Alternatived Products of [ 100823-03-8 ]
Product Details of [ 100823-03-8 ]
CAS No. : | 100823-03-8 |
MDL No. : | MFCD03085319 |
Formula : |
C20H22N2O2
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | NRPIRIUWEKTNGQ-UHFFFAOYSA-N |
M.W : |
322.40
|
Pubchem ID : | 1235479 |
Synonyms : |
|
Safety of [ 100823-03-8 ]
Application In Synthesis of [ 100823-03-8 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 100823-03-8 ]
- 1
-
[ 75-36-5 ]
-
[ 100823-03-8 ]
-
[ 100823-05-0 ]
Yield | Reaction Conditions | Operation in experiment |
|
With triethylamine In tetrahydrofuran at 20℃; for 1h; |
|
Reference:
[1]Carcache de-Blanco, Esperanza J.; Pandit, Bulbul; Hu, Zhigen; Shi, Jiandong; Lewis, Andrew; Li, Pui-Kai
[Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 21, p. 6031 - 6035]
- 2
-
[ 100823-00-5 ]
-
[ 100823-03-8 ]
Yield | Reaction Conditions | Operation in experiment |
|
With hydrogen In acetone for 2h; Heating; |
|
|
With hydrogen In acetone for 2h; Heating / reflux; |
In another aspect of the present disclosure, a thalidomide analog is synthesized by substituting the glutaramide ring with an aromatic group. In one embodiment, Compound 4 is synthesized by using the reactants 5-nitrophthalic anhydrides and 2,6-diisopropylaniline to produce (2,6-diisopropylphenyl)-5-amino-1H-isoindole-1,3-dione, which is further processed to form Compound 4. In a preferred embodiment, 5nitrophthalic anhydrides and 2,6-diisopropylaniline is refluxed with AcOH for 5 hrs to produce (2,6-diisopropylphenyl)-5-amino-1H-isoindole-1,3-dione. (2,6-diisopropylphenyl)-5-amino-1H-isoindole-1,3-dione is further refluxed with H2, Pd/C, and acetone for 2 hrs to form Compound 4. |
Reference:
[1]Carcache de-Blanco, Esperanza J.; Pandit, Bulbul; Hu, Zhigen; Shi, Jiandong; Lewis, Andrew; Li, Pui-Kai
[Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 21, p. 6031 - 6035]
[2]Current Patent Assignee: CHARLESSON - US2008/306134, 2008, A1
Location in patent: Page/Page column 4; 5; Sheet 7/8