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Multi-step reaction with 4 steps
1.1: n-butyllithium / toluene / 2.5 h / -78 °C
1.2: -78 - 20 °C
2.1: isopropylmagnesium chloride / tetrahydrofuran / 3.67 h / 25 °C / Inert atmosphere
2.2: 25 °C / Inert atmosphere
3.1: hydrogenchloride / tetrahydrofuran; water / 1 h / 20 - 25 °C
4.1: triethylamine / 2-methyl-propan-1-ol / 0.5 h / Cooling with ice
4.2: 4 h / 20 °C
Multi-step reaction with 4 steps
1.1: n-butyllithium / toluene / 2.5 h / -78 °C
1.2: -78 - 20 °C
2.1: isopropylmagnesium chloride / tetrahydrofuran / 3.67 h / 25 °C / Inert atmosphere
2.2: 25 °C / Inert atmosphere
3.1: hydrogenchloride / tetrahydrofuran; water / 1 h / 20 - 25 °C
4.1: triethylamine / 2-methyl-propan-1-ol / 0.5 h / Cooling with ice
4.2: 4 h / 20 °C
Multi-step reaction with 3 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran / 3.67 h / 25 °C / Inert atmosphere
1.2: 25 °C / Inert atmosphere
2.1: hydrogenchloride / tetrahydrofuran; water / 1 h / 20 - 25 °C
3.1: triethylamine / 2-methyl-propan-1-ol / 0.5 h / Cooling with ice
3.2: 4 h / 20 °C
Multi-step reaction with 2 steps
1.1: hydrogenchloride / tetrahydrofuran; water / 1 h / 20 - 25 °C
2.1: triethylamine / 2-methyl-propan-1-ol / 0.5 h / Cooling with ice
2.2: 4 h / 20 °C
Stage #1: 4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexanone; (S)-N-{2-[3-aminopyrrolidin-1-yl]-2-oxoethyl}-3-(trifluoromethyl)benzamide hydrochloride With triethylamine In 2-methyl-propan-1-ol for 0.5h; Cooling with ice;
Stage #2: With sodium tris(acetoxy)borohydride In 2-methyl-propan-1-ol at 20℃; for 4h;