[ CAS No. 104097-04-3 ] {[proInfo.proName]}

Name: 104097-04-3|Diethyl 3-Nitrobenzylphosphonate|95+%
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Quality Control of [ 104097-04-3 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 104097-04-3 ]

SDS Specification

Alternatived Products of [ 104097-04-3 ]

Product Details of [ 104097-04-3 ]

CAS No. :	104097-04-3	MDL No. :	MFCD22574984
Formula :	C₁₁H₁₆NO₅P	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	QNHAEKQJZUMZFT-UHFFFAOYSA-N
M.W :	273.22	Pubchem ID :	13675396
Synonyms :

Calculated chemistry of [ 104097-04-3 ]

Physicochemical Properties

Num. heavy atoms :	18
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.45
Num. rotatable bonds :	7
Num. H-bond acceptors :	5.0
Num. H-bond donors :	0.0
Molar Refractivity :	70.29
TPSA :	91.16 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	No
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	Yes
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.88 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.3
Log Po/w (XLOGP3) :	1.53
Log Po/w (WLOGP) :	3.21
Log Po/w (MLOGP) :	1.08
Log Po/w (SILICOS-IT) :	-0.13
Consensus Log Po/w :	1.6

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.28
Solubility :	1.43 mg/ml ; 0.00522 mol/l
Class :	Soluble
Log S (Ali) :	-3.05
Solubility :	0.242 mg/ml ; 0.000885 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-3.27
Solubility :	0.148 mg/ml ; 0.000543 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	3.0 alert
Leadlikeness :	0.0
Synthetic accessibility :	3.28

Safety of [ 104097-04-3 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P280-P301+P312-P302+P352-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 104097-04-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 104097-04-3 ]

[ 104097-04-3 ] Synthesis Path-Downstream 1~42

1
[ 3958-57-4 ]
[ 122-52-1 ]
[ 104097-04-3 ]

Yield	Reaction Conditions	Operation in experiment
100%	at 140℃; for 2h;	3-nitrobenzyl bromide (1.080g, 5.00 mmol) was mixed with triethyl phosphite (1.04 ml, 6.00 mmol). The mixture was heated to 140 C in an oil bath for 2 h and cooled to room temperature. The excess of triethyl phosphite and the byproduct ethyl bromide were evaporated in vacuo to provide diethyl 3-nitrobenzylphosphonate as a yellow oil (1.460 g, 100%) which did not require further purification. 1H NMR (400 MHz, CDCl3) delta 8.17-8.14 (m, 1H), 8.14-8.10 (m, 1H), 7.69-7.62 (m, 1H), 7.50 (t, J= 7.9 Hz, 1H), 4.09-4.02 (m, 4H), 3.23 (d, J= 21.8 Hz, 2H), 1.26 (t, J= 7.1 Hz, 6H). LC-MS (ESI+) m/z 218.02 (M+H- 2xC2H4)+; HRMS (ESI+) m/z calculated for C11H17NO5P (M+H)+ 274.0839 , found 274.0843.
91%	at 150℃; for 16h;	Step-I : l-(DiethoxyphosphoryImethyl)-3-nitro-benzeneA stirred solution of l-(Bromomethyl)-3-nitro-benzene (4.0 g, 18.5 mmol) and triethyl phosphite (5.3 mL, 31.5 mmol) was heated to 150 C for 16 h. The reaction mixture was cooled to 0 C and added »-pentane (100 mL). Solid formed was filtered through Buckner funnel and dried under reduced pressure to get 4.6 g (91%) of titled compound as a solid. MS (ES) m/z 274.2 (M+l).
91%	at 150℃; for 16h;	Step-I: 1-(Diethoxyphosphorylmethyl)-3-nitro-benzene A stirred solution of 1-(Bromomethyl)-3-nitro-benzene (4.0 g, 18.5 mmol) and triethyl phosphite (5.3 mL, 31.5 mmol) was heated to 150 C. for 16 h. The reaction mixture was cooled to 0 C. and added n-pentane (100 mL). Solid formed was filtered through Buckner funnel and dried under reduced pressure to get 4.6 g (91%) of titled compound as a solid. MS (ES) m/z 274.2 (M+1).

	at 80℃; for 12h;	Dissolve the phosphonate [generate from heating 3-nitobenzyl bromide (786mg, 3.6 mmol) in triethyl phosphite (0. 62ML, 3.6 mmol) at 80C for 12h. ] in DMF (10ML) at RT under nitrogen atmosphere. To this mixture, add sodium hydride (87.3mg, 3. 6MMOL) and stir for LH. Add DIBENZOSUBERENONE (250mg, 1.2mmol) in 2ml of DMF and stir for 18H. Partition the residue between 1N HCL/ETOAC. Dry (MGS04) and concentrate to give 121.6mg of a pale yellow OIL. IH NMR (CDC13) 67. 84 (dt, 1H), 7.72 (t, 1H), 7.45 (d, 1H), 7.4-7. 3 (m, 2H), 7.3-7. 2 (m, 2H), 7.2-7. 0 (m, 4H), 7.0-6. 85 (m, 3H), 6.42 (s, 1H).
	In N,N-dimethyl-formamide; at 90℃; for 16h;Inert atmosphere;	A mixture of 3-nitrobenzyl bromide (2.16 g, I mmol) and triethylphosphite ( 1 .66 g, 1 mmol) in DMF ( 10 mL) is heated at 90 0C under for 16 h under nitrogen atmosphere. The reaction mixture is cooled to RT and diluted with ethyl acetate. The organic layer is washed with water (2 X) and brine. After drying (Na2SO4), the solvent is concentrated. The crude product (2.56 g) (TLC, 80% ethyl acetate/hexanes, Rf 0.35) is used as it is for the next step.
		A stirring suspension of 1 -(bromomethyl)-3-nitrobenzene (46.3mmol, 10g) in triethyl phosphite (69.4mmol, 12.08ml_, 11.54g) was heated at 100C for 4 hours. The reaction mixture was cooled to room temperature and partitioned between water and dichloromethane. The organic layer was separated, dried and concentrated under vacuum. The residue was purified by silica column chromatography (eluent: 0-5% methanol in dichloromethane) to afford the title compound (8g).MS (ESI) m/z 274.0 [M+H]+
	at 150 - 160℃; for 1h;	General procedure: A mixture of 2- or 3-nitrobenzyl bromide (5.4 g, 0.025 mol) and triethyl phosphite (16.6 g, 0.10 mol) was stirred and heated at about 150-160 C (oil bath temperature) for 1 h with continuous distillation of the ethyl bromide produced. The reaction mixture was cooled to room temperature and evaporated to dryness (20 mmHg, boiling water bath). Obtained residue was dissolved in ethyl acetate (100 ml) andwashed with saturated solution of NaHCO3 (6 x 30 ml).The organic phase was dried over anhydrate Na2SO4 and concentratedin vacuum. Obtained thick oily residue was washed withpetroleum ether (5 x 20 ml) and the finally dried in vacuum(~5 mmHg) yielding diethyl 2-nitrobenzylphosphonate (5.4 g, 79%)and diethyl 3-nitrobenzylphosphonate (5.6 g, 82%) as yellow oils.After confirmation of its structure by 1H and 31P NMR spectroscopy,both compounds were used in the next step without further purification.NMR spectra of crude diethyl 2-nitrobenzylphosphonate[19,20] and diethyl 3-nitrobenzylphosphonate [21,22] were inaccordance with literature data.

Reference： [1]MedChemComm,2013,vol. 4,p. 932 - 941
[2]Patent: WO2014/70859,2014,A1 .Location in patent: Page/Page column 65; 67
[3]Patent: WO2013/42139,2013,A1 .Location in patent: Page/Page column 141
[4]Patent: US2015/65464,2015,A1 .Location in patent: Paragraph 0454-0455
[5]Journal of Medicinal Chemistry,2008,vol. 51,p. 2887 - 2890
[6]Journal of the Chemical Society. Perkin transactions II,1973,p. 25 - 33
[7]Journal of the Chemical Society. Chemical communications,1986,p. 1516 - 1517
[8]Bulletin of the Chemical Society of Japan,1987,vol. 60,p. 277 - 282
[9]Patent: WO2004/52847,2004,A2 .Location in patent: Page column 222
[10]Patent: WO2010/110907,2010,A1 .Location in patent: Page/Page column 51-52
[11]Patent: WO2011/51282,2011,A1 .Location in patent: Page/Page column 75
[12]Photochemistry and Photobiology,2015,vol. 91,p. 1324 - 1331
[13]Dyes and Pigments,2017,vol. 142,p. 507 - 515

2
[ 104097-04-3 ]
[ 40299-58-9 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions II,1973,p. 25 - 33
[2]Bulletin of the Chemical Society of Japan,1987,vol. 60,p. 277 - 282

Yield	Reaction Conditions	Operation in experiment
		(E) 2-[(E)-2-(3-Nitrophenyl)-1-ethenyl]-5-phenylfuran The 5-phenyl-2-furaldehyde obtained in (C) (188 mg, 1.09 mmol) and the diethyl (3-nitrobenzyl)phosphonate obtained in (D) (597 mg, 2.18 mmol) were dissolved in DMF (3 ml), and the solution was added with sodium methoxide (118 mg) and stirred at room temperature for 6 hours. The reaction mixture was further added with 5-phenyl-2-furaldehyde (191 mg) and sodium methoxide (118 mg), then added with 60% sodium hydride (88.0 mg) and stirred at room temperature overnight. The reaction mixture was added with methanol, and concentrated under reduced pressure. The resulting residue was diluted with ethyl acetate, and washed with saturated brine.

4
[ 20432-35-3 ]
[ 104097-04-3 ]
p-(N,N-dimethylamino)-m'-nitro-1,4-diphenyl-buta-1(E),3(E)-diene [ No CAS ]

Reference： [1]Photochemistry and Photobiology,2000,vol. 71,p. 387 - 396

5
[ 619-25-0 ]
[ 104097-04-3 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions II,1973,p. 25 - 33

6
[ 4042-14-2 ]
[ 104097-04-3 ]
C₂₂H₁₄ClNO₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hydride; In dimethyl sulfoxide; mineral oil; at 80 - 100℃; for 48h;	Heat a suspension of NaH (60% suspension in mineral oil, 49mg, 1. 2MMOL) in DMSO (6mL) to 80C under N2 until evolution of H2 stops. Dissolve (3-nitro-benzyl)- phosphonic acid diethyl ester (prepared according to procedures as described in Okamoto et. al. , Bull. Chem. Soc. Jpn. (1987), 60 (1), 277-82) (338mg, 1. 2MMOL) IN DMSO (LML) and add to reaction mixture. Add L-CHLORO-10, 11-DIHYDRO-DIBENZO [a, d] cyclohepten-5-one (prepared according to procedures as described in Humber et al. , J. Med. Chem. (1978), 21 (12), 1225-31) (200mg, 0. 824MMOL) at once and heat to 100C for 48h. Cool to room temperature. Dilute reaction mixture with ethyl acetate (50ML) and wash twice with H20. Dry (MGS04) and concentrate organics to a brown oil. Chromatograph on silica gel (lOg), eluting with 2% to 4% ethyl acetate/hexanes to afford a mixture of compounds. Dissolve this mixture in ethanol (lOmL) and add SnCl2 (dihydrate, 508mg, 2. 25MMOL). Heat to reflux for 3h and cool to room temperature. Concentrate reaction mixture, then dissolve residue in diethyl ether. Wash organics with H20, 1. OON aqueous NAOH, then twice with H20. Dry (MGS04) and concentrate organics to a yellow oil. Chromatograph on silica gel (lOg), eluting with 5% to 10% ethyl ACETATE/HEXANES to afford 28mg (10%) of the title compound as a colorless oil. MS (ES) 330 (M+H) ; HPLC reveals 36: 64 mixture of geometric isomers-36% at 4. 977MIN, 64% at 5. 218min-overall 100% purity.

Reference： [1]Patent: WO2004/52847,2004,A2 .Location in patent: Page 246

7
[ 3958-57-4 ]
[ 104097-04-3 ]

Yield	Reaction Conditions	Operation in experiment
90%	In triethyl phosphite;	(D) Diethyl (3-nitrobenzyl)phosphonate 3-Nitrobenzyl bromide (1.00 g, 4.63 mmol) was dissolved in triethyl phosphite (15 ml), and the mixture was stirred at 100C for 3 hours. The reaction mixture wasleft stand for cooing, and then added with ether. The deposited insoluble substances were removed by filtration, and the mother liquor was evaporated. The residue was purified by silica gel chromatography (n-hexane:ethyl acetate, 4:1 ? 1:1, v/v) to obtain the title compound (1.14 g, 90%). 1H-NMR (CDCl3) delta: 1.27 (6H, t, J=7.3Hz), 3.21 (1H, s), 3.27 (1H, s), 4.07 (4H, q, J=7.3Hz), 7.50 (1H, dd, J=8.3, 7.8Hz), 7.66 (1H, d, J=7.8Hz), 8.14 (1H, d, J=8.3Hz), 8.16 (1H, d, J=2.0Hz)

Reference： [1]Patent: EP1227084,2002,A1

8
[ 104097-04-3 ]
[ 79099-07-3 ]
[ 583031-22-5 ]

Yield	Reaction Conditions	Operation in experiment
		Step 1 : A suspension of sodium hydride (10.98mmol, 0.439g) in tetrahydrofuran (40ml_) was added to a stirred solution of <strong>[104097-04-3]diethyl 3-nitrobenzylphosphonate</strong>(7.32mmol, 2g) in tetrahydrofuran (40mL) at 0C and the reaction stirred for 30 minutes. tert-Butyl 4-oxopiperidine-1 -carboxylate (7.32mmol, 1.459g) was added and the reaction mixture stirred at room temperature overnight. The reaction mixture was concentrated under vacuum and the residue partitioned between dichloromethane and water. The organic layer was separated, dried and concentrated under vacuum. The residue was purified by silica column chromatography (eluent: 0-2% methanol in dichloromethane) to afford the intermediate tert-butyl 4-(3-nitrobenzylidene)- piperidine-1 -carboxylate (2g).

Reference： [1]Journal of Medicinal Chemistry,2008,vol. 51,p. 2887 - 2890
[2]Patent: WO2011/51282,2011,A1 .Location in patent: Page/Page column 75

9
[ 104097-04-3 ]
[ 100-52-7 ]
[ 1694-20-8 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2009,vol. 19,p. 2509 - 2513

10
[ 104097-04-3 ]
[ 587-04-2 ]
[ 7297-53-2 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2009,vol. 19,p. 2509 - 2513

11
[ 104097-04-3 ]
[ 456-48-4 ]
[ 38694-04-1 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2009,vol. 19,p. 2509 - 2513

12
[ 104097-04-3 ]
[ 104139-11-9 ]

Yield	Reaction Conditions	Operation in experiment
100%	With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; at 20℃;	Diethyl 3-nitrobenzylphosphonate (1.366 g, 5.00 mmol) was dissolved in THF (5 ml). The solution was hydrogenated with Pd/C (10%, 0.100 g) catalyst under H2 atmosphere at room temperature overnight. The catalyst was filtered off through a pad of celite and washed with THF (5 ml x 2). The filtrate was concentrated to dryness affording the aniline 13c (1.300g, 100%) as yellow oil which was used without further purification.
64%	With hydrogen;palladium 10% on activated carbon; In ethanol; at 20℃; for 16h;	The product from step 1 (2.56 g, 9.4 mmol) is dissolved in 10 mL of ethyl alcohol and added to a round bottom flask containing 250 mg of 10% palladium/carbon catalyst. The mixture is purged with H2 and stirred at RT for 16 h under a H2 atmosphere using a balloon. Upon completion of reaction by TLC analysis, the mixture is then passed through a pad of celite and washed with ethanol. The filtrate is concentrated. The pure product ( 1.45 g, 64%) is isolated by silica gel column chromatography using 50 to 75% CH3CN in CH2Cl2. 1 H NMR (500 MHz, DMSOd6) delta 6.9 - 7.0 (t, 1 H), 6.7 (s, I H), 6.4 - 6.5 (m, 2H), 5.3 - 5.6 (br, 2H), 3.9 (m, 4H), 3.4 (s, 2H), 1.2 (t, 6H).

Reference： [1]MedChemComm,2013,vol. 4,p. 932 - 941
[2]Patent: WO2014/70859,2014,A1 .Location in patent: Page/Page column 65; 67
[3]Patent: WO2010/110907,2010,A1 .Location in patent: Page/Page column 52
[4]European Journal of Medicinal Chemistry,2015,vol. 101,p. 384 - 390

13
[ 104097-04-3 ]
[ 100-52-7 ]
[ 4714-26-5 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium ethanolate; In ethanol; at 20℃;	General procedure: With the exception of 10c, 10d and 10i all the anilines required for the synthesis of the isatin analogues were commercially available. Sodium (105 mmol) was allowed to react with ethanol (109 mL) in small portions over a period of 2 h. The resulting mixture was added at room temperature to diethyl 4- or <strong>[104097-04-3]diethyl 3-nitrobenzylphosphonate</strong> (11a, b, 100 mmol)26 and benzaldehyde (12, 100 mmol) or cinnamaldehyde (14, 100 mmol) dissolved in ethanol (164 mL) over a period of 1.5 h. Stirring was continued for 20 h and the thick yellow precipitate was collected by vacuum filtration and washed with 40 mL ethanol followed by 40 mL petroleum ether.27 The nitro-functionalized intermediates 13a, 13b and 15 thus obtained (yield 69-71%) were used without further purification in the following reaction. The nitro derivatives (25 mmol) were suspended in 400 mL methanol and the reaction flask was purged with argon. A quantity of 3% (of the weight of the nitro derivative) of Pd/C (10%) was prewet with 2 mL water and added to 10 mL methanol. This mixture was carefully added to the reaction. The atmosphere was replaced by hydrogen and the reaction was stirred at room temperature for 24 h during which the reaction became a clear solution. The catalyst was removed by filtration through a bed of Celite and the methanol solvent was evaporated under reduced pressure. The resulting aniline derivative was converted to the corresponding hydrochloride salt in CH2Cl2 (70 mL). A volume of 150 mL diethyl ether may be added to the acidic CH2Cl2 solution to facilitate precipitation of the salt (yield 41-95%).

Reference： [1]Bioorganic and Medicinal Chemistry,2011,vol. 19,p. 261 - 274

14
[ 104097-04-3 ]
[ 1299488-89-3 ]

Reference： [1]Patent: WO2011/51282,2011,A1

15
[ 104097-04-3 ]
[ 676528-03-3 ]

Reference： [1]Patent: WO2011/51282,2011,A1

16
[ 104097-04-3 ]
[ 1299488-90-6 ]

Reference： [1]Patent: WO2011/51282,2011,A1

17
[ 104097-04-3 ]
[ 773848-28-5 ]

Reference： [1]Patent: WO2011/51282,2011,A1

18
[ 4746-97-8 ]
[ 104097-04-3 ]
[ 1428929-74-1 ]

Yield	Reaction Conditions	Operation in experiment
90%		Step-II: 8-[(3-Nitrophenyl)methyIene]-l,4-dioxaspiro[4.5]decaneTo a stirred suspension of sodium hydride (1.1 g, 28.17 mmol) in THF (10 mL) was added a solution of l-(diethoxyphosphorylmethyl)-3 -nitrobenzene (4.6 g, 16.9 mmol) in THF (30 mL) at 0 C and stirred for 4 h at room temperature. This was again cooled to 0 C, added a solution of l,4-dioxaspiro[4.5]decan-8-one (2.2 g, 14.1 mmol) in THF (10 mL) and stirring continued for 16 h at room temperature. Reaction mixture was poured onto the ice cold water (150 mL) and extracted with ethyl acetate (2 X 100 mL). Combined organic layer was washed with brine (25 mL), dried over anhydrous sodium sulfate, filtered, concentrated and purified by column chromatography to give 3.5 g (90%) of titled compound.? NMR (400 MHz, CDC13): delta 1.68 (t, J = 6.3 Hz, 2H), 1.81 (t, J = 6.3 Hz, 2H), 2.45-2.52 (m, 4H), 3.99 (s, 4H), 6.33 (s, 1H), 7.45-7.51 (m, 2H), 8.04-8.06 (m, 2H). MS (ES) m/z 276.3 (M+l).
90%		Step-II: 8-[(3-Nitrophenyl)methylene]-1,4-dioxaspiro[4.5]decane To a stirred suspension of sodium hydride (1.1 g, 28.17 mmol) in THF (10 mL) was added a solution of <strong>[104097-04-3]1-(diethoxyphosphorylmethyl)-3-nitrobenzene</strong> (4.6 g, 16.9 mmol) in THF (30 mL) at 0 C. and stirred for 4 h at room temperature. This was again cooled to 0 C., added a solution of 1,4-dioxaspiro[4.5]decan-8-one (2.2 g, 14.1 mmol) in THF (10 mL) and stirring continued for 16 h at room temperature. Reaction mixture was poured onto the ice cold water (150 mL) and extracted with ethyl acetate (2*100 mL). Combined organic layer was washed with brine (25 mL), dried over anhydrous sodium sulfate, filtered, concentrated and purified by column chromatography to give 3.5 g (90%) of titled compound. 1H NMR (400 MHz, CDCl3): delta 1.68 (t, J=6.3 Hz, 2H), 1.81 (t, J=6.3 Hz, 2H), 2.45-2.52 (m, 4H), 3.99 (s, 4H), 6.33 (s, 1H), 7.45-7.51 (m, 2H), 8.04-8.06 (m, 2H). MS (ES) m/z 276.3 (M+1).

Reference： [1]Patent: WO2013/42139,2013,A1 .Location in patent: Page/Page column 141-142
[2]Patent: US2015/65464,2015,A1 .Location in patent: Paragraph 0456-0457

19
[ 104097-04-3 ]
[ 1428927-88-1 ]

Reference： [1]Patent: US2015/65464,2015,A1
[2]Patent: WO2013/42139,2013,A1

20
[ 104097-04-3 ]
[ 1428929-75-2 ]

Reference： [1]Patent: US2015/65464,2015,A1
[2]Patent: WO2013/42139,2013,A1

21
[ 104097-04-3 ]
[ 1428929-76-3 ]

Reference： [1]Patent: US2015/65464,2015,A1
[2]Patent: WO2013/42139,2013,A1

22
[ 104097-04-3 ]
[ 1428929-77-4 ]

Reference： [1]Patent: US2015/65464,2015,A1
[2]Patent: WO2013/42139,2013,A1

23
[ 104097-04-3 ]
[ 1428929-78-5 ]

Reference： [1]Patent: US2015/65464,2015,A1
[2]Patent: WO2013/42139,2013,A1

24
[ 104097-04-3 ]
[ 1456602-22-4 ]

Reference： [1]MedChemComm,2013,vol. 4,p. 932 - 941

25
[ 104097-04-3 ]
[ 1456602-26-8 ]

Reference： [1]MedChemComm,2013,vol. 4,p. 932 - 941

26
[ 104097-04-3 ]
3-(N-(4-cyclohexylbenzyl)-4-phenoxybenzamido)benzylphosphonic acid [ No CAS ]

Reference： [1]MedChemComm,2013,vol. 4,p. 932 - 941

27
[ 104097-04-3 ]
(E)-2-(3-isocyanostyryl)pyridine [ No CAS ]