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Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
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CAS No. : | 960055-56-5 | MDL No. : | N/A |
Formula : | C24H29N3O5 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 439.50 | Pubchem ID : | - |
Synonyms : |
LBH589 lactate;NVP-LBH589 lactate
|
Chemical Name : | (E)-N-Hydroxy-3-(4-(((2-(2-methyl-1H-indol-3-yl)ethyl)amino)methyl)phenyl)acrylamide 2-hydroxypropanoate |
Signal Word: | Danger | Class: | 6.1 |
Precautionary Statements: | P201-P202-P260-P264-P270-P271-P280-P301+P310+P330-P302+P352-P304+P340+P311-P305+P351+P338+P310-P308+P313-P332+P313-P403+P233-P405-P501 | UN#: | 2811 |
Hazard Statements: | H301+H331-H315-H318-H360-H373 | Packing Group: | Ⅲ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
86.2% | In water; acetone; at 0 - 20℃;Cooling with ice;Product distribution / selectivity; | 3.67 g (10 mmol) of the free base form HA (N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide) and 75 mL of acetone were charged in a 250 mL 3-neck flask equipped with a magnetic stirrer and an addition funnel. To the stirred suspension were added dropwise 10 mL of 1 M lactic acid in water (10 mmol) dissolved in 20 mL acetone, affording a clear solution. Stirring continued at ambient and a white solid precipitated out after approximately 1 hour. The mixture was cooled in an ice bath and stirred for an additional hour. The white solid was recovered by filtration and washed once with cold acetone (15 mL). It was subsequently dried under vacuum to yield 3.94 g of the DL-lactate monohydrate salt of N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide (86.2%). |
In isopropyl alcohol; at 4℃;Product distribution / selectivity; | EXAMPLE 7; Formation of Monohydrate Lactate Salt; About 40 to 50 mg of N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide free base was suspended in 1 ml of a solvent as listed in Table 7. A stoichiometric amount of lactic acid was subsequently added to the suspension. The mixture was stirred at ambient temperature and when a clear solution formed, stirring continued at 4 C. Solids were collected by filtration and analyzed by XRPD, TGA and 1H-NMR.; The salt forming reaction in isopropyl alcohol and acetone at 4 C. produced a stoichiometric (1:1) lactate salt, a monohydrate. The salt is crystalline, begins to dehydrate above 77 C., and decomposes above 150 C. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In methanol; | <strong>[404950-80-7]Panobinostat</strong> base (2.0 g) and DL- lactic acid (0.85 g) are dissolved in methanol (20.0 ml). The clear solution was evaporated to obtain solid. XPRD of the solid gives pure amorphous form of<strong>[404950-80-7]Panobinostat</strong> DL-lactate. |
A165763[ 404950-80-7 ]
(E)-N-Hydroxy-3-(4-(((2-(2-methyl-1H-indol-3-yl)ethyl)amino)methyl)phenyl)acrylamide
Reason: Free-salt