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[ CAS No. 93076-03-0 ] {[proInfo.proName]}

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Chemical Structure| 93076-03-0
Chemical Structure| 93076-03-0
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Product Details of [ 93076-03-0 ]

CAS No. :93076-03-0 MDL No. :MFCD09031252
Formula : C11H16Cl2N2O Boiling Point : -
Linear Structure Formula :- InChI Key :OPYLAGAQMHMBNY-UHFFFAOYSA-N
M.W : 263.16 Pubchem ID :15605782
Synonyms :

Calculated chemistry of [ 93076-03-0 ]

Physicochemical Properties

Num. heavy atoms : 16
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.64
Num. rotatable bonds : 2
Num. H-bond acceptors : 2.0
Num. H-bond donors : 0.0
Molar Refractivity : 68.72
TPSA : 34.89 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : Yes
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.56 cm/s

Lipophilicity

Log Po/w (iLOGP) : 0.0
Log Po/w (XLOGP3) : 1.89
Log Po/w (WLOGP) : 2.47
Log Po/w (MLOGP) : 2.26
Log Po/w (SILICOS-IT) : 3.11
Consensus Log Po/w : 1.95

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 0.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -2.81
Solubility : 0.41 mg/ml ; 0.00156 mol/l
Class : Soluble
Log S (Ali) : -2.25
Solubility : 1.5 mg/ml ; 0.00569 mol/l
Class : Soluble
Log S (SILICOS-IT) : -3.66
Solubility : 0.057 mg/ml ; 0.000217 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 1.0 alert
Leadlikeness : 0.0
Synthetic accessibility : 2.72

Safety of [ 93076-03-0 ]

Signal Word:Danger Class:8
Precautionary Statements:P501-P260-P270-P264-P280-P303+P361+P353-P301+P330+P331-P363-P301+P312+P330-P304+P340+P310-P305+P351+P338+P310-P405 UN#:3261
Hazard Statements:H302-H314 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 93076-03-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 93076-03-0 ]

[ 93076-03-0 ] Synthesis Path-Downstream   1~5

  • 1
  • 3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one monohydrochloride [ No CAS ]
  • [ 84163-46-2 ]
  • [ 106266-06-2 ]
YieldReaction ConditionsOperation in experiment
99.4%Chromat. In one liter four neck round bottom flask 250 ml of isopropyl alcohol was taken at room temperature i. e. 20 to 35°ree;C. To the reaction flask, 25 gm of (2,4-difluorophenyl) (4-piperidinyl) methanone oxime was added followed by addition of 30 gm of3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2a] pyrimidin-4-one hydrochloride and 75 gm of sodium Carbonate. To it 3.75 gm of Potassium lodide was added. Reaction mixture was stirred for 5-10 minutes. The reaction mixture was slowly heated to reflux (80-82°ree;C), and the temperature maintained for next 4 hours. The reaction mixture was then cooled to room temperature (20-35°ree;C). Potassium hydroxide solution (30 gm KOH in 60ml water) was prepared separately and cooled to15°ree;C. Potassium hydroxide solution was added slowly to the reaction mixture and stirred at30-40°ree;C for 6 hours. The reaction mixture is quenched slowly by addition of the reaction mixture in a 5 lit. 4-neck round bottom flask containing 2 lit. water at room temperature (20-35°ree;C). The mixture stirred at room temperature (20-35°ree;C) for 1 hour and 30 minutes. The product filtered and washed with 500 ml of water till neutral pH to get 43 gm of wet resperidone, which was further dried at 65°ree;C for 6hours to get 32.0 gm of dry respiredone with 99.4% purity (by HPLC).
In 250 ml four neck round bottom flask 100 mi of isopropyl alcohol was taken at room temperature i. e. 20 to 35°ree;C. To the reaction flask, 10 gm of (2,4-difluorophenyl-)(4-piperidinyl) methanone, oxime was added followed by addition of 11 gm of 3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one hydrochloride and 15 gm of sodium carbonate. To it 1.0 gm of Potassiumlodide was added. Reaction mixture was stirred for 5-10 minutes. The reaction mixture was slowly heated toreflux (80-82°ree;C), and maintained the temperature for next 5 hours. The reaction mixture was then cooled to room temperature (20-35°ree;C). Piperidine 18 gm was charged slowly to the reaction mixture and stirred at 25-30°ree;C for 12 hours. Quench the reaction mixture slowly by addition of the reaction mixture in a 5 lit. 4-neck round bottom flask containing 750 mi water at room temperature (20-35°ree;C). Stirred the mixture at room temperature (20-35°ree;C) for 2 hour and 30 minutes. Filtered the product and washed with 240 ml of water till neutral pH to get 8.3 gm of wet crude Risperidone, which was further dried at 65°ree;C for 6 hours to get 7.5 gm of dry Risperidone.
In 250 ml four neck round bottom flask, 100 mi of isopropyl alcohol (IPA) was taken at room temperature i. e. 25 to 30°ree;C. To the reaction flask, 10 gm of (2,4-difluorophenyl-)(4-piperidinyl) methanone, oxime was added followed by addition of 11 gm of 3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a] pyrimidin-4-one hydrochloride and 15 gm of sodium carbonate. To it 1.0 gm of potassium iodide was added. Reaction mixture was stirred for 5-10 minutes. The reaction mixture was slowly heated to reflux (80-82°ree;C), and maintained the temperature for next 5 hours. The reaction mixture was then cooled to room temperature (20-35°ree;C). Sodium hydroxide solution (8.5 gm NaOH in 8.5 ml water) was prepared separately and cooled to15°ree;C. Sodium hydroxide solution was added slowly to the reaction mixture and stirred at25-30°ree;C for 12 hours. Quench the reaction mixture slowly by addition of the reaction mixture in a 5 lit. 4-neck round bottom flask containing 750 ml water at room temperature(20-35°ree;C). Stirred the mixture at room temperature (20-35°ree;C) for 2 hour and 30 minutes. Filtered the product and washed with 240 ml of water till neutral pH to get 12.2 gm of wet crude Risperidone, which was further dried at 65°ree;C for 6 hours to get 11.5 gm of dry Risperidone. HPLC PURITY = 97.5%
In 250 ml four neck round bottom flask 100 ml of Isopropyl alcohol was taken at room temperature i. e. 20 to 35°ree;C. To the reaction flask, 10 gm of (2,4-difluorophenyl-)(4-piperidinyl) methanone, oxime was added followed by addition of 11 gm of 3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a] pyrimidin-4-one hydrochloride and 5.9 gm of sodium hydroxide. To it 1.0 gm of Potassium lodide was added. Reaction mixture was stirred for 5-10 minutes. The reaction mixture was slowly heated to reflux(80-82°ree;C), and maintained the temperature for next 5 hours. The reaction mixture was then cooled to room temperature (20-35°ree;C). Sodium hydroxide solution (8.5 gm NaOH in 8.5 ml water) was prepared separately and cooled to15°ree;C. Sodium hydroxide solution was added slowly to the reaction mixture and stirred at 25-30°ree;C for 12 hours. Quench the reaction mixture slowly by addition of the reaction mixture in a 5 lit. 4-neck round bottom flask containing 750 ml water at room temperature (20-35°ree;C). Stirred the mixture at room temperature (20-35°ree;C) for 2 hour and 30 minutes. Filtered the product and washed with 240 ml of water till neutral pH to get 8.5 gm of wet crude Risperidone, which was further dried at 65°ree;C for 6 hours to get 7.0 gm of dry Risperidone. HPLC PURITY= 94.74%

  • 2
  • 3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one monohydrochloride [ No CAS ]
  • [ 135634-18-3 ]
  • [ 106266-06-2 ]
YieldReaction ConditionsOperation in experiment
81% With sodium carbonate;potassium iodide; In acetonitrile; for 32h;Heating / reflux; A mixture of 4.75 g of 3- (2-chloroethyl)-6, 7,8, 9-tetrahydro-2-methyl-4H-pyrido [[1,] [2-A] PYRIMIDIN-4-ONE] hydrochloride, 5.1 g of [4- (2,] 4-difluorobenzoyl) piperidine oxime hydrochloride, 0.46 g of potassium iodide, 5 g of anhydrous sodium carbonate and 30 ml of acetonitrile was stirred and refluxed for 32 hours. The reaction mixture was cooled and water (120 ml) was added under stirring. Separated solid stirred at [5 FOR 1] hour, filtered, washed with water and crystallized from ethyl acetate yielding 6 g (81%) of [3- [2- [4- (6-FLUORO-] [1,] [2-BENZISOXAZOLE-3-YL) PIPERIDINO] ETHYL]-6,] 7,8, [9-TETRAHYDRO-2-METHYL-4H-PYRIDO [ 1,] 2-a] [PYRIMIDIN-4-ONE.]
79 - 81% With potassium carbonate;potassium iodide; In acetonitrile; for 30h;Heating / reflux; A mixture of 4.75 g of [3-(2-CHLOROETHYL)-6,] 7,8, 9-tetrahydro-2-methyl-4H-pyrido [1, 2-a] pyrimidin-4-one hydrochloride, 5. 1 g of [4- (2, 4-DIFLUOROBENZOYL)] piperidine oxime hydrochloride, 0.46 g of potassium iodide, 6.5 g of anhydrous powdered potassium carbonate and 30 ml of acetonitrile was stirred and refluxed for 30 hours. Reaction monitoring by HPLC analysis indicated in situ formation of risperidone. After the completion of reaction, the reaction mixture was cooled and water (120 ml) was added under stirring. Separated solid stirred at [5C] for [1] hour, filtered, washed with water and crystallized from ethyl acetate yielding 6 g [(81%) OF 3- [2- [4- (6-FLUORO-L,] 2-benzisoxazole-3-yl) piperidino] [ETHYL-6,] 7,8, 9- [TETRAHYDRO-2-METHYL-4H-PYRIDO [1,] 2-a] pyrimidin-4-one. Example-5 A mixture of 4.75 g of [3- (2-CHLOROETHYL)-6,] 7,8, 9-tetrahydro-2-methyl-4H-pyrido [[1,] 2-a] [PYRIMIDIN-4-ONE,] 6.0 g [OF 4- (2,] 4-difluorobenzoyl) piperidine oxime hydrochloride, [0.] 46 g of potassium iodide, 6.1 g of anhydrous powdered potassium carbonate and 40 ml of acetonitrile was stirred and refluxed for 30 hours. The reaction mixture was cooled and water (120 [ML)] was added under stirring. Separated solid stirred at [5C] for 1 hour, filtered, washed with water. Crude product was purified by crystallization in ethyl acetate to afford 6. [8] g (79%) of [3- [2- [4- (6-FLUORO-1, 2-BENZISOXAZOLE-3-YL) PIPERIDINO] ETHYL]-6,] 7,8, 9-tetrahydro-2- methyl-4H-pyrido [1, 2-a] [PYRIMIDIN-4-ONE.]
77% With potassium carbonate;potassium iodide; In DMF (N,N-dimethyl-formamide); at 95 - 100℃; for 18h; A mixture of 4.75 g of [3.] [(2-CHLOROETHYL)-6,] 7,8, 9-tetrahydro-2-methyl-4H-pyrido [[1,] 2-a] [PYRIMIDIN-4-ONE] hydrochloride, [5.] [1] g of 4- (2, 4-difluorobenzoyl) piperidine oxime hydrochloride, 0.46 g of potassium iodide, 6.5 g of anhydrous powdered potassium carbonate and 30 ml [OF N, N-DIMETHYLFORMAMIDE] was stirred at [95-100C] for 18 hours. The reaction mixture was cooled and water (120 [ML)] was added under stirring. Separated solid stirred at [5C] for 1 hour, filtered, washed with. water and crystallized from ethyl acetate yielding 5.7 g [(77%)] of [3- [2- [4- (6-FLUORO-1,] 2-benzisoxazole-3-yl) piperidino] ethyl]-6, 7,8, 9-tetrahydro-2- [METHYL-4H-PYRIDO [1, 2-A] PYRIMIDIN-4-ONE.]
73% With potassium carbonate;potassium iodide; In 4-methyl-2-pentanone; at 100 - 105℃; for 30h; A mixture of 4.75 g of [3- (2-CHLOROETHYL)-6,] 7,8, [9-TETRAHYDRO-2-METHYL-4H-PYRIDO] [[1,] 2-a] pyrimidin-4-one hydrochloride, 5.1 g of 4-(2, 4-difluorobenzoyl) piperidine oxime hydrochloride, 0.46 g of potassium iodide, 6.5 g of anhydrous powdered potassium carbonate and 30 ml [OF MIBK] was stirred at [100105C] for 30 hours. The reaction mixture was cooled and water (150 ml) was added under stirring. Separated solid stirred at [5C] for 1 hour, filtered, washed with water and crystallized from ethyl acetate yielding 5.4 g (73%) of [3- [2- [4- (6-FLUORO-1, 2-BENZISOXAZOLE-3-YL) PIPERIDINO] ETHYL]-6,] 7,8, 9-tetrahydro-2-methyl-4H- [PYRIDO] [[1,] 2-a] [PYRIMIDIN-4-ONE.]

  • 3
  • 3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one monohydrochloride [ No CAS ]
  • [ 84163-13-3 ]
  • [ 106266-06-2 ]
YieldReaction ConditionsOperation in experiment
93.6% With sodium carbonate; In methanol; at 73 - 75℃; for 4 - 4.5h;Product distribution / selectivity; Example 1; Preparation of the risperidone of the formula (I) from the hydrochlorid salt of 3-(2-cUoroemyl)-2-methyl-6,7,8,9-te1xahydro-4H-pyrido[l,2-a]pyrimidme-4-one of the formula (II) and the hydrochloride salt of 6-fluoro-3-(4-piperidinyl)-l,2-benzisoxazole of the formula (III). In a pressure vessel into a mixture of 13.3 g (0.052 mol) of <strong>[84163-13-3]6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride</strong>, 15.0 g (0.057 mol) of 3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[l,2-a]pyrimidine-4-one hydrochloride, 20.67 g of dry sodium carbonate and 200 ml of dry methanol nitrogen is introduced and the mixture is stirred for 4-4.5 hours at 73-75 C. Then the pressure is brought to atmospheric level, the mixture is concentrated to about 150 g, 100 ml of ion exchanged water is added, then the mixture is cooled to a temperature between 0 C and 5 C and filtered. To the filter cake 100 ml of ion exchanged water is added, stirred for an hour at 23-25 C and filtered. The crystals arewashed with ion exchanged water (3 x 20 ml), filtered and dried at a temperature below 60 C to yield 20.0 g of risperidone (93.6 % based on the starting benzisoxazole derivative).Mp: 171-172 C; purity is at least 99 %, determined by HPLC
With sodium carbonate; In water; at 25 - 55℃; for 9h;Product distribution / selectivity; Example 1 : Condensation reaction in water medium 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hyrochloride (Formula - 2.HCl, 100G) IS added to a solution of sodium carbonate (180g) in 400ml water at 25- 30C. STOW . Y THE REACTION mass is warmed to 50-55C and then a SOLUTON of 3- (2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one HYDROCHLORIDE (FORMULA-3. HCI, 150G) IN water (300MT) is added graduaty over a period of 5 hours at 50-55C. THE REACTION mass temperature is maintained further for another 4 hours. The reaction mass is cooled to room temperature and diluted VFI (200ML) WATER THE PRECIPITATED RISPERIDONE IS SEPARATED by filtration, washed with water (50ml) and dried to get crude risperidone. Crude nsperidone weight = 135gm PURITR-90-95% (HPLC); Example 2: Condensation reaction in water medium 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride (Formula - 2.HCl, LONG) is added to a SOTUTION of sodium carbonate(180g) in 400ml water at 25- 30C. Slowly the reaction mass is warmed to 50-55C and then a solution of 3- (2-chloroethyl)-6, 7,8, 9-tetrahydro-2-methyl-4H-pyrido[]1, 2-ALPYRIMIDIN-4-ONE HYDROCHIOHDE (Formula-3. HCl, 150g) in water (300ml) is added gradually over a period of 5 hours at 50-55C. The reaction mass temperature is maintained further for another 4 hours. The reaction mass is cooled to room temperature and diluted with (200ml) water the precipitated risperidone is extracted with DICHLOROMETHANE (3X450ML). The dichloromethane extract is used for further work-up according to Method A or Method B, as given below to get crude risperidone.
With sodium carbonate; In water; acetonitrile; at 25 - 75℃; for 8h;Product distribution / selectivity; Example 3 : Condensation reaction in mixture of water and water-miscible solvents 6-Fluoro-3-(4-iperidinyl)-1, 2 benzisoxazole hydrochloride (100G) is added to a suspension of sodium carbonate (180G) in ACETONITRITE (500ml) at 25-30C. Slowly, the reaction mass is warmed TO 70-75"C and then a solution of 3-(2- CHLOROETHO)-6. 7, 8, 9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one hydrochloride (1109) IN water (200ML) is added gradually over a period of 4 hours at 70-75C. The reaction mass is maintained at the same temperature for an ADDITIONAL 4 hours. The reaction mass is then cooled to room temperature and diluted with water (500ML). The resulting mixture is extracted with dichloromethane (3X450M .). The dichloromethane extract is worked up as EXP . AINED TOR METHOD A in Example 1 to produce crude risperidone
  • 4
  • 3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one monohydrochloride [ No CAS ]
  • [ 84163-77-9 ]
  • [ 106266-06-2 ]
YieldReaction ConditionsOperation in experiment
3.8 parts (46%) With potassium iodide; sodium carbonate; In N,N-dimethyl-formamide; EXAMPLE 5 A mixture of 5.3 parts of 3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one monohydrochloride, 4.4 parts of 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole, 8 parts of sodium carbonate, 0.1 parts of potassium iodide and 90 parts of N,N-dimethylformamide was stirred overnight at 85-90 C. After cooling, the reaction mixture was poured into water. The product was filtered off and crystallized from a mixture of N,N-dimethylformamide and 2-propanol. The product was filtered off and dried, yielding 3.8 parts (46%) of 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one; mp. 170.0 C. (compound 1).
  • 5
  • [ 63234-80-0 ]
  • 3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one monohydrochloride [ No CAS ]
  • [ 106266-06-2 ]
YieldReaction ConditionsOperation in experiment
With sodium carbonate;potassium iodide; In water; 4-methyl-2-pentanone; at 20 - 90℃; for 12h;Product distribution / selectivity; Example 1: Preparation of Risperidone; Water (300 mL), methyl isobutyl ketone (400 mL) and 6-fluoro-3-(4- piperidinyl)-l, 2-benzisoxazole monohydrochloride (97.5 g) were taken in a reaction vessel and NaOH solution (30.40 g in 300 mL water) was slowly added, stirred the reaction mass for 5 to 10 min. the organic layer separated and washed with water (150 mL). Water (300 mL), methyl isobutyl ketone (200 mL) were taken in another reaction vessel and 3-(2-chloroethyl)-6, 7, 8, 9-tetrahydro-2-methyl-4H-pyrido [1,2-a] pyrimidin-4-one monohydrochloride (100 g) and KI (5.0 g) were added to the reaction vessel. Sodium carbonate (100.70 g) was slowly added to the reaction mass and then methyl isobutyl ketone layer of 6-fluoro-3-(4-piperidinyl)-l, 2-benzisoxazole base was added to the reaction mass and then the contents were heated up to 85 to 900C and maintained up to 8 hrs. Cooled the reaction mass to room temperature and stirred at room temperature for 4 hrs. Water (300 mL) was added and stirred for 10 min., filtered <n="9"/>the solid and washed with water (200 mL) followed by methyl isobutyl ketone (200 mL) to get the Crude Risperidone, which was taken in another reaction vessel and isopropyl alcohol (1800 mL) was added and the solution was heated to 70 to 8O0C to get a clear solution. Carbon (10 g) was added to the solution and stirred for 20 to30 min., filtered the carbon through highflo. washed the bed with isopropyl alcohol (300 mL) and distilled the filtrate up to residual volume 7 times the 3-(2-chloroethyl)-6, 7, 8, 9-tetrahydro-2-methyl-4H-pyrido [1,2-a] pyriniidin-4-one monohydrochloride quantity. Heated the suspension to 70 to 8O0C to get the clear solution and dimethylformamide (70 mL) was added. Cooled the reaction mass to room temperature' and stirred at room temperature for 3 to 6 hrs., filtered the solid, washed with isopropyl alcohol (100 mL) and dried the solid at 60 to70°C for 2 hrs. Micronized the material and dried at 80 to 850C for 12 hrs to get Risperidone. (80 g) having HPLC Purity more than 99.70 percent.; Example 3: Preparation of Risperidone Water (300 mL), methyl isobutyf ketone (400 mL) and 6-fluoro-3-(4- piperidinyl)-l, 2-benzisoxazole monohydrochloride (97.5 g) were taken in a reaction vessel and NaOH solution (30.40 g in 300 mL water) was slowly added, stirred the reaction mass for 5 to 10 min., the organic layer was separated and washed with water (150 mL). Water (300 mL), methyl isobutyl ketone (200 mL) were taken in another reaction vessel and 3-(2-chloroethyl)-6, 7, 8, 9-tetrahydro-2-methyl-4H-pyrido [1,2-a] pyrimidin-4-one monohydrochloride (100 g), potassium iodide (5.0 g) were added to the reaction vessel. Sodium carbonate (100.70 g) slowly added in to the reaction mass and then methyl isobutyl ketone layer of 6-fluoro-3-(4-pirhoeridinyl)-l, 2-benzisoxazole <n="10"/>base was added to the reaction mass and then heated the contents up to 85 to 900C and maintained up to 8 hrs. Cooled the reaction mass to room temperature and stirred at room temperature for 4 hrs. Water (300 mL) was added and stirred for 10 min. filtered the solid and washed with water (200 mL) followed by methyl isobutyl ketone (200 mL) to get the solid which is dried at 60 to70°C under vacuum for 2 hrs to get crude Risperidone 80g.
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Historical Records

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[ 93076-03-0 ]

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[ 135634-18-3 ]

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Chemical Structure| 1190317-09-9

[ 1190317-09-9 ]

2-oxo-2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine-6-carbonitrile

Similarity: 0.66

Chemical Structure| 1013916-37-4

[ 1013916-37-4 ]

2-Chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one

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