There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 1121-22-8 | MDL No. : | MFCD00063747 |
Formula : | C6H14N2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | SSJXIUAHEKJCMH-PHDIDXHHSA-N |
M.W : | 114.19 | Pubchem ID : | 43806 |
Synonyms : |
|
Num. heavy atoms : | 8 |
Num. arom. heavy atoms : | 0 |
Fraction Csp3 : | 1.0 |
Num. rotatable bonds : | 0 |
Num. H-bond acceptors : | 2.0 |
Num. H-bond donors : | 2.0 |
Molar Refractivity : | 34.26 |
TPSA : | 52.04 Ų |
GI absorption : | High |
BBB permeant : | No |
P-gp substrate : | No |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -7.22 cm/s |
Log Po/w (iLOGP) : | 1.49 |
Log Po/w (XLOGP3) : | -0.32 |
Log Po/w (WLOGP) : | 0.21 |
Log Po/w (MLOGP) : | 0.21 |
Log Po/w (SILICOS-IT) : | 0.15 |
Consensus Log Po/w : | 0.35 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 1.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -0.35 |
Solubility : | 51.4 mg/ml ; 0.45 mol/l |
Class : | Very soluble |
Log S (Ali) : | -0.31 |
Solubility : | 55.7 mg/ml ; 0.488 mol/l |
Class : | Very soluble |
Log S (SILICOS-IT) : | -0.31 |
Solubility : | 55.8 mg/ml ; 0.489 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 0.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 1.81 |
Signal Word: | Danger | Class: | 8 |
Precautionary Statements: | P210-P261-P264-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338+P310-P312-P363-P370+P378-P403+P233-P403+P235-P405-P501 | UN#: | 2735 |
Hazard Statements: | H227-H303-H314-H335 | Packing Group: | Ⅲ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
28.1 g | at 90 - 95℃; | To the reaction flask was added epoxycyclohexane (39.2 g, 0.4 mol) and 30percent aqueous ammonia (1.0 mol) Stirred at room temperature for 1.5 hours, the solution gradually clear,The reaction was complete and the mixture was cooled under reduced pressure and cooled to give a white solid,Add 35 grams of water to complete the mixingAfter dissolution, cool down to ° C,Slowly add 50percent sulfuric acid aqueous solution, the entire process temperature control does not exceed 30 ° C,Stirring,Decompression gradually heated to 80 ° C in addition to water, the system gradually sticky curing,Stop stirring, continue to vacuum for 4 hours, remove the solid crushed, Continue to warm up to 120 ° C vacuum for 12 hours, Karl Fischer titration of water is 0.22percent. In another reaction bottle,Adding sodium hydroxide solution,The temperature was raised to 40 ° C, and the above solid powder was added in batches,The whole process of temperature control does not exceed 50 ° C,After joining,Raise the temperature to 60 ° C, stir until fully clear,The reaction was completed, where the pH was 9-10 and 1,2-dichloroethane was added After extraction and distillation, 27.2 g of aziridine was obtained, GC: 99.6percentThe two-step yield was 70percent; aziridine (27.2 g,0.28 mol)30percent aqueous ammonia (0.48 mol) and inorganic boronic acid (3.5 g, 56 mmol) were added,Heated to 90-95 ° C overnight ,After the reaction was completed, the trans-cyclohexanediamine was obtained by distillation under reduced pressure,Cooled and solidified to 28.1 g of a white solid, GC: 99.7percent Yield 88percent, no cis isomer detection, HNMR consistent with the literature. |
[ 99363-25-4 ]
trans-Cyclopentane-1,2-diamine dihydrochloride
Similarity: 0.82
[ 498532-32-4 ]
(1R,3S)-rel-Cyclohexane-1,3-diamine dihydrochloride
Similarity: 0.76
[ 61798-24-1 ]
N1,N2-Dimethylcyclohexane-1,2-diamine
Similarity: 0.75
[ 99363-25-4 ]
trans-Cyclopentane-1,2-diamine dihydrochloride
Similarity: 0.82
[ 498532-32-4 ]
(1R,3S)-rel-Cyclohexane-1,3-diamine dihydrochloride
Similarity: 0.76
[ 216237-52-4 ]
(S)-Pentan-2-amine hydrochloride
Similarity: 0.75