There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 888731-75-7 | MDL No. : | MFCD18393154 |
Formula : | C7H4Cl2O2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 191.01 | Pubchem ID : | - |
Synonyms : |
|
Signal Word: | Danger | Class: | 6.1,8 |
Precautionary Statements: | P260-P264-P280-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P405-P501 | UN#: | 2928 |
Hazard Statements: | H301-H311-H314-H331 | Packing Group: | Ⅱ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With thionyl chloride; In N,N-dimethyl-formamide; toluene; | Step 1 Production of 4-chloro-3-hydroxybenzoyl chloride 4-Chloro-3-hydroxybenzoic acid (510 mg) was suspended in toluene (6 mL), and thionyl chloride (0.28 mL) and N,N-dimethylformamide (1 drop) were added. After stirring with heating at 70 C. for 2 hrs, and the mixture was concentrated and azeotroped with toluene to give the title compound. | |
With thionyl chloride; In tetrahydrofuran; dichloromethane; at 50℃; for 2h; | A mixture of <strong>[34113-69-4]4-chloro-3-hydroxybenzoic acid</strong> (5 g, 29 mmol) and thionyl chloride (31 ml, 0.43 mol) in CH2Cl2/tetrahydrofuran (1:1; 50 ml) is stirred for 2 h at 50 C. The reaction mixture is evaporated in vacuo. After addition of CH2Cl2 (50 ml), the mixture is cooled to 5 C. and treated by dropwise addition of cyclopropylamine (8.1 ml, 115 mmol) during 1 h. The cooling bath is removed and the reaction stirred for 14 h at RT. After dilution with CH2Cl2, the organic phase is washed with a saturated NaHCO3-solution and part of the solvent is removed in vacuo. The crystals thus formed are filtered off and dried to afford 4-chloro-N-cyclopropyl-3-hydroxy-benzamide as white crystals. MS: 212.2 [M+H]+; tR (HPLC, Nucleosil C18; 5-100% CH3CN+0.1% TFA/H2O+0.1% TFA for 8 min, flow 1.5 ml/min): 4.12 min. | |
With thionyl chloride; In N,N-dimethyl-formamide; toluene; at 70℃; for 2h; | Step 1 Production of 4-chloro-3-hydroxybenzoyl chloride 4-Chloro-3-hydroxybenzoic acid (510 mg) was suspended in toluene (6 mL), and thionyl chloride (0.28 mL) and N,N-dimethylformamide (1 drop) were added. After stirring with heating at 70 C. for 2 hrs, and the mixture was concentrated and azeotroped with toluene to give the title compound. |
With thionyl chloride;N,N-dimethyl-formamide; In toluene; at 70℃; for 2h; | Step 1 Production of 4-chloro-3-hydroxybenzoyl chloride 4-Chloro-3-hydroxybenzoic acid (510 mg) was suspended in toluene (6 mL), and thionyl chloride (0.28 mL) and N,N-dimethylformamide (1 drop) were added. After stirring with heating at 70 C. for 2 hrs, and the mixture was concentrated and azeotroped with toluene to give the title compound. |