Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 84392-17-6 | MDL No. : | MFCD00075353 |
Formula : | C14H9F3O2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | IQOMYCGTGFGDFN-UHFFFAOYSA-N |
M.W : | 266.22 | Pubchem ID : | 55251 |
Synonyms : |
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
74.55% | With 20% palladium hydroxide-activated charcoal; sodium carbonate In water at 80 - 90℃; for 6 h; | 2-Iodobenzoic acid (100 gm, 0.4032 moles) , 4-(Trifluoromethyl)phenyl boronic acid (99.55 gm, 0.524 moles), sodium carbonate (164 gm, 1.55 moles) and 20 percent palladium hydroxide on carbon (15 gm) in water (3.0 L) was heated to 80-90°C for 6 hrs. The progress of the reaction was monitored by HPLC. After completion of the reaction the reaction mass was cooled 70-80°C and filtered through hyflow bed. The filtrate was cooled to room temperature and the pH was adjusted to 1-2 with hydrochloric acid. The precipitated solid was filtered and washed with 1.0 L water. The solid was dissolved in 376 ml ethanol at 60-70°C and charcolised. The solution was filtered through hyflow bed at 60°C and washed with 180 mL hot ethanol. Water (1.086 L ) was added to the filtrate at 50 -60°C and the precipitated solid was cooled to room temperature. The solid was filtered and dried in air oven for 12 hrs at 60°C to afford 80 gm of 4'- (Trifluoromethyl)biphenyl-2-carboxylic acid as a white solid (Yield 74.55 percent, HPLC purity 99.98 percent). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
72% | Stage #1: With potassium hydroxide In 1-methyl-pyrrolidin-2-one at 20 - 95℃; Reflux Stage #2: With hydrogenchloride In 1-methyl-pyrrolidin-2-one; water at 10 - 20℃; for 3 h; |
8. Preparation of 4percent Trifluoromethylbiphenyl-2-carboxylic Acid At room temperature, 50.7 g of isopropyl 4-trifluoromethylbiphenyl-2-carboxylate (0.165 mol) 200 g of N-methylpyrrolidone were introduced as initial charge in a 0.5 l sulphonation beaker with precision-ground glass stirrer and reflux condenser and admixed with 196 g of a 20percent strength potassium hydroxide solution. The reaction mixture was stirred overnight at 90 to 95° C. It was then cooled to room temperature and acidified to pH 1-2 with 300 ml of a 20percent strength hydrochloric acid. The reaction suspension was cooled to 10° C. and after-stirred for 3 h. The precipitate was filtered off and the filter residue was washed with copious amounts of water. The wet product was then dried overnight in a vacuum drying cabinet at 40° C. and 20 mbar. This gave 31.7 g of 4-trifluoromethylbiphenyl-2-carboxylic acid (0.119 mol, 72percent) as a colourless solid. |
[ 454-92-2 ]
3-(Trifluoromethyl)benzoic acid
Similarity: 0.94
[ 261952-01-6 ]
4-Methyl-3-(trifluoromethyl)benzoic acid
Similarity: 0.94
[ 455-24-3 ]
4-(Trifluoromethyl)benzoic acid
Similarity: 0.94
[ 13055-63-5 ]
2-Methyl-5-(trifluoromethyl)benzoic acid
Similarity: 0.94
[ 62089-35-4 ]
2-Methyl-3-(trifluoromethyl)benzoic acid
Similarity: 0.92
[ 454-92-2 ]
3-(Trifluoromethyl)benzoic acid
Similarity: 0.94
[ 261952-01-6 ]
4-Methyl-3-(trifluoromethyl)benzoic acid
Similarity: 0.94
[ 455-24-3 ]
4-(Trifluoromethyl)benzoic acid
Similarity: 0.94
[ 13055-63-5 ]
2-Methyl-5-(trifluoromethyl)benzoic acid
Similarity: 0.94
[ 62089-35-4 ]
2-Methyl-3-(trifluoromethyl)benzoic acid
Similarity: 0.92
[ 454-92-2 ]
3-(Trifluoromethyl)benzoic acid
Similarity: 0.94
[ 261952-01-6 ]
4-Methyl-3-(trifluoromethyl)benzoic acid
Similarity: 0.94
[ 455-24-3 ]
4-(Trifluoromethyl)benzoic acid
Similarity: 0.94
[ 13055-63-5 ]
2-Methyl-5-(trifluoromethyl)benzoic acid
Similarity: 0.94
[ 62089-35-4 ]
2-Methyl-3-(trifluoromethyl)benzoic acid
Similarity: 0.92
[ 454-92-2 ]
3-(Trifluoromethyl)benzoic acid
Similarity: 0.94
[ 261952-01-6 ]
4-Methyl-3-(trifluoromethyl)benzoic acid
Similarity: 0.94
[ 455-24-3 ]
4-(Trifluoromethyl)benzoic acid
Similarity: 0.94
[ 13055-63-5 ]
2-Methyl-5-(trifluoromethyl)benzoic acid
Similarity: 0.94
[ 62089-35-4 ]
2-Methyl-3-(trifluoromethyl)benzoic acid
Similarity: 0.92