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With palladium diacetate; potassium carbonate; di-(1-adamantyl)-n-butylphosphine In 1,4-dioxane; lithium hydroxide monohydrate at 95℃; for 12h; Inert atmosphere;
2 Procedure a:
n a 100 mL round-bottomed flask, add 3,3-dibromooctahydrobinaphthol (3.0 mmol, 1.0 equiv), p-isobutoxyphenylboronic acid (9.0 mmol, 3.0 equiv), Palladium acetate (0.15 mmol, 5.0 mol%), diadamantane-n-butylphosphine (0.15 mmol, 5.0 mol%), then 30 mL of 1,4-dioxane and 20 mL of potassium carbonate aqueous solution (concentration 1 mol/L).The reaction was stirred under an argon atmosphere in a 95°C oil bath for 12 hours and then cooled to room temperature.To the reaction was added 20 mL of water and extracted twice with ethyl acetate (30 mL each).The organic layers were combined, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The crude product is separated by column chromatography and obtains compound E2 (petroleum ether: ethyl acetate=50:1, volume ratio), productive rate 96%, output 1.70 grams;