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CAS No. : | 850879-09-3 | MDL No. : | MFCD16038298 |
Formula : | C23H21N5O3S | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | FOFDIMHVKGYHRU-UHFFFAOYSA-N |
M.W : | 447.51 | Pubchem ID : | 11282283 |
Synonyms : |
MP470;HPK 56
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
37% | With pyridine In dichloromethane | EXAMPLE 21 4-Benzo[4,5]furo[3,2-d]pyrimidin-4-yl-piperazine-1-carbothioic acid (benzof1, 31dioxol-5-ylmethvl)-amide (3) To a solution of 4-piperazinobenzofurano [3,2-d] pyrimidine (200 mg, 0.79 mmol) and pyridine (0.5 mL, 7.9 mmol) in dichloromethane (20 mL) was added a solution of product 1c in dichloromethane (20mL) and this was stirred overnight. Methanol was added to quench excess thiophosgene, and the residue after removal of solvent was purified by silica gel column chromatography eluting with 5percent methanol/dichloromethane and further recrystallized from dichloromethane/hexane to give 150 mg (37percent). HNMR (CDCl3, 300MHZ) a 4.09 (s, 4H), 4.27 (s, 4H), 4.82 (d, J = 4.7Hz, 2H), 5.99 (s, 2H), 6.77-6. 79 (m, 1 H), 6.80-6. 83 (m, 1H), 6.89 (s, 1 H), 7.47-7. 52 (m, 1 H), 7.61-7. 65 (m, 1 H), 7.66-7. 70 (m, 1 H), 8.33 (d, J = 7. 0Hz, 1 H). FAB HRMS [M+H] + calcd for C23H21N503S : 447.1365 ; found 448. 1443. Combustion Analysis: C23H21N5O3S Requires C 61.73percent, H 4.73percent, N 15.65percent, O 10.73percent, S 7.17percent ; Found C 61. 95percent, H 4.99percent, N 15.93percent, 0 11. 13percent, S 7. 55percent. |