There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
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CAS No. : | 89786-04-9 | MDL No. : | MFCD00867002 |
Formula : | C10H12N4O5S | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | LPQZKKCYTLCDGQ-WEDXCCLWSA-N |
M.W : | 300.29 | Pubchem ID : | 123630 |
Synonyms : |
YTR-830H;CL-298741;Tazobactamum;Tazobactam
|
Num. heavy atoms : | 20 |
Num. arom. heavy atoms : | 5 |
Fraction Csp3 : | 0.6 |
Num. rotatable bonds : | 3 |
Num. H-bond acceptors : | 7.0 |
Num. H-bond donors : | 1.0 |
Molar Refractivity : | 68.49 |
TPSA : | 130.84 Ų |
GI absorption : | High |
BBB permeant : | No |
P-gp substrate : | No |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -9.54 cm/s |
Log Po/w (iLOGP) : | 0.05 |
Log Po/w (XLOGP3) : | -1.98 |
Log Po/w (WLOGP) : | -0.82 |
Log Po/w (MLOGP) : | -0.44 |
Log Po/w (SILICOS-IT) : | -2.0 |
Consensus Log Po/w : | -1.04 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 0.0 |
Bioavailability Score : | 0.56 |
Log S (ESOL) : | -0.44 |
Solubility : | 109.0 mg/ml ; 0.362 mol/l |
Class : | Very soluble |
Log S (Ali) : | -0.24 |
Solubility : | 171.0 mg/ml ; 0.57 mol/l |
Class : | Very soluble |
Log S (SILICOS-IT) : | -0.25 |
Solubility : | 168.0 mg/ml ; 0.56 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 0.0 alert |
Leadlikeness : | 0.0 |
Synthetic accessibility : | 4.23 |
Signal Word: | Danger | Class: | 6.1 |
Precautionary Statements: | P261-P280-P284-P342+P311-P304+P340-P333+P313 | UN#: | 2811 |
Hazard Statements: | H317-H334 | Packing Group: | Ⅲ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
21.11 g | With trifluoroacetic acid In methanol; dichloromethane at -15 - 10℃; for 5 h; | A solution of compound G in methylene chloride was transferred to a 1000 mL four-necked flask, 100 mL of methanol was added, cooled to -15 to -10 ° C, 100 mL of trifluoroacetic acid, 11.35 g (0.105 mol) of anisole, And the reaction was carried out for 5 hours. When the residue of the compound G was less than 1percent, the reaction was terminated.To the reaction system was added 100 mL of pure water, the mass fraction was 10percentNaOH aqueous solution to adjust the pH value to 7.2 ~ 7.5, then continue to stir for 10min, standing stratified, the water layer with a 10percent hydrochloric acid aqueous solution to adjust the pH value to 1.5 ~ 2.0, filter, filter the cake with cold water, The resulting filter cake was vacuum dried at 40 ° C for 6 h to give 21.11 g of tazobactam, HPLC purity of 99.63percent and a two-step molar yield of 70.29percent. |