]
YieldReaction ConditionsOperation in experiment
In N,N-dimethyl-formamide at 100℃; for 2.5h;
  • 9
  • [ 937-63-3 ]
  • [ 153631-19-7 ]
  • [ 719302-94-0 ]
YieldReaction ConditionsOperation in experiment
86% With dmap In acetonitrile at 20℃;
  • 10
  • [ 153631-19-7 ]
  • 1-{(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-methoxy-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: 86 percent / (N,N-dimethylamino)pyridine / acetonitrile / 20 °C 2: 10 percent / AIBN / benzene / Heating
  • 11
  • [ 153631-19-7 ]
  • [ 200067-01-2 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 7 steps 1.1: 86 percent / (N,N-dimethylamino)pyridine / acetonitrile / 20 °C 2.1: 45 percent / AIBN / benzene / Heating 3.1: NaIO4; OsO4 / H2O / 5 h / 20 °C 4.1: acetic acid / CH2Cl2; toluene / 35 °C / atmospheric pressure 5.1: 0.54 g / Cl3CCO2H / CH2Cl2 / 0.17 h / 20 °C 6.1: sodium cyanoborohydride; glacial acetic acid / 1.25 h / 5 - 20 °C 6.2: sodium cyanoborohydride / H2O / 1.25 h / 5 - 20 °C 7.1: 0.26 g / tetrabutylammonium fluoride / tetrahydrofuran / 0 °C
  • 12
  • [ 153631-19-7 ]
  • [ 719303-08-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: 86 percent / (N,N-dimethylamino)pyridine / acetonitrile / 20 °C 2: 45 percent / AIBN / benzene / Heating 3: NaIO4; OsO4 / H2O / 5 h / 20 °C 4: acetic acid / CH2Cl2; toluene / 35 °C / atmospheric pressure 5: 0.17 g / Cl3CCO2H / CH2Cl2 / 0.17 h / 20 °C
  • 13
  • [ 153631-19-7 ]
  • [ 719303-10-3 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: 86 percent / (N,N-dimethylamino)pyridine / acetonitrile / 20 °C 2: 45 percent / AIBN / benzene / Heating 3: NaIO4; OsO4 / H2O / 5 h / 20 °C 4: acetic acid / CH2Cl2; toluene / 35 °C / atmospheric pressure 5: 0.54 g / Cl3CCO2H / CH2Cl2 / 0.17 h / 20 °C
  • 14
  • [ 153631-19-7 ]
  • C39H50FN5O10Si [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1.1: 86 percent / (N,N-dimethylamino)pyridine / acetonitrile / 20 °C 2.1: 45 percent / AIBN / benzene / Heating 3.1: NaIO4; OsO4 / H2O / 5 h / 20 °C 4.1: acetic acid / CH2Cl2; toluene / 35 °C / atmospheric pressure 5.1: 0.54 g / Cl3CCO2H / CH2Cl2 / 0.17 h / 20 °C 6.1: sodium cyanoborohydride; glacial acetic acid / 1.25 h / 5 - 20 °C 6.2: sodium cyanoborohydride / H2O / 1.25 h / 5 - 20 °C
  • 15
  • [ 153631-19-7 ]
  • [ 719303-09-0 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1.1: 86 percent / (N,N-dimethylamino)pyridine / acetonitrile / 20 °C 2.1: 45 percent / AIBN / benzene / Heating 3.1: NaIO4; OsO4 / H2O / 5 h / 20 °C 4.1: acetic acid / CH2Cl2; toluene / 35 °C / atmospheric pressure 5.1: 0.17 g / Cl3CCO2H / CH2Cl2 / 0.17 h / 20 °C 6.1: sodium cyanoborohydride; glacial acetic acid / 1.25 h / 5 - 20 °C 6.2: sodium cyanoborohydride / H2O / 1.25 h / 5 - 20 °C
  • 16
  • [ 153631-19-7 ]
  • [ 719302-99-5 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 8 steps 1.1: 86 percent / (N,N-dimethylamino)pyridine / acetonitrile / 20 °C 2.1: 45 percent / AIBN / benzene / Heating 3.1: NaIO4; OsO4 / H2O / 5 h / 20 °C 4.1: acetic acid / CH2Cl2; toluene / 35 °C / atmospheric pressure 5.1: 0.54 g / Cl3CCO2H / CH2Cl2 / 0.17 h / 20 °C 6.1: sodium cyanoborohydride; glacial acetic acid / 1.25 h / 5 - 20 °C 6.2: sodium cyanoborohydride / H2O / 1.25 h / 5 - 20 °C 7.1: 0.26 g / tetrabutylammonium fluoride / tetrahydrofuran / 0 °C 8.1: 89 percent / (N,N-dimethylamino)pyridine; triethylamine; pyridine / CH2Cl2 / 20 °C
  • 17
  • [ 153631-19-7 ]
  • [ 198703-60-5 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: 86 percent / (N,N-dimethylamino)pyridine / acetonitrile / 20 °C 2: 45 percent / AIBN / benzene / Heating 3: NaIO4; OsO4 / H2O / 5 h / 20 °C
Multi-step reaction with 3 steps 1: DMAP / CH2Cl2 / 18 h / 0 - 20 °C 2: 1,1'-azobis(cyclohexanecarbonitrile) / chlorobenzene / 80 - 100 °C 3: OsO4, NaIO4 / H2O; dioxane
  • 18
  • [ 153631-19-7 ]
  • [ 318246-97-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: 86 percent / (N,N-dimethylamino)pyridine / acetonitrile / 20 °C 2: 45 percent / AIBN / benzene / Heating
Multi-step reaction with 2 steps 1: DMAP / CH2Cl2 / 18 h / 0 - 20 °C 2: 1,1'-azobis(cyclohexanecarbonitrile) / chlorobenzene / 80 - 100 °C
  • 19
  • [ 22423-26-3 ]
  • [ 153631-19-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: pyridine; DMAP / 20 °C 2: dimethylformamide / 2.5 h / 100 °C
  • 20
  • [ 40615-36-9 ]
  • [ 153631-19-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: pyridine; DMAP / 20 °C 2: dimethylformamide / 2.5 h / 100 °C
  • 21
  • [ 153631-19-7 ]
  • [ 606972-27-4 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: pyridine / 20 °C 2: 93 mg / trifluoroacetic acid / CH2Cl2 / 0.5 h / 20 °C
Multi-step reaction with 2 steps 1: pyridine / 20 °C 2: acetic acid / water / 20 °C
  • 22
  • [ 153631-19-7 ]
  • [ 606972-26-3 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1.1: pyridine / 20 °C 2.1: 93 mg / trifluoroacetic acid / CH2Cl2 / 0.5 h / 20 °C 3.1: tetrazole / acetonitrile / 0.5 h / 20 °C 4.1: iodine; 2,6-lutidine / acetonitrile; tetrahydrofuran; H2O / 0.33 h / 20 °C 5.1: NH3 / methanol; H2O / 20 °C 5.2: 8 mg / acetic acid / H2O / 6 h / 20 °C
  • 23
  • [ 153631-19-7 ]
  • C22H31N4O14P [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1.1: pyridine / 20 °C 2.1: 93 mg / trifluoroacetic acid / CH2Cl2 / 0.5 h / 20 °C 3.1: tetrazole / acetonitrile / 0.5 h / 20 °C 4.1: iodine; 2,6-lutidine / acetonitrile; tetrahydrofuran; H2O / 0.33 h / 20 °C 5.1: NH3 / methanol; H2O / 20 °C 5.2: 8 mg / acetic acid / H2O / 6 h / 20 °C 6.1: D2O / 7.5 h / UV-irradiation
  • 24
  • [ 153631-19-7 ]
  • C22H31N4O14P [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1.1: pyridine / 20 °C 2.1: 93 mg / trifluoroacetic acid / CH2Cl2 / 0.5 h / 20 °C 3.1: tetrazole / acetonitrile / 0.5 h / 20 °C 4.1: iodine; 2,6-lutidine / acetonitrile; tetrahydrofuran; H2O / 0.33 h / 20 °C 5.1: NH3 / methanol; H2O / 20 °C 5.2: 8 mg / acetic acid / H2O / 6 h / 20 °C 6.1: D2O / 7.5 h / UV-irradiation
  • 25
  • [ 153631-19-7 ]
  • C48H54N5O16P [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: pyridine / 20 °C 2: 93 mg / trifluoroacetic acid / CH2Cl2 / 0.5 h / 20 °C 3: tetrazole / acetonitrile / 0.5 h / 20 °C
  • 26
  • [ 153631-19-7 ]
  • [ 1055036-95-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: pyridine / 20 °C 2: 93 mg / trifluoroacetic acid / CH2Cl2 / 0.5 h / 20 °C 3: tetrazole / acetonitrile / 0.5 h / 20 °C 4: iodine; 2,6-lutidine / acetonitrile; tetrahydrofuran; H2O / 0.33 h / 20 °C
  • 27
  • [ 153631-19-7 ]
  • 3'-deoxy-5'-O-(4,4'-dimethoxytriphenylmethyl)-3'-iodo-2'-O-methyl-5-methyluridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: 1.) pyridine / 1) CH2Cl2, -10 deg C, 0.75 h; 2) CH2Cl2, pyridine, -10 deg C, 2.5 h 2: Bu4NI / toluene / 0.5 h / 80 °C
  • 28
  • [ 50-69-1 ]
  • [ 153631-19-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 11 steps 1: 1.) cc. H2SO4, 2.) NaH / 1.) 4 deg C, 16 h, 2.) DMF, 40 deg C 2: 125.9 g / SnCl4 / CH2Cl2 / 35 h / 3 °C 3: pyridine, 4-(dimethylamino)-pyridine / 17 h 4: 1.) N,O-bis(trimethylsilyl)acetamide, 2.) TfOSiMe3 / 1.) ClCH2CH2Cl, reflux, 10 min, 2.) ClCH2CH2Cl, 70 deg C, 20 h 5: 1,8-diazabicyclo<5.4.0>undec-7-ene / acetonitrile / 10 h 6: 98 percent / 30percent NaOMe / methanol / 3 h / Ambient temperature 7: 98 percent / NaH / tetrahydrofuran / 40 - 70 °C 8: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 9: 30percent NaOMe / methanol / Ambient temperature; pH 11 10: 84 percent / H2, NaOAc / 5percent Pd/C / methanol / 45 °C / 2250.2 Torr 11: pyridine / 5 h / Ambient temperature
  • 29
  • [ 153631-19-7 ]
  • Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-5-(5-methyl-2-oxo-4-[1,2,4]triazol-1-yl-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: 96 percent / diisopropylammonium-tetrazolide / CH2Cl2 / Ambient temperature 2: 92 percent / Et3N, POCl3 / acetonitrile / 16 h / Ambient temperature
  • 30
  • [ 168427-35-8 ]
  • [ 153631-19-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 9 steps 1: pyridine, 4-(dimethylamino)-pyridine / 17 h 2: 1.) N,O-bis(trimethylsilyl)acetamide, 2.) TfOSiMe3 / 1.) ClCH2CH2Cl, reflux, 10 min, 2.) ClCH2CH2Cl, 70 deg C, 20 h 3: 1,8-diazabicyclo<5.4.0>undec-7-ene / acetonitrile / 10 h 4: 98 percent / 30percent NaOMe / methanol / 3 h / Ambient temperature 5: 98 percent / NaH / tetrahydrofuran / 40 - 70 °C 6: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 7: 30percent NaOMe / methanol / Ambient temperature; pH 11 8: 84 percent / H2, NaOAc / 5percent Pd/C / methanol / 45 °C / 2250.2 Torr 9: pyridine / 5 h / Ambient temperature
  • 31
  • [ 163759-42-0 ]
  • [ 153631-19-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 8 steps 1: 1.) N,O-bis(trimethylsilyl)acetamide, 2.) TfOSiMe3 / 1.) ClCH2CH2Cl, reflux, 10 min, 2.) ClCH2CH2Cl, 70 deg C, 20 h 2: 1,8-diazabicyclo<5.4.0>undec-7-ene / acetonitrile / 10 h 3: 98 percent / 30percent NaOMe / methanol / 3 h / Ambient temperature 4: 98 percent / NaH / tetrahydrofuran / 40 - 70 °C 5: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 6: 30percent NaOMe / methanol / Ambient temperature; pH 11 7: 84 percent / H2, NaOAc / 5percent Pd/C / methanol / 45 °C / 2250.2 Torr 8: pyridine / 5 h / Ambient temperature
  • 32
  • [ 163759-40-8 ]
  • [ 153631-19-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 10 steps 1: 125.9 g / SnCl4 / CH2Cl2 / 35 h / 3 °C 2: pyridine, 4-(dimethylamino)-pyridine / 17 h 3: 1.) N,O-bis(trimethylsilyl)acetamide, 2.) TfOSiMe3 / 1.) ClCH2CH2Cl, reflux, 10 min, 2.) ClCH2CH2Cl, 70 deg C, 20 h 4: 1,8-diazabicyclo<5.4.0>undec-7-ene / acetonitrile / 10 h 5: 98 percent / 30percent NaOMe / methanol / 3 h / Ambient temperature 6: 98 percent / NaH / tetrahydrofuran / 40 - 70 °C 7: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 8: 30percent NaOMe / methanol / Ambient temperature; pH 11 9: 84 percent / H2, NaOAc / 5percent Pd/C / methanol / 45 °C / 2250.2 Torr 10: pyridine / 5 h / Ambient temperature
  • 33
  • [ 168427-64-3 ]
  • [ 153631-19-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: 84 percent / H2, NaOAc / 5percent Pd/C / methanol / 45 °C / 2250.2 Torr 2: pyridine / 5 h / Ambient temperature
  • 34
  • 1-[(2R,3R,4R,5R)-4-(2,4-Dichloro-benzyloxy)-5-(2,4-dichloro-benzyloxymethyl)-3-methoxy-tetrahydro-furan-2-yl]-3-hydroxymethyl-5-methyl-1H-pyrimidine-2,4-dione [ No CAS ]
  • [ 153631-19-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: 30percent NaOMe / methanol / Ambient temperature; pH 11 2: 84 percent / H2, NaOAc / 5percent Pd/C / methanol / 45 °C / 2250.2 Torr 3: pyridine / 5 h / Ambient temperature
  • 35
  • [ 163759-43-1 ]
  • [ 153631-19-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 7 steps 1: 1,8-diazabicyclo<5.4.0>undec-7-ene / acetonitrile / 10 h 2: 98 percent / 30percent NaOMe / methanol / 3 h / Ambient temperature 3: 98 percent / NaH / tetrahydrofuran / 40 - 70 °C 4: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 5: 30percent NaOMe / methanol / Ambient temperature; pH 11 6: 84 percent / H2, NaOAc / 5percent Pd/C / methanol / 45 °C / 2250.2 Torr 7: pyridine / 5 h / Ambient temperature
  • 36
  • [ 163759-45-3 ]
  • [ 153631-19-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: 98 percent / NaH / tetrahydrofuran / 40 - 70 °C 2: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 3: 30percent NaOMe / methanol / Ambient temperature; pH 11 4: 84 percent / H2, NaOAc / 5percent Pd/C / methanol / 45 °C / 2250.2 Torr 5: pyridine / 5 h / Ambient temperature
  • 37
  • [ 168427-40-5 ]
  • [ 153631-19-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 2: 30percent NaOMe / methanol / Ambient temperature; pH 11 3: 84 percent / H2, NaOAc / 5percent Pd/C / methanol / 45 °C / 2250.2 Torr 4: pyridine / 5 h / Ambient temperature
  • 38
  • [ 163759-44-2 ]
  • [ 153631-19-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1: 98 percent / 30percent NaOMe / methanol / 3 h / Ambient temperature 2: 98 percent / NaH / tetrahydrofuran / 40 - 70 °C 3: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 4: 30percent NaOMe / methanol / Ambient temperature; pH 11 5: 84 percent / H2, NaOAc / 5percent Pd/C / methanol / 45 °C / 2250.2 Torr 6: pyridine / 5 h / Ambient temperature
  • 39
  • [ 3180-76-5 ]
  • [ 153631-19-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: 90 percent / NaOMe / methanol / 24 h / Ambient temperature 2: 71 percent / pyridine / 1.25 h / Ambient temperature 3: 65 percent / tetrabutylammonium hydroxide, pyridine / acetonitrile / 48 h / Heating 4: 1.) NaH / 1.) DMF, -40 deg C, 0.75 h, 2.) DMF, a) from -40 to -30 deg C, 0.75 h, b) RT, 4 h 5: 71 percent / potassium t-butoxide / CH2Cl2 / 1.5 h / Ambient temperature
  • 40
  • [ 65-71-4 ]
  • [ 153631-19-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 7 steps 1: 1,1,1,3,3,3-hexamethyldisilazane, chlorotrimethyl silane / acetonitrile / 4 h / Heating 2: acetonitrile / 0.5 h / Heating 3: 90 percent / NaOMe / methanol / 24 h / Ambient temperature 4: 71 percent / pyridine / 1.25 h / Ambient temperature 5: 65 percent / tetrabutylammonium hydroxide, pyridine / acetonitrile / 48 h / Heating 6: 1.) NaH / 1.) DMF, -40 deg C, 0.75 h, 2.) DMF, a) from -40 to -30 deg C, 0.75 h, b) RT, 4 h 7: 71 percent / potassium t-butoxide / CH2Cl2 / 1.5 h / Ambient temperature
  • 41
  • [ 138239-62-0 ]
  • [ 153631-19-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: 65 percent / tetrabutylammonium hydroxide, pyridine / acetonitrile / 48 h / Heating 2: 1.) NaH / 1.) DMF, -40 deg C, 0.75 h, 2.) DMF, a) from -40 to -30 deg C, 0.75 h, b) RT, 4 h 3: 71 percent / potassium t-butoxide / CH2Cl2 / 1.5 h / Ambient temperature
  • 42
  • [ 153631-17-5 ]
  • [ 153631-19-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: 1.) NaH / 1.) DMF, -40 deg C, 0.75 h, 2.) DMF, a) from -40 to -30 deg C, 0.75 h, b) RT, 4 h 2: 71 percent / potassium t-butoxide / CH2Cl2 / 1.5 h / Ambient temperature
  • 43
  • [ 7288-28-0 ]
  • [ 153631-19-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1: acetonitrile / 0.5 h / Heating 2: 90 percent / NaOMe / methanol / 24 h / Ambient temperature 3: 71 percent / pyridine / 1.25 h / Ambient temperature 4: 65 percent / tetrabutylammonium hydroxide, pyridine / acetonitrile / 48 h / Heating 5: 1.) NaH / 1.) DMF, -40 deg C, 0.75 h, 2.) DMF, a) from -40 to -30 deg C, 0.75 h, b) RT, 4 h 6: 71 percent / potassium t-butoxide / CH2Cl2 / 1.5 h / Ambient temperature
  • 44
  • [ 1463-10-1 ]
  • [ 153631-19-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: 71 percent / pyridine / 1.25 h / Ambient temperature 2: 65 percent / tetrabutylammonium hydroxide, pyridine / acetonitrile / 48 h / Heating 3: 1.) NaH / 1.) DMF, -40 deg C, 0.75 h, 2.) DMF, a) from -40 to -30 deg C, 0.75 h, b) RT, 4 h 4: 71 percent / potassium t-butoxide / CH2Cl2 / 1.5 h / Ambient temperature
  • 45
  • [ 153631-19-7 ]
  • C28H41F3N5O11P [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 2: dicyclohexyl-carbodiimide / dimethyl sulfoxide 3: dicyclohexyl-carbodiimide 4: pyridine 5: triethylamine tris(hydrogen fluoride)
Multi-step reaction with 5 steps 2: dicyclohexyl-carbodiimide / dimethyl sulfoxide 3: thionyl chloride 4: pyridine; 2,2-dimethoxy-propane 5: N-ethyl-N,N-diisopropylamine
  • 46
  • [ 153631-19-7 ]
  • C28H44N5O11P [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 2: dicyclohexyl-carbodiimide / dimethyl sulfoxide 3: dicyclohexyl-carbodiimide 4: pyridine 5: triethylamine tris(hydrogen fluoride)
Multi-step reaction with 5 steps 2: dicyclohexyl-carbodiimide / dimethyl sulfoxide 3: thionyl chloride 4: pyridine / N,N-dimethyl-formamide 5: N-ethyl-N,N-diisopropylamine
  • 47
  • [ 153631-19-7 ]
  • 1-[3-O-acetyl-2-O-methyl-5-O-(p-toluenesulfonyl)-β-D-ribofuranosyl]uracil [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: pyridine / 20 °C 2: acetic acid / water / 20 °C 3: pyridine; p-toluenesulfonyl chloride / 12 h / 20 °C
  • 48
  • [ 153631-19-7 ]
  • 3'-O-acetyl-2,5'-anhydro-2'-O-5-dimethyluridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: pyridine / 20 °C 2: acetic acid / water / 20 °C 3: pyridine; p-toluenesulfonyl chloride / 12 h / 20 °C 4: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / Reflux
  • 49
  • [ 153631-19-7 ]
  • 2,5'-anhydro-2'-O-methyl-5-methyluridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: pyridine / 20 °C 2: acetic acid / water / 20 °C 3: pyridine; p-toluenesulfonyl chloride / 12 h / 20 °C 4: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / Reflux 5: potassium carbonate / methanol / 0.33 h
  • 50
  • [ 18162-48-6 ]
  • [ 153631-19-7 ]
  • C38H48N2O8Si [ No CAS ]
YieldReaction ConditionsOperation in experiment
83% With 1H-imidazole In N,N-dimethyl-formamide at 20℃;
Same Skeleton Products
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