[ CAS No. 875-66-1 ] {[proInfo.proName]}

Name: 875-66-1|Cinnolin-4-ol|95%
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Quality Control of [ 875-66-1 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 875-66-1 ]

Product Details of [ 875-66-1 ]

CAS No. :	875-66-1	MDL No. :	MFCD00956158
Formula :	C₈H₆N₂O	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	UFMBERDMCRCVSM-UHFFFAOYSA-N
M.W :	146.15	Pubchem ID :	255799
Synonyms :

Calculated chemistry of [ 875-66-1 ]

Physicochemical Properties

Num. heavy atoms :	11
Num. arom. heavy atoms :	10
Fraction Csp3 :	0.0
Num. rotatable bonds :	0
Num. H-bond acceptors :	3.0
Num. H-bond donors :	1.0
Molar Refractivity :	41.56
TPSA :	46.01 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.22 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.32
Log Po/w (XLOGP3) :	1.37
Log Po/w (WLOGP) :	1.34
Log Po/w (MLOGP) :	0.8
Log Po/w (SILICOS-IT) :	1.5
Consensus Log Po/w :	1.27

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.28
Solubility :	0.764 mg/ml ; 0.00522 mol/l
Class :	Soluble
Log S (Ali) :	-1.94
Solubility :	1.68 mg/ml ; 0.0115 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-2.73
Solubility :	0.272 mg/ml ; 0.00186 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.72

Safety of [ 875-66-1 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 875-66-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 875-66-1 ]
Downstream synthetic route of [ 875-66-1 ]

[ 875-66-1 ] Synthesis Path-Upstream 1~7

1
[ 875-66-1 ]
[ 5152-83-0 ]

Reference： [1] Tetrahedron, 1995, vol. 51, # 47, p. 13045 - 13060

2
[ 103529-16-4 ]
[ 875-66-1 ]

Reference： [1] Tetrahedron, 2000, vol. 56, # 30, p. 5499 - 5507

3
[ 551-93-9 ]
[ 875-66-1 ]

Reference： [1] Journal of Medicinal Chemistry, 2014, vol. 57, # 12, p. 5419 - 5434

4
[ 615-43-0 ]
[ 875-66-1 ]

Reference： [1] Tetrahedron, 2000, vol. 56, # 30, p. 5499 - 5507

5
[ 53512-17-7 ]
[ 875-66-1 ]

Reference： [1] Pharmazie, 1997, vol. 52, # 2, p. 91 - 97

6
[ 143232-59-1 ]
[ 875-66-1 ]

Reference： [1] Pharmazie, 1997, vol. 52, # 2, p. 91 - 97
[2] Pharmazie, 1997, vol. 52, # 2, p. 91 - 97

7
[ 5152-83-0 ]
[ 875-66-1 ]

Reference： [1] Pharmazie, 1997, vol. 52, # 2, p. 91 - 97

[ 875-66-1 ] Synthesis Path-Downstream 1~70

1
[ 105-36-2 ]
[ 875-66-1 ]
[ 158631-50-6 ]

Reference： [1]Pharmazie,1994,vol. 49,p. 406 - 412

2
[ 79-11-8 ]
[ 875-66-1 ]
[ 158631-50-6 ]

Reference： [1]Pharmazie,1994,vol. 49,p. 406 - 412

3
[ 875-66-1 ]
[ 5152-84-1 ]

Yield	Reaction Conditions	Operation in experiment
82%	With pyridine; trichlorophosphate; In chlorobenzene; for 1h;Heating / reflux;	a. [4-CHLOROCINNOLINE] (9b). A mixture of <strong>[875-66-1]4-hydroxycinnoline</strong> (2.0 g, 13.7 mmol), phosphorus oxychloride (1.94 mL, 20.5 mmol), and pyridine (0.33 mL, 4.1 mmol) in [CHLOROBENZENE] (50 mL) was refluxed for 1 hour. Then the mixture was cooled and the solvent evaporated under vacuum, water was added, and the mixture was neutralized with solid sodium bicarbonate and extracted with chloroform (3 x 100 mL), washed with water (3 x 100 mL), dried [(MGS04)] and evaporated under vacuum, giving 1.84 g, in 82 % yield; [MP] [76-77 C] (lit mp 78 [C)] [; IH] NMR [(CDC13)] [8] 7.91 (m, 2H), 8.20 (dd, 1H, [J=6.] 2, [J=2.] 1), 8.57 (dd, 1H, J=6. 6, J=1. 8), 9.34 (s, [1H)] ; [13C NMR (CDCL3) No. ] 123.0, 124.9, 130.2, 131.6, 132.3, 133.8, 134.9, 144.4.
74%	With trichlorophosphate;Reflux;	(0509) Compound 110 (292 mg, 2.00 mmol) was refluxed in POCl3 overnight. It was cooled to room temperature and poured into ice water, neutralized with Na2C03. The precipitation was filtered out and washed with water, dried by pulling air through. Product was obtained as light yellow solid. (0510) (243mg, 74%). 1H NMR (400 MHz, chloroform-i/) delta 9.35 (s, 1H), 8.57 (ddd, J= 8.5, 1.4, 0.7 Hz, 1H), 8.20 (ddd, J= 8.2, 1.6, 0.7 Hz, 1H), 7.97 - 7.83 (m, 2H).

Reference： [1]Tetrahedron,1995,vol. 51,p. 13045 - 13060
[2]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 795 - 806
[3]Patent: WO2004/14906,2004,A2 .Location in patent: Page 37
[4]Journal of Medicinal Chemistry,2014,vol. 57,p. 5419 - 5434
[5]Tetrahedron,2000,vol. 56,p. 5499 - 5507
[6]Patent: WO2019/89648,2019,A1 .Location in patent: Page/Page column 65

4
[ 5152-83-0 ]
[ 875-66-1 ]

Reference： [1]Pharmazie,1997,vol. 52,p. 91 - 97

5
[ 53512-17-7 ]
[ 875-66-1 ]

Reference： [1]Pharmazie,1997,vol. 52,p. 91 - 97

6
[ 100-39-0 ]
[ 875-66-1 ]
[ 5155-71-5 ]

Reference： [1]Acta poloniae pharmaceutica,1997,vol. 54,p. 381 - 387

Yield	Reaction Conditions	Operation in experiment
		2.3 g of 1 was obtained by washing the dichloromethane phase with 1N aqueous sodium hydroxide solution (3*50 ml), then acidifying the combined alkaline extracts with concentrated hydrochloric acid.

9
[ 1066-54-2 ]
polystyrene-CH₂N(Bn)N=N-(2-XPh) [ No CAS ]
[ 875-66-1 ]

Reference： [1]Tetrahedron Letters,1999,vol. 40,p. 6201 - 6203

10
[ 103529-16-4 ]
[ 875-66-1 ]

Reference： [1]Tetrahedron,2000,vol. 56,p. 5499 - 5507

11
[ 875-66-1 ]
[ 658710-34-0 ]

Reference： [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 795 - 806

12
[ 875-66-1 ]
11-(2-dimethylamino-ethyl)-11<i>H</i>-5,6,11-triaza-chrysen-12-one [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 795 - 806

13
[ 875-66-1 ]
[ 872337-78-5 ]

Reference： [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 795 - 806

14
[ 875-66-1 ]
11-(2-dimethylaminoethyl)-2,3-dimethoxy-11H-5,6,11-triazachrysen-12-one [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 795 - 806

15
[ 875-66-1 ]
[ 658710-35-1 ]

Reference： [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 795 - 806

16
[ 615-43-0 ]
[ 875-66-1 ]

Reference： [1]Tetrahedron,2000,vol. 56,p. 5499 - 5507

17
[ 875-66-1 ]
[ 90141-86-9 ]

Reference： [1]Tetrahedron,2000,vol. 56,p. 5499 - 5507

18
[ 875-66-1 ]
[ 297133-99-4 ]

Reference： [1]Tetrahedron,2000,vol. 56,p. 5499 - 5507

19
[ 875-66-1 ]
[ 297133-98-3 ]

Reference： [1]Tetrahedron,2000,vol. 56,p. 5499 - 5507

20
[ 875-66-1 ]
[ 297134-02-2 ]

Reference： [1]Tetrahedron,2000,vol. 56,p. 5499 - 5507

21
[ 875-66-1 ]
4-(3'-nitrophenyl)-3-trimethylsilylcinnoline [ No CAS ]

Reference： [1]Tetrahedron,2000,vol. 56,p. 5499 - 5507

22
[ 875-66-1 ]
[ 297134-04-4 ]

Reference： [1]Tetrahedron,2000,vol. 56,p. 5499 - 5507

23
[ 875-66-1 ]
[ 297134-00-0 ]

Reference： [1]Tetrahedron,2000,vol. 56,p. 5499 - 5507

24
[ 875-66-1 ]
4-(4'-methoxyphenyl)-8-(3'-nitrophenyl)cinnoline [ No CAS ]

Reference： [1]Tetrahedron,2000,vol. 56,p. 5499 - 5507
[2]Tetrahedron,2000,vol. 56,p. 5499 - 5507

25
[ 875-66-1 ]
8-(2'-thienyl)-4-(4'-trifluoromethylphenyl)cinnoline [ No CAS ]

Reference： [1]Tetrahedron,2000,vol. 56,p. 5499 - 5507

26
[ 875-66-1 ]
8-(4'-methoxyphenyl)-4-(4'-trifluoromethylphenyl)cinnoline [ No CAS ]

Reference： [1]Tetrahedron,2000,vol. 56,p. 5499 - 5507
[2]Tetrahedron,2000,vol. 56,p. 5499 - 5507

27
[ 875-66-1 ]
4-(4'-methoxyphenyl)-8-(4'-trifluoromethylphenyl)cinnoline [ No CAS ]

Reference： [1]Tetrahedron,2000,vol. 56,p. 5499 - 5507

28
[ 875-66-1 ]
[ 297134-03-3 ]

Reference： [1]Tetrahedron,2000,vol. 56,p. 5499 - 5507

29
[ 875-66-1 ]
[ 297134-10-2 ]

Reference： [1]Tetrahedron,2000,vol. 56,p. 5499 - 5507

30
[ 875-66-1 ]
[ 297134-06-6 ]

Reference： [1]Tetrahedron,2000,vol. 56,p. 5499 - 5507

31
[ 875-66-1 ]
[ 297134-08-8 ]

Reference： [1]Tetrahedron,2000,vol. 56,p. 5499 - 5507

32
[ 875-66-1 ]
[ 297134-05-5 ]

Reference： [1]Tetrahedron,2000,vol. 56,p. 5499 - 5507

33
[ 875-66-1 ]
2-Benzyl-2,3-dihydro-1H-cinnolin-4-one [ No CAS ]

Reference： [1]Acta poloniae pharmaceutica,1997,vol. 54,p. 381 - 387

34
[ 143232-59-1 ]
[ 875-66-1 ]

Reference： [1]Pharmazie,1997,vol. 52,p. 91 - 97
[2]Pharmazie,1997,vol. 52,p. 91 - 97

35
[ 875-66-1 ]
[ 5152-83-0 ]

Reference： [1]Tetrahedron,1995,vol. 51,p. 13045 - 13060

36
[ 875-66-1 ]
[ 173415-33-3 ]

Reference： [1]Tetrahedron,1995,vol. 51,p. 13045 - 13060

37
[ 875-66-1 ]
[ 82452-99-1 ]

Reference： [1]Tetrahedron,1995,vol. 51,p. 13045 - 13060
[2]Tetrahedron,1995,vol. 51,p. 13045 - 13060

38
[ 875-66-1 ]
1-(4-chloro-3-cinnolinyl)ethanol [ No CAS ]

Reference： [1]Tetrahedron,1995,vol. 51,p. 13045 - 13060

39
[ 875-66-1 ]
4-chlorocinnoline 3-carboxylic acid [ No CAS ]

Reference： [1]Tetrahedron,1995,vol. 51,p. 13045 - 13060

40
[ 875-66-1 ]
4-chloro-3,8-diiodocinnoline [ No CAS ]

Reference： [1]Tetrahedron,1995,vol. 51,p. 13045 - 13060

41
[ 875-66-1 ]
4-pivaloylaminocinnoline [ No CAS ]

Reference： [1]Tetrahedron,1995,vol. 51,p. 13045 - 13060

42
[ 875-66-1 ]
[ 173415-28-6 ]

Reference： [1]Tetrahedron,1995,vol. 51,p. 13045 - 13060

43
[ 875-66-1 ]
7-oxo-7H-benzopyrano<2,3-c>cinnoline [ No CAS ]

Reference： [1]Tetrahedron,1995,vol. 51,p. 13045 - 13060

44
[ 875-66-1 ]
[ 173415-11-7 ]

Reference： [1]Tetrahedron,1995,vol. 51,p. 13045 - 13060

45
[ 875-66-1 ]
[ 173415-29-7 ]

Reference： [1]Tetrahedron,1995,vol. 51,p. 13045 - 13060

46
[ 875-66-1 ]
2,3-dihydro-1H-5-phenylcinnolino<3,4-b><1,4>diazepine [ No CAS ]

Reference： [1]Tetrahedron,1995,vol. 51,p. 13045 - 13060

47
[ 875-66-1 ]
1-pivaloyl-4-pivaloylimino-1,4-dihydrocinnoline [ No CAS ]

Reference： [1]Tetrahedron,1995,vol. 51,p. 13045 - 13060

48
[ 875-66-1 ]
[ 173415-12-8 ]

Reference： [1]Tetrahedron,1995,vol. 51,p. 13045 - 13060

49
[ 875-66-1 ]
7-phenyl-13H-benzo<f>cinnolino<3,4-b><1,4>diazepine [ No CAS ]

Reference： [1]Tetrahedron,1995,vol. 51,p. 13045 - 13060

50
[ 875-66-1 ]
[ 4964-44-7 ]

Reference： [1]Pharmazie,1994,vol. 49,p. 406 - 412
[2]Pharmazie,1994,vol. 49,p. 406 - 412

51
[ 875-66-1 ]
[ 158631-67-5 ]

Reference： [1]Pharmazie,1994,vol. 49,p. 406 - 412
[2]Pharmazie,1994,vol. 49,p. 406 - 412

52
[ 875-66-1 ]
C₁₅H₁₇N₃O₂ [ No CAS ]

Reference： [1]Pharmazie,1994,vol. 49,p. 406 - 412
[2]Pharmazie,1994,vol. 49,p. 406 - 412

53
[ 875-66-1 ]
C₁₅H₁₈N₄O₂ [ No CAS ]

Reference： [1]Pharmazie,1994,vol. 49,p. 406 - 412
[2]Pharmazie,1994,vol. 49,p. 406 - 412

54
[ 875-66-1 ]
4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acid hydrochloride [ No CAS ]

Reference： [1]Pharmazie,1994,vol. 49,p. 406 - 412
[2]Pharmazie,1994,vol. 49,p. 406 - 412

55
[ 875-66-1 ]
4-hydroxy-2-cinnoliniumacetic acid ethyl ester chloride [ No CAS ]

Reference： [1]Pharmazie,1994,vol. 49,p. 406 - 412
[2]Pharmazie,1994,vol. 49,p. 406 - 412

56
[ 271587-47-4 ]
[ 875-66-1 ]
[ 727375-11-3 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium ethanolate; In ethanol; at 85℃; for 16h;	Example 20: Synthesis of 1- [4- (5-FLUORO-2-METHOXYPHENYL)-2-HYDROXY-4-METHYL-2- TRIFLUOROMETHYLPENTYL]-LH-CINNOLIN-4-ONE To a suspension of 2- [2- (5-fluoro-2-methoxyphenyl)-2-methylpropyl]-2-trifluoromethyloxirane (216 mg) and <strong>[875-66-1]cinnolin-4-ol</strong> (V. G. Chapoulaud et AL., Tetrahedron, 2000,56, pp. 5499-5507) (216 mg) in anhydrous ethanol (1.2 ML) was added sodium ethoxide (21 wt. % solution in ethanol, 276 PL). After heating at 85C for 16 hours, the reaction mixture was diluted with ethyl acetate, dried over sodium sulfate, filtered, and concentrated in vacuo. The residue was purified by preparative TLC (eluted with 40% ethyl acetate-hexanes) to give the title compound as a pale yellow solid (26 mg), m. p. 122C-123C.

Reference： [1]Patent: WO2004/63163,2004,A1 .Location in patent: Page 158

57
[ 875-66-1 ]
[ 611-35-8 ]

Yield	Reaction Conditions	Operation in experiment
	With trichlorophosphate;	a. 4-Chloro-8-nitroquinoline (6a). This intermediate was prepared from 4-chloroquinoline (obtained by treating 4-hydroxyquinoline with [POC13] as [ DESCRIBED BY GOULEY, R. W., ET AL. , J. AMER. CHEM. SOC., 1947, 69, 303-306.4-] Chloroquinoline (10.0 g, 61.3 mmol) was added in small portions to sulfuric acid (45 mL) taking care to maintain the temperature at or below 15 C. Then the solution was cooled and maintained at-15 C during the addition of fuming nitric acid (9 mL). The mixture was allowed to warm to room temperature and stirred for an additional 3 hours. The reaction mix was poured on ice and basified (pH 9) with NH40H. The resulting precipitate was filtered, washed well with water, dried, and recrystallized from methanol to provide 7.5 g of 6a, in 59 % yield; m. p. = [128-129 C] (lit. m. p. = [129-130 C) ; IH] NMR [(CDC13)] [8] 7.67 (d, [1H,] J=4. 5), 7.75 (dd, 1H, J=8. 6 [HZ,] J=7. 6), 8.10 (dd, 1H, J=7. 6, J=1. 3), 8. 48 (dd, 1H,. [J=8.] [6,] J=1.3), 8.94 (d, 1H, J=4. 5); [13C] NMR [(CDC13)] [8] 123.0, 124.4, 126.5, 127.5, 128.3, 140.6, 143.2, 148.7, 152.1.

Reference： [1]Patent: WO2004/14906,2004,A2 .Location in patent: Page 19

Yield	Reaction Conditions	Operation in experiment
		The resulting diazonium salt solution was poured into a vigorously stirred mixture of 180 g of anhydrous sodium acetate, 500 ml of water and 250 ml of dichloromethane at 5 C. The resulting mixture was stirred for 7 hours, the internal temperature of the mixture being maintained at 10-15 C., then stirred overnight at room temperature, and until the mixture gave a negative spot test with 2-naphthol. The resulting mixture was filtered, the collected solids were washed with cold water and dried in a vacuum oven (50 C./0.1 Torr) to give 1, m.p.: 228-231 C. (Leonard and Boyd, 232-233 C.). An analytical sample, recrystallized from ethanol, melted at 237 C. (Leonard and Boyd, 236 C.).

59
[ 875-66-1 ]
[ 57260-71-6 ]
[ 853679-86-4 ]

Yield	Reaction Conditions	Operation in experiment
38%		To a suspension of NaH (60% in mineral oil, 0.099 g, 2.46 mmol) in DMF (5 mL) was added <strong>[875-66-1]cinnolin-4-ol</strong> (prepared from 2-aminoacetophenone according to the procedures described in U. S. Patent No. 4,620, 000), 0. 300 g, 2.05 mmol) in DMF (2 mL) dropwise. The reaction mixture was warmed at 40 C and stirred for 30 minutes. After cooling, N-phenyltrifluoromethanesulfonimide (0.880 g, 2.46 mmol) in DMF (2 mL) was added, and the reaction mixture was stirred at room temperature for 1 hour. 1-Boc piperazine (0.765 g, 4.11 mmol) was added to the mixture. The reaction was stirred at 80 C for 4 hours. After cooling, the mixture was partitioned between EtOAc and water. The aqueous phase was extracted with EtOAc. The combined organic layers were washed with water, brine, dried and concentrated. The residue was purified by column chromatography (1: 1 to 1: 3 hexanes/EtOAc) to give 4- Cinnolin-4-yl-piperazine-l-carboxylic acid tert-butyl ester (0.246 g, 38%) as a yellow oil. 1H NMR (CDC13, 400 MHz) 8 8. 91 (s, 1H), 8. 47 (d, J= 8.4 Hz, 1H), 7.97 (d, J= 8. 4 Hz, 1H), 7.80 (t, J= 7.2 Hz, 1H), 7.69 (t, J= 7.2 Hz, 1H), 3.74 (m, 4H), 3. 34 (m, 4H), 1.51 (s, 9H). LCMS (APCI+) tnlz 315 [M+H]' ; Rt = 2.14 minutes.

Reference： [1]Patent: WO2005/51304,2005,A2 .Location in patent: Page/Page column 94-95

60
[ 551-93-9 ]
[ 875-66-1 ]

Reference： [1]Journal of Medicinal Chemistry,2014,vol. 57,p. 5419 - 5434
[2]Synthetic Communications,2020

61
[ 875-66-1 ]
[ 1613288-97-3 ]

Reference： [1]Journal of Medicinal Chemistry,2014,vol. 57,p. 5419 - 5434

62
[ 875-66-1 ]
[ 1613289-47-6 ]

Reference： [1]Journal of Medicinal Chemistry,2014,vol. 57,p. 5419 - 5434

63
[ 875-66-1 ]
[ 1275086-86-6 ]

Reference： [1]Journal of Medicinal Chemistry,2014,vol. 57,p. 5419 - 5434

64
[ 613-89-8 ]
[ 875-66-1 ]

Yield	Reaction Conditions	Operation in experiment
96%	With hydrogenchloride; sodium nitrite; In water; at -5 - 65℃; for 3h;	(0507) A mixture of 2-aminoacetophenone (295 mu, 1.55 mol) in concentrated HC1 (2 mL) is cooled to - 5C. A solution of sodium nitrite (129 g, 1.87 mol) in water (5 mL) is added slowly maintaining the temperature below 0C. After that the mixture is stirred at 65C for 3 h. The mixture is cooled to room temperature. The precipitate is filtered off, washed with ether, dried and dissolved in water (minimal amount). Sodium hydrocarbonate (1 g) is carefully added to the solution, the mixture is stirred for 1 h and filtered. The precipitate is washed with water and dried on air to give of the title compound (218 mg, 96% yield). 1H NMR (400 MHz, Methanol-c/4) delta 8.18 (ddd, J= 8.3, 1.4, 0.7 Hz, 1H), 7.86 (s, 1H), 7.83 (ddd, J = 8.5, 6.9, 1.4 Hz, 1H), 7.64 (dt, J= 8.6, 0.9 Hz, 1H), 7.50 (ddd, J= 8.1, 7.0, 1.0 Hz, 1H).

Reference： [1]Patent: WO2019/89648,2019,A1 .Location in patent: Page/Page column 65

65
[ 106-96-7 ]
[ 875-66-1 ]
4-(prop-2-yn-1-yloxy)cinnoline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
65.5%	With potassium carbonate; In acetonitrile; at 80℃;	Cinnolin-4(1H)-one (5.0 g, 34.24 mol) was added to the K2CO3 ( 7.08 g, 51.36 mol) and 3- bromoprop-1-yne (3.11 mL, 41.09 mol) in ACN (20 mL) and the mixture stirred at 80 C for 4-8 h then reaction mixture was cool to rt. The mixture was concentrated, diluted with H2O (30 mL), and extracted with EtOAc (3 × 50 mL). The combined organic layers were dried (MgSO4), filtered and concentrated. Flash chromatography gave 4-(prop-2-yn-1-yloxy)cinnoline (13a). Synthesis of 4-(prop-2-yn-1-yloxy)cinnoline (4a). Yield (2.60 g, 65.5%). m.p. 100-110 C. Colourless solid.1H NMR (400 MHz, CDCl3) delta 8.34 (dd, J = 1.2, 1.2 Hz, 1H, Ar), 7.81-7.77 (m, 2H, Ar), 7.60 (d, J = 8.8 Hz, 1H, Ar), 7.46 (t, J = 8.0 Hz,1H, Ar), 5.14 (d, J = 2.4 Hz, 1H, -OCH2), 2.51 (t, J = 2.4 Hz, 1H, Alky). 13C NMR (100 MHz, CDCl3) delta 171.2, 140.6, 140.1, 134.0, 126.0, 125.2, 124.6, 115.1, 76.0, 75.7, 46.2. ESI-MS: m/z 185.27 [M+H]+. Anal. Calc. (C11H8N2O) C: 71.73; H: 4.38; N: 15.21. Found C: 71.80; H: 4.04; N: 15.28%.

Reference： [1]Synthetic Communications,2020

66
[ 875-66-1 ]
4-((1-benzyl-1H-1,2,3-triazol-4-yl)methoxy)cinnoline [ No CAS ]

Reference： [1]Synthetic Communications,2020

67
[ 875-66-1 ]
4-((1-(3-(trifluoromethyl)benzyl)-1H-1,2,3-triazol-4-yl)methoxy)cinnoline [ No CAS ]

Reference： [1]Synthetic Communications,2020

68
[ 875-66-1 ]
(4-(1-(4-methoxybenzyl)-1H-1,2,3-triazol-4-yl)methoxy)cinnoline [ No CAS ]

Reference： [1]Synthetic Communications,2020

69
[ 875-66-1 ]
4-(3-(4-((cinnolin-4-yloxy)methyl)-1H-1,2,3-triazol-1-yl)propyl)morpholine [ No CAS ]

Reference： [1]Synthetic Communications,2020

70
[ 875-66-1 ]
4-((1-(4-(trifluoromethyl)benzyl)-1H-1,2,3-triazol-4-yl)methoxy)cinnoline [ No CAS ]

Reference： [1]Synthetic Communications,2020

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[ 875-66-1 ]

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[ 875-66-1 ]

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Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 875-66-1 ] {[proInfo.proName]}

Quality Control of [ 875-66-1 ]

Related Doc. of [ 875-66-1 ]

Product Details of [ 875-66-1 ]

Calculated chemistry of [ 875-66-1 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 875-66-1 ]

Application In Synthesis of [ 875-66-1 ]

[ 875-66-1 ] Synthesis Path-Upstream 1~7

[ 875-66-1 ] Synthesis Path-Downstream 1~70

Related Functional Groups of [ 875-66-1 ]

Alcohols

Related Parent Nucleus of [ 875-66-1 ]

Cinnolines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 875-66-1 ]

Related Parent Nucleus of
[ 875-66-1 ]