* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
With hydrogenchloride In 1,4-dioxane at 20℃; for 16 h;
(2S)-3-(3-Bromophenyl)-2-(ter^butoxycarbonylamino)propionic acid (5.0 g, 14.5 mmol) was suspended in 4M HCl in 1 ,4-dioxane (75 mL) and stirred for 16 h at r.t. The white precipitate was filtered and washed with Et2O to give the title compound (3.2 g, 89percent) as a white solid that required no further purification. δH (CDCl3) 8.32 (2H, s), 7.50- 7.48 (2H, m), 7.34-7.29 (2H, m), 4.22 (IH, t, J6.2 Hz), 3.13-3.11 (2H, m).
89%
With hydrogenchloride In 1,4-dioxane at 20℃; for 16 h;
INTERMEDIATE 65 3 -Bromo-L-phenylalanine(2jS)-3-(3-Bromophenyl)-2-(tert-butoxycarbonylamino)propiomc acid (5.0 g, 14.5 mmol) was suspended in 4M HCl in 1,4-dioxane (75 mL) and stirred for 16 h at r.t.. The white precipitate was filtered and washed with Et2O to give the title compound as a white solid (3.2 g, 89percent) that required no further purification. δH (CDCl3) 8.32 (2H, s), 7.50- 7.48 (2H, m), 7.34-7.29 (2H, m), 4.22 (IH, t, J 6.2 Hz), 3.13-3.11 (2H, m). An exchangeable proton was not observed.
Reference：
[1] Journal of Organic Chemistry, 2009, vol. 74, # 23, p. 9152 - 9157
[2] Tetrahedron, 2016, vol. 72, # 46, p. 7343 - 7347
3
[ 14473-91-7 ]
[ 82311-69-1 ]
Reference：
[1] Catalysis Science and Technology, 2016, vol. 6, # 12, p. 4086 - 4089
4
[ 117391-50-1 ]
[ 14473-91-7 ]
[ 82311-69-1 ]
Reference：
[1] Advanced Synthesis and Catalysis, 2017, vol. 359, # 9, p. 1570 - 1576
5
[ 14473-91-7 ]
[ 82311-69-1 ]
Reference：
[1] Journal of the American Chemical Society, 2015, vol. 137, # 40, p. 12977 - 12983
6
[ 14473-91-7 ]
[ 82311-69-1 ]
Reference：
[1] Journal of the American Chemical Society, 2015, vol. 137, # 40, p. 12977 - 12983
7
[ 3132-99-8 ]
[ 82311-69-1 ]
Reference：
[1] Advanced Synthesis and Catalysis, 2017, vol. 359, # 9, p. 1570 - 1576
8
[ 14473-91-7 ]
[ 82311-69-1 ]
Reference：
[1] Journal of the American Chemical Society, 2015, vol. 137, # 40, p. 12977 - 12983
9
[ 24424-99-5 ]
[ 82311-69-1 ]
[ 82278-73-7 ]
Yield
Reaction Conditions
Operation in experiment
98%
With sodium hydrogencarbonate In 1,4-dioxane; water
[00121] t-Butylcarbamate (Boc) protection of the amino group of bromophenylalaninewas accomplished, using sodium bicarbonate (3 equivalents), t-butyl dicarbonate (Boc2O, 1.1equivalent) in dioxane and water, to obtain compound 7 in 98percent yield. A methyl sulfone functionality was introduced by treating the bromo compound 7 with copper iodide (0.4 equivalents), cesium carbonate (0.5 equivalents), L-proline (0.8 equivalents), and the sodium salt of methanesulfinic acid (3.9 equivalents) in dimethylsulfoxide (DMSO) at 95-100°C for a totalof 9 hours, with two further additions of copper iodide (0.2 equivalents) and L-proline (0.4 equivalents) during that period. Compound 8 was isolated in 96percent yield. The carboxylic acid of compound 8 was converted to the benzyl ester, compound 9, in 99percent yield, using benzyl alcohol (1 .1 equivalent), dimethylaminopyridine (DMAP, 0.1 equivalent) and N-(3 - dimethylaminopropyl)-N-ethylcarbodiimide (EDC, 1.0 equivalent). The amino group ofcompound 9 is deprotected by adding a 4N solution of HC1 in dioxane to compound 9 at 0°C in methylene chloride. The HC1 salt of the free amino species, compound 10 was isolated in 94percent yield.
B. D,L-m-Bromophenylalanine The product from Part A (107 grams; 0.32 m.) was suspended in a solution of 58.8 grams (1.47 m.) of sodium hydroxide pellets and 220 ml. of water. The resulting mixture was refluxed for 24 hours. The mixture then was cooled to room temperature, and the pH was adjusted to 6.5 with 6 N HCl. The resulting precipitate was collected and dried to give 41.01 grams (53%) of the title compound.
10.9 grams (109%)
D. L-m-Bromophenylalanine To 500 ml. of water were added 28 grams (0.082 m.) of the product from Part C. The mixture was stirred, and 2 N NaOH was added until a clear solution (pH 7.2) was obtained. Carboxypeptidase A (25 mg.) was added, and the solution was maintained at 37 C. by a thermostatically-controlled water bath and at pH 7.2 by a Radiometer pH-stat. After five days of gentle stirring, the solution was adjusted to pH 5.0, carbon was added, and the mixture filtered. The filtrate was adjusted to pH 3.0 with 1 N HCl and extracted three times with ethyl acetate. The aqueous solution then was adjusted to pH 7.0 with 2 N NaOH and concentrated in vacuo until the L isomer began to crystallize. The mixture then was allowed to cool to room temperature. The resulting precipitate was collected and dried to give 10.9 grams (109%) of the title compound.
2
[ 82311-69-1 ]
3-[124I]iodo-L-phenylalanine[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
With sodium metabisulfite; sodium (124)I-iodide; phosphoric acid; ascorbic acid;copper(II) sulfate; In water; at 170℃; for 0.5 - 0.75h;Product distribution / selectivity;
A solution of carrier free sodium [124l]iodide, sodium [125l]iodide or sodium [131l]iodide (up to 5 GBq) and 5 mul aqueous Na2S2O5 (4.0 mg Na2S2O5ZmI) was evaporated to dryness by passing a stream of nitrogen through a reaction vessel at 1000C, followed by addition of 200 mul of the corresponding L-bromophenylalanine (0.25 - 0.5 mg/ ml 0.1 N H3PO4), 20 mul aqueous L-ascorbic acid (10 mg/ml) and 20 mul aqueous Cu(II) sulphate (0.10 mol/l). The reaction vessel was heated for 30 min at 1700C, cooled and the mixture diluted with up to 500 mul water. The radioiodinated product was separated from unreacted starting materials and radioactive impurities by HPLC. Generally, 3/4- IPA-124, 3/4-IPA-125 and m/p-IPA-131 were obtained in 88 +/- 10% radiochemical yield, with a specific activity > 500 GBq / mumol. The fraction containing the radioiodinated products was collected into a sterile tube, buffered with 0.5 M <n="23"/>phosphate buffered saline (pH 7.0; Braun, Melsungen, Germany), and sterile filtered through a 0.22 mum sterile membrane (Millex GS, Millipore, Molsheim, France) to an isotonic and injectable radiopharmaceutical for in vitro and in vivo investigations.
With sodium metabisulfite; sodium (¹²?I)iodide; phosphoric acid; ascorbic acid;copper(II) sulfate; In water; at 170℃; for 0.5 - 0.75h;Product distribution / selectivity;
A solution of carrier free sodium [124l]iodide, sodium [125l]iodide or sodium [131l]iodide (up to 5 GBq) and 5 mul aqueous Na2S2O5 (4.0 mg Na2S2O5ZmI) was evaporated to dryness by passing a stream of nitrogen through a reaction vessel at 1000C, followed by addition of 200 mul of the corresponding L-bromophenylalanine (0.25 - 0.5 mg/ ml 0.1 N H3PO4), 20 mul aqueous L-ascorbic acid (10 mg/ml) and 20 mul aqueous Cu(II) sulphate (0.10 mol/l). The reaction vessel was heated for 30 min at 1700C, cooled and the mixture diluted with up to 500 mul water. The radioiodinated product was separated from unreacted starting materials and radioactive impurities by HPLC. Generally, 3/4- IPA-124, 3/4-IPA-125 and m/p-IPA-131 were obtained in 88 +/- 10% radiochemical yield, with a specific activity > 500 GBq / mumol. The fraction containing the radioiodinated products was collected into a sterile tube, buffered with 0.5 M <n="23"/>phosphate buffered saline (pH 7.0; Braun, Melsungen, Germany), and sterile filtered through a 0.22 mum sterile membrane (Millex GS, Millipore, Molsheim, France) to an isotonic and injectable radiopharmaceutical for in vitro and in vivo investigations.
With sodium metabisulfite; [131I]-sodium iodide; phosphoric acid; ascorbic acid;copper(II) sulfate; In water; at 170℃; for 0.5 - 0.75h;Product distribution / selectivity;
A solution of carrier free sodium [124l]iodide, sodium [125l]iodide or sodium [131l]iodide (up to 5 GBq) and 5 mul aqueous Na2S2O5 (4.0 mg Na2S2O5ZmI) was evaporated to dryness by passing a stream of nitrogen through a reaction vessel at 1000C, followed by addition of 200 mul of the corresponding L-bromophenylalanine (0.25 - 0.5 mg/ ml 0.1 N H3PO4), 20 mul aqueous L-ascorbic acid (10 mg/ml) and 20 mul aqueous Cu(II) sulphate (0.10 mol/l). The reaction vessel was heated for 30 min at 1700C, cooled and the mixture diluted with up to 500 mul water. The radioiodinated product was separated from unreacted starting materials and radioactive impurities by HPLC. Generally, 3/4- IPA-124, 3/4-IPA-125 and m/p-IPA-131 were obtained in 88 +/- 10% radiochemical yield, with a specific activity > 500 GBq / mumol. The fraction containing the radioiodinated products was collected into a sterile tube, buffered with 0.5 M <n="23"/>phosphate buffered saline (pH 7.0; Braun, Melsungen, Germany), and sterile filtered through a 0.22 mum sterile membrane (Millex GS, Millipore, Molsheim, France) to an isotonic and injectable radiopharmaceutical for in vitro and in vivo investigations.
With phenylalanine ammonia lyase from Rhodotorula graminis; ammonium carbamate; In aq. buffer; at 30℃;pH 9.0;Kinetics;
General procedure: Solutions of the substrates under investigation were made up in 0.5M ammonium carbamate/1M Tris, pH 9.0 and dilutions were made with the following concentrations: 3, 2, 1, 0.5, 0.2, 0.02, 0.002 and 0mM of cinnamic acid. Scopoletin solution - 288.25mg of scopoletin was dissolved in 50mL dH2O to make a stock solution. This stock solution was then diluted 1/5 to create a working solution that had a fluorescence of approximately 30,000 RFU. The screening was set up in a 96-well plate and each well contained the following: 100muL substrate solution, 10muL HRP (1mg/mL in dH2O), 10muL l-AAO (1 in 10 dilution of stock in dH2O), 40muL scopoletin solution, 40muL purified PAL. Kinetic data was measured on a plate reader at 30C. Excitation wavelength 360nm; emission wavelength 480nm; 15s interval.
3'-[(2S)-2-[(trans-4-[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)carbonyl]amino}-3-(1H-indazol-6-ylamino)-3-oxopropyl]biphenyl-4-carboxylic acid[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-[5'-(benzylsulphamoyl)-2'-methylbiphenyl-3-yl]-1-oxo-1-[4-(1H-tetrazol-5-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-[2'-methyl-5'-(pyrrolidin-1-ylsulphonyl)biphenyl-3-yl]-1-oxo-1-[4-(1H-tetrazol-5-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-[2'-methyl-5'-(morpholin-4-ylsulphonyl)biphenyl-3-yl]-1-oxo-1-[4-(1H-tetrazol-5-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-[5'-(dimethylsulphamoyl)-2'-methylbiphenyl-3-yl]-1-oxo-1-[4-(1H-tetrazol-5-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-1-oxo-3-(3'-sulphamoylbiphenyl-3-yl)-1-[4-(1H-tetrazol-5-yl)phenyl]-amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-[3'-(cyclopropylsulphamoyl)biphenyl-3-yl]-1-oxo-1-[4-(1H-tetrazol-5-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-[4'-(dimethylsulphamoyl)-2'-methylbiphenyl-3-yl]-1-oxo-1-[4-(1H-tetrazol-5-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-[4'-methoxy-3'-(morpholin-4-ylsulphonyl)biphenyl-3-yl]-1-oxo-1-[4-(1H-tetrazol-5-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-[2'-methyl-5'-(morpholin-4-ylsulphonyl)biphenyl-3-yl]-1-oxo-1-[4-(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [trans-4-({(2S)-3-[2'-methyl-5'-(morpholin-4-ylsulphonyl)biphenyl-3-yl]-1-oxo-1-[(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)amino]propan-2-yl}carbamoyl)cyclohexyl]methyl}carbamate[ No CAS ]
tert-butyl [trans-4-({(2S)-3-[2'-methyl-5'-(pyrrolidin-1-ylsulphonyl)biphenyl-3-yl]-1-oxo-1-[(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)amino]propan-2-yl}carbamoyl)cyclohexyl]methyl}carbamate[ No CAS ]
tert-butyl [trans-4-({(2S)-3-[5'-(benzylsulphamoyl)-2'-methylbiphenyl-3-yl]-1-oxo-1-[(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)amino]propan-2-yl}carbamoyl)cyclohexyl]methyl}carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-[5'-(benzylsulphamoyl)-2'-methylbiphenyl-3-yl]-1-oxo-1-[4-(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl 4-[({3'-[(2S)-2-[(trans-4-[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)carbonyl]-amino}-3-oxo-3-[4-(1H-tetrazol-5-yl)phenyl]amino}propyl]-6-methylbiphenyl-3-yl}carbonyl)amino]piperidine-1-carboxylate[ No CAS ]
tert-butyl 4-[({3'-[(2S)-2-[(trans-4-[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)carbonyl]amino}-3-oxo-3-[4-(1H-tetrazol-5-yl)phenyl]amino}propyl]-2-methylbiphenyl-4-yl}carbonyl)amino]piperidine-1-carboxylate[ No CAS ]
tert-butyl 6-[({3'-[(2S)-2-[(trans-4-[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)carbonyl]amino}-3-oxo-3-[4-(1H-tetrazol-5-yl)phenyl]amino}propyl]-6-methylbiphenyl-3-yl}carbonyl)amino]-3-azabicyclo[3.1.0]hexane-3-carboxylate[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-[5'-({2-[2-(2-methoxyethoxy)ethoxy]ethyl}carbamoyl)-2'-methylbiphenyl-3-yl]-1-oxo-1-[4-(1H-tetrazol-5-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)3-[5'-({2-[2-(2-hydroxyethoxy)ethoxy]ethyl}carbamoyl)-2'-methylbiphenyl-3-yl]-1-oxo-1-[4-(1H-tetrazol-5-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-[4'-({2-[2-(2-methoxyethoxy)ethoxy]ethyl}carbamoyl)-2'-methylbiphenyl-3-yl]-1-oxo-1-[4-(1H-tetrazol-5-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-[5'-(dimethylsulphamoyl)-2'-methylbiphenyl-3-yl]-1-oxo-1-[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-1-[4-(3-chloro-4H-1,2,4-triazol-5-yl)phenyl]amino}-3-{3'-[(4-methylpiperazin-1-yl)carbonyl]biphenyl-3-yl}-1-oxopropan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-[4'-({2-[2-(2-hydroxyethoxy)ethoxy]ethyl}carbamnoyl)-2'-methylbiphenyl-3-yl]-1-oxo-1-[4-(1H-tetrazol-5-yl)phenyl]amino}propan-2-yl]carbamoyl}-cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [trans-4-({(2S)-1-[4-(3-chloro-4H-1,2,4-triazol-5-yl)phenyl]amino}-3-[4'-(morpholin-4-ylcarbonyl)biphenyl-3-yl]-1-oxopropan-2-yl}carbamoyl)cyclohexyl]methyl}carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-1-[4-(3-chloro-4H-1,2,4-triazol-5-yl)phenyl]amino}-3-{4'-[(4-methylpiperazin-1-yl)carbonyl]biphenyl-3-yl}-1-oxopropan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-(3'-[2-(morpholin-4-yl)ethyl]carbamoyl}biphenyl-3-yl)-1-oxo-1-[4-(1H-tetrazol-5-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-1-[4-(3-chloro-4H-1,2,4-triazol-5-yl)phenyl]amino}-1-oxo-3-(3'-[1-(propan-2-yl)piperidin-4-yl]carbamoyl}biphenyl-3-yl)propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-{3'-[(4-methylpiperazin-1-yl)carbonyl]biphenyl-3-yl}-1-oxo-1-[4-(1H-tetrazol-5-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-1-oxo-3-(3'-[1-(propan-2-yl)piperidin-4-yl]carbamoyl}biphenyl-3-yl)-1-[4-(1H-tetrazol-5-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl 6-[({3'-[(2S)-2-[(trans-4-[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)carbonyl]amino}-3-oxo-3-[4-(1H-tetrazol-5-yl)phenyl]amino}propyl]-2-methylbiphenyl-4-yl}carbonyl)amino]-3-azabicyclo[3.1.0]hexane-3-carboxylate[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-(3'-[2-(diethylamino)ethyl]carbamoyl}biphenyl-3-yl)-1-oxo-1-[4-(1H-tetrazol-5-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-[2'-methyl-5'-(pyrrolidin-1-ylsulphonyl)biphenyl-3-yol]-1-oxo-1-[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-1-oxo-3-(4'-[2-(piperidin-1-yl)ethyl]carbamoyl}biphenyl-3-yl)-1-[4-(1H-tetrazol-5-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-(5'-carbamoyl-2'-chlorobiphenyl-3-yl)-1-oxo-1-[4-(1H-tetrazol-5-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-(3'-[2-(dimethylamino)ethyl]carbamoyl}biphenyl-3-yl)-1-oxo-1-[4-(1H-tetrazol-5-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-1-[4-(3-chloro-4H-1,2,4-triazol-5-yl)phenyl]amino}-3-(3'-[2-(diethylamino)ethyl]carbamoyl}biphenyl-3-yl)-1-oxopropan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-1-oxo-3-(4'-[2-(pyrrolidin-1-yl)ethyl]carbamoyl}biphenyl-3-yl)-1-[4-(1H-tetrazol-5-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-(4'-[2-(diethylamino)ethyl]carbamoyl}biphenyl-3-yl)-1-oxo-1-[4-(1H-tetrazol-5-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-[3'-(dimethylcarbamoyl)biphenyl-3-yl]-1-oxo-1-[4-(1H-tetrazol-5-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [trans-4-({(2S)-3-[5'-(dimethylsulphamoyl)-2'-methylbiphenyl-3-yl]-1-oxo-1-[(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)amino]propan-2-yl}carbamoyl)cyclohexyl]methyl}carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-{2'-fluoro-5'-[methoxy(methyl)carbamoyl]biphenyl-3-yl}-1-oxo-1-[4-(1H-tetrazol-5-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-{4'-[(4-methylpiperazin-1-yl)carbonyl]biphenyl-3-yl}-1-oxo-1-[4-(1H-tetrazol-5-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-[3'-(morpholin-4-ylcarbonyl)biphenyl-3-yl]-1-oxo-1-[4-(1H-tetrazol-5-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-(4'-[4-(2-hydroxyethyl)piperazin-1-yl]carbonyl}biphenyl-3-yl)-1-oxo-1-[4-(1H-tetrazol-5-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-[4'-({2-[(tert-butoxycarbonyl)amino]ethyl}carbamoyl)biphenyl-3-yl]-1-(1H-indazol-6-ylamino)-1-oxopropan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate trifluoroacetate[ No CAS ]
tert-butyl 4-[({3'-[(2S)-2-[(trans-4-[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)carbonyl]amino}-3-(1H-indazol-6-ylamino)-3-oxopropyl]biphenyl-4-yl}carbonyl)amino]piperidine-1-carboxylate trifluoroacetate[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-[2'-methyl-5'-(morpholin-4-ylsulphonyl)biphenyl-3-yl]-1-oxo-1-[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-(4'-[2-(diethylamino)ethyl]carbamoyl}biphenyl-3-yl)-1-(1H-indazol-6-ylamino)-1-oxopropan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate trifluoroacetate[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-[2'-(morpholin-4-ylsulphonyl)biphenyl-3-yl]-1-oxo-1-[4-(2H-tetrazol-5-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl 4-[({3'-[(2S)-2-[(trans-4-[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)carbonyl]amino}-3-[4-(3-chloro-4H-1,2,4-triazol-5-yl)phenyl]amino}-3-oxopropyl]-2-methylbiphenyl-4-yl}sulphonyl)amino]piperidine-1-carboxylate[ No CAS ]
N-alpha-[(trans-4-[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)carbonyl]-3-{6-[3-(dimethylamino)propoxy]pyridin-3-yl}-N-[4-(1H-tetrazol-5-yl)phenyl]-L-phenylalaninamide[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-[5'-(benzylsulphamoyl)-2'-methylbiphenyl-3-yl]-1-oxo-1-[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-1-oxo-3-(3'-[2-(pyrrolidin-1-yl)ethyl]carbamoyl}biphenyl-3-yl)-1-[4-(1H-tetrazol-5-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-[2'-fluoro-5'-(methylcarbamoyl)biphenyl-3-yl]-1-oxo-1-[4-(1H-tetrazol-5-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-(2'-methyl-4'-[(3R)-2-oxopiperidin-3-yl]carbamoyl}biphenyl-3-yl)-1-oxo-1-[2-(pentafluoroethyl)-1H-benzimidazol-6-yl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate[ No CAS ]
tert-butyl [(trans-4-[(2S)-3-(4'-[4-(dimethylamino)cyclohexyl]carbamoyl}-2'-methylbiphenyl-3-yl)-1-[3-fluoro-4-(1H-tetrazol-5-yl)phenyl]amino}-1-oxopropan-2-yl]carbamoyl}cyclohexyl)-methyl]carbamate[ No CAS ]
N-alpha-[(trans-4-[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)carbonyl]-3-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-N-[4-(1H-tetrazol-5-yl)phenyl]-L-phenylalaninamide[ No CAS ]
3-(6-amino-2-methylpyridin-3-yl)-N-alpha-[(trans-4-[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)carbonyl]-N-[4-(1H-tetrazol-5-yl)phenyl]-L-phenylalaninamide[ No CAS ]
tert-butyl 4-[5-(3-{(2S)-2-[(trans-4-[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)carbonyl]amino}-3-oxo-3-[(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)amino]propyl}phenyl)pyrimidin-2-yl]piperazine-1-carboxylate[ No CAS ]
tert-butyl 4-(5-{3-[(2S)-2-[(trans-4-[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)carbonyl]-amino}-3-oxo-3-[4-(1H-tetrazol-5-yl)phenyl]amino}propyl]phenyl}pyrimidin-2-yl)piperazine-1-carboxylate[ No CAS ]
N-alpha-[(trans-4-[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)carbonyl]-3-[2-(4-methylpiperazin-1-yl)pyrimidin-5-yl]-N-[4-(1H-tetrazol-5-yl)phenyl]-L-phenylalaninamide[ No CAS ]
N-alpha-[(trans-4-[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)carbonyl]-3-[2-(dimethylamino)pyrimidin-5-yl]-N-[4-(1H-tetrazol-5-yl)phenyl]-L-phenylalaninamide[ No CAS ]
N-alpha-[(trans-4-[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)carbonyl]-3-[6-(dimethylamino)pyridin-3-yl]-N-[4-(1H-tetrazol-5-yl)phenyl]-L-phenylalaninamide[ No CAS ]
3-(5-aminopyridin-3-yl)-N-alpha-[(trans-4-[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)carbonyl]-N-[4-(1H-tetrazol-5-yl)phenyl]-L-phenylalaninamide[ No CAS ]
N-alpha-[(trans-4-[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)carbonyl]-3-[2-(dimethylamino)pyrimidin-5-yl]-N-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-L-phenylalaninamide[ No CAS ]
N-alpha-[(trans-4-[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)carbonyl]-3-[2-(morpholin-4-yl)pyrimidin-5-yl]-N-[4-(1H-tetrazol-5-yl)phenyl]-L-phenylalaninamide[ No CAS ]
Chemistry
Pharmaceutical Intermediates
Inhibitors/Agonists
Material Science
For Research Only
110K+ Compounds
Competitive Price
1-2 Day Shipping
