* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
With sodium hydroxide; In ethanol; water; at 30℃; for 0.5h;
1) Adding <strong>[834-28-6]<strong>[834-28-6]phenformin</strong> hydrochloride</strong> and sodium hydroxide at a molar ratio of 1:1 to a mixture of water and ethanol in a 1:1 volume ratio.Stirring and dissolving at a temperature of 30°C;The water and ethanol mixture is added in an amount of 20 times the total mass of <strong>[834-28-6]<strong>[834-28-6]phenformin</strong> hydrochloride</strong> and sodium hydroxide;2) Dissolve chromium trichloride in water to obtain a chromium trichloride solution with a concentration of 0.5 mol/L.And a solution of chromium trichloride was slowly added dropwise to the solution prepared in step 1) at a rate of 50 drops per minute,The molar ratio of the amount of chromium trichloride used in this step to the amount of <strong>[834-28-6]<strong>[834-28-6]phenformin</strong> hydrochloride</strong> used in step 1) is:1:3; stirring at 30°C for 30 minutes to stop the reaction,Let stand for 2h, filter, wash the solid with distilled water and ether, then dry naturally.The resulting red solid is the <strong>[834-28-6]phenformin</strong> Cr (III) complex.
6-(3-(2,4-dichlorophenyl)-1-(4-nitrophenyl)-1H-pyrazol-4-yl)-3,6-dihydro-N<SUP>2</SUP>-phenethyl-1,3,5-triazine-2,4-diamine[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
48%
With acetic acid; at 120℃;
General procedure: Synthesized intermediate compounds (1 mmol) and Moroxydine hydrochloride, metformin hydrochloride or <strong>[834-28-6]<strong>[834-28-6]phenformin</strong> hydrochloride</strong> (1 mmol) were refluxed in glacial acetic acid (10 mL) at 120°C for 4?6 h. The whole processes of the reactions were traced by TLC, then removed solvent under reduced pressure. The crude products were purified by column chromatography (dichloromethane : methanol = 20 : 1).