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[ CAS No. 1363281-27-9 ] {[proInfo.proName]}

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Chemical Structure| 1363281-27-9
Chemical Structure| 1363281-27-9
Structure of 1363281-27-9 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1363281-27-9 ]

CAS No. :1363281-27-9 MDL No. :MFCD29047143
Formula : C20H17FN2O3 Boiling Point : -
Linear Structure Formula :- InChI Key :QUZLMKNNIUSREV-UHFFFAOYSA-N
M.W : 352.36 Pubchem ID :56846694
Synonyms :
VU 0409551

Safety of [ 1363281-27-9 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1363281-27-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1363281-27-9 ]

[ 1363281-27-9 ] Synthesis Path-Downstream   1~22

  • 1
  • [ 95629-02-0 ]
  • [ 1363281-27-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 7 steps 1: 60 h / 125 °C / silica gel 2: 4-methylmorpholine N-oxide / osmium(VIII) oxide / water; <i>tert</i>-butyl alcohol; tetrahydrofuran; methanol / 16 h / 20 °C 3: sodium periodate / water; tetrahydrofuran; methanol / 2 h / 20 °C 4: sodium tetrahydroborate; methanol / 0.33 h / 0 - 20 °C 5: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 0.33 h / 0 - 20 °C 6: water; lithium hydroxide / 1,4-dioxane / 90 h / 125 °C / Inert atmosphere 7: triethylamine / dichloromethane / 0.25 h / 0 - 20 °C
  • 2
  • [ 1363286-28-5 ]
  • [ 403-43-0 ]
  • [ 1363281-27-9 ]
YieldReaction ConditionsOperation in experiment
88% With triethylamine In dichloromethane at 0 - 20℃;
67% With triethylamine In dichloromethane at 0 - 20℃; for 0.25h; 6.a 4-Fluorobenzoyl chloride (0.25 mL, 2.12 mmol) was added dropwise to a stirred solution of 4,5,6,7-tetrahydro-2-(phenoxymethyl)-oxazolo[5,4-c]pyridine (0.37 g, 1.63 mmol) and TEA (0.34 mL, 2.44 mmol) in DCM (8.15 mL) at 0 °C. The reaction mixture was stirred at room temperature for 15 minutes and then diluted with a saturated solution of NaHC03. The organic layer was separated, dried (Na2S04), filtered and the solvent evaporated in vacuo. The crude product was purified by flash column chromatography (silica; AcOEt in DCM 0/100 to 30/70). The desired fractions were collected and the solvents evaporated in vacuo. The crude product was triturated with heptane to yield 5-(4-fluorobenzoyl)-4,5,6,7-tetrahydro- 2-(phenoxymethyl)-oxazolo[5,4-c]pyridine (0.38 g, 67% yield) as a white solid.C2oH17FN203. 1H NMR (400 MHz, CDC13) δ ppm 2.73 (br. s., 2 H), 3.69 (br. s., 1.4 H), 3.99 (br. s., 0.6 H), 4.57 (br. s., 0.6 H), 4.78 (br. s., 1.4 H), 5.12 (br. s., 2 H), 7.02 (d, J=7.4 Hz, 3 H), 7.14 (t, J=8.6 Hz, 2 H), 7.31 (t, J=7.7 Hz, 2 H), 7.43 - 7.51 (m, 2 H).
  • 3
  • [ 701-99-5 ]
  • [ 1363281-27-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: triethylamine / dichloromethane / 1 h / 0 - 20 °C 2: Dess-Martin periodane / dichloromethane / 16 h / 20 °C 3: trichlorophosphate / 1,4-dioxane / 2 h / 100 °C 4: water; lithium hydroxide / 1,4-dioxane / 90 h / 125 °C / Inert atmosphere 5: triethylamine / dichloromethane / 0.25 h / 0 - 20 °C
Multi-step reaction with 5 steps 1: triethylamine / dichloromethane / 1 h / 0 - 20 °C 2: Dess-Martin periodane / dichloromethane / 16 h / 20 °C 3: trichlorophosphate / 1,4-dioxane / 2 h / 100 °C 4: lithium hydroxide / 1,4-dioxane; water / 60 h / Reflux 5: triethylamine / dichloromethane / 0 - 20 °C
  • 4
  • ethyl (3S,4R)-4-amino-3-hydroxypiperidine-1-carboxylate [ No CAS ]
  • [ 1363281-27-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: triethylamine / dichloromethane / 1 h / 0 - 20 °C 2: Dess-Martin periodane / dichloromethane / 16 h / 20 °C 3: trichlorophosphate / 1,4-dioxane / 2 h / 100 °C 4: water; lithium hydroxide / 1,4-dioxane / 90 h / 125 °C / Inert atmosphere 5: triethylamine / dichloromethane / 0.25 h / 0 - 20 °C
  • 5
  • [ 29976-53-2 ]
  • [ 1363281-27-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 8 steps 1: bromine; hydrogen bromide / water; tetrahydrofuran / 0.25 h / 0 - 20 °C 2: 60 h / 125 °C / silica gel 3: 4-methylmorpholine N-oxide / osmium(VIII) oxide / water; <i>tert</i>-butyl alcohol; tetrahydrofuran; methanol / 16 h / 20 °C 4: sodium periodate / water; tetrahydrofuran; methanol / 2 h / 20 °C 5: sodium tetrahydroborate; methanol / 0.33 h / 0 - 20 °C 6: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 0.33 h / 0 - 20 °C 7: water; lithium hydroxide / 1,4-dioxane / 90 h / 125 °C / Inert atmosphere 8: triethylamine / dichloromethane / 0.25 h / 0 - 20 °C
  • 6
  • [ 1363286-13-8 ]
  • [ 1363281-27-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1: 4-methylmorpholine N-oxide / osmium(VIII) oxide / water; <i>tert</i>-butyl alcohol; tetrahydrofuran; methanol / 16 h / 20 °C 2: sodium periodate / water; tetrahydrofuran; methanol / 2 h / 20 °C 3: sodium tetrahydroborate; methanol / 0.33 h / 0 - 20 °C 4: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 0.33 h / 0 - 20 °C 5: water; lithium hydroxide / 1,4-dioxane / 90 h / 125 °C / Inert atmosphere 6: triethylamine / dichloromethane / 0.25 h / 0 - 20 °C
  • 7
  • [ 1363286-16-1 ]
  • [ 1363281-27-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: sodium periodate / water; tetrahydrofuran; methanol / 2 h / 20 °C 2: sodium tetrahydroborate; methanol / 0.33 h / 0 - 20 °C 3: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 0.33 h / 0 - 20 °C 4: water; lithium hydroxide / 1,4-dioxane / 90 h / 125 °C / Inert atmosphere 5: triethylamine / dichloromethane / 0.25 h / 0 - 20 °C
  • 8
  • [ 1363286-19-4 ]
  • [ 1363281-27-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: sodium tetrahydroborate; methanol / 0.33 h / 0 - 20 °C 2: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 0.33 h / 0 - 20 °C 3: water; lithium hydroxide / 1,4-dioxane / 90 h / 125 °C / Inert atmosphere 4: triethylamine / dichloromethane / 0.25 h / 0 - 20 °C
  • 9
  • [ 1363286-22-9 ]
  • [ 1363281-27-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 0.33 h / 0 - 20 °C 2: water; lithium hydroxide / 1,4-dioxane / 90 h / 125 °C / Inert atmosphere 3: triethylamine / dichloromethane / 0.25 h / 0 - 20 °C
  • 11
  • (3R,4S)-3-hydroxy-4-(2-phenoxy-acetylamino)-piperidine-1-carboxylic acid ethyl ester [ No CAS ]
  • [ 1363281-27-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: Dess-Martin periodane / dichloromethane / 16 h / 20 °C 2: trichlorophosphate / 1,4-dioxane / 2 h / 100 °C 3: water; lithium hydroxide / 1,4-dioxane / 90 h / 125 °C / Inert atmosphere 4: triethylamine / dichloromethane / 0.25 h / 0 - 20 °C
  • 12
  • [ 1363287-26-6 ]
  • [ 1363281-27-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: trichlorophosphate / 1,4-dioxane / 2 h / 100 °C 2: water; lithium hydroxide / 1,4-dioxane / 90 h / 125 °C / Inert atmosphere 3: triethylamine / dichloromethane / 0.25 h / 0 - 20 °C
Multi-step reaction with 3 steps 1: trichlorophosphate / 1,4-dioxane / 2 h / 100 °C 2: lithium hydroxide / 1,4-dioxane; water / 60 h / Reflux 3: triethylamine / dichloromethane / 0 - 20 °C
  • 13
  • ethyl 3-hydroxy-4-[(2-phenoxyacetyl)amino]piperidine-1-carboxylate [ No CAS ]
  • [ 1363281-27-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: Dess-Martin periodane / dichloromethane / 16 h / 20 °C 2: trichlorophosphate / 1,4-dioxane / 2 h / 100 °C 3: lithium hydroxide / 1,4-dioxane; water / 60 h / Reflux 4: triethylamine / dichloromethane / 0 - 20 °C
  • 14
  • ethyl 4-amino-3-hydroxy-piperidine-1-carboxylate [ No CAS ]
  • [ 1363281-27-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: triethylamine / dichloromethane / 1 h / 0 - 20 °C 2: Dess-Martin periodane / dichloromethane / 16 h / 20 °C 3: trichlorophosphate / 1,4-dioxane / 2 h / 100 °C 4: lithium hydroxide / 1,4-dioxane; water / 60 h / Reflux 5: triethylamine / dichloromethane / 0 - 20 °C
  • 16
  • [ 1363281-27-9 ]
  • C19H16FN3O3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: boron tribromide / 1,2-dichloro-ethane / 0 °C 2: di-tert-butyl-diazodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.33 h / 0 - 20 °C
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