[ CAS No. 65090-78-0 ] {[proInfo.proName]}

Name: 65090-78-0|2-Bromo-3-methoxypropanoic acid|95%
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Quality Control of [ 65090-78-0 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 65090-78-0 ]

Product Details of [ 65090-78-0 ]

CAS No. :	65090-78-0	MDL No. :	MFCD13185991
Formula :	C₄H₇BrO₃	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	PSAODTDHXIDDAT-UHFFFAOYSA-N
M.W :	183.00	Pubchem ID :	14606922
Synonyms :

Calculated chemistry of [ 65090-78-0 ]

Physicochemical Properties

Num. heavy atoms :	8
Num. arom. heavy atoms :	0
Fraction Csp3 :	0.75
Num. rotatable bonds :	3
Num. H-bond acceptors :	3.0
Num. H-bond donors :	1.0
Molar Refractivity :	32.07
TPSA :	46.53 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-7.08 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.12
Log Po/w (XLOGP3) :	0.47
Log Po/w (WLOGP) :	0.48
Log Po/w (MLOGP) :	0.21
Log Po/w (SILICOS-IT) :	0.35
Consensus Log Po/w :	0.53

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	2.0
Bioavailability Score :	0.56

Water Solubility

Log S (ESOL) :	-1.07
Solubility :	15.5 mg/ml ; 0.0846 mol/l
Class :	Very soluble
Log S (Ali) :	-1.02
Solubility :	17.6 mg/ml ; 0.0964 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-0.69
Solubility :	37.6 mg/ml ; 0.206 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	1.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.44

Safety of [ 65090-78-0 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 65090-78-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 65090-78-0 ]
Downstream synthetic route of [ 65090-78-0 ]

[ 65090-78-0 ] Synthesis Path-Upstream 1~4

1
[ 65090-78-0 ]
[ 19794-53-7 ]

Reference： [1] Journal of Agricultural and Food Chemistry, 1995, vol. 43, # 4, p. 867 - 871

2
[ 27704-96-7 ]
[ 65090-78-0 ]

Reference： [1] Org.Synth.Coll.Vol., 1955, vol. III, p. 775
[2] Journal of Biological Chemistry, 1936, vol. 116, p. 796
[3] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 11, p. 3079 - 3096
[4] Journal of Agricultural and Food Chemistry, 1995, vol. 43, # 4, p. 867 - 871
[5] Patent: WO2004/47538, 2004, A1, . Location in patent: Page 53
[6] Patent: WO2004/48316, 2004, A1, . Location in patent: Page 42
[7] Patent: WO2004/108694, 2004, A1, . Location in patent: Page 52

3
[ 124-41-4 ]
[ 3674-13-3 ]
[ 65090-78-0 ]

Reference： [1] Patent: WO2010/52011, 2010, A1, . Location in patent: Page/Page column 26

4
[ 10443-65-9 ]
[ 124-41-4 ]
[ 6214-29-5 ]
[ 65090-78-0 ]

Reference： [1] Journal of the Chemical Society, 1947, p. 1033

[ 65090-78-0 ] Synthesis Path-Downstream 1~11

1
[ 10443-65-9 ]
[ 124-41-4 ]
[ 6214-29-5 ]
[ 65090-78-0 ]

Reference： [1]Journal of the Chemical Society,1947,p. 1033

2
[ 65090-78-0 ]
[ 51293-45-9 ]

Reference： [1]Arhiv za Kemiju,1955,vol. 27,p. 149,152

3
[ 27704-96-7 ]
[ 65090-78-0 ]

Yield	Reaction Conditions	Operation in experiment
		Methyl 2-bromo-3-methoxypropionate (L. OOG) in tetrahydrofuran (8ml) was stirred at 10C and lithium hydroxide monohydrate (0.21g) in water (1. 5ML) was added dropwise. On complete addition, the mixture was stirred for 1.5 hours, the colourless solution was evaporated under reduced pressure to a small volume then the aqueous solution was taken to pH 3 with dilute sulphuric acid. The mixture was extracted with diethyl ether (SOML) and the organic phase separated, washed with brine, dried over magnesium sulphate then evaporated under reduced pressure to give the required product (0.6g) as a colourless liquid. IH NMR (CDC13) 8 : 3.45 (3H, s); 3.78 (1H, M) ; 3.92 (1H, M) ; 4.38 (1H, M) ; 6.65 (1H, br s).
	With lithium hydroxide; water; In tetrahydrofuran; at 10℃; for 1.5h;	EXAMPLE 3 This Example illustrates the preparation OF 2-(3-CYANO-5-METHOXYPHENOXY)-N-(2- methylpent-3-yn-2-yl) -3-methoxypropionamide (Compound No. 16 in Table 1) Stage 1: Preparation OF 2-BROMO-N-(4-METHYLPENT-2-AN-4-YL) 3-METHOXYPROPIONAMIDE. Step 1: Preparation of 2-bromo-3-methoxypropionic acid. Methyl 2-BROMO-3-METHOXYPROPIONATE (1. OOG) in tetrahydrofuran (8ml) was stirred at 10C and lithium hydroxide monohydrate (0. 21G) in water (1. 5ML) was added dropwise. On complete addition, the mixture was stirred for 1.5 hours. The colourless solution was evaporated under reduced pressure to a small volume and the aqueous solution was taken to pH 3 with dilute sulphuric acid. The mixture was extracted with diethyl ether (50ML) and the organic phase separated, washed with brine, dried over magnesium sulphate then evaporated under reduced pressure to give the required product (0.6g) as a colourless liquid. 'H NMR (CDC13) 8 : 3.45 (3H, s); 3.78 (1H, m); 3.92 (1H, m); 4.38 (1H, m); 6.65 (1H, br s).
		Methyl 2-bromo-3-methoxypropionate (l.OOg) in tetrahydrofuran (8ml) was stirred at10C and lithium hydroxide monohydrate (0.21g) in water (1.5ml) was added dropwise.On complete addition, the mixture was stirred for 1.5 hours. The colourless solution wasevaporated under reduced pressure to a small volume and the aqueous solution was takento pH 3 with dilute sulphuric acid. The mixture was extracted with diethyl ether (50ml)and the organic phase separated, washed with brine, dried over magnesium sulphate thenevaporated under reduced pressure to give the required product (0.6g) as a colourlessliquid.'H NMR (CDC13) 5: 3.45(3H, s); 3.78(1H, m); 3.92(1H, m); 4.38(1H, m); 6.65(1H, bs).

Reference： [1]Organic syntheses. Collective volume,1955,vol. III,p. 775
[2]Journal of Agricultural and Food Chemistry,1995,vol. 43,p. 867 - 871
[3]Patent: WO2004/47538,2004,A1 .Location in patent: Page 53
[4]Patent: WO2004/48316,2004,A1 .Location in patent: Page 42
[5]Patent: WO2004/108694,2004,A1 .Location in patent: Page 52

4
[ 65090-78-0 ]
[ 74-89-5 ]
[ 6666-40-6 ]

Reference： [1]Nippon Kagaku Zasshi,1950,vol. 71,p. 214
Kyushu Mem.med.Sci.,1952,vol. 3,p. 1,7

5
[ 65090-78-0 ]
[ 18612-99-2 ]
[ 126135-45-3 ]

Reference： [1]Journal of Organic Chemistry,1990,vol. 55,p. 3498 - 3502

6
[ 65090-78-0 ]
[ 19794-53-7 ]

Reference： [1]Journal of Agricultural and Food Chemistry,1995,vol. 43,p. 867 - 871

8
2-acetoxymercurio-3-methoxy-propionic acid [ No CAS ]
[ 65090-78-0 ]

Reference： [1]Nippon Kagaku Zasshi,1950,vol. 71,p. 214
Kyushu Mem.med.Sci.,1952,vol. 3,p. 1,7

9
[ 65090-78-0 ]
[ 100-46-9 ]
[ 705283-58-5 ]

Yield	Reaction Conditions	Operation in experiment
		The solution of <strong>[65090-78-0]2-bromo-3-methoxy propionic acid</strong> (VId) (1 equiv, amount calculated by w/w assay) in isobutylacetate from previous step is cooled to -5 0C under stirring. Ethyl chloroformiate (1.1 equiv) is added so as to obtain a mass temperature between -5 and O0C. The addition funnel is rinsed with 0.1 volume isobutylacetate. N- methylmorpholine (1.1 equiv) is added slowly so as to obtain a mass temperature between -5 and 0C. The addition funnel is rinsed with 0.1 volume isobutylacetate. The solution is post-stirred for 30 min at -5/0 0C. Benzylamine (1.1 equiv) is added so as to obtain a mass temperature between -5C and 00C. The addition funnel is rinsed with 0.25 volume isobutylacetate. The reaction mixture is allowed to warm up to 25-30 C and post-stirred for about 1 hour (HPLC area of (VId) lower than 0,2%). 1 volume of water with respect to the initial solution of (VId) is added and the mixture stirred for 15 min. The aqueous layer is separated and the organic layer washed with water (0.5 volume). The solution is concentrated to ca. 2.5 - 3 volumes of isobutylacetate at 400C under vacuum and seeded with compound (Va) at 30-35 and the suspension cooled to room temperature till the crystallization is well initiated. At the same temperature, about 5 volumes of heptane are slowly added. Then the suspension is progressively cooled to -10 0C. The crystals are filtered, washed with chilled 1:2 iButOAc/heptane (1 volume) and heptane (2 volumes) and dried at 40 C under vacuum. 2-bromo-N-benzyl-3-methoxypropion-amide (Va) is isolated with a yield of 70% (vs ethyl dibromopropionate used in Step 1). (Va): mp 74-75 C; 1H NMR (CDCI3) delta 3.43 (s, OCH3), 3.87 (dd, J = 5.0, 10.7 Hz, CHH'O), 3.95 (dd, J = 4.6, 10.7 Hz, CHH'O), 4.43-4.50 (m, CH and CH2Ph), 6.93 (br s, NH), 7.24- 7.37 (m, 5 PhH); 13C NMR (CDCI3) 44.0, 47.9, 59.2, 73.6, 127.4, 127.5, 128.7, 137.4, 167.0 ppm.

Reference： [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 3079 - 3096
[2]Patent: WO2010/52011,2010,A1 .Location in patent: Page/Page column 27

10
[ 65090-78-0 ]
[ 412018-41-8 ]

Yield	Reaction Conditions	Operation in experiment
	With oxalyl dichloride; In DMF (N,N-dimethyl-formamide); dichloromethane; at 20℃; for 2.0h;	2-Bromo-3-methoxypropionic acid (0.366g) was dissolved in dry dichloro- methane (4ml) containing dry N, N-DIMETHYLFORMAMIDE (0. 05ML) with stirring and oxalyl chloride (0.254g) was added. The mixture was stirred at ambient temperature for 2 hours then evaporated under reduced pressure to give <strong>[65090-78-0]2-bromo-3-methoxypropionic acid</strong> chloride (C=O, v 1780CMS-1). The acid chloride was dissolved in dry dichloromethane (6ML) and 4-AMINO-4-METHYLPENT-2-YNE hydrochloride (0.267g) was added then the mixture was cooled to 3C and triethylamine (0.404g) was added dropwise, keeping the reaction temperature between 0-5C. The suspension that had formed was stirred at ambient temperature for 1 hour, diluted with further dichloromethane, washed with hydrochloric acid (2M) and the organic phase separated, dried over magnesium sulfate then evaporated under reduced pressure to give a gum. The gum was fractionated by chromatography (silica: hexane/ethyl acetate, 3: 2 by volume) to give the required product (0.3g) as a colourless solid. IH NMR (CDC13) 5 : 1.63 (6H, s); 1.82 (3H, s); 3.44 (3H, s); 3. 88 (2H, M) ; 4.32 (1H, M) ; 6.62 (1H, s)
	With oxalyl dichloride; In DMF (N,N-dimethyl-formamide); dichloromethane; at 20℃; for 2.0h;	2-Bromo-3-methoxypropionic acid (0. 51g) was dissolved in dry dichloromethane (LOML) containing DRYN, N-DIMETHYLFORMAMIDE (0. 05ML) with stirring and oxalyl chloride (0.36g) was added. The mixture was stirred at ambient temperature for 2 hours then evaporated under reduced pressure to give <strong>[65090-78-0]2-bromo-3-methoxypropionic acid</strong> chloride (C=O, v 1780CMS~L). The acid chloride was dissolved in dry dichloromethane (5ML) and added to 4-AMINO-1-METHOXY-4-METHYLPENT-2-YNE hydrochloride (0.46g) in dry dichloromethane (10ml) at 0C with stirring. Triethylamine (0. 78ML) was added dropwise, while keeping the reaction temperature between 4-9C. The suspension that had formed was stirred at ambient temperature for 2 hours, stored at ambient temperature for 18 hours, diluted with further dichloromethane and washed with aqueous sodium hydrogen carbonate then water (twice). The organic phase was separated, dried over magnesium sulphate and evaporated under reduced pressure to give a gum. The gum was fractionated by chromatography (silica: hexane/ethyl acetate) to give the required product (0.36g) as a colourless OIL, 1H NMR (CDC13) 8 : 1.66 (6H, s); 3.38 (3H, s); 3.44 (3H, s); 3.82-3. 90 (2H, q); 4.12 (2H, s); 4.30-4. 32 (1H, t); 6.62 (1H, s)
	With oxalyl dichloride; In DMF (N,N-dimethyl-formamide); dichloromethane; for 2.0h;	STEP 2: PREPARATION OF 2-BROMO-N-(4-METHYLPENT-2-YN-4-YL) 3-METHOXYPROPIONAMIDE. 2-BROMO-3-METHOXYPROPIONIC acid (0.366g) was dissolved in dry dichloro- methane (4ML) containing dry N, N-DIMETHYLFORMAMIDE (0. 05ML) with stirring and oxalyl chloride (0.254g) was added. The mixture was stirred at ambient temperature for 2 hours then evaporated under reduced pressure to give 2-BROMO-3-METHOXYPROPIONIC acid chloride (C=O, v 1780CMS~1). The acid chloride was dissolved in dry dichloromethane (6ML) and 4-amino-4-methylpent-2-yne hydrochloride (0.267g) was added. The mixture was cooled to 3C and triethylamine (0.404g) was added dropwise, while keeping the reaction temperature between 0-5C. The suspension that had formed was stirred at ambient temperature for 1 hour, diluted with further dichloromethane and washed with hydrochloric acid (2M). The organic phase was separated, dried over magnesium sulfate and evaporated under reduced pressure to give a gum. The gum was fractionated by chromatography (silica: hexane/ethyl acetate, 3: 2 by volume) to give the required product (0.300g) as a colourless SOLID.'H NMR (CDC13) 8 : 1. 63 (6H, s); 1.82 (3H, s); 3.44 (3H, s); 3.88 (2H, M) ; 4.32 (1H, m); 6.62 (1H, s).

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20℃; for 2.0h;

2-Bromo-3-methoxypropionic acid (Q.366g) was dissolved in dry dichloro-methane (4ml) containing dry TV, W-dimethylformamide (0.05ml) with stirring and oxalylchloride (0.254g)' was added. The mixture was stirred at ambient temperature for 2 hoursthen evaporated under reduced pressure to give <strong>[65090-78-0]2-bromo-3-methoxypropionic acid</strong>chloride ( C=O, v IVSOcms"1). The acid chloride was dissolved in dry dichloromethane(6ml) and 4-amino-4-methylpent-2-yne hydrochloride (0.267g) was added. The mixturewas cooled to 3C and triethylamine (0.404g) was added dropwise, while keeping thereaction temperature between 0-5C. The suspension that had formed was stirred atambient temperature for 1 hour, diluted with further dichloromethane and washed withhydrochloric acid (2M). The organic phase was separated, dried over magnesium sulfateand evaporated under reduced pressure to give a gum. The gum was fractionated bychromatography (silica: hexane / ethyl acetate, 3:2 by volume) to give the requiredproduct (0.300g) as a colourless solid.JH NMR (CDC13) 8: 1.63(6H, s); 1.82(3H, s); 3.44(3H, s); 3.88(2H, m); 4.32(1H, m);6.62(1H, s).

Reference： [1]Patent: WO2004/47538,2004,A1 .Location in patent: Page 53
[2]Patent: WO2004/47538,2004,A1 .Location in patent: Page 58
[3]Patent: WO2004/48316,2004,A1 .Location in patent: Page 42
[4]Patent: WO2004/108694,2004,A1 .Location in patent: Page 52-53

11
[ 124-41-4 ]
[ 3674-13-3 ]
[ 65090-78-0 ]

Yield	Reaction Conditions	Operation in experiment
		In a dry equipment under nitrogen, 2,3-dibromo ethyl propionate (VII) available commercially (1 equiv) is dissolved in 4 volumes of dry methanol and the solution is cooled to -10 0C under stirring. A 25% w/w solution of sodium methoxide in methanol (1.1 equiv) is slowly added such as the temperature is maintained below -5 0C. After addition, the mixture is allowed to warm to room temperature and the reaction is post-stirred at 20 0C for 1 hour.20 % aqueous sodium hydroxide (1 equiv) is added slowly at a temperature maintained below 23 0C. The reaction mixture is then stirred at 20 0C for 1 hour.37% aqueous HCI is slowly added till pH 5-6 and the reaction mixture concentrated to the minimal agitation volume, i.e. 1 volume vs compound (VII), under vacuum at a temperature of maximum 40 0C.37% aqueous HCI is added until the pH is 2 and the salty residue is taken in a minimum amount of water (~0.6 volumes) to get a solution and the compound (VId) is extracted with isobutylacetate (3 X 2 volumes). The organic layer is evaporated to ca. 4 volumes affording a solution of 2-bromo-3-methoxy propionic acid (VId).

Reference： [1]Patent: WO2010/52011,2010,A1 .Location in patent: Page/Page column 26

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P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 65090-78-0 ] {[proInfo.proName]}

Quality Control of [ 65090-78-0 ]

Related Doc. of [ 65090-78-0 ]

Product Details of [ 65090-78-0 ]

Calculated chemistry of [ 65090-78-0 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 65090-78-0 ]

Application In Synthesis of [ 65090-78-0 ]

[ 65090-78-0 ] Synthesis Path-Upstream 1~4

[ 65090-78-0 ] Synthesis Path-Downstream 1~11

Pharmaceutical Intermediates of [ 65090-78-0 ]

Lacosamide Intermediates

Lacosamide Intermediates

Related Functional Groups of [ 65090-78-0 ]

Aliphatic Chain Hydrocarbons

Bromides

Ethers

Carboxylic Acids

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Pharmaceutical Intermediates of
[ 65090-78-0 ]

Related Functional Groups of
[ 65090-78-0 ]