There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
USD 200+
Structure of 1121-22-8 * Storage: {[proInfo.prStorage]}
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Reference：
[1] Advanced Synthesis and Catalysis, 2014, vol. 356, # 4, p. 818 - 830
[2] Zeitschrift fuer Anorganische und Allgemeine Chemie, 1937, vol. 233, p. 97,98
[3] Proceedings of the Koninklijke Nederlandse Akademie van Wetenschappen, Series B: Physical Sciences, 1937, vol. 40, p. 12[4] Zeitschrift fuer Anorganische und Allgemeine Chemie, 1937, vol. 233, p. 97,99
[5] Gazzetta Chimica Italiana, 1972, vol. 102, p. 855 - 892
[6] Synlett, 2016, vol. 27, # 1, p. 126 - 130
4
[ 1121-22-8 ]
[ 108-59-8 ]
[ 21436-03-3 ]
[ 186144-56-9 ]
Reference：
[1] Chemical Communications, 1996, # 21, p. 2471 - 2472
5
[ 1121-22-8 ]
[ 108-59-8 ]
[ 20439-47-8 ]
[ 21436-03-3 ]
[ 186144-56-9 ]
Reference：
[1] Chemical Communications, 1996, # 21, p. 2471 - 2472
6
[ 286-18-0 ]
[ 1121-22-8 ]
Yield
Reaction Conditions
Operation in experiment
28.1 g
at 90 - 95℃;
To the reaction flask was added epoxycyclohexane (39.2 g, 0.4 mol) and 30percent aqueous ammonia (1.0 mol) Stirred at room temperature for 1.5 hours, the solution gradually clear,The reaction was complete and the mixture was cooled under reduced pressure and cooled to give a white solid,Add 35 grams of water to complete the mixingAfter dissolution, cool down to ° C,Slowly add 50percent sulfuric acid aqueous solution, the entire process temperature control does not exceed 30 ° C,Stirring,Decompression gradually heated to 80 ° C in addition to water, the system gradually sticky curing,Stop stirring, continue to vacuum for 4 hours, remove the solid crushed, Continue to warm up to 120 ° C vacuum for 12 hours, Karl Fischer titration of water is 0.22percent. In another reaction bottle,Adding sodium hydroxide solution,The temperature was raised to 40 ° C, and the above solid powder was added in batches,The whole process of temperature control does not exceed 50 ° C,After joining,Raise the temperature to 60 ° C, stir until fully clear,The reaction was completed, where the pH was 9-10 and 1,2-dichloroethane was added After extraction and distillation, 27.2 g of aziridine was obtained, GC: 99.6percentThe two-step yield was 70percent; aziridine (27.2 g,0.28 mol)30percent aqueous ammonia (0.48 mol) and inorganic boronic acid (3.5 g, 56 mmol) were added,Heated to 90-95 ° C overnight ,After the reaction was completed, the trans-cyclohexanediamine was obtained by distillation under reduced pressure,Cooled and solidified to 28.1 g of a white solid, GC: 99.7percent Yield 88percent, no cis isomer detection, HNMR consistent with the literature.
Reference：
[1] Bulletin de la Societe Chimique de France, 1956, p. 382,387,1827
[2] Patent: CN106631815, 2017, A, . Location in patent: Paragraph 0013; 0014; 0015
Reference：
[1] Vysokomolekulyarnye Soedineniya, 1959, vol. 1, p. 518,523,524[2] Chem.Abstr., 1960, p. 17948
[3] Patent: US2606925, 1949, ,
11
[ 286-20-4 ]
[ 1121-22-8 ]
Reference：
[1] Patent: CN106631815, 2017, A,
12
[ 492-99-9 ]
[ 1121-22-8 ]
Reference：
[1] Zeitschrift fuer Anorganische und Allgemeine Chemie, 1937, vol. 233, p. 97,98
[2] Proceedings of the Koninklijke Nederlandse Akademie van Wetenschappen, Series B: Physical Sciences, 1936, vol. 39, p. 384,386
[3] Proceedings of the Koninklijke Nederlandse Akademie van Wetenschappen, Series B: Physical Sciences, 1937, vol. 40, p. 12[4] Zeitschrift fuer Anorganische und Allgemeine Chemie, 1937, vol. 233, p. 97,99
13
[ 931-16-8 ]
[ 1121-22-8 ]
Reference：
[1] Bulletin de la Societe Chimique de France, 1956, p. 382,387,1827
14
[ 110-83-8 ]
[ 1121-22-8 ]
Reference：
[1] Journal of the Chemical Society, 1949, p. 2627,2630
15
[ 2802-07-5 ]
[ 26772-34-9 ]
[ 1121-22-8 ]
Reference：
[1] Journal of the Chemical Society, 1956, p. 805,807
16
[ 1121-22-8 ]
[ 146504-07-6 ]
Reference：
[1] Angewandte Chemie - International Edition, 2017, vol. 56, # 15, p. 4272 - 4276[2] Angew. Chem., 2017, vol. 129, p. 4336 - 4340,5
With C36H36N2O10; In methanol; diethyl ether; at 10℃; for 0.5h;pH 4.5;Resolution of racemate;
A 10 mL sample solution containing 1.0 mg/L of trans-cyclohexane-1,2-diamine was placed in a centrifuge tube with narrow neck (~4 mm i.d.), which was specially designed for ease of removing the supernatant phase. A mixture of 1 mL disperser solvent and 300 muL extracting solvent with 2 mmol L-1 of chiral selector was rapidly injected into the sample solution using a 5.0 mL syringe, and mixed by vortex mixer at 500 rpm stirring rate for 20 min, so that a cloudy solution was formed. The cloudy solution was centrifuged for 5 min at 3500 rpm, and the extraction product (supernatant phase) was collected in the neck of the tube. Finally, this supernatant phase was derivatized and injected into the HPLC. All of the experiments were carried out in triplicate and the average of the result was reported.
trans-1-amino-2-(2-hydroxybenzamide)cyclohexane[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
60%
In isopropyl alcohol; at 20℃;
General procedure: A solution of phenyl salicylate (2.13 g, 9.9 mmol) in 2-propanol (30 mL) was added to a 2-propanol solution (10 mL) containing 1,2-diamino-2-methylpropane (0.93 g, 10.6 mmol) dropwise with stirring. The mixture was stirred overnight at room temperature. The resulting white precipitate was collected by filtration, washed with 2-propanol and diethyl ether, and dried in vacuo.
With trifluoroacetic acid; In dichloromethane; at 20℃; for 4h;
To prepare the dilute solution for the modulated evaporation solvent approach, two solutions were first prepared separately and then combined as previously described1, 2. 5 mL of dichloromethane (volatile solvent) (Fisher Scientific, ACS certified) was added to 0.005 g of 1,3,5-triformylbenzene. Then trifluoroacetic acid (Alfa Aesar, 99%) was added to the aldehyde solution. In a separate vial, 0.007 g of (±)-trans-1,2-diaminocyclohexane was added to 5 mL of dichloromethane.3 The two organic linker solutions were then added together. To begin the experiment, a copious amount (1-2 mL) of the dilute solution containing both organic linkers was dropped on the aluminum foil to form a film, and quickly placed in a desiccator. The film-substrate was left in the desiccator for either 4 or 10 days at room temperature. Another experiment was performed for 4 days at 88% RH by doubling the concentration of the dilute solution. So 0.01 g of 1,3,5-triformylbenzene was used, and 0.014 g of of (±)-trans-1,2-diaminocyclohexane was used.
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