[ CAS No. 106946-74-1 ] {[proInfo.proName]}

Name: 106946-74-1|tert-Butyl ((2S,3S)-1-hydroxy-3-methylpentan-2-yl)carbamate|97%
Brand: Ambeed
SKU: A535949
Price: 26.0 USD
Availability: InStock
Rating: 94 (40 reviews)

,{[proInfo.pro_purity]}

Cat. No.: {[proInfo.prAm]}

2D 3D

Structure of 106946-74-1 * Storage: {[proInfo.prStorage]}

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

For Research Only 110K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 106946-74-1 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 106946-74-1 ]

SDS Specification

Alternatived Products of [ 106946-74-1 ]

Product Details of [ 106946-74-1 ]

CAS No. :	106946-74-1	MDL No. :	MFCD00235929
Formula :	C₁₁H₂₃NO₃	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	BPLDQMXXYMKQPW-DTWKUNHWSA-N
M.W :	217.31	Pubchem ID :	14237729
Synonyms :

Calculated chemistry of [ 106946-74-1 ]

Physicochemical Properties

Num. heavy atoms :	15
Num. arom. heavy atoms :	0
Fraction Csp3 :	0.91
Num. rotatable bonds :	7
Num. H-bond acceptors :	3.0
Num. H-bond donors :	2.0
Molar Refractivity :	60.67
TPSA :	58.56 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.21 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.74
Log Po/w (XLOGP3) :	2.0
Log Po/w (WLOGP) :	1.92
Log Po/w (MLOGP) :	1.55
Log Po/w (SILICOS-IT) :	1.29
Consensus Log Po/w :	1.9

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-1.99
Solubility :	2.25 mg/ml ; 0.0103 mol/l
Class :	Very soluble
Log S (Ali) :	-2.86
Solubility :	0.302 mg/ml ; 0.00139 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-1.95
Solubility :	2.47 mg/ml ; 0.0114 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	3.08

Safety of [ 106946-74-1 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P280-P305+P351+P338	UN#:	N/A
Hazard Statements:	H317-H319	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 106946-74-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 106946-74-1 ]

[ 106946-74-1 ] Synthesis Path-Downstream 1~11

1
[ 13139-16-7 ]
[ 141321-52-0 ]

Yield	Reaction Conditions	Operation in experiment
99%	With borane-THF; In tetrahydrofuran; at 0 - 20℃; for 5.83333h;Inert atmosphere;	To a solution of N-Boc-L-isoleucine (13.86 g, 60 mmol) in THF (150 mL) was added dropwise 1 M BH3THF (90 mL, 90 mmol) at 0 C over 20 min under argon atmosphere. After stirring at 0 C for another 30 min, the reaction was allowed to warm to room temperature and stirred for 5 h. The mixture was cooled to 0 C again, quenched by dropwise addition of water. Removing most of the THF under reduced pressure, then ethyl acetate (180 mL) and water (60 mL) was added to the residue. The mixture was separated and the organic layer was washed with water (50 mL) and saturated brine (50 mL), and dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo to give 6 (12.89 g, 99%) as a colorless oil. The compound was used for next step without further purification. [a] 25D 14.8 (c 1.0, MeOH); 1 H NMR (400 MHz, CDCl3) d 5.04 (dd, J 48.3, 13.9 Hz, 1H), 3.73e3.55 (m, 2H), 3.48 (s, 1H), 3.37 (s, 1H), 1.58 (d, J 14.5 Hz, 1H), 1.56e1.48 (m, 1H), 1.45 (s, 10H), 1.23e1.05 (m, 1H), 0.91 (t, J 7.1 Hz, 6H); 13C NMR (100 MHz, CDCl3) d 156.7, 79.3, 63.4, 56.8, 35.9, 28.4, 25.3, 15.5, 11.4; HRMS (ESI; m/z) [MNa] calcd for C11H23NO3Na 240.1570, found 240.1530.

Reference： [1]Tetrahedron,2017,vol. 73,p. 2255 - 2266
[2]Synthesis,2011,p. 1375 - 1382
[3]Organic Letters,2007,vol. 9,p. 3881 - 3884
[4]Journal of Chemical Research - Part S,2003,p. 516 - 517
[5]Journal of Organic Chemistry,1996,vol. 61,p. 826 - 830
[6]Journal of Organic Chemistry,1992,vol. 57,p. 3007 - 3013
[7]Journal of the American Chemical Society,1998,vol. 120,p. 4741 - 4751
[8]Journal of Organic Chemistry,1987,vol. 52,p. 1252 - 1255
[9]Chemical and Pharmaceutical Bulletin,1990,vol. 38,p. 2487 - 2493
[10]Journal of the American Chemical Society,2012,vol. 134,p. 4041 - 4044
[11]Antimicrobial Agents and Chemotherapy,2018,vol. 62

2
[ 106946-74-1 ]
[ 87694-55-1 ]

Yield	Reaction Conditions	Operation in experiment
97%	With sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine In dichloromethane at -10℃;
92%	With Dess-Martin periodane In dichloromethane at 20℃; for 2.25h;	5.11. N-Boc-L-isoleucinal (11) To a solution of N-Boc-L-isoleucinol 10 (11.94 g, 55 mmol) in CH2Cl2 (150 mL) was added Dess-Martin periodinane (28 g, 66 mmol) in portions over 15 min. The resulting suspension was stirred at room temperature for 2 h and filtered through a pad of celite. The filtrate was washed with saturated aqueous solution of sodium bicarbonate (75 mL) and saturated brine (75 mL), and dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo to give 11 (10.88 g, 92%) as a colorless oil. The compound was used for next step without further purification. [a] 25D 2.5 (c 1.0, MeOH); 1 H NMR (400 MHz, CDCl3) d 9.66 (s, 1H), 5.42 (d, J 6.3 Hz, 1H), 4.27 (s, 1H), 2.03 (s, 1H), 1.58e1.34 (m, 10H), 1.34e1.21 (m, 1H), 1.06e0.83 (m, 6H); 13C NMR (100 MHz, CDCl3) d 200.6, 155.6, 79.5, 64.0, 36.1, 28.1, 25.1, 15.5, 11.6; HRMS (ESI; m/z) [MNa] calcd for C11H21NO3Na 238.1414, found 238.1379.
90%	With sulfur trioxide pyridine complex; triethylamine In dichloromethane; dimethyl sulfoxide at 0℃;	20.A Part A. ((75, 25)-l-Formyl-2-methyl-butyl)-carbamic acid tert-butyl esterTo a suspension of N-Boc- -isoleucinol (5g, 23 mmol) in dichloromethane (250 mL) and DMSO (50 mL) at 0°C was added TEA (10 mL, 73 mmol) followed by slow addition of the solution of sulfur trioxide pyridine complex (11 mL, 69 mmol) in DMSO (50 mL) via syringe. The reaction mixture was concentrated and was diluted with ether (200 mL). The layers were separated and the aqueous layer was extracted with ethyl acetate (3 x 200 mL), which was then washed with brine (150 mL), water ( 150 mL) and aHC03 (150 mL) sequentially. The organic layers were dried over MgS04, filtered and concentrated. The residue was dried on pump to afford ((lS,25)-l-formyl-2-methyl-butyl)-carbamic acid tert-butyl ester ( 4.47 g, 90% yield) as light-yellow clear liquid.

72%	With pyridine; chromium(VI) oxide In dichloromethane for 1.5h; 5 deg C to r. t.;
70%	With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In acetonitrile for 0.5h; Reflux;
63%	With oxalyl dichloride; dimethyl sulfoxide; triethylamine In dichloromethane at -60 - -50℃; for 1.25h;
	With sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine In benzene at 20 - 25℃; for 0.333333h;
	With sulfur trioxide pyridine complex; dimethyl sulfoxide In dichloromethane; triethylamine at 10 - 20℃; for 0.166667h;
	With pyridinium chlorochromate In dichloromethane
	With Dess-Martin periodane In dichloromethane; water at 20℃; for 1h;
	Inert atmosphere;

Reference： [1]Catalano, John G; Deaton, David N; Furfine, Eric S; Hassell, Annie M; McFadyen, Robert B; Miller, Aaron B; Miller, Larry R; Shewchuk, Lisa M; Willard Jr., Derril H; Wright, Lois L [Bioorganic and medicinal chemistry letters, 2004, vol. 14, # 1, p. 275 - 278]
[2]Wang, Xin; Dong, Suzhen; Feng, Dengke; Chen, Yazhou; Ma, Mingliang; Hu, Wenhao [Tetrahedron, 2017, vol. 73, # 16, p. 2255 - 2266]
[3]Current Patent Assignee: LEXICON PHARMACEUTICALS INC - WO2011/44212, 2011, A1 Location in patent: Page/Page column 59-60
[4]Rinehart; Sakai; Kishore; Sullins; Li [Journal of Organic Chemistry, 1992, vol. 57, # 11, p. 3007 - 3013]
[5]Haghshenas, Pouyan; Gravel, Michel [Organic Letters, 2016, vol. 18, # 18, p. 4518 - 4521]
[6]Drag, Marcin; Latajka, Rafal; Gumienna-Kontecka, Elzbieta; Kozlowski, Henryk; Kafarski, Pawel [Tetrahedron Asymmetry, 2003, vol. 14, # 13, p. 1837 - 1845]
[7]Iizuka; Kamijo; Harada; Akahane; Kubota; Etoh; Shimaoka; Tsubaki; Murakami; Yamaguchi; Iyobe; Umeyama; Kiso [Chemical and Pharmaceutical Bulletin, 1990, vol. 38, # 9, p. 2487 - 2493]
[8]Hamada, Yasumasa; Shibata, Makoto; Sugiura, Tsuneyuki; Kato, Shinji; Shioiri, Takayuki [Journal of Organic Chemistry, 1987, vol. 52, # 7, p. 1252 - 1255]
[9]Gallardo, Gabriela L.; Butler, Matias; Gallo, Mariana L.; Rodriguez, M. Alejandra; Eberlin, Marcos N.; Cabrera, Gabriela M. [Phytochemistry, 2006, vol. 67, # 21, p. 2403 - 2410]
[10]Jin, Chunyang; Decker, Ann M.; Huang, Xi-Ping; Gilmour, Brian P.; Blough, Bruce E.; Roth, Bryan L.; Hu, Yang; Gill, Joseph B.; Zhang, X. Peter [ACS Chemical Neuroscience, 2014, vol. 5, # 7, p. 576 - 587] Jin, Chunyang; Decker, Ann M.; Harris, Danni L.; Blough, Bruce E. [ACS Chemical Neuroscience, 2016, vol. 7, # 10, p. 1418 - 1432]
[11]Das, Dipendu; Khan, Hina P. A.; Shivahare, Rahul; Gupta, Suman; Sarkar, Jayanta; Siddiqui, Mohd. Imran; Ampapathi, Ravi Sankar; Chakraborty, Tushar Kanti [Organic and Biomolecular Chemistry, 2017, vol. 15, # 15, p. 3337 - 3352]

3
[ 106946-74-1 ]
[ 124590-30-3 ]

Yield	Reaction Conditions	Operation in experiment
77%	With di-isopropyl azodicarboxylate; ZnN₆-pyridine2; triphenylphosphine In toluene for 3h; Ambient temperature;

Reference： [1]Islam, Imadul; Ng, Ka-yun; Chong, Kong Teck; McQuade, Thomas J.; Hui, John O.; et al. [Journal of Medicinal Chemistry, 1994, vol. 37, # 2, p. 293 - 304]

4
[ 17901-01-8 ]
[ 141321-52-0 ]

Yield	Reaction Conditions	Operation in experiment
	With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 25℃; for 4h;	General procedure: To a dried methanol (50 mL) solution of 4 (3.3 g, 20 mmol), thionyl chloride (3.57 g, 30 mmol) was slowly added over 30 minat 0 C, and then, the solution was maintained at room temperature for 18 h. The solvent was evaporated to obtain a solid in quantitative yield, which was dissolved in dichloromethane (120 mL), and triethylamine (12.1 g, 120 mL) and di-tert-butyldicarbonate (9.6 g, 40 mmol) were added to the dichloromethane solution. The reaction mixture was stirred at 25 C for 24 h. Afterc ompletion of the reaction, the solution was washed with phosphoric acid (50 x 3 mL), saturated sodium bicarbonate (50 x 3 mL) and saturated sodium chloride (50 x 3 mL), dried over anhydrous sodium sulfate, filtered and evaporated under reduced pressure to afford a solid to which lithium aluminum hydride (13 mmol) in the presence of dried tetrahydrofuran (25 mL) was added at 0 C. The reaction mixture was maintained at room temperature for 4 h, and then water was added until the lithium aluminum hydride reacted completely. Next, the solution was filtered, and the residue was washed with tetrahydrofuran (20 x 2 mL).The combined organic solvent phase was evaporated under reduced pressure to yield the crude product, which was purified using column chromatography (petroleum ether/acetone) to afford 5a-5g.

Reference： [1]European Journal of Medicinal Chemistry,1989,vol. 24,p. 503 - 510
[2]Collection of Czechoslovak Chemical Communications,1990,vol. 55,p. 761 - 765
[3]Organic and Biomolecular Chemistry,2017,vol. 15,p. 3337 - 3352
[4]Chemical and Pharmaceutical Bulletin,1990,vol. 38,p. 2487 - 2493
[5]Journal of Organic Chemistry,1987,vol. 52,p. 1252 - 1255
[6]Tetrahedron Asymmetry,2003,vol. 14,p. 1837 - 1845
[7]Phytochemistry,2006,vol. 67,p. 2403 - 2410
[8]Bioorganic and Medicinal Chemistry,2014,vol. 22,p. 366 - 373
[9]Antimicrobial Agents and Chemotherapy,2018,vol. 62

5
[ 141321-52-0 ]
[ 98-59-9 ]
[ 122818-29-5 ]

Yield	Reaction Conditions	Operation in experiment
	With dmap; triethylamine; In dichloromethane;	General procedure: To a solution of intermediates 10a-g (1 equiv) in dichloromethane, TsCl (1.2 equiv), DMAP (0.2 equiv) and trimethylamine(3 equiv) were added. The solutionwas stirred at 20 C.The reaction was followed by TLC and quenched with water. Theorganic phase was washed with citric acid (1 N) and saturatedNaHCO3 then dried over Na2SO4 and filtered. The filtrate wasconcentrated and purified by a silica column to afford compounds11a-g as a white solid.

Reference： [1]European Journal of Medicinal Chemistry,1989,vol. 24,p. 503 - 510
[2]Synlett,2007,p. 1893 - 1896
[3]Heterocycles,2009,vol. 77,p. 865 - 872
[4]European Journal of Medicinal Chemistry,2019,vol. 177,p. 374 - 385

6
[ 141321-52-0 ]
[ 77-76-9 ]
tert-butyl (4S)-2,2-dimethyl-4-[(1S)-1-methylpropyl]-1,3-oxazolidine-3-carboxylate [ No CAS ]

Reference： [1]Organic Letters,2007,vol. 9,p. 3881 - 3884

7
[ 24424-99-5 ]
[ 24629-25-2 ]
[ 141321-52-0 ]

Yield	Reaction Conditions	Operation in experiment
91%	With triethylamine; In dichloromethane;	General procedure: L-amino alcohol (1 equiv), (Boc)2O (1.2 equiv) and trimethylamine(2 equiv) were added to dichloromethane. The mixture wasstirred under ice bath conditions. The reactionwas followed by TLCand diluted with dichloromethane. The organic phase was washedwith citric acid (1 N) and saturated NaHCO3 then dried over Na2SO4and filtered. The filtrate was concentrated and purified by a silicacolumn to afford compounds 10a-g.

Reference： [1]European Journal of Medicinal Chemistry,2019,vol. 177,p. 374 - 385
[2]Organic Letters,2016,vol. 18,p. 4518 - 4521
[3]Tetrahedron Asymmetry,2009,vol. 20,p. 2077 - 2089
[4]Heterocycles,2009,vol. 77,p. 865 - 872
[5]ACS Medicinal Chemistry Letters,2013,vol. 4,p. 666 - 670

8
[ 141321-52-0 ]
[ 124-63-0 ]
[ 124577-65-7 ]

Reference： [1]Tetrahedron Asymmetry,2009,vol. 20,p. 2077 - 2089
[2]Angewandte Chemie - International Edition,2010,vol. 49,p. 4467 - 4470

9
[ 1431633-90-7 ]
[ 141321-52-0 ]
[ 1431633-97-4 ]

Yield	Reaction Conditions	Operation in experiment
	With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 25℃; for 12.5h;Inert atmosphere;	General procedure: To diisopropyl azodiformate (DIAD) (0.41 g, 2 mmol), triphenylphosphine (0.41 g, 2 mmol) and dried tetrahydrofuran (5 mL) were slowly added. After 30 min, 5 (3 mmol) in tetrahydrofuran (5 mL) was slowly added to the solution, and then, the tetrahydrofuran (10 mL) solution of 3 (0.24 g, 1 mmol) was added to the solution over the course of 30 min under a nitrogen atmosphere at 0 Cand allowed to proceed for 12 h. After completion of the reaction, the solvent was evaporated to obtain an oil, which was extracted with ethyl acetate/petroleum ether (1:3, 4 10 mL). The organic phase was evaporated under reduced pressure to yield an oil, which was purified by column chromatography with petroleum ether/ethyl acetate (15:1) to obtain a solid. To the solid (0.5 mmol), ethyl acetate with saturated hydrochloric acid (15 mL) was added and reacted for 1 h. The solvent was evaporated under reduced pressure to obtain the crude product, which was recrystallized with methanol/ether to obtain 6a-6s.

Reference： [1]Bioorganic and Medicinal Chemistry,2014,vol. 22,p. 366 - 373

10
[ 1262327-37-6 ]
[ 106946-74-1 ]
[ 2416732-27-7 ]

Yield	Reaction Conditions	Operation in experiment
90%	With triethylamine In toluene at 20℃; for 24h;

Reference： [1]Borisova, Nataliya E.; Chernyshev, Vladimir V.; Chuchelkin, Ilya V.; Firsin, Ilya D.; Gavrilov, Konstantin N.; Gavrilov, Vladislav K.; Goulioukina, Nataliya S.; Maximychev, Alexander V.; Mikhel, Igor S.; Murashova, Elena V.; Perepukhov, Alexander M.; Tafeenko, Victor A.; Zheglov, Sergey V.; Zimarev, Vladislav S. [Dalton Transactions, 2020, vol. 49, # 17, p. 5625 - 5635]

11
[ 106946-74-1 ]
[ 864364-59-0 ]

Yield	Reaction Conditions	Operation in experiment
97%	With p-toluenesulfonyl chloride; potassium hydroxide In diethyl ether at 40℃; Inert atmosphere;

Reference： [1]Cheviet, Thomas; Peyrottes, Suzanne [Journal of Organic Chemistry, 2021, vol. 86, # 4, p. 3107 - 3119]

Same Skeleton Products

Related Products

Historical Records

Related Functional Groups of
[ 106946-74-1 ]

Amino Acid Derivatives

[ 82010-31-9 ]

(S)-tert-Butyl (1-hydroxy-4-methylpentan-2-yl)carbamate

Similarity: 0.98

[ 106930-51-2 ]

Boc-D-Leucinol

Similarity: 0.98

[ 106391-87-1 ]

Boc-D-Valinol

Similarity: 0.96

[ 79069-14-0 ]

(S)-tert-butyl (1-hydroxy-3-methylbutan-2-yl)carbamate

Similarity: 0.96

Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]}	{[ getRatePrice(item.pr_usd, 1,1) ]}	Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]}	{[ item.pr_usastock ]}	Inquiry -	{[ item.pr_chinastock ]}	Inquiry -

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 106946-74-1 ] {[proInfo.proName]}

Quality Control of [ 106946-74-1 ]

Related Doc. of [ 106946-74-1 ]

Product Details of [ 106946-74-1 ]

Calculated chemistry of [ 106946-74-1 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 106946-74-1 ]

Application In Synthesis of [ 106946-74-1 ]

[ 106946-74-1 ] Synthesis Path-Downstream 1~11

Related Functional Groups of [ 106946-74-1 ]

Amino Acid Derivatives

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 106946-74-1 ]