Alternatived Products of [ 13100-82-8 ]
Product Details of [ 13100-82-8 ]
CAS No. : | 13100-82-8 |
MDL No. : | MFCD00065088 |
Formula : |
C3H7NO5S
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
169.16
|
Pubchem ID : | - |
Synonyms : |
|
Application In Synthesis of [ 13100-82-8 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Upstream synthesis route of [ 13100-82-8 ]
- Downstream synthetic route of [ 13100-82-8 ]
- 1
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[ 56-89-3 ]
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[ 13100-82-8 ]
- 2
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[ 59-51-8 ]
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[ 1068-84-4 ]
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[ 13100-82-8 ]
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[ 88547-35-7 ]
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[ 3226-62-8 ]
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[ 56-40-6 ]
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[ 617-45-8 ]
- 3
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[ 498-40-8 ]
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[ 13100-82-8 ]
- 4
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[ 921-01-7 ]
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[ 13100-82-8 ]
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[ 56-89-3 ]
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[ 2381-08-0 ]
- 5
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[ 56-84-8 ]
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[ 13100-82-8 ]
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[ 96-21-9 ]
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2-hydroxypropylene aspartate cysteate
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
|
With sodium hydroxide; sodium carbonate In ethanol; water |
8 Preparation of 2-Hydroxypropylene Aspartate Cysteate (Aspartate:Cysteate Ratio 50:50)
EXAMPLE 8 Preparation of 2-Hydroxypropylene Aspartate Cysteate (Aspartate:Cysteate Ratio 50:50) 8.5 g (0.064 mol) of L-aspartic acid and 12 g (0.0641 mol) L-cysteic acid is dissolved in 160 ml of water containing 10.2 g (0.255 mol) of sodium hydroxide. After dissolution, 6.8 g (0.064) sodium carbonate is added, followed by 80 ml ethanol. While refluxing the solution, 16.8 g (0.077 mol) 1,3-dibromo-2-propanol is added gradually during a period of 4 hours, followed by refluxing overnight. An additional 16.8 g (0.077 mol) of 1,3-dibromo-2-propanol is added, followed by all-day reflux. The solution is distilled to remove solvents and the resulting solid which contains HPAC and other materials is recovered and triturated with methanol/water. The purified solid is triturated again with methanol only and stirred overnight to remove residual materials, followed by dissolution in 10 cc water. |
- 6
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[ 13100-82-8 ]
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[ 96-21-9 ]
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2-Hydroxypropylene Dicysteate
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
|
With sodium hydroxide; sodium carbonate In ethanol; water |
14 Preparation of 2-Hydroxypropylene Dicysteate (HPDC)
EXAMPLE 14 Preparation of 2-Hydroxypropylene Dicysteate (HPDC) 24 g (0.128 mol) of cysteic acid is dissolved in 160 ml of water and 10.2 g (0.255 mol) of sodium hydroxide is added. After dissolution, 6.8 g (0.064) sodium carbonate is added, followed by 80 ml ethanol. While refluxing the solution, 16.8 g (0.077 mol) 1,3-dibromo-2-propanol is added gradually during a period of 4 hours, followed by refluxing overnight. An additional 16.8 g (0.077 mol) of 1,3-dibromo-2-propanol is added, followed by all-day reflux. The solution is distilled to remove solvents and the resulting solid which contains HPDC and other materials is recovered and triturated with methanol/water. The purified solid is triturated again with methanol only and stirred overnight to remove residual materials, followed by dissolution in 10 cc water. Adjustment of the solution pH to 3-5 precipitates out pure HPDC. |
- 7
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[ 21160-83-8 ]
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[ 13100-82-8 ]
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C25H31N3O10S
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
77% |
With sodium hydroxide; In N,N-dimethyl-formamide; for 1.0h;pH 7.5-8.4; |
Cysteic Acid (2.434 g, 14.47 mmol) was weighed into a 250 mL beaker equipped with a stir bar and dissolved in a solution of deionized water (70 ml) and dimethylformamide (30 ml). The mixture was stirred while 1M NaOH was added to bring the pH to 8.4. Crude Z-Lys(Z)-NHS (2.468 g, 4.82 mmol) in dimethylformamide (1 mL) was added dropwise while keeping the pH between 7.5-8.4 with the addition of 1M NaOH. After addition the reaction was allowed to stir for lh. The crude mixture was concentrated under vacuum and purified using a Combiflash Rf 200i, PF 30 C18 HP 450g column with flow rate of 125 ml/min, eluting with deionized water containing 0.1% formic acid with a 5% to 95% linear acetonitrile gradient over 23 min. Fractions containing desired product were combined, frozen and lyophilized to give 2.09 g (77 % yield) of desired product. MS [M - H] calcd 564.17; found 564.17. |