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CAS No. : | 654676-12-7 | MDL No. : | MFCD29089359 |
Formula : | C18H19Br2N | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | YSUUFISKPJBPOH-UHFFFAOYSA-N |
M.W : | 409.16 | Pubchem ID : | 25150458 |
Synonyms : |
|
Num. heavy atoms : | 21 |
Num. arom. heavy atoms : | 13 |
Fraction Csp3 : | 0.33 |
Num. rotatable bonds : | 5 |
Num. H-bond acceptors : | 0.0 |
Num. H-bond donors : | 0.0 |
Molar Refractivity : | 100.14 |
TPSA : | 4.93 Ų |
GI absorption : | Low |
BBB permeant : | No |
P-gp substrate : | Yes |
CYP1A2 inhibitor : | Yes |
CYP2C19 inhibitor : | Yes |
CYP2C9 inhibitor : | Yes |
CYP2D6 inhibitor : | Yes |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -3.83 cm/s |
Log Po/w (iLOGP) : | 4.27 |
Log Po/w (XLOGP3) : | 6.99 |
Log Po/w (WLOGP) : | 6.9 |
Log Po/w (MLOGP) : | 5.57 |
Log Po/w (SILICOS-IT) : | 6.16 |
Consensus Log Po/w : | 5.98 |
Lipinski : | 1.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 1.0 |
Muegge : | 2.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -6.91 |
Solubility : | 0.0000505 mg/ml ; 0.000000123 mol/l |
Class : | Poorly soluble |
Log S (Ali) : | -6.91 |
Solubility : | 0.0000505 mg/ml ; 0.000000124 mol/l |
Class : | Poorly soluble |
Log S (SILICOS-IT) : | -8.16 |
Solubility : | 0.00000282 mg/ml ; 0.0000000069 mol/l |
Class : | Poorly soluble |
PAINS : | 0.0 alert |
Brenk : | 0.0 alert |
Leadlikeness : | 2.0 |
Synthetic accessibility : | 2.09 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
99% | With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water; toluene at 80℃; for 14 h; | General procedure: A mixture of the corresponding 2,7-disubstituted 9H-carbazole (for the synthesis see Supplementary data) (10mmol), alkylbromide (10.5mmol), BnEt3NCl (0.227g, 1mmol), toluene (20mL) and NaOH solution (0.42g, 10.5mol, in water 50percentw/v) was stirred at 80°C for 14h. Then the reaction mixture was cooled to rt., poured into 50mL of water and acidified with 10percent hydrochloric acid to pH∼2. Organic layer was separated and water phase additionally was extracted with toluene (2×10mL). Combined extracts were washed with water (2×25mL), dried over Na2SO4, filtered and evaporated to dryness. The obtained crude products of the alkylation reaction were purified by column chromatography to give N-alkylcarbazoles 1a–f. |
99.8% | With sodium hydride In dimethyl sulfoxide at 20 - 30℃; Inert atmosphere | Under the protection of argon, in 100 ml of the three-port are sequentially added in the bottle 2,7-dibromo diphenylenimine 4.88g (15mmol), hydrogenated sodium 0.72g, DMSO solvent 30 ml, controlling the reaction temperature 20-30°C, dropwise 1-bromo-hexane, HPLC detection reaction is ended. 100 ml water quenching, with 100 ml dichloromethane extraction, layered, for water 50 ml dichloromethane extraction, combined with the phase, drying by anhydrous magnesium sulphate, pressure reducing and recovering the solvent, the crude solid obtained, using dichloromethane-methanol of performing recrystallization, get white product 2,7-di-bromo-N-hexyl carbazole 5.87g, purity 99.8percent (HPLC), the yield of 95.6percent, melting point 70.6-72.5 °C. 1 HNMR (400MHz, CDCl 3), δ: 0.858-0.906 (3H, t), 1.295-1.351 (6H, m), 1.786-1.885 (2H, m), 4.168-4.217 (2H, t), 7.320-7.354 (2H, dd), 7.525-7.530 (2H, d), 7.875-7.903 (2H, d). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
99% | With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide; In water; toluene; at 80℃; for 14h; | General procedure: A mixture of the corresponding 2,7-disubstituted 9H-carbazole (for the synthesis see Supplementary data) (10mmol), alkylbromide (10.5mmol), BnEt3NCl (0.227g, 1mmol), toluene (20mL) and NaOH solution (0.42g, 10.5mol, in water 50%w/v) was stirred at 80C for 14h. Then the reaction mixture was cooled to rt., poured into 50mL of water and acidified with 10% hydrochloric acid to pH∼2. Organic layer was separated and water phase additionally was extracted with toluene (2×10mL). Combined extracts were washed with water (2×25mL), dried over Na2SO4, filtered and evaporated to dryness. The obtained crude products of the alkylation reaction were purified by column chromatography to give N-alkylcarbazoles 1a-f. |
99.8% | With sodium hydride; In dimethyl sulfoxide; at 20 - 30℃;Inert atmosphere; | Under the protection of argon, in 100 ml of the three-port are sequentially added in the bottle 2,7-dibromo diphenylenimine 4.88g (15mmol), hydrogenated sodium 0.72g, DMSO solvent 30 ml, controlling the reaction temperature 20-30C, dropwise 1-bromo-hexane, HPLC detection reaction is ended. 100 ml water quenching, with 100 ml dichloromethane extraction, layered, for water 50 ml dichloromethane extraction, combined with the phase, drying by anhydrous magnesium sulphate, pressure reducing and recovering the solvent, the crude solid obtained, using dichloromethane-methanol of performing recrystallization, get white product 2,7-di-bromo-N-hexyl carbazole 5.87g, purity 99.8% (HPLC), the yield of 95.6%, melting point 70.6-72.5 C. 1 HNMR (400MHz, CDCl 3), δ: 0.858-0.906 (3H, t), 1.295-1.351 (6H, m), 1.786-1.885 (2H, m), 4.168-4.217 (2H, t), 7.320-7.354 (2H, dd), 7.525-7.530 (2H, d), 7.875-7.903 (2H, d). |
87.3% | To a mixture of compound 11 (18.09g, 0.053mol) in THF (74mL) was added KI (0.094g, 0.53mmol), sodium tert-butoxide (21.37g, 0.221mol) and 1-bromohexane (10.2mL, 0.074mol). The resulting solution was stirred at 80C for 9h. Then pyridine (7.4mL) was added and the whole system was refluxed for 30min. The above solution was quenched with 1N HCl to neutral and then extracted with ethyl acetate (50mL×3). The organic layer was collected and dried over MgSO4(S). After filtration and removal of the solvent, the crude product was purified with column chromatography on silica gel using hexane as eluent to afford the white solid with yield of 87.3% (19.85g). 1H NMR (300MHz, CDCl3) δ: 7.81-7.78 (d, J=8.4Hz, 2H, H5), 7.467-7.462 (d, J=1.5Hz, 2H, H2), 7.30-7.27 (dd, J1=8.1Hz, J2=1.5Hz, 2H, H4), 4.10-4.05 (m, 2H, Hf), 1.79-1.74 (m, 2H, He), 1.29 (m, 6H, Hb, Hc, Hd), 0.88-0.83 (m, 3H, Ha); 13C NMR (75MHz, CDCl3) δ: 141.24 (C1), 122.43 (C4), 121.37 (C5), 121.18 (C6), 119.62 (C3), 111.89 (C2), 43.24 (Cf), 31.44 (Ce), 28.69 (Cd), 26.79 (Cc), 22.50 (Cb), 13.96 (Ca); MALDI-TOF (m/z): [M]+ calcd for C18H19Br2N, 409.1639; found, 409.1652. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
78% | General procedure: To a stirred suspension of AlCl3 (2.0g, 15mmol) in 1,2-dichloroethane (30mL) at 0C phthalic anhydride (1.11g, 7.5mmol) was added in one portion. The flask was removed from an ice bath and the reaction mixture was left to warm to rt. After 45min the reaction mixture was again cooled in an ice bath and nitromethane (0.802mL, 15mmol) was added dropwise (synthesis of 2f was carried without nitromethane). The mixture was stirred for 15min and a solution of corresponding 1a-f (3mmol) in 1,2-dichloroethane (3mL) was added dropwise. The resulting red solution was stirred at rt for 48h, then cooled in an ice bath and quenched with 20% hydrochloric acid (10mL). Resulting slurry was stirred for 1h and filtered. Filter cake was washed with water (50mL) and dichloromethane (10mL). Crude products were dried and recrystallized to afford 2a-f as white solids. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
78% | <strong>[654676-12-7]2,7-dibromo-9-hexyl-9H-carbazole</strong> (1.64g, 4.0mmol) was dissolved in 40mL anhydrous THF in a well-dried flask. A solution of n-BuLi (1.7mL, 2.4M) was added dropwise in 10min. After the addition, it was stirred for another 1h and treated with pre-dried DMF (0.37g, 5.0mmol) before moved to room temperature. After stirring overnight, the mixture was quenched with saturated aqueous NH4Cl solution and extracted with ethyl acetate. The organic layer was washed with brine and dried over anhydrous Na2SO4. After removing the solvent, the residue was purified by column chromatography on silica gel (hexane/CH2Cl2, 1:1) to give compound 3 as pale yellow solid (1.11g, 3.1mmol, 78%). 1H NMR (400MHz, CDCl3, δppm): 10.14 (s, 1H), 8.16 (d, J=8.0Hz, 1H), 7.97 (d, J=8.4Hz, 1H), 7.93 (s, 1H), 7.75 (d, J=8.0Hz, 1H), 7.57 (s, 1H), 7.37 (d, J=8.4Hz, 1H), 4.30 (t, J=7.2Hz, 2H), 1.89-1.82 (m, 2H), 1.38-1.26 (m, 6H), 0.88 (t, J=7.2Hz, 3H). 13C NMR (100MHz, CDCl3, δppm): 192.6, 142.8, 140.2, 134.2, 127.5, 122.9, 122.6, 121.8, 121.6, 120.8, 120.6, 112.3, 109.9, 43.5, 31.6, 29.0, 27.0, 22.7, 14.2. ESI-MS: m/z=357.6. Anal. Calcd for C19H20BrNO (Mw=358.28): calcd. C, 63.70; H, 5.63; N, 3.91. found C, 64.13; H, 5.21; N, 3.98. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
65.4% | With tris-(dibenzylideneacetone)dipalladium(0); tris-(o-tolyl)phosphine In ethanol; toluene at 80℃; | 1.2 (2) synthesis of 2,7-bis (4-bromophenyl)-N-hexyl carbazole (b) Under the protection of argon gas, in a 100 ml three-neck bottle P is sequentially added in the boric acid 6.53g (30mmol), 2,7-di-bromo-N-hexyl carbazole 5.87g, potassium phosphate 2.96g, three pairs (TPTP) 0.05g tolyl phosphine, toluene 20 ml, ethanol 5 ml, by adding three (dibenzylidene acetone) two palladium (Pd 2 (dba) 3) 0.04g, control the reaction temperature to 80 °C, HPLC detection reaction is ended, is added to the reaction solution in 30 ml water, 30 ml dichloromethane extraction, anhydrous magnesium sulphate dried, and recovering the solvent under reduced pressure, to obtain yellow solid, by adding methanol is recrystallized, filtering, 10 ml of toluene and 10 ml methanol mixed solvent recrystallization, to obtain white solid 5.26g, purity 97.4% (HPLC), the yield is 65.4%, melting point: 221.7-222.9 °C. 1 HNMR (400MHz, CDCl 3), δ: 0.841-0.876 (3H, t), 1.256-1.887 (6H, m), 1.869-1.943 (2H, m), 4.339-4.375 (2H, t), 7.409-7.433 (2H, dd), 7.520-7.522 (2H, d), 7.561-7.616 (8H, m), 8.113 (1H, s), 8.134 (1H, s). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
51.2% | With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene; at 80℃; for 24h;Inert atmosphere; | To a mixture of compound 12 (19.8g, 48.36mmol) and diphenylamine (8.17g, 48.79mmol) in toluene (98mL) was added 110 BINAP (0.88g, 1.43mmol), Pd2 (dba)3 (0.440g, 0.485mmol), sodium tert-butoxide (2.68g, 27.84mmol) and the resulting solution stirred at 80C under Ar atmosphere for 24h. After cooling to the r.t., H2O (100mL) was added to the reaction mixture which was then extracted with ethyl acetate and the organic layer was dried over MgSO4(S). After filtration and removal of the solvent, the crude product was purified through column chromatography on silica gel using hexane as eluent to give the final purified product as pale-yellow oil with yield of 51.2% (12.36g). 1H NMR (300MHz, CDCl3) δ: 7.88-7.85 (d, J=8.4Hz, 1H, H12), 7.82-7.79 (d, J=8.1Hz, 1H, H13), 7.457-7.452 (d, J=1.5Hz, 1H, H15), 7.29-7.25 (m, 5H, H2, H9), 7.24-7.22 (m, 2H, H1), 7.15-7.14 (m, 1H, H8), 7.12-7.11 (m, 1H, H6), 7.07-6.98 (m, 4H, H3), 4.08-4.03 (m, 2H, Hf), 1.74-1.69 (m, 2H, He), 1.23-1.22 (m, 6H, Hb, Hc, Hd), 0.85-0.81 (m, 3H, Ha); 13C NMR (75MHz, CDCl3) δ: 148.10 (C4), 146.59 (C7), 141.66 (C5), 141.55 (C16), 129.14 (C2), 123.94 (C3), 122.54 (C1), 121.98 (C12), 121.83 (C14), 120.87 (C13), 118.31 (C10), 117.98 (C11), 117.71 (C9), 117.32 (C15), 111.49 (C8), 104.82 (C6), 42.88 (Cf), 31.40 (Ce), 28.63 (Cd), 26.68 (Cc), 22.40 (Cb), 13.96 (Ca); MALDI-TOF (m/z): [M]+ calcd for C30H29BrN2, 496.1514; found, 496.1527. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
49% | A mixtureof <strong>[654676-12-7]2,7-dibromo-9-hexyl-9H-carbazole</strong> (1) (920 mg, 2.3 mmol), CuI (1.7 g, 8.9 mmol), and dry DMF (2 ml) was stirred at room temperature for 10 min. Then, MeONa solution in MeOH (5.4 mol/l, 12.8 ml, 7.8 mmol) was added dropwise to the mixture and it turned yellow-green, the mixture was heated under reflux for 22 h. After that, the mixture was cooled to room temperature, precipitate was filtered off, filter cake was washed with EtOAc. Filtrate was concentrated under reduced pressure, and the residue was purified by column chromatography on silica gel, eluent petroleum ether - EtOAc, 30:1. Yield 340 mg (49%), white crystals, mp 73.9-74.3C. 1H NMR spectrum (Me2CO-d6), δ, ppm (J, Hz): 7.89 (2H, d, J = 8.4, H Ar); 7.06 (2H, d, J = 2.0, H Ar); 6.80 (2H, dd, J = 8.4, J = 2.4, H Ar); 4.35 (2H, t, J = 7.2, NCH2CH2); 3.90 (6H, s, 2OCH3); 1.91-1.83 (2H, m, NCH2CH2); 1.46-1.25 (6H, m, CH2CH2CH2); 0.87 (3H, t, J = 6.8, CH3). 13C NMR spectrum (DMSO-d6), δ, ppm: 158.2; 141.9; 120.5; 116.5; 107.5; 94.1; 55.9; 42.5; 31.5; 28.6; 26.5; 22.5; 14.3. Found, m/z: 312.1958 [M+H]+. C20H26NO2. Calculated, m/z: 312.1958. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
81% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In 1,2-dimethoxyethane; water; at 105℃; for 12h;Inert atmosphere; | 2,7-Dibromo 9-hexyl-9H-carbazole (2mmol, 0.8g), 4-formylphenylboronic acid (4.4mmol, 0.66g), anhydrous potassium carbonate (20mmol, 2.76g), tetrakis(triphenyl) Phosphine) palladium (0.2mmol, 0.23g), deionized water 5mL,Add 20mL of ethylene glycol dimethyl ether into a 100mL three-necked flask together, and vacuum repeatedly,Blow nitrogen gas 3 times, heat to 105C to reflux, and stir vigorously for 12 hours. After the completion of the reaction, 80 mL of water was added to quench the reaction, extracted with dichloromethane, and the organic phase was dried with anhydrous magnesium sulfate and filtered.The solvent was evaporated under reduced pressure, and the crude product was separated and purified by a chromatography column.The eluent is petroleum ether and ethyl acetate with a ratio of 5:1.The obtained crude product was recrystallized with absolute ethanol to obtain 0.75 g of an intermediate aromatic dialdehyde powder with a yield of 81%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
67% | With 1,1'-bis(diphenylphosphanyl)ferrocene; Potassium phosphate, dibasic; [1,2-bis(diphenylphosphino)ethane]dichloronickel(II); palladium diacetate; zinc powder In N,N-dimethyl acetamide at 100℃; for 12h; Inert atmosphere; Molecular sieve; | 17 Example 17 2.0 equiv of benzothiazole methyl sulfide (0.2 mmol, 36.2 mg), 1.0 equiv of 2,7-dibromo-9-hexyl-9H-carbazole (0.1 mmol, 40.9 mg), Pd(OAc) 2 ( 0.02mmol, 4.5mg) and Ni(dppe)Cl2 (0.02mmol, 10.6mg), 1-1'-bis(diphenylphosphorus)ferrocene (0.02mmol, 11.1mg), 2.0 equiv of dipotassium hydrogen phosphate (0.4 mmol, 69.7 mg) and 2.5 equivalents of zinc powder (0.5 mmol, 32.5 mg) were placed in a reaction vial. After three nitrogen purges, dry dimethylacetamide (2.0 mL) was added. After stirring at 100 °C for 12 hours, saturated sodium chloride solution was added to the reaction system to quench the reaction, then the organic phase was extracted three times with dichloromethane, the organic phase was dewatered by anhydrous sodium sulfate, and then the organic solvent was removed under reduced pressure, and the organic phase was removed by rapid Column machine gave a white solid (22.9 mg, 67%). |
67% | With 1,1'-bis(diphenylphosphanyl)ferrocene; Potassium phosphate, dibasic; [1,2-bis(diphenylphosphino)ethane]dichloronickel(II); palladium diacetate; zinc powder In N,N-dimethyl acetamide at 100℃; for 12h; Inert atmosphere; Schlenk technique; Molecular sieve; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / 1,4-dioxane / 8 h / 80 °C / Inert atmosphere 2: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / 1,4-dioxane / 80 °C / Inert atmosphere | ||
Multi-step reaction with 2 steps 1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 8 h / 80 °C / Inert atmosphere 2: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / 1,4-dioxane / 80 °C / Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane at 80℃; Inert atmosphere; | 2.3 (3) Take 0.5 g of the product obtained in step (1), dissolve it in 20 mL of 1,4-dioxane solution, add 0.9 equivalent of p-cyanophenylboronic acid, 5% equivalent of tetrakis(triphenylphosphine) palladium , 3 equivalents of potassium carbonate, were reacted at 80°C under the protection of argon for 8 hours, and the product was obtained by column chromatography. | |
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane at 80℃; Inert atmosphere; | 2.3 (3) Take 0.5 g of the product obtained in step (1), dissolve it in 20 mL of 1,4-dioxane solution, add 0.9 equivalent of p-cyanophenylboronic acid, 5% equivalent of tetrakis(triphenylphosphine) palladium , 3 equivalents of potassium carbonate, were reacted at 80°C under the protection of argon for 8 hours, and the product was obtained by column chromatography. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In 1,4-dioxane at 80℃; Inert atmosphere; | 2.2 (2) Take 0.5 g of the product obtained in step (1), add 20 mL of 1,4-dioxane solution, add 3 equivalents of bis(pinacolato)diboron, 3 equivalents of potassium acetate, 5% equivalents of [1, 1'-bis(diphenylphosphino)ferrocene]palladium dichloride, was reacted for 8 hours at 80°C under the protection of argon, and the product was obtained by column chromatography. | |
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In 1,4-dioxane at 80℃; Inert atmosphere; | 2.2 (2) Take 0.5 g of the product obtained in step (1), add 20 mL of 1,4-dioxane solution, add 3 equivalents of bis(pinacolato)diboron, 3 equivalents of potassium acetate, 5% equivalents of [1, 1'-bis(diphenylphosphino)ferrocene]palladium dichloride, was reacted for 8 hours at 80°C under the protection of argon, and the product was obtained by column chromatography. |
Tags: 654676-12-7 synthesis path| 654676-12-7 SDS| 654676-12-7 COA| 654676-12-7 purity| 654676-12-7 application| 654676-12-7 NMR| 654676-12-7 COA| 654676-12-7 structure
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P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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