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Heat METHANESULFONIC acid 2- [4- (2-PYRIDIN-2-YL-5, 6-dihydro-4H-pyrrolo [1, 2- B] PYRAZOL-3-YL) -QUINOLIN-7-YLOXY]-ETHYL ESTER (87 MG, 0.19 MMOL) WITH MORPHOLINE (1 mL) at 50 C for 4 hours. Remove the morpholine in vacuo and then extract the product with isopropyl alcohol : chloroform (1: 3). Wash the organic layer with sodium chloride and dry over sodium sulfate. Concentrate in vacuo to give the desired title product as a slight yellow solid (83 mg, 100percent). MS ES+m/e 442.0 (M+1).
Reference:
[1] Patent: WO2004/48382, 2004, A1, . Location in patent: Page 7
[2] Journal of Medicinal Chemistry, 2008, vol. 51, # 7, p. 2302 - 2306