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With triethylamine; In N,N-dimethyl-formamide; at 20℃; for 18h;
Example 6 (S)-pyrrolidine-1 ,2-dicarboxylic acid 2-amide 1-[(2-tert-butyl-4'-methyl- [4,5']bithiazolyl-2'-yl)-amide]; A mixture of imidazole-1-carboxylic acid (2-tert-butyl-4'-methyl-[4,5']bithiazolyl-2'-yl)-amide (40 mg), L-proline amide (20 mg) and triethylamine (0.02 ml) in DMF (1 ml) is allowed to stand at room temperature for 18 hours. Following evaporation of the reaction mixture purification by crystallisation from aqueous methanol gives the title compound as a white solid. Hplc/MS (Method B) RT 2.40 minutes, M+H 394.1 and M-H 392.3.